Conserved Protein Domain Family
JCAD

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pfam15351: JCAD 
Junctional protein associated with coronary artery disease
JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.
Statistics
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PSSM-Id: 434658
Aligned: 18 rows
Threshold Bit Score: 1746.15
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002919699    1 MYSVEDLLISHGYKVSRSIPAPTEDEREGRRQARSRARAGQGLLNGCDDGPAALPPSKPSQGKGPASTSEN------SHH 74  
ELW73032        1 MYSVEDLLISHGYKLSRDHPAAREDDREGRQPARTRTRAGHRLLNGYEDGPAALAHSRPSLGKGHVSDSES------RRS 74  
Q9P266          1 MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAGKGHVSDSES------RRS 74   human
XP_003786908    1 MYSVEDLLISHGYKPSRDLSAPREDDPEGRQAARTRARAGHGLVNGHEDGSAASAHRKTPAGRGHVSDPESr-----RRS 75  
XP_003771892    1 MYSVEDLLISHGYKLSRNPPAPHGDRYDGYQQDCSESRAGHGTLNGYEAHPTAFAYNKKSLGKGYLSDNEH------SGA 74  
XP_418578       1 MFSVEVLLISHGYKLSKNPPASYENRYDGYRHEAAGNRSAQRTLNGFEADPRA-AYCKKPLTKTNSSSTESshgsqgRQA 79  
XP_017203135    1 MYSVEDLLISHGYAPSRELPAPRPESPEGRPQARTRTRTGHGLLNGCEDGPAAPARRKTPPGKGHVNDPDR------RRR 74  
EHB16764        1 MYSVEDLLISHGYKPARDLPGQRGAKADGHPQAKTRPRGSQGLQNGCEDGIAALAPSRQAPGPGPVSAPEG------HQG 74  
XP_003468764    1 MYSVEDLLISHGYRPSRDLPGPRGTKADGHAQARTRPRGSQGLQNGCEDGATTLAPSRPALATSPVSTPEG------HRG 74  
Q5DTX6          1 MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSEN------RIS 74   house mouse
XP_002919699   75 APRARGEPQSALAPRASELGFYHQPVLRWSSQPQTAHDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHTREGP 154 
ELW73032       75 TPRGHGEPHSTSASRASAAGFYNQPALAWPSQPPPCDDRAYWRRGGQGVRSLLGPREREDREAGGMAQAHSLSVHTREGP 154 
Q9P266         75 TPRGHGEPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQ-KPREHENLEARGMAQAHSLPVHVREGP 153  human
XP_003786908   76 TPRGPREPQGASASRTSEAGFYNQPTLVWYPQPQAGSDQAHRKRGGPEVSRSLGPRDREDLEVRGMAQAYSLPGHVREGP 155 
XP_003771892   75 GLGSHRDPPNSSAFHHSKEGFYNQPPLEWSSQPKP--DLAYWRRKGQDFSVLLDYTDRGNLETPRMAEPHGMNRNVREGQ 152 
XP_418578      80 GPGYHHDLQGLSTFHTSEGGVYDRPQLAWPSQPKSDKDLAYWRRRGQDFSVLLGHSQKGGAEMQGLAAAHGAPRHPKDAQ 159 
XP_017203135   75 EPPS-----------AAEAGFSNRPALVWSAQPPPRDDPGHWRR-GPEGSGLLGSRERKELGIRAMAQAHSLPAPMQEGP 142 
EHB16764       75 VPRHHVEHHRTSASRAPEAGFYKQPALAWSSQAQIGNDQVCRRR-GQKASSSLGPRDRDEPEGRGVAQARSLPVHMREGP 153 
XP_003468764   75 APRHHVEPHRTSASGAAEAGFYNQAASVRSSQSQIGTDQACWRR-GQKATSLLGPQDPDDLEVRGVAQACGLPAHMREGP 153 
