1EAR,1GMV


Conserved Protein Domain Family
UreE
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cd00571: UreE 
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UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-terminal region of UreE contains a histidine rich nickel binding site.
Links
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Statistics
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PSSM-Id: 238320
Aligned: 33 rows
Threshold Bit Score: 105.767
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:residues critical for activity, which is Ni2+ incorporation into urease active site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1EAR_A      1 MVITKIVghiddls-----hqikkvDWLEVEWEDLNKRILRKETENGtDIAIKLen-sGTLRYGDVLYesd--dtLIAIR 72  Sporosarcina paste...
1GMV_A      2 LYLTQRLeipa-----------aatASVTLPIDVRVKSRVKVTLNDGrDAGLLLpr-gLLLRGGDVLSnee-gteFVQVI 68  Klebsiella aerogenes
Q9Z3B7      1 MIIESISgnihdlpg--edledvhvESVVLPLADLTKRIQRVRSDHGtELGIRLapgaPDLREGDILLrne--rgIVVVR 76  Actinomyces naeslu...
Q9RHM3      1 MIITAIDtniydqpe---fvegrdvIGVRFEDLVLDKRIQRVALPGGeELGLRLnhghPILREGDVLKadd--ktVFVVE 75  Corynebacterium gl...
Q07401      1 MMVEKVVgnittle-----krvphiERVYMRSDDLVKRVKRVVTDHGkEIGIRLke-hQELQDGDILYmdd--hnMIVIS 72  Bacillus sp. TB-90
Q56559      2 TVFKEILdnianik----nvesyqiENIHLTSDDVLKRVIIISSDQNvEYGIRLee-dKKLMDGDILYkdd--ykLVVIR 74  Ureaplasma parvum
Q55055      1 MIFTKVDalvkdiy-----vdkyhiETVILSSDDLNKKIIRVKSDHGnEFGIRLdk-gQKLQNGSAFFidd--hhVLAIG 72  Streptococcus sali...
NP_539563   2 IIIEGIVgnshdpqwr-drladakiDWLVLDQWEAQKSRLRKATSGDvELALSLdr-nTHLHDGDILLwnegdkcAVVAR 79  Brucella melitensi...
P42869      2 ILIEHILgnvkkdpvwqeklkdatfDLLVLDQREAQKSRCRKLSTQGlDLGISLdr-hVVLADGDVLAwdektnvAVVVQ 80  Yersinia enterocol...
Q9X525      1 MVLTEVYrnvddip----nigsyhiETAMVKSDDLMKNILRVKTDHGnEYGIRLdnedQILENGSAFKlgd--kqLLVLS 74  Lactobacillus ferm...

Feature 1                                         #                            #              
1EAR_A     73 TKLEKVYVIKPqt---------mqEMGKMAFEIGNRHTMCIIED------------DEILVRy--DKTLEKLIDEVG-VS 128 Sporosarcina paste...
1GMV_A     69 AADEEVSVVRCdd---------pfMLAKACYHLGNRHVPLQIMP------------GELRYHa--DHVLDDMLRQFG-LT 124 Klebsiella aerogenes
Q9Z3B7     77 LEPTDVLVIAPvt---------vrEMGVVAHNLGNRHLPAQFFGpaepfpgleghdGVMVIQy--DHTAEHYLEHLG-VR 144 Actinomyces naeslu...
Q9RHM3     76 IIPTDVLVITPsd---------ihQMGFVAHSLGNRHLPAQFSKpgel-----tekAAMIVQy--DHTVVSFLDEHG-IE 138 Corynebacterium gl...
Q07401     73 VLEDDVLTIKPts---------mqQMGEIAHQLGNRHLPAQFEG------------NEMIVQy--DYLVEELLQKLS-IP 128 Bacillus sp. TB-90
Q56559     75 LELSDVLIITAht---------igEMAKIAHNLGNRHMPAQFTE------------TQMIVPy--DYLVEEYLQDNK-AL 130 Ureaplasma parvum
Q55055     73 VESQDLIVISPkd---------mdEMGITAHILGNTHKPIEVKD------------AKIYLEv--DPVVEQVLTQKE-IA 128 Streptococcus sali...
NP_539563  80 VHLKEVMVIDLasvigedgnaivrTVFELGHALGNQHWPAVVKE------------TKVFVPltvDRKVMASVMKTHnLP 147 Brucella melitensi...
P42869     81 INLRDVMVIDLselksrspdelikTCFELGHALGNQHWKAVTKN------------NEVYVPltvATTMMDSVMRTHgFQ 148 Yersinia enterocol...
Q9X525     75 VIADEMIEITPrd---------inEMGLVAHFLGNLHKPVQIKD------------GKISLLl--DKVVIKMLDKHD-IN 130 Lactobacillus ferm...

Feature 1             
1EAR_A    129 YEQSERRF 136 Sporosarcina pasteurii
1GMV_A    125 VTFGQLPF 132 Klebsiella aerogenes
Q9Z3B7    145 HARMERSM 152 Actinomyces naeslundii
Q9RHM3    139 YQRTELVP 146 Corynebacterium glutamicum
Q07401    129 FTRENRKM 136 Bacillus sp. TB-90
Q56559    131 YERKKIKL 138 Ureaplasma parvum
Q55055    129 YTIEEVVL 136 Streptococcus salivarius
NP_539563 148 GVTYEFMP 155 Brucella melitensis 16M
P42869    149 HLPFRFVK 156 Yersinia enterocolitica
Q9X525    131 YELKKVQL 138 Lactobacillus fermentum

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