6MTC


Conserved Protein Domain Family
IFRD

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pfam05004: IFRD 
Interferon-related developmental regulator (IFRD)
Interferon-related developmental regulator (IFRD1) is the human homolog of the rat early response protein PC4 and its murine homolog TIS7. The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.
Statistics
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PSSM-Id: 461515
Aligned: 71 rows
Threshold Bit Score: 113.872
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MTC_v        49 Sl-lSTTaedslgGDT------VD-EQGPQEDLEEKLKEYVDGLT-----DKSAKTRQGALESLRLAL-AS-RLLPDFLl 113
XP_007273854  74 StlsNGT------DSGd-----EGiGGASDASWATLLQDRIVELQdr--kRTNTKGRETTLMSYLHLV-KH-HYGGRQIs 138
ENH82002      74 StlsNGS------DSGa--------EDASESSWTTNLHDHIVDLQdr--kRTNTKIREATLMSYLHII-KH-HYAARQVs 135
EFX04796     101 DdnsDTT------GEG------ERgTAASQNTPEDTLHACITLLQdr--kRTSYEARINALETYLQLV-QD-HYLGSCVa 164
XP_003346355  79 SsanSVS------GED-------VnEDDTNNTWPDRLQDRITELLdr--kRSSAQGREATMKAYEHIL-KH-HYAQKYIe 141
Q2GY70        74 S---ANS------VDG-------DeDVGSTTTWVERLQDRVTELQdr--kRSSVQGREATLGGYNHLL-KH-HFAQGQLq 133 Chaetomium glob...
EMR66248      68 SvlnS--------DDG-------EdNNGVTTAWTDRLQDRITELLdr--kRSSAKGRESTLNAYAHLI-RH-HYAAEQVe 128
CAY67635      80 SpnsSKK------LKEpsdldqVKrNKEITNQDLYSTDNLISSLTstsrtQVSQESRELLLAQLFNLYtTSsRYQHTYDe 153
O42973        21 SilsGSM------DQLsvgsmeDSgILKGSKTWLEELESTIDDLIev--kKIGAKEREEHLEKIYVIC-TR-HYAKR-Is 89  Schizosaccharom...
XP_013024407  19 SilsSSV------DQLsvgsseDLnMVENPRTWNQQFESIVDELLev--rKVGSKEREGHLRKLYNLC-TR-YYVKR-Va 87 
6MTC_v       114 ERRFTLADALEKCLKKGKGE--EQALAAAVLGLLCVQlgpgPKGEE---LFHSLQPLLLS-VLSDSTa-SPAARLHCASA 186
XP_007273854 139 GSINEIVSALMKNIRSGGSTv-ERIYSLKSLQATLLT----SPSEV---LFDDIYPQLEK-TCEDDE--DSDVKAAAIWA 207
ENH82002     136 PHLNAIVSALVRSVRSGNSSv-ERLFAIKSLQATLLT----CPSED---LFEDLHSQLEQ-VCENDE--DNNIKTAAIWA 204
EFX04796     165 DALPTVLEQLLKSIRRSNTDpeEQMLALQALIVTTLT----CPKEDsarILESTFSPVRA-VCKAADv-HEKSKVIAVEA 238
XP_003346355 142 RNISDISAALIRSIRSGSSDq-ERLFALKALTATILT----CPSET---IFDHVWSVLKV-ATEDGE--EDKIKVEAINA 210
Q2GY70       134 RSVAEIMPVLLRDVKNGSSDe-ERLRALKAFTLTVLT----CSSDT---VFEQALPILKA-ACHDSE--EEDNKIEAIHA 202 Chaetomium glob...
EMR66248     129 GHFGELVPALLRSVRGGANHe-ETVAALKALTLTILS----AQSET---VYDQVWNSLKG-ACENSD--EESVKVEAIDA 197
CAY67635     154 FQLEQLIRVFINAKTEN-----EKLFALKCGAYMga----iDTEESsqiIVDEFLPLLKRdIIVDDDsvSVTLKANYIMA 224
O42973        90 ENVASLEELLLKIFNGPRSDk-ELILTIRIMCTFCLAs--vFQVEE---LWTKTEGRFNA-LANDAE--SSGIKCESILC 160 Schizosaccharom...