Q5DTX6         75 RPRGHREHQST--SRTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENL 152  house mouse
XP_002919699  155 WEVGGRTENVMKKAVWEEELRMAGPAKWQNISLESWNQPRKLGRQMSDGDGEKMFQD----LYPFMQGEQALNSQSKGKS 230 
ELW73032      155 WEVGRRTEDVMKKAIWEEELRTSGAAKWQNVSLDSWNQPRKIGRQMSDGDGEKLFQD----LYPFIEGQRVLNPQNKRKS 230 
Q9P266        154 WEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQD----LYPFIQGEHVLNSQNKGKS 229  human
XP_003786908  156 WEVGRRTEHVTKKAAWEEELRASGPAKWQNVSLESWNQPRKLGRQMSDGAGERFFQD----LYPFIQGGHMLNSQNKRKS 231 
XP_003771892  153 LEVGSRLENTMKRAVLEDSWKISRDPKWQNTNFESWNQPRRLGRQMSDGDGEKLLQD----VYSFTKGDNTFNSQNKGKS 228 
XP_418578     160 LKVGLSTEYV-RRSGLPESCEGPGECKWQNLRTESWNQPKKVGRQMSDGDREKLLQE----LYSLTLGDDVLGSHNKGKS 234 
XP_017203135  143 WEVGGRTEKVTRKATWEEELRTS-PGRWPDGSLESWSQPRQLGRQMSDGGGQRLPHN----LYPLGPAEPAWTAQSKRKS 217 
EHB16764      154 WDVRGRTEHVMKKAVWEEEPRMSGPAKWQNVSLESWNQPRKLGRQMSDGGGEKLFQD----LYPFIQGEHALTSQNKKKS 229 
XP_003468764  154 WDVGVRTEYVMKKAVWEEEPRMSGPDKWQNVSLESWNQPRKLGRQMSDGDREKLFQD----LYPFTQGEHALTSQNKKKS 229 
Q5DTX6        153 WEVAGRTEHVMKNAIWEEELRM------QDMSLESWKKPRELGRQASDGDGRKRPQEkfegLYPFVHGEH--TSQNRKKS 224  house mouse
XP_002919699  231 QSLPRVLSPESLSCMDIPIPLNDGHFPGVPKMPFHPPNCAPNLESTRNPEKSGSSVPLPRPKFGRPLKPPSYDSHQHSra 310 
ELW73032      231 QSLPRVLSPEGLSCTEIPISMGDGHLPGVSKMPPYPPNCAPSLESTRNPDKGGSAGPGPRPKFGRPLKPASFGSHQSR-- 308 
Q9P266        230 RSLPRVLSPESLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSrg 306  human
XP_003786908  232 RSLPRVLGPENLSCTEIPIPLSDGYL---PKMPPYPPTCPPNLEPTRHPEKGGSSVPLPRPKFGKPLKPPSHGSHQPSrg 308 
XP_003771892  229 QSLPRVLSPDSLRCVEMPILINDYHFPGDTKMLFYSTNSTSNLEYLRNPEKVDPYIPLQKPKYGRPLKPPSYEFHRQTrs 308 
XP_418578     235 QSLPRVLLQESMRCVEMPSLTNSNNSLSVSKAPSYPSHRL-TVESAKHHETGGHFLPLVKPKYGRPLKPPSYELQRQSra 313 
XP_017203135  218 RSLPRVLSPESLRYMEVPIPFSDGHVPGVPQMLPY-PNCAPSLDCKRNPEKA----PLPRPKFGRPVKq----------g 282 
EHB16764      230 QSLPRVLSPESLSYVEVPIALNVGHLPGVPKVPPCPPSGAPHLESTKTSEKAGTSAPFPRPKFGRPLKPPSYSSHSQPrg 309 
XP_003468764  230 QSLPRVLSPESLSYKEIPIPLDDGHLPGIPKVPPYAPNCAPHSELVRNPEKAGSSAPFPRPKFGRPIRP-LYGSHPQPrg 308 
Q5DTX6        225 QSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPr- 303  house mouse
XP_002919699  311 GVENSDSPDSQRADLCVSYLSRAHEPRLELCASDSGLEPPVYVPPPSYRSPPQPITNPYV-EEAAPRPVCGGPRQQQL-- 387 
ELW73032      309 GVESSASQDSLQTDLSVSGSTTAQDPRHELCASDSGLEPPVYVPPPSYRSPPQHIPNPYL-EDTAPRHAHGSHGQPQH-- 385 
