7EMF


Conserved Protein Domain Family
Med8

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pfam10232: Med8 
Mediator of RNA polymerase II transcription complex subunit 8
Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.
Statistics
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PSSM-Id: 463012
Aligned: 37 rows
Threshold Bit Score: 131.7
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7EMF_H         1 MQ-REEKQLEAsLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLkHEKTPLFRNQVIIPL 79 
XP_002376999   1 MAtPTQEQLKT-LEQSRQRLVQLTRSLASLITSLNQSDPLPSWSSLQSQASIISNNLLSVSDHL-SDNRDLLTSLVAYPG 78 
A1CHE9         1 MAsPSQDQIKV-LEQSRQRLVQLTRSLGSLIGSLNQSDPLPSWSSLQSQASIISNNLLSVSEHL-SDNCDLLSALVAYPG 78  Aspergillus cla...
Q4WP83         1 MAsLNQDQIKI-LEQSRQRLVQLTRSLASLIGSLNQSDPLPSWSSLQSQAGIISNNLVSISEHL-ADNKDLLSALVAYPG 78  Aspergillus fum...
A2QID5         1 MSsLNQDQIKT-LEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHL-SDNRDLLSNIVAYPD 78  Aspergillus nig...
XP_002559238   1 MSnLTQEQIKV-LEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQL-SDQRDLLSNLVAYPG 78 
EEQ87974       1 MAsISPEQLKV-LEQTRQRLVQLTQSLASLINNINQSDPLPSWSSLQSQATIISNNLLNVSEQL-TDHHDLLSSLVAYPT 78 
EEH07092       1 MAsISPEQLKV-LEQTRQRLVQLTQSLASLINNINQSDPLPSWSSLQSQATIISNNLVNVSQQL-TDHHDLLSSLVAYPT 78 
XP_002794656   1 MAsISPDQLKV-LEQTRQRLVQLTQSLASFINNINQSDPLPSWSSLQSQATIISNNLLNVSQQL-TDHHDLFASLVAYPT 78 
XP_008080896   3 yasltpEELKA-LDATRQKFFQLTSSIQSLKNDLARTHPLPQWSSLQVTTAMLSNYMDSITRHL-AEHSELMNKVVVYPS 80 
7EMF_H        80 VLSPDRDEDlmrqtegrvpvfshE--VVPDHLRTKPDPEVE--------------------------------------- 118
XP_002376999  79 PDYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargrkagasaled---------------ksglaeae 127
A1CHE9        79 PEYPGRTQA--------------S--TLEQLLRTKLDPRIEdwvargrragasaled---------------kdalsete 127 Aspergillus cla...
Q4WP83        79 PSYPGRTQA--------------P--TLEQLLRTKLDPRVEdwvsrgrragasaled---------------rgalsesa 127 Aspergillus fum...
A2QID5        79 ASYPSRVPA--------------NnvALEQVLRTKLDPRVEdwvargrragapttssdagagalgqyqtssgqrllsdda 144 Aspergillus nig...
XP_002559238  79 PEYPGRTQA--------------N--TLEQLLRTKLDPRVEdwvargraagtestgpsnfsd------pdaaykplsdaq 136
EEQ87974      79 PQFPGRTEA--------------A--MLSQLLRTKLEPRVEdwvsqglsmgnadatrr--------------rtgltaeq 128
EEH07092      79 PQFPGRTEA--------------A--MLSQLLRTKLEPRVEdwvsqglsmgnpdatrl--------------rtglteqq 128
XP_002794656  79 PQFPGRTEA--------------S--MLSQLLRTKLEPRVEdwvfqglsmgnadatrl--------------rtgltehq 128
XP_008080896  81 TNYPGREQE--------------G--LLGMLLRKKLEPPVEalveeareieiknpka---------------vsqeneef 129
7EMF_H       119 --------EQEKQLTTDAARIGADAA-QKQIQSLNKMCSNLLEKI------------SK--EERESESGGLRPNKQTFNP 175
XP_002376999 128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGVQNVVTGLARVLede-------gsESe----DEEEGEE--------- 187
A1CHE9       128 laelwdwaPVEANQEARRRNWGGDYTlEEREMGIQNVVTGLRRQLedde-----rdeDEdeDDEEEEEGEG-------ED 195 Aspergillus cla...
