2CKI


Conserved Protein Domain Family
ZnMc_pappalysin_like
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cd04275: ZnMc_pappalysin_like 
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Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.
Links
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Statistics
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PSSM-Id: 239802
Aligned: 29 rows
Threshold Bit Score: 175.22
Created: 24-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2CKI; Methanosarcina Ulilysin with bound zinc and dipeptide
    - View structure with Cn3D
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2CKI_B         4 IVKIPVVVHVVWnee------------eeNISDAQIQSQIDILNKDFrklnsdvsqvpsvwsnliadlGIEFFLAtkdpn 71   Methanosarcina...
ABG58257       3 SITQPHMKYIYLllflfcs---plfvfsqNYSDTDTSKTVKLSSDAIsryyssgrnlrtsaandivplKIHVVIPessas 79   Cytophaga hutc...
BAA09140      69 SYVIPVVFHIYGdvq-----------sgkTVTYQKIVNHLQHLNDDFngrnadyqtvdpffqarrgtlKIEFKLA----- 132  Cytophaga sp.
BAD47449      40 HYNLPVIFHVLYkdknnp------lqyvkQDRLAKILDTVNKLYKDKtks---------------vdmNLTFTLAttdek 98   Bacteroides fr...
AAO75278     124 HYQLPVIFHVLYqnen---------dinqYIKEDHLKDVLVRTNHFYqsekc------------gidiNLEFVLAtkdkn 182  Bacteroides th...
ZP_00949300   85 VLTIPVVIHIIHdgdpinv---aggelseNISYAQAVSQVDVLNEDFrrlmgtpgag-etnynagvdvEIEFCLAtqdpn 160  Croceibacter a...
ZP_01053211  122 IVNIPVYVHVVYsns------------neNISDAQINSQIAVLNDDFrrtnndanntpsafagvaadtEITFSLA----- 184  Tenacibaculum ...
XP_426627   1032 PLHLPTSIFTFCnssan-------cargrLACETGLALRFAVLERVFsetal-----------nqeqlGFLGVNV----- 1088 chicken
CAG12416     428 DVCNPECNHPLTgydagdcmsghrsrcpeSKQGNGICDPECNWENFSydl----------------gdCCNPNITd---- 487  Tetraodon nigr...
ABG60213      69 IIRIPVVVHVIHnnaagii----ggtnntNISDAQVISQIVVLNKDYqhknadsvntraafkpvaancKFEFCLAevdpn 144  Cytophaga hutc...

Feature 1                                                                                        
2CKI_B        72 --gnqttGITRTQTSVtff---------ttSDEVKFass--------ggeDAWpa--drYLNIWVchvlks-eigqdILG 129  Methanosarcina...
ABG58257      80 --yidsiSIMREIGKAnlvfa-----sigiEFQLCG--------------AIDfipnnrWLNLDSyde------qweLLD 132  Cytophaga hutc...
BAA09140     133 -------KIDPNGGCTsg----------vvFHPAKNgfgngggyddqiaaDAWdn--tkYMNVYIqndlya-dgalnNSG 192  Cytophaga sp.
BAD47449      99 gnslptpGVKYVLWEEsypid----cdvfmNDETGKyv-----------kYIWep--nnYINVMVynfkddestnstTLG 161  Bacteroides fr...
AAO75278     183 gttlpepGVERVPFNElpidc----ekfmrDNTGKYt------------sLLWep--neYINIMVypft-----dsqILG 239  Bacteroides th...
ZP_00949300  161 --gaasnGVNRVNLCQesws------tadiDGIVKP--------------ETIwdp-tkYMNMWSvnft-----dssLLG 212  Croceibacter a...
ZP_01053211  185 -------GTFRNASTTtaw---------gtNNAVKS--------------AYPpvtpetHMNIWVani------gggILG 228  Tenacibaculum ...
XP_426627   1089 -------KQSPSHFSPkpvlvqhgstrgvtVLLVPCq------------gHCDle---aALSWKEcpvl----edmrESG 1142 chicken
CAG12416     488 -------VTRTCFNRSspyk------ayldVKELKE--------------ILQldg-stHLNIFFanss-----dedLAG 534  Tetraodon nigr...
ABG60213     145 --gnsttGITRTYTSKanft-------iaeETQLKS--------------LAYwps-dqYLNIWVcdlrgt-pstqlLLG 199  Cytophaga hutc...