Q9P266        307 GADSSDSQDSQQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYL-EDTVPINVCGGHSQQQS-- 375  human
XP_003786908  309 GVELSDRQDSRQADLHV--------PRHEPCAVESGLEPPVYVPPPSYRSPPEHIPNPYLeEDPAPRPVCSGHSQQLP-- 378 
XP_003771892  309 GVETSRYQDNYQRD-CVSFLPQTNDPRQDPYNPDPNLEPPMYVPPPSYRSPPQQNTNPHF-LNEVPHFQYDGHIQQQQqr 386 
XP_418578     314 PAETVGFQDHYQKDEPIPYLAKASEPRQDPCVQDPALEPPVYVPPPSYKSPPHHTASPHP-LSEVPNNATYASSDQQD-- 390 
XP_017203135  283 GGGHGDPQASQHGAPHVSCWSKANEPRHELCGSDPGLEPPVYVPPPSYRSPPEHIPNPYL-EDAAPTPSSSGHGQQPH-- 359 
EHB16764      310 G-ERGSPQDG-------SCFPRTSDPGHEPSAPDCGLEPPVYVPPPSYRSPPLHIPNPYL-EDTMPKHMSGGHSPQHH-- 378 
XP_003468764  309 G-ERSSLQDSQQVDLHSSCLNRTSGPTHEPSVPDCGLEPPVYVPPPSYRSPPQHIPNPYL-EDSVPSYVSGEHGSQHQ-- 384 
Q5DTX6        304 --gEGGFQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYL-EDPVPRHVSSNQSQQQV-- 378  house mouse
XP_002919699  388 -AMELAGASCQLPAGPLGAGNESGASPRS-PRGVPQQPRPTTAYDSSVLYIPFDDPRIRHFKLAHPQGFCQETKVDEKSY 465 
ELW73032      386 -AAEKAGAGCPLPPGPLGTGTEYGAGPRS-PRGLPPHPRLAAAFEGSVQYIPFDDPRIRHIKLAQPQGFYEEAKLGPKLW 463 
Q9P266        376 -PTEKAGASGQPPSGPPGTGNEYGVSPRL-PQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSY 453  human
XP_003786908  379 -LTEKAGASGQLPPGPFGTGNEYGASPRC-PRG-----PSATAHDSFVQYIPFDDPRIRHIKLAQPQGFCEESKLDGKSR 451 
XP_003771892  387 lMMEKPIAGHYSSSSSYRSGNQYGASGCP-PHGFSGHPQHVEACNSSVQYIPFNDPRIRHIKMTHHQDLGQQTKFLETLC 465 
XP_418578     391 -TAERAVACQRPAVNSVEMGAAPCKDNHL-PPGKQSHLRRPADYLRSVQYIPFDDPRIRHIKIAPPGGLQDNIKYIDNAH 468 
XP_017203135  360 -LTEKP----RLPSS--GSGDEYGVGQCS-P------------CPAGVQYIPFDDPRIRHIKLAWPHGDRQDATPEGSSC 419 
EHB16764      379 -PIEKPRASGPLPPGLLRTGNEYGVSSGS-PQSLRPHPRPVATYEGSVQYIPFDDPRIRHIKLAQPLGFGEEVKSDDRPY 456 
XP_003468764  385 -PTEKPGARGPLPPGLLRTRNECDAGPAS-PQSLPPHPRSVTTHEGSVQYIPFDDPRIRHIKLAQPLGFCEEVKPGDRNY 462 
Q5DTX6        379 -P-EKPETSCPLPSGSLAARDLYDAMPGSpPQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSY 456  house mouse
XP_002919699  466 SSSPGPAGAPAPGHSQHDGAVFSPQSvmtppGSVRGSTTTDAS-PRWLWGHLPRDAENGgFSNQREHSAVRgqwpaagGS 544 
ELW73032      464 SSDLIPPQEPAPGEVLRDGAVLSPQT-----GYERGATSAQLS-PRWLRGHLPRDGEDG-FPEQSDLRVVR-------GS 529 
Q9P266        454 NSSPVTAQEPAHGGMQPDGAIWNPQSlippsGDERGLVLADSS-PRWLWGQPPGDGENSgLPNQRDRCVARgqwpdvrGS 532  human
XP_003786908  452 NSSPVTPQEPPRGKMQPDGAVWDPQGltplsGDERGLALAGAQ-PWWLWGQLSRDGEPSgFPDQRDHCVTRgqrpevgGS 530 
XP_003771892  466 TTGPSDFQGPARVQAQDDGAFSHPESqvpttKSENDPATYAPNlGGWLPAATPPDREICaLPDQRDNCVLSeqqpdkgSS 545 
