6SKL


Conserved Protein Domain Family
TIMELESS

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pfam04821: TIMELESS 
Timeless protein
The timeless gene in Drosophila melanogaster and its homologs in a number of other insects and mammals (including human) are involved in circadian rhythm control. This family includes a related proteins from a number of fungal species.
Statistics
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PSSM-Id: 461444
Aligned: 118 rows
Threshold Bit Score: 112.665
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SKL_X            44 PYKLGDDCLACLKDLKRWFKLvdDQQKRWDVAMAVAEYRILTDDLLPILIDWENkCslaaklaknnpdheefrnkayyDK 123 
EGC32123          73 TFECGEDCLEAARILYRMLKE--DDEIDRAVFHYLGKNNIVKNKLIPLLITQAS-N----------------------TD 127 
2_pfamImport       1 VLLRGENCDDWVHDLQRAVRR--DHAKHRLVTKQLGKWKILQKKLLPLLVHHQH-D----------------------WK 55  
jgi:PHATR_33206   67 RIVPVADCLNWLQDLQRALRR--DDDQYRPISLLMAQWKIVPQKLLPLVDSCRY-D----------------------TD 121 
CBN76654          40 RFVRGENCLEWLQDLQRALRR--DDENTREICITLSSWRVVQHKLVPLILECRD-D----------------------AV 94  
ERN05033          26 GYDRRTYCLENLKDLQRFLRR--DDPQTRDVFKLVSKWNIASNHLIPIIEHYQG-D----------------------CE 80  
XP_015692759      26 GYAKGEHCLDNLKDLQRFLRR--DDPQRREVFKQVCKWKIASRDLVPIIENFQS-D----------------------RN 80  
XP_018677494      26 GYAKGEYCLDNLKDLQRFLRR--DDPRQRDVFKQICKWNTVSRNLVPLIEYYQS-D----------------------RN 80  
XP_006606156      26 GYIKGQYCLDNLKDLLRFLRR--DDPQTRDVFKQVCKWNIVSKYLIPTIELYHE-D----------------------SN 80  
XP_013726777      40 GYSKSDYCLDNLKDLLRFLRR--DDPQSREVFKQVCAWNIVSKDLIPIIEHYQD-E----------------------HS 94  
6SKL_X           124 IALNCLQLLVLMT--WPLIV-TEQ------------SSSN------QITLYGELKKHQLVYKKTILSMes---------- 172 
EGC32123         128 LVISILRIYVNLTyqLPINI--------------------------ESYEIPKQNLYMLNFKESFLNR------------ 169 
2_pfamImport      56 LVFSILKVLVMLTtkPPR----------------------------DSTNIAQQLKYLRQYKHEFLRC------------ 95  
jgi:PHATR_33206  122 LVLTVAKILVILT--KPLAEsTERagklpietktktTEAVireqirLRENAVQQAEARMEYKRAICHYhhghthdsnptk 199 
CBN76654          95 LVNTLFKIYVMLT--MPLSKqSEEalskpinpkaqgDVRDqq--mrRRENAMSQQAALHAFKRAFISK------------ 158 
ERN05033          81 LVINAVKVMVFLT--MPIDP--------------------------TSDDISGQMEYLWNIKVAVTRN------------ 120 
XP_015692759      81 LVITAVKVLVFLT--MPVEP--------------------------SSEGVAQQIEYLWDLKAALTRN------------ 120 
XP_018677494      81 LVINAVKILVFLT--MPIDH--------------------------SSDGIAQQIEYLWDLKAALTRP------------ 120 
XP_006606156      81 LLLNAVKVLVFLT--MPIEP--------------------------SSTDISQQLEYLWGLKSALTNS------------ 120 
XP_013726777      95 LVLNAVKVLVFLT--MPLES--------------------------DSDDVPQQIEYLWGLKSAFTVS------------ 134 
6SKL_X           173 --gKVLRAAIRLALDVI-KIDRLSRTPRDNMVLKLVLNFFRNVIAIEPGeftinTKKSMPKKgitsidtlppnvsM--DD 247 
EGC32123         170 ---ELLKTFLRILNEPMtRLSLSSGSNQDYLIIELILTLIKNVLQIQDPissvs-------------------lefeyRC 227 
