5ZZW


Conserved Protein Domain Family
Methyltransf_28

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pfam02636: Methyltransf_28 
Putative S-adenosyl-L-methionine-dependent methyltransferase
This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase. In eukaryotes it plays a role in mitochondrial complex I activity.
Statistics
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PSSM-Id: 460634
Aligned: 70 rows
Threshold Bit Score: 142.399
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZZW_B        76 MIGIWCVATWEAM---GKPK----K-LQIVEMGPGRGTLMKDILRSTKVF-K-EFYDSISVHLVEASPANKKTQKQNLLY 145 Dictyostelium d...
P36052        91 CLAKWLLVNYKLN---DYPYyd-lNiVNIYTDLPQAIQICKNLMSYLKSTlSdNMFQKIKYFMVPLY-KCDKIPSKLLDG 165 Saccharomyces c...
Q4CY00       249 VLAEYLVTMMRAKfd-------prEpLVVYDIGAGTGALAVSVLDYLAEHfS-AVYAQCEYHVVEQNPQLVQVLRNRLIT 320 Trypanosoma cruzi
XP_001415722 131 ALVRYVLETHRGD----CGDdealEpLRVYEIGGGAGTFASGFLDAVKREaP-KVYEKMRYTSIDISKRLCDDQLNRVRR 205
A0BQV8        73 TLGNYINQQFRFTr---------kEkLRIVEIGAGYGAACEGVLYYMRNHqP-QTFSNMEYHLVDISPEACAQAQIRLSQ 142 Paramecium tetr...
EDO03707      84 AIARYLVNNYKIWqy-------pyHdLIIYEMGAGNGTLMLNILDYIRLTeP-EVYARTKFKIIEISSNLASLQKSHLLR 155
Q5APE5       199 ALARYILVNYKLNvy-------pyNdLIIYEMGGGNGTLMCDILNYIRKHqP-EIYEKTQYKIIEISSQLASKQMKNALD 270 Candida albicans
Q54XU0       206 SISNYIIEKFKQI-----QIknsdSkLKIYEIGAGSGTNALNILNHIRDNhK-EIYENMEYKIIEISKPLAQKQLTRIKQ 279 Dictyostelium d...
Q7VBT2        67 LLASQVVDWVEALlhtDVTS----EvISIIDIGPGEGDLLFHLIEALQKKsP-SLFKKIKLILIEINEGMKDRQKRRLAP 141 Prochlorococcus...
Q7V7S2        67 LLAIQLVDWFQQL---QQ-RvdkgKsLSLIEVGPGEGDLSADLISALEDLcP-ALIPRLELVLVESNKAMALRQRERLKS 141 Prochlorococcus...
5ZZW_B       146 Fkdkainfd--hktigetPNGIKvtW--VG-KLEEVPtdIPTLFLAQEFFDALPIHVFRFSREKndW-CEVLVDEDIte- 218 Dictyostelium d...
P36052       166 Ipgsv---------slvqDYPVSpyF--LQ-KKFHIEd-PIQILMLNDVIKYTTHDLVRYSSDDkgW-QQCFVDINKng- 230 Saccharomyces c...
Q4CY00       321 Hyhhvk--------ihniSILN---WrqLE---R-----RRCVLLGVELLSGMPHDCVLLSGDG--VcNEHWFGFQQhdn 379 Trypanosoma cruzi
XP_001415722 206 Sghandvhd--atvgdatSLQT---WgaTN---E-----ETCFVIALEVLDNLPHDRVWRPKRG--EgEWMQTEIVRnlt 270
A0BQV8       143 Dfkqqikkg--nlrifnqDFLN---YkqHTqNN------EMWFFVFLEVFDNLAHDKVI---DG----KQVYVENMQefa 204 Paramecium tetr...
EDO03707     156 Nansrghls--kveiinkSVFE---WnqIVp--------SPCFFLAMEVFDNFAHDSIRYDPVT----EEPLQGTVLisn 218
Q5APE5       271 NkltsqgldsskleifnkSIFE---WkkVVd--------DPCFFIALEVFDNFSHDLIRYDNDS----GKPYEGKVVide 335 Candida albicans
Q54XU0       280 Shpklni------nitnaNILE---WnqAE-EK------DECFIILTEVIDNLPHDKITITSNG--I-FESIVDSTVfet 340 Dictyostelium d...
Q7VBT2       142 F------------------KDIPicWmsMK-ELSDVP--VKGIMIAHEILDALPVDRVVSNNNK--L-FMQGVKLSTl-- 195 Prochlorococcus...
Q7V7S2       142 V------------------TSVPihWrsLN-ELAQAP--AIGVMLAHEMLDALPVERLVWRDQRl-W-RQGVC-LENv-- 195 Prochlorococcus...
5ZZW_B       219 --------------------------------hgEYY---------L---RFVqsKgptlmttaVKHLLPEFGL------ 248 Dictyostelium d...
P36052       231 ---------------------------------qKSKs--------F---DSA--Idy-----sCELALEQMFNdrs--- 256 Saccharomyces c...