XP_418578     469 SPSSGTSQERDL-EVRCNSAFLDASHksssvKGERTSDSSAHS-SRWLAPSV-RDQENCaLLDQRDSCSTanhs-pcnEA 544 
XP_017203135  420 GLGPVAPPEPARNITQLDGAGRNPRNptppsGDDRGLAFAEPS-PQWLWGQLPRNRDNGgPPDPTDHRITr-------DG 491 
EHB16764      457 DACPVPAPEPAQGKRHRDGAVLNAQSltptlGTGTGPAFVDPG-PWWLWGQLPGDGEYAsFPYQ------RgqpapgeGG 529 
XP_003468764  463 DARPVPAPEPAQERRHHDSAILNVQSltpplGTERRPTLVDPG-PQWLWDQLLGDGKNAgVPDQREHCIVRgqqapgeGG 541 
Q5DTX6        457 NPGLLTTQEPAIGKRQYDDAPSVPRGptpspVNEQSSAFVHSS-PRWLQGQLPLGIGPGgFHGQTEHHVMGglttnvtDI 535  house mouse
XP_002919699  545 RHGHTEGPAPSPSPQG-ESTCETRTKLKKLG--TGTQSKESSRKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSTHK 621 
ELW73032      530 QHGHAEGQLSSPDAPG-ERTCEMQTKLRTFE--TGMQTKKSSKKKTSETIFCLVSIPVKSESHLPATDTNNNDLKPTADR 606 
Q9P266        533 QHGHTGRQVSSPYSQG-ESTCETQTKLKKFQ--TGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQ 609  human
XP_003786908  531 QQRHAEGQVSSPHLQG-ASTCETQAKLKKFE--AGIQTRKSSKKKTNETIFCLVSIPVKSESHLPDIDTNNNDLKQGGDK 607 
XP_003771892  546 RQQCTKGRVSSQIPQW-ESTCETITKLKTFQ--TGIQTKKSSKKKVNETVFCLVSVPVKSEPHLPDTDRNNNDLKQNADK 622 
XP_418578     545 STEYTKGKLLVRNSHM-DSTCETVTKVKKFEpgTGMQSKKSSKKKMNETIFCLVSIPVKSESNLPDTDRNNN-ITQSPD- 621 
XP_017203135  492 EHGHTEGLVSRASPHG-ESLCETQAKLKKSE--TGPELKRRSKKKVNETIFCLVSIPVKSESQLPDTDRNNNDLKQGARQ 568 
EHB16764      530 QHGHAGSHVFSPDPQRsERTCETQTKLRMFA--TGMQTKKSSKRKPNETVFCLVSIPVKSESHLPAIDRNNNDLKQSADQ 607 
XP_003468764  542 QHGHAGGYVSSPDPQGsERTCETHTKLRMFE--TGMQTKKSSKKKTNETIFCLVSIPVKSESHLPEIDTNNNDLKQSADK 619 
Q5DTX6        536 K---AEGHASSPQPQS-EGTCKTYTKLRKFE--TGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADK 609  house mouse
XP_002919699  622 KNGLDKSTVLQEQSLLSMSSTDLELQALTGSMAGRTEFQKQDLGEPEEGKQTNDLRFIHPTKHRELKYSGSWPGHQYRDQ 701 
ELW73032      607 KDGCDKSAALQEQSLLSLSSTDLELQALTGSMVGGTGFRKQDLGEPEVHKQTNDLRFIHLTKHRELQASGFWPGHQYRDQ 686 
Q9P266        610 KNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQ 689  human
XP_003786908  608 KNGSDKSAALQEQSLLSLSSTDLELQALTGSMGGRPEFQKQDLGEPEDDKQTNDLRFVHFTQHRELKYAGSWPGHQYRDQ 687 
XP_003771892  623 KNGNDKNGVLQEQSLLSMSSTDLELQALTGNMASKTELQKQGPGGPKQYKQTNDLRFSHPIKHRELRYSGSWPGDQYRDQ 702 
XP_418578     622 KNGFDNNGALQEQSLLSMSSTDLELQALTGSMTNKNELQKQELWRPEEFKQMNDLRFIQPAKHRELKYSGSWPGDQYKDQ 701 
XP_017203135  569 VNGADKSP-------LSASCTDLELQALTGSLVGRPALCTQAPGEPEKDRHANDLRFLYLTGHTELTYPGVWPGHQYRDQ 641 
EHB16764      608 KPGADKSLALQEQSLLSLSSSDLELQALTGSMAGQTEFPKQGLGVPG-DRHADELRFIHLAEHRALQYSGSWPGHQYRDQ 686 
