4FDG


Conserved Protein Domain Family
Mcm2

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COG1241: Mcm2 
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
Statistics
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PSSM-Id: 440854
Aligned: 79 rows
Threshold Bit Score: 688.074
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FDG_A        12 KQIDYRDVFIEFLTT-------FkgnnnqnkYIERINELVAY--RKKSLIIEFSDVLSFNE---NLAYEIINNTKIILPI 79 
BAJ50918       2 aEQPLEERLVNFFKS-------Ek-------YRELLREAAVK--KRRSIPIDFNDLIKFDE---KFARELVNKPYTLLKV 62 
AJF61408       2 EPTAIIKRFQKFLEK-------N--------HLPELSEKVRK--GEKHLVVDFGLLAMHDP---ELSEEMLENTEEVLKA 61 
AOV95248       2 DYGEAVNEFEEFFSE-------S--------YYAEVSEAVKD--GDDAIVVDYQQLDMFSP---DVTDYLHDKPENGIGA 61 
WP_048061327   5 DKSKTLTKFEEFFSL-------Qd-------YKDRVFEAIEKypNVRSIEVDYLDLEMFDP---DLADLLIEKPDDVIRA 67 
WP_011405965  11 LTPSSTLKLEEFFST-------R--------CKDEVFAVLDMfpEEKSVVVDYNELEMFDP---DSADLLIEKPDETLEA 72 
WP_012309995   9 SSEELVEKYKSFIRYyrdennePi-------YQKALAQLIEE--QRRSLSVNWYHLYNFNPdfrEIAEDIVMNPSLHISA 79 
WP_012955393   6 KTKASLARFEEFFST-------I--------YKDDVFEVLEKypDERSLTVDYNDLEMFDP---DLADLLIDKPDEVITT 67 
WP_048165041   2 EKEEMIHGFIEFLRSyadskgnKi-------YVNKIKDLLTVt-pKKSIAIDWSHLNAFNP---PLAQELMDNPEEVILA 70 
WP_103287207  10 VIRSIYDEIVEFIKGfrdangvYk-------YREQIETLKIK--DSKSITVDHNDLALYNQ---DVITRLAEEPSAVLKE 77 
4FDG_A        80 LEGALYDHILql---dpTYQR-DIE-KVHVRIVGIPR--VIELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHih 152
BAJ50918      63 LNRACFRQLQie---dpEYAS-AVK-SFTARVVSLPA--VTAIREVRSEHLRKLVMIDGMVSKASAVKPLLRVGVFRC-- 133
AJF61408      62 GELALEQFELe----------gDIK-NFRLRVKNLPQttSIMIKDVRSSHINKFISTKGLVRQKSDVRPQVTSARFEC-- 128
AOV95248      62 AEEGLQVHEQv-----------TSE-DLTVRFSNFPEheFVLLKNLRSEHIGRFIPIEGMIKRASQVKPEVVSAVFEC-- 127
WP_048061327  68 AQQAIRNIDRl----------rKNV-DLNIRFSGISN--VIPLRELRSKFIGKFVAVDGIVRKTDEIRPRIVKAVFEC-- 132
WP_011405965  73 ATKSIVNIDPq----------rKNA-KLNVRFKNVRN--NIPLRFLRSEFIGKFIAVDGIVRKTDEIHPRIMSAVFEC-- 137
WP_012309995  80 GSSAIKELVMelmpmteEFRIySEG-DFHLRFYNVPT--KASFRDLTKFSIGRLIEIEGIITRVSDIYDKLVRASFIC-- 154
WP_012955393  68 SQKAIKNIDPl----------mKDA-NLNIRFENLTN--NVPLSDLLSKYIGKFVSADGIVRKTDEIRPRIEKGVFEC-- 132
WP_048165041  71 AKDALRIILSe------DFDE-EEL-KINPRFYNLPH--TLLVKELGAEHINRLIQVEGIITRVSEVKPFVQKSVFVC-- 138
WP_103287207  78 FSNAVYDVLKev---daKYAD-SIKdEIIVRISNYPY--QVKMRDIDADLIGRLISTAGMVVRASEVKPFISRYYYRC-- 149
4FDG_A       153 PDc--MQEFEWP-E--------------DEEmpeVLE-------MPTICP--KCGk--PGQFRLIPEKTKLIDWQKAVIQ 204
BAJ50918     134 RYc--GNLQEVE-Q--------------VSQ---KLM-------TPEACLdrTCRgskRPSFELVPEESSYMDYQVLGVQ 186
