Conserved Protein Domain Family
VESA1_N

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pfam12785: VESA1_N 
Variant erythrocyte surface antigen-1
This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.
Statistics
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PSSM-Id: 463704
Aligned: 40 rows
Threshold Bit Score: 533.007
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001609756   50 AAVTDLLQSVELEYHgkysvvhqlitvpGYEGDGN--------ANGGATDADKTpqQHINDLFSLVQGLGGTAVVRTYID 121 
EDO06369       14 AAVTDLLQSVQLEYH-------------GYEGESE---------GKGANSDKVK--EHLNGLFSLVQGLGGTSVVRTYID 69  
EDO05473       17 meITIVQNSVQLEYH-------------GYQGDTKet-----daSKGASEQQVK--EHLNGLFSLVQGLGGTAVVRTYID 76  
XP_001609935   51 AAVTDLLQSVELEYN-------------GYQGEPK---------DKGATQDDVT--KHLNGLFSLVQGLGGTAVVRTYID 106 
EDO06999       46 AAVTDLLQSVELEYHgdv--------knGAEGDSK--------TTKGASADTVK--GHLNGLFSLVQGLGGTAVVRTYID 107 
XP_001609040   48 AAVTDLLQSVELEYH-------------GYQGDVKngaegdskTTKGASADTVK--GHLNGLFSLVQGLGGTAVVRTYID 112 
XP_001610497   47 AAVTDLLQSVELEYN-------------GYQGDVKdg----tdTSKGATEQQVK--GHLNGLFSLVQGLGGTAVVRTYID 107 
XP_001609168   24 AAVTDLLQSVQLEYH-------------GYEGEGAd-------TSKGATQEQVK--ERLNGLFSLVQGLVGTAVVRTYID 81  
XP_001611442   48 AAVADLLQSVELEYH-------------GYQGDTKead--ttgKNNLATEKQVT--DRLNGLFSLVQGLGGTAVVRTYID 110 
XP_001611736   49 AAVTDLLQSVELEYY-------------GYEGDVKegitdssgNDNRANAETVK--GHLNGLFSLVQGLGGTAVVRTYID 113 
XP_001609756  122 QLAQALSAIVGWSRIMKCQKydcntgtcqrgrgtghgkfK-CCCGNNGNHngglrcckgqngadggkcrngkvcdgsskg 200 
EDO06369       70 QLAQVLSALVGWSKITKCDN-------------------S-GCKGTSGTSgd---------------------------- 101 
EDO05473       77 QLAQVLSALVGWSRIEKCTGn------------------G-GCNGTSGTSgd---------------------------- 109 
XP_001609935  107 QLAQVLSALVGWSKIEKCGNgs----------------nG-KCQKDNKKH------------------------------ 139 
EDO06999      108 QLAQVLSALVGWSRIDKCPDk------------------G-TCVKDDKLH------------------------------ 138 
XP_001609040  113 QLAQVLSALVGWSRIVKCDGn------------------G-ECNGN---------------------------------- 139 
XP_001610497  108 QLAQVLSALVGWSKIDKCWEgk----------------nG-KCTKGGKVH------------------------------ 140 
XP_001609168   82 QLAQVLSALVGWSKIEKCTGs-----------------dGsGCGGTGGDSk----------------------------- 115 
XP_001611442  111 QLAQILSALVGWSKIETCKGsgcks----------tdgsR-NCKYGGKGHggsqcccssggaaqhkgsp----wcckeng 175 
XP_001611736  114 QLAQVLSALVGWSRIEKCKNggce-----------gdkaK-KCTRGRNSGhskfscccgtgdthnpgi------ecckgt 175 
XP_001609756  201 dscrvvcangccSHGGTG----CKYLDDVKLENS-CNDCQC-KIVAGK------GHHLAKGCTKCSSDDGkk-----tkS 263 
EDO06369      102 ----------snPHGQSSsggsCEYLNEVTANKP-CEQCRCmKWDVPDagdhtkGHHLGRGCTRCKDSGGss-----saQ 165 
EDO05473      110 ----------snPHGQSGgsgkCEYLDDVEQSNK-CADCECmKWKVPDagdhtkGHHLGRGCTKCKGSGTeed---akkQ 175 