2_pfamImport      96 ---GVVPIMMTILVEPL-SRKGSARTPQDFLNMEIVLTLLRNLLAIPNE-----DPRFVTST-------------TsyFS 153 
jgi:PHATR_33206  200 sggGILSIFVSLLAEPL-SKSGTARTEADHLKIELVLHLFRNLLSAEPLlh--sSAAAVAQA-------------Q---- 259 
CBN76654         159 ---DVLSVVVGMLEEPL-SHTGVARTDADNFSIELCLTLLRNVLNIQDPtp--gMATSLGDH-------------Y---T 216 
ERN05033         121 ---DAIAVIVSLLEDPLeHLECEAFSEDDWKLVQLVLTLFRNLLSIHEIsp--qQQASGCTN-------------Q--FL 180 
XP_015692759     121 ---VAMAVIVSLLEDPLdRLERASFTEDDWKLVQLVLTLFRNVLAIQEItl--aQKASGEAT-------------Q--LL 180 
XP_018677494     121 ---VTIAVIVCLLEDPLdHLECKTFTDDDWKLVQLVLTLFRNVLAIQDItl--qQKSSGSST-------------Q--FF 180 
XP_006606156     121 ---DVAAVIVSFLERPLeNLERGTFSEDDWKLVQLVLTLFRNILAVQEIpt--hQKSGGLAT-------------Q--LL 180 
XP_013726777     135 ---NIVAVVVSLLETPLeNLELDEFNEEDWKLVQLVLTLFRNLLAIHDIsp--lQKAGESTC-------------Y--FL 194 
6SKL_X           248 ISLNTVISSFHKNKVFGFLLTLTSSLSKEF---DQDFINIPLLEIMFYFTKDVNQELLF------------PRQFETgth 312 
EGC32123         228 HMHSKLIELLEESEILELFLILSETIKKDKifkSITNYSLLLLEIFTLLLKNDTPNEIWsne------sttSTPSSA--- 298 
2_pfamImport     154 HLQEDFICTLHDENVYEMILLFTQDIEAP----ENREWNLLIMEMIDLTLDCSQPKCVVayaknqltgktsSSSSGQ--- 226 
jgi:PHATR_33206  260 TLHDDCVVLLDQELVLEILLVLGADIEQR----ENLQYNLLLMELVHHLLRHYDPAVVAr-----------AVPSPT--- 321 
CBN76654         217 QMHEQLVALFKDALLLDILLLLAQDVHAR----ENAKLNLLLVEIFHFIIRDQEPGAIIavhr----lqaqRGASKG--- 285 
ERN05033         181 CLRDGFLEILFSENVMDLILVLTQHITDFHg--YIHQDKLLLLEIYHYIFLHQKPQLVA----------------KV--- 239 
XP_015692759     181 CLADSFLELMFQENVMDLILVLTQHIDEPSg--YLKQENLLLLEIFHYLFLGRDPELIAr-----------ASTEVS--- 244 
XP_018677494     181 CLTDRFLELMFQEYVLDLILVLTQHVDGCSg--YLQQDNLLLLETFYYIFLGREPELIA-------------KVSKR--- 242 
XP_006606156     181 SMRDRFLELLFRENVMDIMLVISQCVGSSNv--YLRQDNLLLLEIFHYILMGQDPELIV-------------RAHLK--- 242 
XP_013726777     195 SLRNQFLELLSRENVMDIFIVITQTIECNN---LLRHDNLLLLEIYHYIFLGQDMELIA----------------LA--- 252 
6SKL_X           313 skvvnkneSSSANNIVtSAGFELS--KLLQKEHQMRKNVI-KHT-SARHSRFGGLLSI 366 
EGC32123         299 --------STSTLNDElEKKESLI--NLLKKEKKLSTKLItN----SNTSRFIGAYSS 342 
2_pfamImport     227 --------AAATTTPSgARNAASAggNLLAKLDSEKKASAlHQSgSHRHSNFGGIMKM 276 
jgi:PHATR_33206  322 --------GAAAALPPkPRPGLLS--QSLQREKQKFHAPI-----MSRHAHFGGTLVV 364 
CBN76654         286 --------SAGLPSPArQSGGSLM--SVLAKEKTKRGLGA--GQmHSRHARFGGTLQV 331 
ERN05033         240 --------SQKNQSKGeTSPSSFR--SIKEEEEKRRVTRSkN---LIRHSLFSGTFVR 284 
XP_015692759     245 --------KEHVEGNIdTSVHSLR--LMMEDEERKKRMFRqRn--SEHHSISGIFTCT 290 
XP_018677494     243 --------SSKVKEDItTTVDSLR--TIMDEEEEKRRIIRlRn--LERHSQFSGTFTR 288 
XP_006606156     243 --------ESKEDEQPqTSLNSLQ--FILEEEKKRRNICKlNn--LSRHSQFSGTFAR 288 
XP_013726777     253 --------PEKLDQGKkAAVESLK--KLMEAEEAKRKLARlN-NaNQRHSQFGGTFTR 299 
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