Feature 1                                                                          ##  #     #   
2CKI_B       130 YAQFPGGPA----------------------ETDGVVIVDAAFGTtgtal------ppfdKGRTATHEIGHWLNLYHIWG 181  Methanosarcina...
ABG58257     133 AYNDPRTVDlfi----------------vaqINQISACGYASLGWdgdgfiv--iqnpcyNEDVLLHELGHYFNLYHTHD 194  Cytophaga hutc...
BAA09140     193 VAWYPDSGMta-------------------sNTARVVFNGAYLYDnsy---------steFSATLTHEFGHFLNLIHTFE 244  Cytophaga sp.
BAD47449     162 IAHIPFSTVgsnyleglsktqksylekqnlkFPYSVSINSLFINDqststq----ystadITVTLAHELGHYLGLHHAFS 237  Bacteroides fr...
AAO75278     240 ISTFPYSLKdfflegtqqvs-aswitlenlsFPYCISINSSYIYEqstder----inqndAAITLAHELGHYLGLRHVFS 314  Bacteroides th...
ZP_00949300  213 YAQFPNSSGlgglnt-----------nngpaDTDGVVSNYNAFGTlaqddgsfilnntynLGRTMTHEVGHYLGLRHIWG 281  Croceibacter a...
ZP_01053211  229 YAQFPGGSL----------------------ATDGIVVSPQYFGTtgyva------apfdGGRTTTHEVGHYLNLRHIWG 280  Tenacibaculum ...
XP_426627   1143 AAISSKDAVae------------------alLRGGVVLSPAYYGMp-------------gHTNTMIHEVGHVLGLYHVFK 1191 chicken
CAG12416     535 VATWPWDKEal-------------------tHLGGIVLNPSFYGTf-------------gHTDTMVHEIGHSLGLYHVFR 582  Tetraodon nigr...
ABG60213     200 YSSQPGGLPggdsn-------------dpqaNTDGVVINYKAFGTvgtlf------tkynLGRTASHEIGHWLGLLHTWG 260  Cytophaga hutc...

Feature 1                                                                                        
2CKI_B       182 delr----------fedpCSRSDEVDDTPNQADp-----NFGAPsy----------------pHVSCSNgp---nGDXFX 227  Methanosarcina...
ABG58257     195 dlygkel-----vngsncSTAGDFICDTPADPNlynmvsSQTCQy------------------TSSQTDangtvyHPNPA 251  Cytophaga hutc...
BAA09140     245 g----------------gCTGTDEVDDTPLEDGk----hTLACTq------------------GTNCNGd-----RVNNE 281  Cytophaga sp.
BAD47449     238 endeg---------iydgCFDSDYCDDTPTYNKv-----EYDADyaytakndpanftfdylvkRKNCKTn----qTFTST 299  Bacteroides fr...
AAO75278     315 eggt-----------tsmCTDTDYCKDTPSYNRs-----EYEQWlnnldkqnk--yqlkdlakRYSCEKg-----EYEAH 371  Bacteroides th...
ZP_00949300  282 dg---------------aCSVDDFCDDTPNSDGa-----NFGCAm------------------DSSCGS------MDMSE 317  Croceibacter a...
ZP_01053211  281 dg---------------rCNRDDFVADTPSSDRp-----NYGCPt-----------------tAYHCRS------NDQFM 317  Tenacibaculum ...
XP_426627   1192 gvserescddpcrettpsMETGDLCADTAPTPKs----kLCRDPdp----------------tNDTCGQmh--ftGTPFN 1249 chicken
CAG12416     583 gisevescndacletepsMETGDLCADTNPTPKy----kGCHDPdp----------------gNETCGCqd--ftHTPFN 640  Tetraodon nigr...
ABG60213     261 nfd------------sgyCNQTDYCTDTPVCANafa-aaSPACSdn----------------pPVKCTPd----iARMIE 307  Cytophaga hutc...

Feature 1                                                                                        
2CKI_B       228 NYXDYVDd-----------------------------------------------------------------------k 236  Methanosarcina...
ABG58257     252 NFMSYAPq-----------------------------------------------------------------------n 260  Cytophaga hutc...
BAA09140     282 NYMGYNGaq----------------------------------------------------------------------g 291  Cytophaga sp.
BAD47449     300 NIMDYSVs------------------------------------------------------------------------ 307  Bacteroides fr...
AAO75278     372 NIMDYAYc------------------------------------------------------------------------ 379  Bacteroides th...
ZP_00949300  318 NYMDYSDd-----------------------------------------------------------------------s 326  Croceibacter a...
ZP_01053211  318 NYMDYTDd-----------------------------------------------------------------------a 326  Tenacibaculum ...
XP_426627   1250 NYMSYTGvlrrdgvppvstgdpkpagwwhcpgagvamtaggdtrpprigaavrllrqchlvalgthdtseawpgsrrhdd 1329 chicken
CAG12416     641 NYMSYADd-----------------------------------------------------------------------s 649  Tetraodon nigr...
ABG60213     308 NYMDYSDd-----------------------------------------------------------------------a 316  Cytophaga hutc...

Feature 1                          
2CKI_B       237 CXVXFTQGQATRVNACLD 254  Methanosarcina acetivorans
ABG58257     261 CRNTFTPQQLQRMRFFYD 278  Cytophaga hutchinsonii ATCC 33406
BAA09140     292 CYKMYTQGQIDRMVAALE 309  Cytophaga sp.
BAD47449     308 YSDRFTNDQRSRIRHVLT 325  Bacteroides fragilis YCH46
AAO75278     380 FYNEITLEQRKRIRHILN 397  Bacteroides thetaiotaomicron VPI-5482
ZP_00949300  327 CMNTFTEDQKTRMLTVMM 344  Croceibacter atlanticus HTCC2559
ZP_01053211  327 CMNMFSEGQKERMRALFA 344  Tenacibaculum sp. MED152
XP_426627   1330 CTNTFTPNQVARMHCYLD 1347 chicken
CAG12416     650 CTDSFTLNQVARMHCYLD 667  Tetraodon nigroviridis
ABG60213     317 CMNLFTQDQKTRMRSSIE 334  Cytophaga hutchinsonii ATCC 33406

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