AJF61408     129 PSc--GNIITVL-Q--------------LDS---KFK-------EPSRCG---CGr--KGKFRLL--SKELVDAQKIVLE 174
AOV95248     128 VQc--GDLYEKE-Q--------------DSS---KLK-------SPYKCD---CGs-----KKFEVQEKIMTDTQVVTLE 172
WP_048061327 133 RGc--MRHHAVT-Q--------------STN---MIT-------EPSLCS--ECG---GRSFRLLQDESEFLDTQTLKLQ 180
WP_011405965 138 RSc--MRMHEVE-Q--------------KSN---IIH-------EPAVCQ--ECG---GRSFRLVQDESRYMDTQTVKLQ 185
WP_012309995 155 TNc--GRIEEID-I--------------IGE---KLR-------VLEKCP--ECG----APMKLDHEMSKFIRWRSVRIQ 201
WP_012955393 133 RGc--MRQQEVE-Qt-------------SSS---RIM-------EPSMCT--ECG---GRSFRLLQEESKYIDTQSARMQ 181
WP_048165041 139 KDc--GNEMTRL-Qr-------------PYS---QMV-------KPPRCE--NCG---SRNLELDVEKSSFMNLQTFRLQ 187
WP_103287207 150 VNehdGYISRIDyQrwkrkgssgsnsnkKGE---EGEdrderrgGALTCK--KCG----AEISVDIEKSKFSNIQMIRLQ 220
4FDG_A       205 ERPEEVPSGQLPRQLEIILEDDLVD-----SARPGDRVKVTGILDIKQDSpV-KRGSRAVFDIYMKVSSIEV-------- 270
BAJ50918     187 EKPEDLPPGQLPRVIEVRVRDDLVD-----VVRPGDRVIAVGVVESVQER-G-AEGPLKTFRIYLDAVSVEP-------- 251
AJF61408     175 EAPEDLDGGEQPKRLDVFLKSDLVSpmsekRTNPGSKIIINGVLKEVPIP-AkEGGKLTRFDLMIEANYIEP-------- 245
AOV95248     173 ENPESREGSEQPTSLSVRLEGDLVDpefqkRVVPGNVVEVTGVMRETPLQ-Kd----SKKYDIYMEASHVNP-------- 239
WP_048061327 181 EPLENLSGGEQPRQITVVLEDDLVD-----TLTPGDIVRVTGTLRTVRDE-R-----TKRFKNFIYGNYTEF-------- 241
WP_011405965 186 EPLENLSGGDQPRQINIILEDDLVD-----TLAPGDKVRITGTLKTQRDE-R-----TKRFNNFIYGNYIEP-------- 246
WP_012309995 202 ERPEDLPPGMMPEHVDGILTDDIVD-----DVKPGDRVRVTGIIRIKPAR-RdEGREGLIYKRYLEIIHVEV-------- 267
WP_012955393 182 EPLENLSGGTEPKQMLMVLEDDLVD-----ELSPGDKVRITGTLKTFREE-K-----SGKFKNYIYVNHIEP-------- 242
WP_048165041 188 DRPESLKGGQMPRFVDAILLDDLVD-----VALPGDRVIATGVLRIIME----SREKRPIFKKILEVNHIEQ-------- 250
WP_103287207 221 ELPEDLPPGQLPYHIDVMLIHDLVD-----NARPGDRIILTGIVDVEKDL-EsSRMDVPLFRIRIEGNNIEFlasrdgvk 294
4FDG_A       271 --SQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALALALFGGVPKVLED-TRIRGDIHILIIGD 347
BAJ50918     252 --ASKEPQSVQITPEDERLFKKMAEDPFIINKLTESVAPSIYGLEHIKKSILLLLIGGRTKVFPDgLRVRGDINVLLVGD 329
AJF61408     246 --IEEDFLDLNVSEEEQEQIKKLAEDPNVFEKIVESIAPTIYGHTKIKEALVLQAMGGVKKSRQKgSRTRGDMHILLLGD 323
AOV95248     240 --TQQEFEQLELSQEEIDEIKTMSEREDIFQQINDSIAPSIYGHDRIKEAIALQMFGGVKKTRDDgVKSRGDLHILLIGE 317
WP_048061327 242 --LEQEFEELQISEEDEEKIKELAGDPNIYEKIIRSTAPSIHGYREVKEAIALQLFGGTGKELDDkTRLRGDIHILIVGD 319
WP_011405965 247 --LEQEFEELHIDEEDEEKIIELAKSPDIYQKIIESTAPSIRGYFEVKEAIAFQLFGGTAKVLEDkTHIRGDMHILIVGD 324
WP_012309995 268 --PNRVYEKLEITPEDEEEILKLSEREDLEELIVKSIAPSVFGWADVKRAIAYALFGGSTKILADgSKVRGEINVLLVGD 345