XP_003468764  620 KPGIDKSLALQEQSLLSMSSTDLELQALTGSMAGKTEFPKQDQEEPEGDKQTDDFRFIHLAKHRALKYSGSWPGNQYRDQ 699 
Q5DTX6        610 TRGLCQGSALQEQSLLSMSSTDLELQALMGSMAWRRTSPRQGLRESE-DGQIDDPRILHLIKPKELQASSPWPGHQYRDQ 688  house mouse
XP_002919699  702 QTQTTFTEDTKSPQPLPAEKAGGSPKAVL-TPRFSDPV-------A-SKPHVPVALASSDQNQRPKAPPLKGQMS-LSPS 771 
ELW73032      687 QTQTSFPEESQGTQLPPGAEHRGPSPSTP-GAKCPEPA-------A-FEPHVHTALASRDQKQKPSAPSPQGQTS-LSPS 756 
Q9P266        690 QTQTSFSEEPQSSQLLPGAKLGGPSRAAL-SPKCSDPA-------A-SEAQTHTAFPTGDHKQRPSARNLKGHRS-LSPS 759  human
XP_003786908  688 QTQTSFPEESQSVQLLPGAQPGGPSDTGP-APQHPDPA-------A-SEGQMHTALASGDHRQRPSAHPLRGQRS-LSPS 757 
XP_003771892  703 QTQTPITQESRTSQFLPARKMESQHNALP-LPKVSDPTlklsepsA-SETLKTTASPPSDWKMRPNTCNLKGQMY-FSPS 779 
XP_418578     702 QTQTSFSEEPKNPQIFHGTKPGQPSSNKPlSPKQLGCT-------AsTAGSKQTGSPSDDRGCRQGAYGMKGQMY-LSQS 773 
XP_017203135  642 QTQTSFPEEPKSSQ--QPTELGAAGHVAP-TPRRADPA-------A-SDPGTHTVACAS----RDHAQNLQGQASpLSPA 706 
EHB16764      687 QTQTSFPEDSKSSQLLPAARLGDLSDTAP-DPKCLDPT-------A-SDLPVHVALGSSDPNWKACAPHPKGQMS-LSPS 756 
XP_003468764  700 QTQTSFPEESKSSQLLPASMLGELSDTAP-MPERLE---------A-TGSHRHVPFGSSDQKQKAYAPNLKGQTS-LNPS 767 
Q5DTX6        689 QTQTSFHEDSKSSQLLPATKPGEASNVAP-TPTCPDTT-------A-SEVCLHTALAFSDQNQKPSVPHLQGQTS-LSPS 758  house mouse
XP_002919699  772 NNSAFSRTTSCIHQAPAPKAGPGR---ACVDGQGRGSSPGPRGEVVKGET-TGPCNSRQLFGQFLLKPVSRRPWDLISQL 847 
ELW73032      757 SNSAFSRTSWSVNQAPVSKACPRE---PCADVRVPAASPGPQREVVKGEP-TGPCNSQQLFGQFLLKPVSRRPWDLISQL 832 
Q9P266        760 SNSAFSRTSLSVDQAPTPKAGRSQ---PCVDVHGLGAHPGPKREVVKGEP-TGPCNSKQLFGQFLLKPVSRRPWDLISQL 835  human
XP_003786908  758 GNSVFSRTSSSTHQAPAPKAGRSQ---PSVDVQGHGASPKPLCEVVKGEP-TGPCNSKQLFGQFLLKPVSRRPWDLISQL 833 
XP_003771892  780 SNSAFSRTASST--IPTSKAVQSQphgPSANINERDTKPVSKGQVVKGEL-SAPCNSKELFGQFLLKPVSRRPWDVISQL 856 
XP_418578     774 SNSAFSRTATSIPQASSPKGHQSQ---P-LPTQEREAGLPPRADVVKAEA-GAPCNSKELFGQFLLKPVSRRPWDAISEL 848 
XP_017203135  707 SNSAFSRASSSSSSTTWAPAAKAG---PSVDGR------APQPEVVKGETaAGSCNSQQPFGQFLLKPVSRRPWDLISQL 777 
EHB16764      757 SHSAFSRTSPSATQAPVPKAGQTQ---PCMDVRGQGASPVPKPEVVKGEStAGPCNSKQLFGQFLLKPVSRRPWDLISQL 833 
XP_003468764  768 SNSAFSRTSPTTSQAPVLKAGQPH---PCLDVRGQGASPVPKPEVVKGEPtAGPCNSKQLFGQFLLKPVSRRPWDLISQL 844 
Q5DTX6        759 RNSAFSRTSSAINQASMSKGTSDQ---------LPGANPVPKPEVVKGEStTGQCNSTQLFGQFLLKPVSRRPWDLISQL 829  house mouse
XP_002919699  848 ESFNKELQEEEECg---qSGSDSRSE----DSDTEWPCEGYADATGKNWGWREDSGAWRAEDPRKRLALEEPGAQpGRVK 920 
