Conserved Protein Domain Family
MIG-14_Wnt-bd
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pfam06664: MIG-14_Wnt-bd (this model, PSSM-Id:399568 is obsolete and has been replaced by 461980)
Wnt-binding factor required for Wnt secretion
MIG-14 is a Wnt-binding factor. Newly synthesized EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion.
Links
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Statistics
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PSSM-Id: 399568
Aligned: 60 rows
Threshold Bit Score: 122.755
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002631526 179 NCDMLDLFELGSSSYPFYL----VNIRIPIDQhacqynPKNPNCQIgKLsgLRLIEIHQNGGFTLLWLWTKTLMTPIVGA 254 Caenorhabditis ...
XP_004226940 160 lCNSTQLLRLEPVTYHQYM----MVVTFP--R------NFSPKAKI-LK--INAKAIFQTKRFTLTFIGIRLVPTLILLI 224 vase tunicate
XP_001579036 154 LCT----------DFDTLL----IAVKLENK--------------IeSCtgITIKWQYGHPHAPLLQFFVRCLLAHQSIR 205 Trichomonas vag...
EAY20131     155 lTTSITLFTDIILDYNKVE----IDLTFDHP-----------YTHF-SS--FILTYSIGTPDHAYFQIYFRFLFSIVSAI 216 Trichomonas vag...
XP_001320784 147 tSDQILLYSSPLIEYDAIR----IDIVVTDA------------EHL-RA--AQVSHYLATIQHSYYEIYFRTAFAIIEFM 207 Trichomonas vag...
XP_001309127 155 ETYPIILYTQKLLNFDSIH----FECTIDVP------------PMY-TS--LTLRFVHGFTQYTIFQIYFKLIFALIELI 215 Trichomonas vag...
EGG21985     258 SCTSILMVNHIGIFNPNYY----IDITIFNNTyt--gtYFDG------Q--LEFTFAYMNSTYSLMEIMIRLAFICITVL 323 Cavenderia fasc...
EDS89558     202 ECNRFSFIYLRNVFNSSYTfiffFKVGFYNT--------------------LVMDSKRGIPGYSLFKISFVTFLVILSVI 261 Entamoeba histo...
A0DVL3       226 ICDWNVLVYVPILDYHDYL----FVIDFR-------------QINMtSQakIVLEGVTVDPSYSDSVLAVRYTFFAFSVL 288 Paramecium tetr...
XP_001023727 180 FCDEITLIYHSKIDHSNYA----FVVHFDSD----------FQWDLsPQ--IAFQHEYVNSDYTSFLLALRYTCVIVSII 243 Tetrahymena the...

XP_002631526 255 CLWW---YYNRiNQLARN---PLLLERAILYLGLSLAILDFPIEWISLTHR-LPFLLLVSDLRQGLFYTVLFSFWLIFAg 327 Caenorhabditis ...
XP_004226940 225 TTFWf-hNVIS-HLPSK-----TALHRSIILLGITTALVDFPFELIVMFFDaGWLLAIIRLLTQANY-AALLIFWVVFM- 295 vase tunicate
XP_001579036 206 CLIKy-lDFLS-RSSYRT---WHLEQKLTFMLLILCVFAAHPLYILEFFDP-SQLGIIFTIFTETLLFSYIKFFIIVLF- 278 Trichomonas vag...
EAY20131     217 FLALm-lYFLR-GLEVKL---WHLEQKLTVPLVALLIFYNNPFYIFHVYNP-SPVFVILDRILDSIFHSYMCFFILVLF- 289 Trichomonas vag...
XP_001320784 208 LLILf-vFSLR-KVSYSF---WHLEQKLTLHLQFLSMLFNNPLIYLTITYP-SKTGLILDILIKSIFTTYFRYFVLVLF- 280 Trichomonas vag...
XP_001309127 216 FLVLf-vLRLS-TAQFKY---WHLEQKLTCPLLLLSFLYNNIFEFFFVKHK-SNSVVLLEILVNSLFSAYLKFFILVLF- 288 Trichomonas vag...
EGG21985     324 TLAGm-vFSLR-KYNWRS---WTIEQQCVVILLVALFFYDNPFYLMTLLFS-GIGAETIDGLFGYIFVSILFYFWFVLF- 396 Cavenderia fasc...
EDS89558     262 ATILysiLYFFmKLYKNDedhFYINS---FIMIILLNFYNNPFNILRFFFN-ADWISCIDTCIYTIYQIVLISFIFLHI- 336 Entamoeba histo...
A0DVL3       289 TLALf-gYRIK-QLAMHN---WVIEQKFVVVLSFLLPWFNDPLYAATLLAP-NRVTAVIGVIFFSNFICCLFLYWLVLY- 361 Paramecium tetr...
XP_001023727 244 MTIAy-vRKLQ-RISYFH---WVIEQRLIVLLSGLLILFNNPFYATTILIP-NMASAFFDVFFLVNFFVCLLVFFLVIL- 316 Tetrahymena the...