WP_012955393 243 --LEQEFEELHLSEEDEAKILELSQDPNIHDKIINSTAPSIRGYREVKEAIALQLFGGSVKHLEDkTRLRGDIHILIVGD 320
WP_048165041 251 --ISKDVEELEISPEDEQKIRELAKRPDVIDAIVGSIAPAIWGHKEVKKGIALALFGGVHRQLPDgTKLRGESHVLLVGD 328
WP_103287207 295 daSARSDGRFIISDDDEREIKRIASRPDVYDLLISSFAPHIYGHEIIKEAILLQIVGSPQRELEDaTKLRGDINILLVGD 374
4FDG_A       348 PGTAKSQMLQFISRVAPRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEAM 427
BAJ50918     330 PGTGKSQLLQYVASLAPRGIYTSGRGSTAAGLTAAVIREK-EGGMVLEAGAMVLADMGVCCIDEIDKMREEDRVAIHEAM 408
AJF61408     324 PGAGKSQLLKRISQVVPKSRYISGKGASGAGLTATVVKDEFIRGYALEAGALVLTNGGLCCIDELDKMSKEDTSAMHEAL 403
AOV95248     318 PGTGKSQLLKFTGEIAPKGRYVVGKSSTGAGLTASVVKEESTGEFSLEAGAVVLAHKGMAAIDEIDKMDKEDRSSLHEAM 397
WP_048061327 320 PGIGKSQMLKYVSKLAPRGIYTSGKGTSGVGLTAAAVRDE-FGGWSLEAGALVLGDKGNVCVDELDKMREEDRSAIHEAL 398
WP_011405965 325 PGIGKSQILKYVSKLAPRGIYTSGKGTSGVGLTAAAVRDD-LGGWSLEAGALVLGDKGNVCVDELDKMREEDRSAIHEAL 403
WP_012309995 346 PGVAKSQLLKYTAQLAPRGLYTTGKGSTAAGLTAAVVRDSATGGWTLEAGALVLADMGVACIDEFDKMSEDDRRSIHEAM 425
WP_012955393 321 PGIGKSQILKYVSKLAPRSVYTSGKGTSGAGLTAAAVRDE-LGGWSLEAGALVLGDQGNVCVDELDKMRSEDRSALHEAL 399
WP_048165041 329 PGVAKSQILRYVANLAPRAIYTSGKSSSAAGLTAAAVRDELTGSWVLEAGVLVLADMGVALIDEFDKMSDRDRSAIHEAL 408
WP_103287207 375 PGTAKSELLKYAARIAPRGLYTSGRGSTAAGLTAAVIRDK-SGMMMLEAGAVVLGDQGLVCIDELDKMRAEDRSALHEVM 453
4FDG_A       428 EQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFILKDQPG-EQDRELANYILDVHS 506
BAJ50918     409 AQQTVSVAKGGIVATLNARTAVLAAANPYLGRYDPYKNFIENINLPITILSRFDLMFVLRDEPNpDTDRKISSHISALHQ 488
AJF61408     404 EQQTVTISKANIQATLRAETTVLAAANPKFGRFDPYEVIGKQIDLPSTLINRFDLIFPIKDLPDeVKDEKMATFILDLHT 483
AOV95248     398 EQQQISVSKANIQATLNAETSILAAGNPKLGRFDPYEPVAEQISIGDTLLSRFDFIFPVMDEPDkERDTELADAILQNHI 477
WP_048061327 399 EQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSYKSIAEQIDLPSTILSRFDLIFVVEDKPDeEKDRELARHILKTHK 478
WP_011405965 404 EQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDRYKSIAEQIDLPSPILSRFDLIFIIEDKPNaERDHDLAGHILKIHQ 483
WP_012309995 426 EQQTISIAKAGIVATLNARTTIIAAANPKKGKYDDYVTVAENINLPPTILSRFDLVFIMKDRPGvESDSMVAEHILITRM 505
WP_012955393 400 EQQTVSIAKAGIMATLNTRCSVLAAANPKFGRFDRYKTLADQIDLPSPILSRFDLTFVIEDKPNiENDRKLAQHILKIHQ 479
WP_048165041 409 EQQSISISKAGITATLNSRTTVIAAANPKYGRFNRAKPLPEQLDLPPTLLSRFDLIFVLLDEPDeNIDSDIATHILKVRR 488
WP_103287207 454 EQQTCSVAKGGIVATLNARTSILAAANPILGKYDPYRNITENVNLPIPLLTRFDLIFAIRDEPSkEGDANLARHILGIHR 533
4FDG_A       507 G--KSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKS-----SEtP----DSPILITPRQLEALIRIS 575
BAJ50918     489 IgePEKAPPIAPDVLRKYIAYAKR-IEPSISPKALKQLEDFYLKMRAMY------E-K----TATVSITARQFESLIRLT 556