Q4CY00       380 lstvheryyalkdpv-ilrylrylrwlqeesfhsLKVlcltggrenIdppPFT--SiepnmndpLRVIITKLIWth---- 452 Trypanosoma cruzi
XP_001415722 271 tgelaqreap------------ladaliqrtlqaIDL-------------TADlaVdgdggaynPRGFMHSIRRalts-- 323
A0BQV8       205 etisdpli----------------kevyamyqqfKQQn-----------kDQDenLedrflfntLRKVISKYYGn----- 252 Paramecium tetr...
EDO03707     219 tgefyefytpt---------idpiasrflrvrhaATNg------------KYPhpLpqnklirsLRNSM-PFAPn----- 271
Q5APE5       336 ngdffefftpelsyysnaylnlrenskysvlkqsSSVggylsa-lksfysDDVhpLlhssaklkLKNTILPYDSn----- 409 Candida albicans
Q54XU0       341 vkgkdniiqkk----------qisgfhcedsrplTDPiik-------eylEYEksMdsnslssfINNIINFYKVniks-- 401 Dictyostelium d...
Q7VBT2       196 ----------------------------------NNKh-------yI---EFT--Nlpl--sdsIKNSIIDISNkidisi 227 Prochlorococcus...
Q7V7S2       196 ---------------------------------dSVAh--------L---RFT--Elfl--tdaLHSALTEARMclgiqi 227 Prochlorococcus...
5ZZW_B       249 ------DGYQVELGLAGLAISQQIANRIDKsgGAALIIDYGY--DKI------VKSSL---QAI---------------- 295 Dictyostelium d...
P36052       257 ---hvsPGKELYIPTKLIEILMTIKNNIPE--HRLFIVDTPQrsSPTii---sLLKSLispRPT---------------- 312 Saccharomyces c...
Q4CY00       453 -----sPFRTLWLPTVAMLFLETCAAFFPR--HHLFLVDWSGvrQALp----gVNGPVc-qCKV---------------- 504 Trypanosoma cruzi
XP_001415722 324 --lassGDETWFVPTGSMQLMETLHAKRPN--HRFIAADFDTlpNVRie---gVNAPLv-aTQR---------------- 379
A0BQV8       253 -----qKSNSIFLPTGALQVLKHIKSNFQN--PSLVIADFDLlkNNFtq--esINAPIv-sKKLa--------------- 307 Paramecium tetr...
EDO03707     272 ------LSQPEYIPTRLMQFFDILAKYFPA--HRLVTSDFHSlpDTIk----gVNAPVv-qTRY---------------- 322
Q5APE5       410 ------LTPGEFIPTRLLQFFQILKHRFPN--HSLISSDFNYlpKTIpg---cFNGPVv-qTVL---------------- 461 Candida albicans
Q54XU0       402 ---ffkGDETKYLPTVCFKLFQIFAYYFPK--HHIILADFDElpSLVs----gENAPTv-qEKIpittgkidnpyhilgt 471 Dictyostelium d...
Q7VBT2       228 ppqnseEGWSTEWHSCLNNWFKETSLCLTE--GPLLIIDYALe-ANRyysksrSEGTI---ISY---------------- 285 Prochlorococcus...
Q7V7S2       228 pppdaaDGWCSEWHGELKSWLSQAASALLC--GPLLVIDYALe-ARRyysamrPCGTL---MAY---------------- 285 Prochlorococcus...
5ZZW_B       296 RDHEFV---------D-IL---DKPGTADLSVWVDFQTIRKTVKLLknkSTAIGPV 338 Dictyostelium discoideum
P36052       313 GSSQIVqpy----sdS-IF---SDKRSGRICFMTDFLQLQNIYNGInsssssceve 360 Saccharomyces cerevisiae S288C
Q4CY00       505 ---RVAkdmylrrpaDsLH---GNAGMVDICFPTDFEHLAVVYRNIc-gAHKD-IS 552 Trypanosoma cruzi
XP_001415722 380 VGGQTDd-------hDtYLlpeRLAGSADVFFPTCFDTLRAIDFATs-sQNTHRAN 427
A0BQV8       308 KPHERLd-------yEsYL---VERGVADIFFPTDFNFVQHMVKQIl-gMDSQIFK 352 Paramecium tetraurelia
EDO03707     323 KRRTVPv--------StPF---VHQGYFDILFPTDFAVMDNVYRAIt-gKFTQVLS 366
Q5APE5       462 QNRMVDv--------StYM---VHQGYFDIMFATDFNIASEMYKQVt-sRVPRVES 505 Candida albicans
Q54XU0       472 NKHGYEsi-----erDeIL---VQPGTCDIFFPHDWKNLHNMYCYTn--KDRPNFQ 517 Dictyostelium discoideum AX4
Q7VBT2       286 SSQVSNs--------N-IL---EKIGTTDITSHLCLEIIYLLA-IKn-nWNFVGER 327 Prochlorococcus marinus
Q7V7S2       286 RQQRASg--------A-LL---QDPGRWDLTAHLCLETLQLQA-EQq-gWTFLGes 327 Prochlorococcus marinus str. MIT 9313
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