Conserved Protein Domain Family
rad2

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TIGR00600: rad2 
DNA excision repair protein (rad2)
All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273166
Aligned: 5 rows
Threshold Bit Score: 1370.75
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P07276      1 MGVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAVKNSHITGFFRRICKLLYFGIRPVFVFDGGV 80   Saccharomyces cer...
CAA47291    1 MGVSGLWNILEPVKRPVKLETLVNKRLAIDASIWIYQFLKAVRDKEGNQLKSSHVVGFFRRICKLLFFGIKPVFVFDGGA 80   fission yeast
P28715      1 MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFHRLCKLLFFRIRPIFVFDGDA 80   human
P14629      1 MGVQGLWKLLECSGRPINPGTLEGKILAVDISIWLNQAVKGARDRQGNAIQNAHLLTLFHRLCKLLFFRIRPIFVFDGEA 80   African clawed frog
BAA03813    1 MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRDSHGNVIENAHLLTLFHRLCKLLFFRIRPIFVFDGDA 80   house mouse
P07276     81 PVLKRETIRQRKERRQGKRESAKSTARKLLALQLQNGS---NDNVKNstPSSGSSVQifk-------------------- 137  Saccharomyces cer...
CAA47291   81 PSLKRQTIQKRQARRLDREENATVTANKLLALQMRHQAmllEENNKKatALANASVQnerqmpssmtldnseikpvlnqr 160  fission yeast
P28715     81 PLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAiktAFRSKR--DEALPSLTqvr-------------------- 138  human
P14629     81 PLLKRQTLAKRRQRTDKASNDARKTNEKLLRTFLKRQAikaALSGNKqsNEELPSFSqvpr------------------- 141  African clawed frog
BAA03813   81 PLLKKQTLAKRRQRKDSASIDSRKTTEKLLKTFLKRQAlktAFRSSR--HEAPPSLTqvq-------------------- 138  house mouse
P07276    138 ----pqDEWDLPDIPgfkydkE----DARVNSNKTFEKLMNSI-NGDGLEDIDLDTINPASAEFEELPKATQYLILSSLR 208  Saccharomyces cer...
CAA47291  161 knylkpDPYQLPEMDvsf-dkLgssyDPRIMSQDELTQYVSSFtKIEDINLFDFSNIDFDSELFQSLPDTDKYSILSAAR 239  fission yeast
P28715    139 ---renDLYVLPPLQ------EeekhSSEEEDEKEWQERMNQKqALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMK 209  human
P14629    142 --keteDLYILPPLE------DnennSSEEEEEREWEERMNQKqRLQEDFFANPSSVDIESEEFKSLPPEVKHEILTDMK 213  African clawed frog
BAA03813  139 ---rqdDIYVLPPLP------EeekhSSEEEDEKQWQARMDQKqALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMK 209  house mouse
P07276    209 LKSRLRMgyskEQLETIFPNSMDFSRFQIDMVKRRNFFTQKLINTTGFQDGGASklneevinRISGQKSKEYKLTKTN-- 286  Saccharomyces cer...
CAA47291  240 LRSRLRMglssEQLSEMFPNRMDFSRFQIERLKERNDLTQRLMDFTGMNEFGPS--------RVVSEKNREYILVKNEga 311  fission yeast
P28715    210 EFTKRRR----TLFEAMPEESDDFSQYQLKGLLKKNYLNQHIEHVQKEMNQQHSghir-rqyEDEGGFLKEVESRRVVse 284  human
P14629    214 DFTKRRR----TLFEAMPEDSSDFSQYQLKGLLKKNDLNKCIDNVRKELNQQYSgevq-aqfESEGGFLKEVETRRLVse 288  African clawed frog
BAA03813  210 EFTKRRR----TLFEAMPEESNDFSQYQLKGLLKKNYLNQHIENVQKEMNQQHSgqiq-rqyQDEGGFLKEVESRRVVse 284  house mouse
P07276    287 -NGWILGlgANDGSDaQKAIVIddKDAGAlVKQLDsnAEDGDVLRWDDLEDNSLKivRHESSNATTAPQKRSNRSEDEgc 365  Saccharomyces cer...
CAA47291  312 eGGWALG--VISGSTnNEPIIIddEATKLsSNLID--EDEDEAFYDVPLPSRSHSmnPRELVAAKLKEIKENSFSENQ-- 385  fission yeast
P28715    285 dTSHYILikGIQAKT-VAEVDS--ESLPS-SSKMHgmSFDVKSSPCEKLKTEKEP--DATPPSPRTLLAMQAALLGSSse 358  human
P14629    289 dDSHYILikGIQSKQeEKKVDSppQSITFnSSQTPktYLDLKLASAHKTKPLQTSsaEAAPPSPRTLFAIQEAMAESWdh 368  African clawed frog
BAA03813  285 dTSHYILikGIQGKK-VMDVDS--ESLPS-SSNVHsvSSNLKSSPHEKVKPEREP--EAAPPSPRTLLAIQAAMLGSSse 358  house mouse
P07276    366 DSDECEWEevelkpknvkFVEDFSLKAARLPYMGQSLNNAGS-----KSFLDKRHDQASPSKTTPTMRISRISVEDDDED 440  Saccharomyces cer...