ELW73032      833 ESFNKELQEEEEE-----EDSHSSSE----DSEAEWLQEDPADPRPESSGFHRHGQEVRVEQEPRMLVPEDPAWL-GRVQ 902 
Q9P266        836 ESFNKELQEEEESss-ssSSSSSSSE----ESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRsGRGE 910  human
XP_003786908  834 ESFNKELQEGEESss-ssSSSSSSSE----DSEAEHQREDHAGSRPENPSSPGHSPGLRAELQSGAWVLEPPVWLsGREE 908 
XP_003771892  857 ESFNKELQEQEESss-nsSRSNSSIDgevaESEQQMQEDVGADADLKDYKPDEPSQEMTVRLQPRITAPEIPVFKsGRVK 935 
XP_418578     849 ESFNKELQGQEES-----MSSEEDLE------SAGASPQPCALPQRRSPRNGNQ--EPKRGGKLETVVPEVPVFKsGRVK 915 
XP_017203135  778 ESFNKELQEEEEShpdsdGRRGSGSE----GSEGQGPWEDGDPSLEKHPGFPESHREEREERQPKAWGPQHPEFRsGGAK 853 
EHB16764      834 ESFNKELQEEEDSp---dGSSGSSSE----ENEIEQRQEDCVGSRPRSWGFHEDSCDGRGEQQPRRLVLEDRGGWwGRVE 906 
XP_003468764  845 ESFNKELQEGEDSp---dGSSGSSGE----ENEIE-RQEDYVDSRPRNWGFYEDS-EKSVKPPPRELVLEHPERWsGRVK 915 
Q5DTX6        830 ESFNKELQEEEES------HGGSGSE----DSEAE-QPEDCADSRTKSWALQGT----RTAQQPAGLALEN-VASpDRRL 893  house mouse
XP_002919699  921 SKSESWSEEQKPSRPRAPPQSpPGPTTTVGGGAEDYPWAHGSLVTQEGHQDVEQRMNKLAVSPGPVHRVMSSRSSDANPV 1000
ELW73032      903 SKPESWSGEPKPGLPHAQPQS-SGPTQGGDGRGEPWQSVGWSPATEERRREDGSGESRLALSPGPEKGRVSSRSSDTKPS 981 
Q9P266        911 SKSESWSEELQPGHPRAWPPS-PGRFRVEEGGGAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPL 988  human
XP_003786908  909 RQSEPWSEGPGAS---SSPR--PAPSQVECGRGDSFWLADGSW-----NNEVDREVNEPVVSPGPVQGLVSSRSSGQKPV 978 
XP_003771892  936 S-VELISD-----FICDYPQA-QIPLQRRDSKGESVKPLVESMIPETRKQEMEYRIDRLAISPDPGKRMTSSNLMKTAPN 1008
XP_418578     916 SKSESWSTGIEHGAEMDCVGS-QCS-SQPGGSNEGVRPADGSLITEMRTEEAKNRANSQPVRPGPIKRFLSSSPSSSYHG 993 
XP_017203135  854 SQSGGWSEQVAPGWPQACPRSpRGPPQAEDGRGAVFLAADGGAIIEKRDQAEGRSAREPVHSPSPPRRAESSRASDAWPA 933 
EHB16764      907 RGCETWSREPGAGHPLAHPPS-PGFSQVEDGRGQPFGSAGGSLVTETREWAMVNGTDGPPGGPGPGRRGASSRASDTRPV 985 
XP_003468764  916 SKSESWSEELKAGHLSTCPQS-PDFSKVKDSRSDPFGSADGSLVTENRKQEIVNGLDELIARPGPVKRVVSFRQSDTKPV 994 
Q5DTX6        894 NDSQSWNEEPKPGHSSVHPQS-LGPSQEEGSRGVPVQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIA---PIDTKAA 969  house mouse
XP_002919699 1001 PSSHAAELRPPQGSQDLPN-----ASLSGELSTPTPRTTGaGGERSPLLP--LSLASKPRGLSAPDLRSVGLLPAQEQSA 1073
ELW73032      982 LLSYLAEPREPQDSWEFTS-----AVSSTRPSHMLPRTAD-GEERGTAVP--LSFTDKSRGLSAPDLRSLGLPAGQEQET 1053
Q9P266        989 PASYPAEPREPQESPKITS-----AFSSVKPSEAVPRKFDsGGERGAGLP--LSLSNKNRGLSAPDLRSVGLTPGQEQGA 1061 human
XP_003786908  979 SPPSPAEPREPQEIQKLIG-----AFTSAKPSIAGPPRVDsGRQRGAVLS--RSLTGKNRGLSAPDLRLVGLAPGQEQST 1051