XP_013024407  88 EKIGPLEEILLKLFHSSRSDa-EVIITMRLLCALCLAs--vFSVEG---LWTATEGRFNA-LVNDAQ--STAVKCEAMLS 158
6MTC_v       187 LG--LGCYVAAADVQDLVSCLACLEGVFSRSCGTGSSTShvaPASlhgVCCAALQAWALLLTICpsahi----------- 253
XP_007273854 208 MA--IATLYAGGSEEAASEFLEYIVTIVESDGESISAAD---SGE---VVTAALESWVFVASQIddit------------ 267
ENH82002     205 MA--VAALYGGASESSATELLDYLVTIVESDGVSIGAED---SAD---VVTAALESWAFVASQIddia------------ 264
EFX04796     239 LT--MVVVFGGGTKASANELLKFLLDIVSSDGQTAEAMD---SAG---VVTAALRMWAFVASYMmpdnhdsdnededssg 310
XP_003346355 211 IS--IAVTLGGGSSSAAEEVLDFLLEIIESDGQNVGAPD---NGS---VVAAALRAWAFVASYVddls------------ 270
Q2GY70       203 LS--IAVTYGGGSTEAAEEVLDFLLEIIESDGHSVTAAD---SAP---VVTAALQAWAFVASHLddlt------------ 262 Chaetomium glob...
EMR66248     198 MS--IAVMCGGGSVEAAEDLMDFLVEIVESDGHSVDAPD---NGP---VVAAALTAWGFVASHLddlq------------ 257
CAY67635     225 FSslLLVVMDGSGCYGIEENSEMFLEVIEGQLNSKNPST---S-----IVVNSLQSVGIILTLIysgrggpss------- 289
O42973       161 FS--LLTALLDSE-ADVIEFGDFLISILESDGAVVNSED---DEG---VVGCACQALGLLLTCVttes------------ 219 Schizosaccharom...
XP_013024407 159 LS--LLTVLLDSE-PDIIDFGYQLASIIESDGAVVNAED---NED---VVGIACQSLGLLLTGItsys------------ 217
6MTC_v       254 -------------shildRQLPRLPQLLSSESVNLRIAAGETIALLFELARDLeEDF---------------------VY 299
XP_007273854 268 --------------envyAAIDAFVEQLDSTDVDVQTSAGFNIAFIFEAA----RDLeeetg------------epmnLQ 317
ENH82002     265 --------------dsihTALEAFVEQLDSTDVNVHTSAGFNVAFIFEMA----REYeeetg------------etmnLQ 314
EFX04796     311 degptndiydnslvaegqTALEAFIDQLQSTATEVQIAASEAIGLLFEMS----RRYeavte------------dqfgLR 374
XP_003346355 271 --------------vqsdQAMEAFMEQLDSTDSDVQTGAGVNIALLFEAA----RDYeeetg------------eksdLQ 320
Q2GY70       263 --------------dqseTAIEAFMEQLDSSDPDVQTGAGVNIALLFEAA----RDYeeetg------------qsfdMQ 312 Chaetomium glob...
EMR66248     258 --------------aqseQALEAFTEQLESTDAAVQIAAGINIALIFEAA----REYeeaegegdeengngassgawnLQ 319
CAY67635     290 -----------slndylieIAPRVVAVIDHPDFQIQLAATKLIGLIYELFDYDeGNEdeeeyde--------seafqpSP 350
O42973       220 --------------eflaSAAEALSEQLDAASIDVQLAAGQALAALFERVNEIrPDKdeendesdv----sqtskfddII 281 Schizosaccharom...
XP_013024407 218 --------------efvsSAAEALAEQLEAASIDVQMGAGQALAALYERITDThSEEengkg-----------sidndIF 272
6MTC_v       300 EDMEALCSTLRTLA-------TDSNKYRAKADRRRQRSTFRAVLHYVE 340
XP_007273854 318 YDPKRLISRMREAS-------KLSVKQTSRKDRRHLRKQFASIVTSLE 358
ENH82002     315 YDPKRLINRMREAS-------KASVKQTSRKDRRHMNKQFASIATSLE 355
EFX04796     375 EDPIKLAEQLRYISrgilpdgRSNTKSASRLDRRNLRETFISVATSLE 422
XP_003346355 321 YNQHRIMTRMAEIV-------RDSSKAVSKSDRKQLKTNFQSIITSLE 361
Q2GY70       313 YNQHRIMTRMAEIV-------RDSSKTISKKGRRNLRSNFSSIVTSLE 353 Chaetomium globosum CBS 148.51
EMR66248     320 YDQHRLVQRMTALA-------RESSKAVSKKDRKQLHASFNSVLTSLE 360
CAY67635     351 YHDEEILYSLRELY-------NKGNKKTSKRDKSDTKSVFKDVIQSIE 391
O42973       282 PDRNQLLITLRDLA-------SESSKSIGKKQRKVLHQVFRNVLQTIE 322 Schizosaccharomyces pombe 972h-
XP_013024407 273 PDRIHLLSILRDLS-------TESSKSIAKKHRKVLHQTFRNVLQTIE 313
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