CAA47291  386 QSDEADYN----------VTDDLILQLATQQSLEENKKSKEL-----FSLSASEFDKLNSEKKTFEILSTDIPAEDSMNS 450  fission yeast
P28715    359 EELESENRrqargrnapaAVDEGSISPRTLSAIKRALDDDED-----VKVCAGDDVQTGGPGAEEMRINSSTENSDEGLK 433  human
P14629    369 EKHEKPsv--------sgCEAEGNVSPRTLQAIYQVLAEDEAgesnkIKVVLQSDEER--KPKTKVLVISSSDEEDDCLN 438  African clawed frog
BAA03813  359 DEPESREGrqskernsgaTADAGSISPRTRAAIQKALDDDND-----EKVSGSSD-----DLAEKMLLGSRLEQEEHADE 428  house mouse
P07276    441 YLKQIEEIEMMEAVQLSkmEKkPEADDKSKI-----AKPVTSKG-------Te------ARPPIVQYglLg--------- 493  Saccharomyces cer...
CAA47291  451 LLNDEENLKLEHVGDVS--ND-SLAFAEKKH-----PENGTSIF-------Md------ALPSASRE--K---------- 497  fission yeast
P28715    434 VRD-GKGIPFTATLASSsvNSaEEHVASTNE-----GREPTDS-----------------VPKEQMSlvHv--------- 481  human
P14629    439 YQD-GTKTTLGASLIKSisPSsMQCQESTADslpnyTRSKPVSQieepmadHnlqgdncNVPNAKDKliVppslgnvdkp 517  African clawed frog
BAA03813  429 TAERGGGVPFDTAPLTPsvTEvKECVTSGSS-----ANEQTDSAhsfttasHr-----cDTPKETVSlaSa--------- 489  house mouse
P07276    494 --AQPDSKQPYHVTNLNSKSESVIKRTSKTvlsefrPPSQQEDKGAILTEGEQNLNFISHkipqfdfNNENSLLFQKNTE 571  Saccharomyces cer...
CAA47291  498 --KTNDLIDPLPFQPMDWGKSIFFEKLKKP------TETFMDSKTDIPSEAPDNSKLVED-------TNLHTINATVNIE 562  fission yeast
P28715    482 --GTEAFPISDESMIKDRKDRLPLESAVVRhsdapgLPNGRELTPASPTC-TNSVSKNEThaevleqQNELCPYESKFDS 558  human
P14629    518 iiLSNTIPVNSEFRIPLLPVNMSMRETVIIpnntgsLGSSRYISLERDAT--K--QGFSDnpvgdlvRS---PDEPALNA 590  African clawed frog
BAA03813  490 --VKEASQISSECEVEGRPAALSPAFIGTPsshvsgVLSEREPTLAPPTTRTHSDQGIDIhpedpelQNGLYPLETKCNS 567  house mouse
P07276    572 SnvSQEATKEKSPI---------PEMPSWFSSTASQQLYNPYNTTNFVEDKNVRNEQESgAETTNKGSSYElltglNATE 642  Saccharomyces cer...
CAA47291  563 S--DLDAAKPGIEN---------PIISPLLPVKDDEKDLDLRELNPLEPFENMKEQADDgTVTNPLNVSSD-----KAMS 626  fission yeast
P28715    559 SllSSDDETKCKPNsasevigpvSLQETSSIVSVPSEAVDNVENVVSFNAKEHENFLET-IQEQQTTESAGqdlisIPKA 637  human
P14629    591 SsaLSDRKTSATQSllc----nnIECTEQSMVQGCSNTLDVTQTTQPSGGSEVNKPAEYnPQDKKVFGSNDssamyVPMT 666  African clawed frog
BAA03813  568 SrlSSDDETEGGQN---------PAPKACSTVHVPAEAMSNLENALPSNAEERGDFQET-IQLREVPEAAArelisAPKP 637  house mouse
P07276    643 ILERES-------EKESSNDENKDDDLEVLSEELFEDVPTKSQISKEAEDNDSRKVESINKEHRKpLIFDYDFSEDEEDN 715  Saccharomyces cer...
