Conserved Protein Domain Family
CH_GAS2L1_2
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cd21268: CH_GAS2L1_2 
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409117
Aligned: 17 rows
Threshold Bit Score: 201.391
Created: 9-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #   #                                                                
Q99501         18 PFRSSEAYVEAMKEDLAEWLNALYGlglpgggDGFLTGLATGTTLCQHANAVTEAARalaaarparg------------- 84   human
XP_009018582    5 PFKTKDEYLYAMKEDLAEWFHDLYNlpv--tvDNFFEHLDNGTLLCKHANTILKNTNtaaaaaatttt------------ 70   Helobdella ro...
CBY33108       30 PYNTQNEYLFAMKEDLSEWLQILHSeti--naYSFFRKLETGILLCKHANTVTLHAEefkmtnpdhpsltkvk------- 100  Oikopleura di...
PIK36417       35 PYRTKDEYLYAMREDLTEWLNDLYSlki--spEDFFESLDNGVLLCKHGNRLQTLALefrqlnnvinntemd-------- 104  Japanese sea ...
XP_002599705    4 RFNSTEEYMSVIRNGLSDWLNSLYNlnv--tpDDLIEYLSTGVVLCHHANTWEVERGtkyrvhf---------------- 65   Florida lancelet
XP_013410968   26 PFKTKDEYLYAMKEDLAEWFKTLYEgle-ilvDNFFEVLDTGVLLCKHANNVQQYAKeyekqhpgspnfanv-------- 96   Lingula anatina
NP_572331      11 PFKSSEEYLEAMREDLAEWLSTLYPels-inaDNFMDRLDTGVALCKHANYVRQAAVdylarrqarnksmtrsmtsglag 89   fruit fly
EEC16085       20 PFKSSEEYLWAMKEDLAEWLNTLYGlkl--taEGFLDSLDDGVLLCRHANKVLEIARsdgrlaslslpd----------- 86   black-legged ...
EFX75447       30 PFKSSEEYLVAMKEDLAEWLHRLYHpqlnidfDNFMDVLEDGVALCKHANNVRRTAMaykekleqrdsqr---------- 99   common water ...
XP_018099489   17 PFRSSEEYLEAMKEDLTDWLNMLYDldi--eaGTFLESLETGYILCQHANNLNHLARdfqqqhpevasgmrl-------- 86   African clawe...

Feature 1                            # ##  ## #          #########     # ## ##  ##  #       
Q99501         85 ------vafqahsvvpGSFMARDNVATFIGWCRvelgvPEVLMFETEDLVlRKNEKSVVLCLLEVARRGARLGL 152  human
XP_009018582   71 ------tltyrnsaqiGTFQARDNISTFIAWCRsflgiPDTILFETEDLVsRKNERNVVLCLLEVGRRGSKFGV 138  Helobdella robusta
CBY33108      101 vpqncvkfnegrhvkaESFFARDNVAVFIKWCReelgiSDIIMFETDDLIlRKNEKNFILTLLEVARRGAKFGM 174  Oikopleura dioica
PIK36417      105 --fhsgdikfrdsaksGTFQARDNISNFIHWCRnclkiNSVLMFETDDLVlRKNDRSFILCLLEVARRGGLVGM 176  Japanese sea cucumber
XP_002599705   66 ----------spratqGSFQARDNVSLFINWCRrslqfPETLLFETNDLVeGRNEHNFLVCLLEVARKGSEVGL 129  Florida lancelet
XP_013410968   97 -kfprgevqyrenvkpKSFQARDNISNFIAWCRgl-giMDVLLFETDDLVlRKNEKSVILCLLEVARKGAKFGM 168  Lingula anatina
NP_572331      90 pilamgnvhylpaaksGTFFARDNVSNFITWCRkslkiIECLLFETDDLImRKNEKHVILCLLEVARRGAKFGM 163  fruit fly
EEC16085       87 -----rdvvyraevqrGTFLARDNVSNFIAFCRal-siKECLLFETEDLVmRKNERSFILCLLEVARRGARLGM 154  black-legged tick
EFX75447      100 ---rrkfsthldipdrDSFFARDNVHNFIQWCRll-giYECLLFETDDLVlRKNEKSFILCLLEVARRGANFGM 169  common water flea
XP_018099489   87 --pqkevifqvkgavpGSFVARDNVSNFIAWCRqelgiPEVLMFETNDLVlRKGEKSFVLCLLEVARRGARLGM 158  African clawed frog

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