XP_001609935  140 -------------HGLDG----CAYLNDIKPENK-CETCGCmKWDVSDadreekGHHLGRRCTRCSDSGGkr------hT 195 
EDO06999      139 -------------HGLDG----CMYLDDIAPSNK-CEKCECmKWDVKKpd--qeGTPLGRKCQRCKGSGDa--------Q 190 
XP_001609040  140 ------------PHGKGK----CEYLKDLTPNDMsCGKCGClKVGAE-------NHHLGRGCDKCDGDKCgkpgagggcQ 196 
XP_001610497  141 -------------HGQNGs---CKYLLDVKPNMP-CTECKCmKWKQPDpi--neGVQLGRRCTRCKDSGSs-------sD 194 
XP_001609168  116 ------------PHGQES----CEYLNEVTANDP-CDKCGCmKWDVPKaddldkGHHLGRGCQRCKDSGDsa------hR 172 
XP_001611442  176 grrtmncangccSHGGPS----CKYLDDVNDNDN-CDKCECkIFDDN-------GHHLGRGCTRCKGSGGs--------D 235 
XP_001611736  176 nykngvcangccSHGGKG----CKYIDELEKN-L-CNECECiKGGS--------SSHLGRGCTKCKDSGDpk------hT 235 
XP_001609756  264 CHCKS-----STCSP---ENCQCAKAGKCCKCCCT--SCsGTCKE--KCICDKV-------------DPNGYRSAYPKTT 318 
EDO06369      166 CSCGS-----GTCTP---DKCQCAIEGKCCKCYCKe-GCkDKCKKdaKCSCIETdtngl----drrvYKETYQSAYGGFL 232 
EDO05473      176 CQCSTgg-ggGGCQGgpgKECECAKEGKCCKCCCT--GCtGKCNEkaKCSCVKEeeiic----rdnySAKRYISAYVGS- 247 
XP_001609935  196 CSCGPg---dGTCQGp--DSCKCALAGKCCKCCCKgkGC--GCSD--KCSCYKEdgsy------criYHDSYQSAYTAS- 259 
EDO06999      191 CSCST-----GGCSPg--EECQCAKKGKCCKCCCT--GC-TKCKTnaKCSCVKE-------------EEKGYRSAYPHKT 247 
XP_001609040  197 CQCKGg---aSGCTSa--SDCKCDR-----KCGCT---------------------------------IDTYRSAYRGRY 233 
XP_001610497  195 CKCST-----GGCAAg--QECKCAKEGKCCKCCCKd-KC-GTCSD--KCSCVKEkdiyg---lglygHNDSYTSAYPNNT 260 
XP_001609168  173 CSCTGggsgsSTCTA---ESCQCYKKGKCCKCCCK--GC-DGCKK--ECRC------------------DGYKSAYPKT- 225 
XP_001611442  236 CSCE------SDCTTs--GKCKCAGKGKCCKCYCT--SC-SKCKMdaKCVCTTEesiilsrstyvevSIERYMSSYsknk 304 
XP_001611736  236 CKCGTs----GTCKGp--DKCQCAKEGKCCKCSCK--DC-RGCKEnaKCSCTTEksitlirttygeaSMKSYMSSYSNNN 306 
XP_001609756  319 GmwvEGGFTI---------TWVQLGDTTFds-----ngAMPPSQRRQQCARILLGSVCLIWSGITYMYWTGRYAESSPRW 384 
EDO06369      233 S---FDSYVGgknqayrqpIWNDLNGKLPsgdtifglpDATPSQRRQKCAQILLGSVCLIWSGITYMYWTGRYAKGSPYW 309 
EDO05473      248 ----LRSWVDggglyehkpKWNELITTGGttsgteikdGLTPSQRRHQCAQTLLGSVCLIWSGITYMYWTGKYEKTSPRW 323 
XP_001609935  260 ----NDPYIEkhy---mttTWNALDRYTGtfr----diSTTSSQRRHQCAQILLGSVCLIWSGVTYMHWTGKYAKGSPYW 328 
EDO06999      248 Tl-vKSSYVEdrta-yifhPWNDLDPSTKpgyl-yfddKLTPSHRRHQCAQILLGSVCLIWSGVTYMHWTGKYAAGSPYW 324 
XP_001609040  234 S---SESYVGetitayrecMWN----------------SPTNTTSRHQCARILLGSVCLIWSGLTYMYWTGKWHGTSPRW 294 
XP_001610497  261 Hnp---------------pTWKDL---------------KESATKRHHCARIFLGSVCLIWSGITYMYWTGKWHGTSPRW 310 
XP_001609168  226 ----TVSWIEggh----tiTWKQLKDTTFdn-----tgDGTPSNKRLQCARIFLGSVCLIWSGITYMYWTGKWAQSSPRW 292 
XP_001611442  305 ---------------hnhpTWNDL---------------KESASNRHHCAQILLGSVCLIWSGITYMYWTGKWATGSPYW 354 