CAA47291  627 VYLLSS-------ENAKDTGDIKSESIDAVLPTLETSSPSLSIPTDFQKEASPNKGAAALSSKVEpEVVEKLLDEEEEEM 699  fission yeast
P28715    638 VEPMEI-------DSEESESDGSFIEVQSVISDEELQAEFPETSKPPSEQGEEELVGTREGEAPA-ESESLLRDNSERDD 709  human
P14629    667 PESIIVsdeefvnEKEDSDSDDSFIEVDSEFSTSNSQHVVFKEPGD-TRETATNFQAVEEGNSGS-QDIPLEHDSGEPHE 744  African clawed frog
BAA03813  638 MGPMEM-------ESEESESDGSFIEVQSVVSNSELQTESSEASTHLSEKDAEEPREILEEGTSR-DTECLLQDSSDIEA 709  house mouse
P07276    716 IVEnMIKEQEEFDTFKNTTLSTSAERNVAENAFVEDELFEQQMKD---KRDSDEVTMDMIKEVQELLSRFGIPYITAPME 792  Saccharomyces cer...
CAA47291  700 IIR-MAEEEKEYDRFVSELNQRHETEEWNQEAFEKRLKEAQKSKKgseKRDADEVTQVMIKECQELLRLFGLPYIVAPQE 778  fission yeast
P28715    710 VDGePQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKqqqERIAATVTGQMFLESQELLRLFGIPYIQAPME 789  human
P14629    745 QSN--SEESKDLDDVSNEWQDISVEELESLENNLYVQQTSLQAQQqqqERIAATVTGQMCLESQELLQLFGIPYIVAPME 822  African clawed frog
BAA03813  710 MEG-HREADIDAEDMPNEWQDINLEELDALESNLLAEQNSLKAQKqqqDRIAASVTGQMFLESQELLRLFGVPYIQAPME 788  house mouse
P07276    793 AEAQCAELLQLNLVDGIITDDSDVFLFGGTKIYKNMFHEKNYVEFYDAESILKLLGLDRKNMIELAQLLGSDYTNGLKGM 872  Saccharomyces cer...
CAA47291  779 AEAQCSKLLELKLVDGIVTDDSDVFLFGGTRVYRNMFNQNKFVELYLMDDMKREFNVNQMDLIKLAHLLGSDYTMGLSRV 858  fission yeast
P28715    790 AEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDFHNQLGLDRNKLINLAYLLGSDYTEGIPTV 869  human
P14629    823 AEAQCAILDLTDQTSGTITDDSDIWLFGARHVYKNFFSQNKHVEYYQYADIHNQLGLDRSKLINLAYLLGSDYTEGIPTV 902  African clawed frog
BAA03813  789 AEAQCAMLDLSDQTSGTITDDSDIWLFGARHVYKNFFNKNKFVEYYQYVDFYSQLGLDRNKLINLAYLLGSDYTEGIPTV 868  house mouse
P07276    873 GPVSSIEVIAEFG-----NLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNneiiLDDDFPSVMVYDAYMRPEVDHDT 947  Saccharomyces cer...
CAA47291  859 GPVLALEILHEFPgd--tGLFEFKKWFQRLSTGHASKNDVNTPVKKRINKLVGki-iLPSEFPNPLVDEAYLHPAVDDSK 935  fission yeast
P28715    870 GCVTAMEILNEFPghglePLLKFSEWWHEAQKNPKIRPNPHDTKVKKKLRTLQ----LTPGFPNPAVAEAYLKPVVDDSK 945  human
P14629    903 GYVSAMEILNEFPgqglePLVKFKEWWSEAQKDKKMRPNPNDTKVKKKLRLLD----LQQSFPNPAVASAYLKPVVDESK 978  African clawed frog
BAA03813  869 GCVTAMEILNEFPgrgldPLLKFSEWWHEAQNNKKVAENPYDTKVKKKLRKLQ----LTPGFPNPAVADAYLRPVVDDSR 944  house mouse
P07276    948 TPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRdvnKRKKKGKQKRINEFFP----REYISGDKKLNTSKRISTAT 1023 Saccharomyces cer...
CAA47291  936 QSFQWGIPDLDELRQFLMATVGWSKQRTNEVLLPVIQdmhKKQFVGTQSNLTQFFEggntNVYAPRVAYHFKSKRLENAL 1015 fission yeast
P28715    946 GSFLWGKPDLDKIREFCQRYFGWNRTKTDESLFPVLK---QLDAQQTQLRIDSFFRlaqqEKEDAKRIKSQRLNRAVTCM 1022 human
P14629    979 SAFSWGRPDLEQIREFCESRFGWYRLKTDEVLLPVLK---QLNAQQTQLRIDSFFRleqhEAAG---LKSQRLRRAVTCM 1052 African clawed frog
BAA03813  945 GSFLWGKPDVDKIREFXQRYFGWNRMKTDESLYPVLK---HLNAHQTQLRIDSFFRlaqqEKQDAKLIKSHRLSRAVTCM 1021 house mouse
P07276   1024 GKLKKRK 1030 Saccharomyces cerevisiae S288c
CAA47291 1016 SSFKNQI 1022 fission yeast
P28715   1023 LRKEKEA 1029 human
P14629   1053 KRKERDV 1059 African clawed frog
BAA03813 1022 LRKEREE 1028 house mouse
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