XP_003771892 1009 SSSYPTDIREPQENRQYSN-----VLNSLQPSQMIHPRSDgVKERESEGH--ISLVNKTQGLSEPEVKFVEHDMGPVHRA 1081
XP_418578     994 NPFNNPVLQEMSEDQN--------YLHFVKLSKGAAPQNDtQLERGSAVC--LSLTKRNQGCSEPDLRAVGLDTAPGPGA 1063
XP_017203135  934 APACAAGLREPTR-----------DASALRVSGAAPPEAG-----ETPAP--LPLAARSRGLSAPDLRCVGL---REQHP 992 
EHB16764      986 PPAWLAAPREPAESERLTDewlpgALGSVWQSGVVPPELPgAEEGATEAP--LTLTSKGRGLSEPDLRSIGLMMRPEPSA 1063
XP_003468764  995 SPSWLAEPKEPAQREKLTD-----AFTSVQLREEAPLEVGlAEERGTGVP--LTLTNKSRGLSAPDLRSVGLIMRPEPST 1067
Q5DTX6        970 PLYCLSEPRGSQELTKFGD-----AVGSVQLGRETPTQVGnGGDTEVLPCvlLPLADKYRGHSTPDFRSLELTLGQEQNA 1044 house mouse
XP_002919699 1074 HKLDGSLGEASAIEIP--PNESLQARAARILGIEVAVESLLPGARRTGQNQHPEP--DGSARGPEAPREGSESS-SAQPD 1148
ELW73032     1054 PGLDGTLGEARAVAAP--PSESLQARAARILGIEVAMESLLPGARKEGQSQLPEPvtNTNTCSPGPCMEELPVS-PAPAG 1130
Q9P266       1062 SELEGSLGEASTIEIP--PGESLQARAARILGIEVAVESLLPGIRRAGQNQPAEP--DASACTPESPQEELLSR-PAPAD 1136 human
XP_003786908 1052 SQVDGSSGE--AIEIP--PGESLQARAARILGIEVAVETLLWGSRRAGQSQPPLP--DASACSPESPRDEPSSSgSAPAD 1125
XP_003771892 1082 NKLDGILEKPGAIEIP--PNEPLQTRAARILGIEVAVESLMHGNKDKGTHLPPGPaeNIPKADFLAVETSYNLV-QPNPA 1158
XP_418578    1064 SNSD-HSSNANSVEIP--VNESLQARAARILGIEIAVESLLPDD-HVGPQPGARP--ASDAHDFGSSAESTVSG------ 1131
XP_017203135  993 IGSDGSWGDSSAAEIP--PGETLQARAARILGIEVAVESLLPDSSRTRQSQRPEP-----------PREASQAS-SAPSD 1058
EHB16764     1064 SKLDRPLGEGRAAVIPpsPNESLQARAARILGIEVAMESLLPGTGTAGPSQSTEP--DTSVCSLEPPREGPLPS------ 1135
XP_003468764 1068 SELDRPLGESTAAEIP--PSESLQARAARILGIEVAMESLLPGTRTAGLSQSPEP--DASTCSLEPLREESSPS-SAMSF 1142
Q5DTX6       1045 YKLE-CLDLENTVEVL--PSESLQERAERILGIEVAVESLLPSARRTEQSQLPEP--DASACNPSSSREDSSHS-LALPV 1118 house mouse
XP_002919699 1149 DPPASMDAFYGRRKCGWTESPLFVGERDSARRPPPAAEHSRV------DRTvpsKAPSPEPQPSPQESQSFNPKDMGTKS 1222
ELW73032     1131 GPPAPADAFYGRRKCGWTQSPLFVGERDGARRAPQASEHMGV------DGL---RAPSPEPQPDPGELKTFDPKDEEARP 1201
Q9P266       1137 VPRVSTDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDV------DGVvtsTDPVPEPEPSPLESKFFEQKDVETKP 1210 human
XP_003786908 1126 VLTVPTDAFYGRRKCGWTQSPLFVGERDSARRASPMSDQSSV------DGVitsEASSPEPPLNLLESRSFNQKDMGARP 1199
XP_003771892 1159 ESTSSKSAFDSRRKCGWTESPLFVGERDTHLKTRVIRQDSELnpdgngDDTtnsLVPKLEPKSS---SKLHDQKDLRTNQ 1235
XP_418578    1132 KEGKKDSSYEGRRKCGWTESALFVGERDRSLYPDEC------------------QTTHQEGSSKMLVKEQAFEQPV---S 1190