XP_001611736  307 YlkiKNTIT----------TWKDL---------------ISSASNRHQCARIFLGSVCLIWSGITYMYWTGKWHGSSPRW 361 
XP_001609756  385 NNHILDGTGLDDGSLSQWLQAVGFPHAMLNNSVPENRLDQVITDEFRDRFYLGFPdTSNS--AVHGRDNNANTFRSPANL 462 
EDO06369      310 NNHILDGSGIDDGSLSQWLQALGFPRDMLNNSGPGNRWDAVIWDGLSDKLLLGFAkPSGA----SGWDTEGNTARNPFAM 385 
EDO05473      324 NNHILDGSGLDDGTLSQWLQALGFPREMLNNHGPGNRLDAIIWDGLSDKLLLGFAvPSGLigSGVANDYNGNTARNPFAM 403 
XP_001609935  329 NNHILDGSGLDDGTLSQWLQALGFPRDMLNNAAPKNRLDKVIWDGLRDKFFLGFLePSGLndGGKVNDINGNTARSPFGM 408 
EDO06999      325 NNHILDGSGLDDGTLSQWLQALGFPRGMLNNGGPQNRLDKVIWDGFRDKFFLGFLePKGLsdSGEANDQNGNTARSPFGM 404 
XP_001609040  295 NNHILDGSGLDDGTLSQWLQALGFPKDMLNNSGPQNRLDKVIWDGLRDKFLLGFLePSGLd-SGSVSDTNGNTARSPYGM 373 
XP_001610497  311 NNHILDGRGLDDGSLSQWLQALGFPREMLNDAGPGNRLDAIIWDGLRDKLYLGFLePSGLn-TSDVKDENGNTARSPFGM 389 
XP_001609168  293 NNHILDGSGLDDGTLSQWLQALGFPREMLNNAGPGNRLDAVIWDGLMGKLFLGFLePSGLnkNGEVNDTNGNTARSPFGM 372 
XP_001611442  355 NNHILDGSGLDDGTLSQWLQALGFPRDMLNNGGPGNRMDGLINDELKERLFLGFIhPDDE----AAKETWGNTARVPTSM 430 
XP_001611736  362 NNHILDGSGLDDGTLFQWLQALGFPKDMLNNSGPGNRLDGIINDEVMEKLFLGFKePDYN----SARDGWGNTARNPTSM 437 
XP_001609756  463 TYGGFIHKINKGAFDKD--GPFKDYTE--------AKIDNNKLGPILKLHILSCAYFTGLQKRrvlAS-TQSTTNTPKTI 531 
EDO06369      386 NFAGFVHTAHRDSFNNSa-IVFHKNGNda----siPDTNQHKRGALFKLYILSCAYFTGLQKK---NT-TESTPRTPKTI 456 
EDO05473      404 NYAGFVHTAHRDSFNEQa-IVFNNGEGss-----tSDIDQHKRGALFKLYILSCAYFTGLQKRn-----SESTTRTPKTI 472 
XP_001609935  409 NYAGFVHTAHRDSFNNEa-TVFTNGSGss-----iTETNQHKNGAIFKLYILSCAYFTGLQKKa-----IPTTTKTPKTI 477 
EDO06999      405 NYAGFVHTAHRDSFNKDa-TVFKKNGSasgttgqiSDTNQHKNGANFKLYILSCAYFTGLQKKateSTtHSTTSNTPKTI 483 
XP_001609040  374 NYPGFIHTAHRDSFNTDaaTVFTNGSSttn---riSDTDQNKNGALFKLYILSCAYFTGLQKKnseST-TGTTANNPKTI 449 
XP_001610497  390 NYAGFIHTAHRDSFNSDa-TVFPNGTSsssa-gqiSDTNTNKCGALYKLYILSCAYFTGLQQK---AP-PKADNKTPRTI 463 
XP_001609168  373 NYPGFVHTAHRDSFNTDqaTVFRNGTGssta-gqiSETNQHKNGAIFKLYILSCAYFTGLQNK---AP-PKADNKAPRTI 447 
XP_001611442  431 NCAGFVHTIHRDSFHQGa-TVFRNGTTsgn---tdQDINQHKRGALFKLYILSCAYFTGLQKK---TT-ESNSLRHPKTI 502 
XP_001611736  438 NYPGFIHTAHRDSFNNEa-KVFPNG----------TDTNQHKRGALFKLYILSCAYFTGLQKKp--IT-QNSTPKNPKTI 503 
XP_001609756  532 REILYWLSALPYSPAYKGLLNHCKEKL 558 
EDO06369      457 REILYWLSALPYSQAYKDTLDYAKGRL 483 
EDO05473      473 REILYWLSALPYSQAYKEMLEYSKGRL 499 
XP_001609935  478 REILYWLSALPYSQAYKEMLTYAKNKL 504 
EDO06999      484 REILYWLSALPYSQAYKQLLDHSKESL 510 
XP_001609040  450 REILYWLSALPYSPAYKEMLDYAKRRL 476 
XP_001610497  464 REILYWLSALPYSQAYKDMLDYAKKRL 490 
XP_001609168  448 REILYWLSALPYSTAYPKILKHGKHRL 474 
XP_001611442  503 REILYWLSALPYSTAYPKILQHGKERL 529 
XP_001611736  504 REILYWLSALPYSKAYPKILKHGKERL 530 
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