AJF61408     484 Kk-TEIVSEISTDMLKKYFAYARQSVHPTLTAAANEEIKKYYVDMRKAG-----SD-Dg--gVKSIPISPRQLEALVRLA 554
AOV95248     478 Ep-EETNPDITGEKLRKYVAFAKKNKRPQLSREASDKIQEFYVSMRQEG-----DD-E----GGGVPITARQLEATVRTA 546
WP_048061327 479 E--DHMPFEIDPELLRKYIAYARKNVRPVLTDEAMQVLEDFYVSMRASA-----AD-E----DSPVPITARQLEALVRLS 546
WP_011405965 484 D--STIPYVIEPELMRKYIAYARKSVQPTLTKEAAEVLQDFYVTMRSGA-----ID-E----ESPVPITARQLEALVRLA 551
WP_012309995 506 GrnPEAKPPIDPNLLKKYIAYAKQNIDPILTDEAAERIKNYYVDVRGRGi---kES-EegivQDLISITPRQLEALIRLS 581
WP_012955393 480 S--ESVNYEIEPDLLRKYIAYARKNINPVLTDEANKVLEDFYVSVRSAG-----VE-E----DTPVPITARQLEAIIRLA 547
WP_048165041 489 GeaEAVAPKVPYDLLKKYIAYARKNIHPVLSKEAMDEIKRYYIRMRKRAkvgnsEE-G----VKPMPITARQLEALIRLS 563
WP_103287207 534 RigYEHLPPIPIDLLRKYLAYAKR-FNPLLSKEAEDRIFEYYMQMRANAs------------PDAITITARQLEALIRLA 600
4FDG_A       576 EAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAV-SSECAKVKDI 654
BAJ50918     557 EAHARARLRNVADEEDAAAAILLMRKSLQEVGVDIESGAPDIDTIMTGKPKSVREKMKLVIDTIKKFEEq-SGYAAEQEL 635
AJF61408     555 EASAKVRLSDKVTRKDARRAIELVHYCLSQIGQDPETGKFDIDRITSGVTATERGNIVQVKEIITEIEVkSGRTVAIEDI 634
AOV95248     547 EASARAHLRDEVTVEDAERAIDLLTYSLKLVGMDPETGEFDIDMIESGVSSSQRNRLQTIKHIIEELAD--GDSAEIEEV 624
WP_048061327 547 EASAKIKLKEHVEAEDARKAIKLSQACLKQVGYDPETGKIDIDKVEGRTPKSERDKFRLLLELIKEYEDdYGGRAPTNIL 626
WP_011405965 552 EASARIRLSNEVLKEDAQRAIKLQEDCMKQVGYDPDTGKVDIDKVEGRTSKSERDKINIIIDVIKELSDeYEGSAPKNIV 631
WP_012309995 582 EARARMHLRREVTAEDAEMAINLMEITLKGAAYDIVSGHFDITGWMTGISFPEVKRREVVFQIIKQLAEgSEDGLVDRDV 661
WP_012955393 548 EASAKLQLKDKVEAVDAQRAITLQRKTLEQIGLDPETGQLDISRVEGGTTTSDRERMQKIEEEIKLLEQeF-ERAPIDTL 626
WP_048165041 564 EAHARMRLSDVVTREDAKEAIAIMEYALKQVAMD-EEGMLDISILEVGKSSKQINKIERMVSIIKRLENkNEWGAPIDDI 642
WP_103287207 601 TARARLMLRNTVTVEDAERAIYIFNVMLNKVGIDVKTGKVDLGVLH-GMPSSERSKMQLFLDVFNALSGkDQNPVEEQAL 679
4FDG_A       655 LKEA-QQVGI----EKSNIEKLLTDMRKSGIIYEAKPECYKKV 692
BAJ50918     636 RTAL-LQEGL----SEEEITRLLTRLITDGRIFMPRTGAYKVT 673
AJF61408     635 FIEA-SSRGL----SQDQVMEVIEKLKRSGDIYEPKKGYISKI 672
AOV95248     625 LERA-DGEGI----SEDKAEEIIEKLKREGELFEPQQGHVQKI 662
WP_048061327 627 ITEMmDRYNV----SEEKVEELIRILKDKGAIFEPARGYLKIV 665
WP_011405965 632 YAELaDKYNV----GEEKVDEVINMLKSKGVIYEPTSDHYKVA 670
WP_012309995 662 VVRM-AAERLnlkgKEYVIEDILRKLNEDGLIIFPPGGKIRLI 703
WP_012955393 627 KENMkEKYDM----SPEKVETLVKKLKGKGIIFEPRNGFFNTA 665
WP_048165041 643 ISEA-VESGM----KKDEARKLIERLFNEGQIYSPRDGYYRVA 680
WP_103287207 680 VTELaKTGKF----TEDEAREWIRKANAQGIIYEVRQGFYKRA 718
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