XP_017203135 1059 GPTATADAFYGRRKCGWTESPLFVGEREGTRRGPPAPEPSAA------DGVlagQVPSPEPQPDALEPKPSECRAGGLAP 1132
EHB16764     1136 ---VTADASYGRRKCGWTQSPLFVGE-----RAPQAPGHSAV------GR----DLASPEPQLGSLESRSSEQKDAGPNP 1197
XP_003468764 1143 GPTATTDAFYGRRRCGWTHSPLFVGE-----RAPQASEHSAV------DRVptsQDTSPEPQLGPLESKPLEQNLVEPKP 1211
Q5DTX6       1119 GPKVATDAFYGRRKCGWTESPLFVGE-----RAPQASICSDV------DGFptsQATSPEP----------GKKDEEAKA 1177 house mouse
XP_002919699 1223 PFRSTLFHFIERTPNVSGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADTMEEAEGLKA 1302
ELW73032     1202 SFRSTLFHVIERTPSVSGPEKKLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVTSVSRMRFLSSKTPDSTEETEELKV 1281
Q9P266       1211 PFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQEDAEELKA 1290 human
XP_003786908 1200 PFRSTLFHFIERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRAAPDRLLRMKEVSSVSRMRVLSCRSTDSTEETEELTA 1279
XP_003771892 1236 SYKSTLFHYLERNSTGMGSEKKFRSTSKVIETIQEKLVSPPTKTAVDRLMRMKEVDSISRIRRLSSKSTDSGEETEEEKI 1315
XP_418578    1191 PSQGGDQNLVSKPTVCQHSEKRVRSTSKVIETLQGKLTSPPSRTAMDRLVRMKEVDSVSRMRRLSIKSADSGEEVDEEKL 1270
XP_017203135 1133 SFRSTLFHVIERTPGAAGSEKRLRSPSKVIESLQEKLAAPPRRADPGRLMRMKEVSSVSRMRCLSFQSADRAAE------ 1206
EHB16764     1198 PFRTTLFHVIERTPSMLGLEKRLRGPSKVIESLQEKLASSPRRADPDRLMRMKEVSSVSRMRSLSFRSADPTTEAEEAKA 1277
XP_003468764 1212 PFKSTLFHVIERTPSVSGLEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRSLSCRSTESSEEAEELKA 1291
Q5DTX6       1178 PFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIRMREVNSLSQMRCLSSKSADSVEEPDPLKV 1257 house mouse
XP_002919699 1303 -ERGPGEPPGGPVSLNAGDMARKAGHPLSVSGGAPSLEEDGPPSAQREKtTVRQDFWCP 1360
ELW73032     1282 -TRGQAGPPEAFVSLNGRDWARRPGHLLPVSKSIISQEENGHPATQRQRrTAEQDFWGP 1339
Q9P266       1291 tTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEK-SMDQDFWCP 1348 human
XP_003786908 1280 -IRGQPGPPRGSSE----------DHTVSGSKQGTSWGESERPAM--EKkDGDQDFWCP 1325
XP_003771892 1316 -QRRLEGQKRSFGSLNGSDPGHKVEDADAVSKHIISLEENGHQTVHSVKkNAEQDFFCL 1373
XP_418578    1271 -------------SKVHEERGSKLAMSGAVSKRVISLSENGYLGGMDKK-KIDRDFSLD 1315
XP_017203135 1207 ----EAGQPAGCGSPRGGDRAHPRGLSSAPARGGVSWEDLGHPAAQRDR-IASEDSWCP 1260
EHB16764     1278 -AGGQALQP-----LSRGDRAWRAGPPPALSEGLITWEENGTVAAPRER-SEAQHFWCP 1329
XP_003468764 1292 -ERGQAWQPGGPMALSRGDRAWRVGHPPSIPKGIVTWEENGHVASQKEK-STSQDFWCP 1348
Q5DTX6       1258 -IKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQ-----NENGHPEVPRDK-MSDQDLWCA 1309 house mouse
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