Conserved Protein Domain Family
aprataxin_related
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cd01278: aprataxin_related 
aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are predominantly eukaryotic in origin.
Links
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Statistics
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PSSM-Id: 238609
Aligned: 8 rows
Threshold Bit Score: 138.287
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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HIT familycatalytic
Feature 1:HIT family signature motif
Evidence:
  • Comment:part of the nucleotide binding domain (HxHxH/Q)
  • Citation:PMID 9164465
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
NP_608634  32 KCFFCDFAHRrqgp--ppiLEVETDEYVIFKDKYPAARLHYLAIPKEHFdsl--kaLNKSHVGLVRRMeqgmme------ 101 fruit fly
NP_505003  10 GCKFCDIVKNkk-----elQLKENKSCVVINDIKPKAKNHYLVLSKQHIakp--tdLTVADVPLLEEMektgrellr-eh 81  Caenorhabditis ele...
XP_308297  12 NCIFCKIATGndp---atdIVFQNERICIFKDIRPASDFHYLAIPNHHLenv--nsLTAADKPLLEELkrelvn------ 80  Anopheles gambiae ...
NP_612638  47 TCVFCRIAGRqdpg--telLHCENEDLICFKDIKPAATHHYLVVPKKHIgnc--rtLRKDQVELVENMvtvgkt------ 116 human
CAE04784   87 STPWTADAVQrpstarcgdAGGRDDRVMAFKDINPSAFRHYLVIPIEHIptvnnlqRTTEDHQLVSHMlavgrd------ 160 Japanese rice
AAK91772  169 QGHWSQDLKVsmqd--ptmQVFKDDKIVVIKDKYPKARYHWLVLPWQSIasl--kvLRAEHLELVQHMdavghn------ 238 African clawed frog
AAO50753  213 LVYFCNKPESfl-----dvVLYYDDKTVAVLDKYPKAKHHYLVIPRVEIntl--deLTPSFIPMLEHMynvadaiineii 285 Dictyostelium disc...
NP_778243 164 LGHWSQGLKIsmqd--pkmQVYKDEQVVVIKDKYPKARYHWLVLPWTSIssl--kaVAREHLELLKHMhtvgek------ 233 human

Feature 1                                # # ### 
NP_608634 102 --flrsqNVDPKEAIVGFHLPPfiSVRHLHLHGIF 134 fruit fly
NP_505003  82 lkkkgeaDTVEDMLRIGFHLPPllSVHHLHMHIIY 116 Caenorhabditis elegans
XP_308297  81 -ymqssrGIDPSEASFGFHIPPftSVKHLHMHAIA 114 Anopheles gambiae str. PEST
NP_612638 117 -ilernnFTDFTNVRMGFHMPPfcSISHLHLHVLA 150 human
CAE04784  161 --llnrdAPNSEEQRFGFHQPPfnSVDHLHLHCLA 193 Japanese rice
AAK91772  239 -iarehtNSKCAPFRFGYHAIP--SMSHVHLHVIS 270 African clawed frog
AAO50753  286 skdndddNLKKSDFKLGFHAIP--SMKRLHLHIIS 318 Dictyostelium discoideum
NP_778243 234 -vivdfaGSSKLRFRLGYHAIP--SMSHVHLHVIS 265 human

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