XP_002631526 328 EHLIddTTR---NNIKS-YRFNLSFI----II--ASGALLIYD--------LIERGVQLYDPFYSVWssptgsqiAY--- 386 Caenorhabditis ...
XP_004226940 296 DQHKvnNHPkrqLRLRI-YIGTICVFlslqAVanLTIQGLVLAnpfn--------------------------------- 341 vase tunicate
XP_001579036 279 DSL---VHRncpKGCCF-FFKRLFVMitdfII--VFAYNIICSdllsldliPFHITPKVSQ------------------- 333 Trichomonas vag...
EAY20131     290 DSLRy-KNRk--TDRCF-YIPKIIMC----SI--ILIVYSIHG--------IYDKLHLIAEHNKNYN------------- 338 Trichomonas vag...
XP_001320784 281 DSLRy-KNRk--TDPCF-FVPKILFSfamfAT--IYLNTMITElpsylpfeLSDE------------------------- 329 Trichomonas vag...
XP_001309127 289 DSLRy-KNRk--TDKCF-FVPKIILC----SI--IYLADVVSEig----ftVFDK------------------------- 329 Trichomonas vag...
EGG21985     397 DSIRknGQEf--TFKSF-YLPKIIMV----CV--FFLINLVHI--------SIYESTIKNNP-------------LDspy 446 Cavenderia fasc...
EDS89558     337 DHSRnqAlg--kKNSVLiWILRATGL----LA--YFVFFLLYF--------ILYYLPSNKSPFSVVDdtmsiglmFG--- 397 Entamoeba histo...
A0DVL3       362 HRIVveNGSk--NSASL-TKPKVLVC----GL--LWLFFVVSY--------SILVIQYTKDPTTSFDdfhhraymAFk-- 422 Paramecium tetr...
XP_001023727 317 DRVIneNGQk--LSKAL-DKKKIIFA----FV--IYIFLLLTY--------IGFSYNHLDDPYTSFQdsfggfydFCk-- 377 Tetrahymena the...

XP_002631526 387 ------VAIFISAICTVAYFGFLLFKIVR------VWTTIKHkrSAqlyqtsenrrlkvEGVIyRFKFlmlFTVLCAGFT 454 Caenorhabditis ...
XP_004226940 342 ---inlTLNLVEAFLGVVMFGYLLANLFAeaasfiSASDTSVcgVL-------------PLTM-RLRLliiHFIITDVVT 404 vase tunicate
XP_001579036 334 ------ILHIGKIIISVFAAILIIISILR------ATYACDTs--------------------eRYKFnayLTTVLIGLG 381 Trichomonas vag...
EAY20131     339 ------TTAITSVAEMVVYLTFLLYTILS------ILISASRvdVT-------------E----RYKFniyLSSGLIAVI 389 Trichomonas vag...
XP_001320784 330 ------VKKYIDTADTALFGVYLVWAAIT------TLFAGCQvdIT-------------E----RYKYviyIISGIAALA 380 Trichomonas vag...
XP_001309127 330 ------KIIFMAYFNIVLFCGYIVWCIFC------IIVASIQvdIT-------------E----RYKYiiyLVSGSVSIA 380 Trichomonas vag...
EGG21985     447 skpswaIFTLMASIMILIFLCYMVYLIAK------GWMTTKT--LP-------------IVNI-KLKLhlvFSMMILVAF 504 Cavenderia fasc...
EDS89558     398 --------ALSTFICFLLYGWTLIYMLF-------TYSEIRSplYK-------------N----RIFWfsiFTSVVLIVT 445 Entamoeba histo...
A0DVL3       423 ------VLSFLFSFAIFVYLLKYLIQFCK------CYETRLW----------------------RYKLiglFNIFFMMCL 468 Paramecium tetr...
XP_001023727 378 ------WTGVVILVAYFLYIIYLYYWVFK------SYNTLIW----------------------RNRLfslFSMYYIVCC 423 Tetrahymena the...

XP_002631526 455 ILAYFMKQYGEaqlhgdearsgfltgstSAFFTGTFGMC------NIYVLILLAMYAPS 507 Caenorhabditis briggsae
XP_004226940 405 VIYSILTEIYKmdvk---------gsscSGLYTITFYLW------NIQAFVIMILYSPR 448 vase tunicate
XP_001579036 382 FYILMLLCSRnkki-----------grtNFGFILYYAIL------IFLVNIFSYLHSPY 423 Trichomonas vaginalis G3
EAY20131     390 IMGACQALSSFklf-----------sesSLSFVIKFAVE------NIFSFLMVYFHWPY 431 Trichomonas vaginalis G3
XP_001320784 381 LLATSELLFKFfkff----------qdsSLQFVEQFSIY------NVFSMLMVYFHWPF 423 Trichomonas vaginalis G3
XP_001309127 381 LIFLYGVIFSFlpkf----------kdsALRFVGVYSIQ------NVFVLLMAYFHWPY 423 Trichomonas vaginalis G3
EGG21985     505 SLGVLFSWfdpk-------------nvsSIIFFSYFTML------NLYTYVLAIIYLPH 544 Cavenderia fasciculata
EDS89558     446 LLHLIFGQ--------------------DMNYLPPISMIcrqllcNLYVYTLTFIFFPK 484 Entamoeba histolytica HM-1:IMSS
A0DVL3       469 GLFILSGSfeiy-------------nltGTEVLISISIL------NLYIYYQQYLWSPS 508 Paramecium tetraurelia
XP_001023727 424 ALFAFSGSmdiy-------------gsvGGRALLFITIL------NLYVYYLHYMYSFS 463 Tetrahymena thermophila SB210
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