1F3O


Conserved Protein Domain Family
ABC_MJ0796_LolCDE_FtsE

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cd03255: ABC_MJ0796_LolCDE_FtsE 
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ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE
This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.
Statistics
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PSSM-Id: 213222
Aligned: 71 rows
Threshold Bit Score: 227.373
Created: 10-Jan-2005
Updated: 26-May-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:
  • Structure:1F3O; Mg-ATP bound, 4.0A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               ## ###                                  
1F3O_A        2 IKLKNVTKTYkxge-eiiyALKNVNLNIKEGEFVSIXGPSGSGKSTXLNIIGCL---DKPTEGEVYIDNiktndld--dd 75  Methanocaldococc...
NP_279782     8 VALDAVRKTYqrgg-qpvhALRDVSLRLPRGSYTAVVGPRGCGASTLLAVLGCL---AAPTSGRVVVDGtdvtqld--pt 81  Halobacterium sa...
NP_601218     3 LHVSNLNLTVadgs-tsrtLLNNITFDVQPGEVVGITGPSGSGKSTLLAVLGCL---QSADSGTATLGDidllnp----q 74  Corynebacterium ...
ZP_00128411   2 LNAQHLSHNFgp-----hwALKNVSFRLDKGDFLFLCGPSGAGKTTLLRMLYGA---LPVYRGSLSVAGfdlrnlk---t 70  Desulfovibrio de...
AAO09228      9 IELQQVSFTWkea---tqpILQIPHFSVARGEHVFIKGPSGCGKSTLLSLLTGI---NQVQSGQLTILGtelaals--ps 80  Vibrio vulnificu...
NP_796680     9 VELKQAQFVWpgs---etaVINIPDLQIATGEHVFIKGPSGCGKSTLLALLTGI---NTLSSGSLSVLNtnlatls--ss 80  Vibrio parahaemo...
NP_906636     4 IVVNGVSKVYhagkanaffALKKVHLEVEKGEVVILKGVSGSGKSTLLSLIGGL---SKPTEGEILVEGhniaklp--dv 78  Wolinella succin...
NP_968039     7 ITIRDLSYTYegq---knpTLHVPEFTVKKGEELFLYGPSGTGKTTLLEILAGV---LRPTSGTVQILGrdfvkms--ds 78  Bdellovibrio bac...
CAI09699      6 IRIEGLKKRYgggd-tavhALKDVAMDVAPGEVVGLIGPSGSGKSTLLKCLGAV---IDPTAGRMTLGDeviyddgwkvr 81  Azoarcus sp. EbN1
P16677        5 IRVEKLAKTFnq-----hqALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLitgDKSVGSHIELLGrtvqregr-la 78  Escherichia coli
Feature 1                     #                                                                 
1F3O_A       76 eltkiRRDKIGFVFQQFNLIPLLTALENVELPlifkyrgaxs------geerrkraleCLKXAELeerfanhkPNQLSGG 149 Methanocaldococc...
NP_279782    82 artdfRAETIGVVFPGTTVLPRRSAVENAALPllfqgvpgr---------qrrrrattALERAGLpashatrpAAALSGV 152 Halobacterium sa...
NP_601218    75 nraalRRNHLGIVFQQPNLLPSLTVLDQLLLIprlgrilppsrs---artqhkdkalsLLNSIGLgdla-krkVSELSGG 150 Corynebacterium ...
ZP_00128411  71 rqlpaLRRQVSVVFQDFKILPRRSVYDNIAIAlevrclqrv---------hidrrvraVARGLGLenrl-aapCGELSGG 140 Desulfovibrio de...
AAO09228     81 qrdkfRADNIGYIFQQFNLLPYLNVLENVLLPcqfsrtrathv-----egdarakaaqLLTRLHLpqslhlksVSELSIG 155 Vibrio vulnificu...
NP_796680    81 rrdrfRADHIGYIFQQFNLLPYLNVIDNVLLPcqfskvrrdrvtpnaskaellvqattLLERLHLptnlhsrpVSELSIG 160 Vibrio parahaemo...
NP_906636    79 msssyRHKSVGFIFQSFNLLAGLTVYQNVMAPlgltqlrga---------eieerihwALGVACIdhkk-hqkVGELSGG 148 Wolinella succin...
NP_968039    79 erdsfRAEHMGYVFQSFNLIPYLSVRENIELPlhlsparkarl----gsvdtemviraLCGNLGIsdll-ekgVTELSVG 153 Bdellovibrio bac...
CAI09699     82 dlralRRDRIGFVFQAPYLIPFLDVTDNVALLpmlagvpna---------earaqaleLLTALDVqhra-gamPSQLSGG 151 Azoarcus sp. EbN1
P16677       79 rdirkSRAHTGYIFQQFNLVNRLSVLENVLIGalgstpfwrtcfs-wftgeqkqralqALTRVGMvhfa-hqrVSTLSGG 156 Escherichia coli
Feature 1                           ##                                #                     
1F3O_A      150 QQQRVAIARALANNPPIILADEPTGALDSKTGEKIXQLLKKLNeedGKTVVVVTHDINVAr--FGERIIYLKDGEV 223 Methanocaldococcus j...
NP_279782   153 HRHRVALARALVADPAVVLVDEPAAALDADAGREIMAAITDQQd-aDTTVLVATHTARVAd--HADRRLALHDGAI 225 Halobacterium salina...
NP_601218   151 QQARVNLARALMNSPKLLLVDEPTAALDQHSASEVTELIVSMAhqyNAPTLFVSHDMDAVn--TLDRSIELVDGHL 224 Corynebacterium glut...
ZP_00128411 141 EQQRVAVARAVVVNPQILLADEPTGNLDPELALRMLDIFRQFHs-yGTTVIVATHNRELVerhPGARVLRLDEGKI 215 Desulfovibrio desulf...
AAO09228    156 QQQRVAAARALIGAPALVIADEPTSALDFDNRSAFIELLMEQAnaaNATLVFVSHDPTLEr--LFDRTVDLRQLNQ 229 Vibrio vulnificus CMCP6
NP_796680   161 QQQRVAAARALIGHPALVIADEPTSALDHDNRMAFIELLMEQAnqaNATLIFVSHDPTLEs--LFDRTINLPEINQ 234 Vibrio parahaemolyti...
NP_906636   149 ERQRCAIARAIVMNPAMILADEPTANLDAQNSLAFVEILKSFKq-mGKSVLIATHDPLFDevgEVDRSLMMRDGEI 223 Wolinella succinogen...
NP_968039   154 QQQRVAVARALLGKPDLLLADEPTSALDADHREKFLKLLFELSelyGTTVVFVSHDRSIEk--LFTRSISLESINK 227 Bdellovibrio bacteri...
CAI09699    152 EQQRVAIARGLVNRPPVILADEPTAPLDSERAMAVIRILNDMArkfETAVIVVTHDEKIIp--TFKRIYHIRDGVT 225 Azoarcus sp. EbN1
P16677      157 QQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINqndGITVVVTLHQVDYAl-rYCERIVALRQGHV 231 Escherichia coli

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