Q4WP83       128 laelwdwaPVEANQEARRRNWGGNFTlEEREMGIQNVVTGLRRQLede-------deEAs---eSEEEVEE--------- 188 Aspergillus fum...
A2QID5       145 iaelwdwaPVAANEEARKRNWGGNYTlEEREMGIENVVTGLSRVLedd-------deEDesDS-EEGEGEA--------- 207 Aspergillus nig...
XP_002559238 137 laelwewaPLEANQEARRRNWGGNFTlEEREAGIENVVTGLRRQLedd-------dgEEesEG-EEEDGE---------- 198
EEQ87974     129 laelwqwaPVEANMEARKRNWGGDYTrEEKEMGVKNVVTGLKRRLnee-------dsGSesGSGDEDEGGKGEEGG-GDG 200
EEH07092     129 llelwrwgPIEANMEARGRNWGGDYTlEEKEMGVKNVVTGLKRKLnee-------dsGSesGSGDEEEGSEGEEGGDGGG 201
XP_002794656 129 laelwqwaPIEANMEARRRNWGGNYTlEEKEMGVKNVVTGLRRNLsee-------esGSesGS-EEGEGLE--------G 192
XP_008080896 130 adwaagwiHQRVATAAQSE-MVENFTqDERIAGVENVRTGLRRKIdlkppkiaseeeESseEEGSEDEEMEDAGLDTAPT 208
7EMF_H       176 TDTNALVAAVAFGKGLSNWrpSGSSGPG---QAGQpgagtilagtsglqqvqmagapsqqqpmlsgvqmaqaGQPgkMPS 252
XP_002376999 188 DEMEI--VGVRRQS-AGAGfeFDIAPA----SAAQhqqqk----------------------------fvepAVP--LED 230
A1CHE9       196 EEMEV--VGVRRRSDAGAGlgFDTAVPT---PASSqqvqk----------------------------gagpVVP--LDD 240 Aspergillus cla...
Q4WP83       189 EEMEV--VGVRRRSGAGAGleFDIAAPAp-gSRQQqqqqk----------------------------aagpAVP--LED 235 Aspergillus fum...
A2QID5       208 DEMEV--VGARRRSGAGAGleFDIAAANtgsGANAgagak----------------------------vvapVVP--LDE 255 Aspergillus nig...
XP_002559238 199 -EMDV--VGVHRKPGA-AEfeYNIAPHHphp--------------------------------------vqpFVP--LDL 234
EEQ87974     201 SGMQV--VGVHRRAGA-GGvqFDIS------SGGGqvppv----------------------------pmspALP--LQD 241
EEH07092     202 NGMGV--VGVHGSPGA-GGvqFDIS------KEGGyvqst----------------------------smspALP--SED 242
XP_002794656 193 AGMEV--VSMQRRPGG-SGvqFEIS-------SAGhgppa----------------------------qlstALS--LED 232
XP_008080896 209 RPVEFGMGTVRKNPNALVRt---------------------------------------------------------eDD 231
7EMF_H       253 GIKTNIKSAsmhP 265
XP_002376999 231 ILRFMTTGAe--P 241
A1CHE9       241 VLRFMTTGTl--P 251 Aspergillus clavatus NRRL 1
Q4WP83       236 ILRYMTTGIp--P 246 Aspergillus fumigatus Af293
A2QID5       256 ILRFMTTGAv--P 266 Aspergillus niger CBS 513.88
XP_002559238 235 ILRYMTTGRmp-- 245
EEQ87974     242 VFRFMMTGAspkg 254
EEH07092     243 VFRFMMTGAvpkg 255
XP_002794656 233 VFRFMMTGAaprg 245
XP_008080896 232 ILRFATNGAtsap 244
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