4Z5D,6LTY,2EBY,6JQ4,2R1J,1LMB,6HPB,3QQ6,4OB4,5A7L,3SCG,1R69


Conserved Protein Domain Family
HTH_3
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pfam01381: HTH_3 (this model, PSSM-Id:396104 is obsolete and has been replaced by 460181)
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Helix-turn-helix
This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.
Links
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Statistics
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PSSM-Id: 396104
Aligned: 175 rows
Threshold Bit Score: 31.3465
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4Z5D_A         14 MKLVRQ--QNGWTQSELAKKIGIKQATISNFENN-PDNTTLTTFFKILQSLE-LSMTLC 68   Escherichia coli K-12
P14327         43 IQRARN--ALKMTQKELAFKINERPGVINEYESG-SAIPSQAVLSKLEKALN-VKLRGK 97   Dictyostelium discoideum
O14467         85 ISRART--DKKMSQKDLATKINEKPTVVNDYEAA-RAIPNQQVLSKLERALG-VKLRGN 139  Saccharomyces cerevisiae S288C
O43116         18 ISQTRQkmEPKMTQKDLATKCNTTETVVAEFERG-SAAPDQKVLAAMERVLN-VKLRGN 74   Colletotrichum gloeosporioides
O94700         82 IQKGRQ--AKGWAQKDLSQRINEKPQVVNDYESG-RAIPNQQVLSKMERALG-IKLRGQ 136  Schizosaccharomyces pombe 972h-
XP_003911109   81 IQQGRQ--SKGLTQKDLATKINEKPQVIADYESG-RAIPNNQVLGKIERAIG-LKLRGK 135  olive baboon
O17504         79 IMQGRQ--AKGMSQKDLATKICEKPQIVNDYEAG-RGIPNNIVLGKIERAIG-IKLRGK 133  domestic silkworm
O24327         87 IMQARM--EKKFTQAQLAQMINEKPQIIQEYESG-KAIPNQQIIGKLERALG-VKLRGK 141  castor bean
Q58940         32 LKKWRN--LFNIQQIELAKYLNVSPSVISDYEVGrRKNPGVNIIKKYVLALIeIDKEKG 88   Methanocaldococcus jannaschii DSM ...
Q57710        432 MKRLRI--LFGMTR----NEVN--VSYYAKYENG-KEIPSYEIVKKFLNSLKpKNLDKK 481  Methanocaldococcus jannaschii DSM ...
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