Conserved Protein Domain Family
Keratin_B2

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pfam01500: Keratin_B2 
Keratin, high sulfur B2 protein
High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Statistics
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PSSM-Id: 366678
Aligned: 8 rows
Threshold Bit Score: 88.6946
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam01500 is classified as a model that may span more than one domain.
pfam01500 is the only member of the superfamily cl37504
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O70148     1 M--ACCATSFCGFPTCSTGGTCGSNCCQPSCSQssccq--------------------------pscsqSSCCQPSCTQS 52  Norway rat
ADV58260   1 M--ACCSTSFCGFPICSTGGTCGSSPCQPTCCQ------------------------------------TSCCQPTSIQT 42 
P08131     1 M--ACCSTSFCGFPTCSTGGTCGSNFCQPTCCQ------------------------------------TSCCQPTSIQT 42  sheep
P02440     1 M--ACCSTSFCGFPICSTAGTCG----------------------------------------------SSCCRSTCSQT 32  sheep
Q07627     1 M--ACCQTSFCGFPSCSTSGTCG----------------------------------------------SSCCQPSCCET 32  human
P02443     1 Tg-SCCG------PTFSSLS-CGGGCLQPCCYRd-----------------------------------PCCCRPVSSTQ 37  sheep
Q28707     1 MvnSCCG------SVCSERG-CGQDFCQE----------------------------------------ESCCRPSCCRP 33  rabbit
Q8IUG1     1 M--TCCQTSFCGYPSCSTSGTCGSSCCQPSCCEtsccqpsccetsccqpsccqtsfcgfpsfstsgtcsSSCCQPSCCET 78  human
O70148    53 SCCQPTCSQSSCCQPTcsqss----------------ccqpsCCQTSCCQPTCCQNSSCQTSC---CGTGSGQEGGSGAT 113 Norway rat
ADV58260  43 SCCQPISIQTSCCQPT--------------------------SIQTSCCQPTCLQTSGCETGCgigGSIGYGQVGSSGAV 96 
P08131    43 SCCQPTSIQTSCCQPTsiqts----------------ccqpiSIQTSCCQPTCLQTSGCETGCgigGSIGYGQVGSSGAV 106 sheep
P02440    33 SCCQPT------------------------------------SIQTSCCQPTCLQTSGCETGCgigGSTGYGQVGSSGAV 76  sheep
Q07627    33 SSCQPRCCETSCCQPSccqtsfcgfpsfstggtcdssccqpsCCETSCCQPSCYQTSSCGTGCgigGGIGYGQEGSSGAV 112 human
P02443    38 TVSRPVTFVSRCTRPIce----------------------------pCRRPVCCDPCSLQEGC----------------- 72  sheep
Q28707    34 QCCQP-----SCCRPTcciss----------------ccrpqCCQSVCCQPTCCRPSCYISSC----------------- 75  rabbit
Q8IUG1    79 S----------------------------------------------CCQPSCCQTSSCGTGCgigGGIGYGQEGSSGAV 112 human
O70148   114 SCRVRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPAC-------CCHcceps-cskpsCSE 185 Norway rat
ADV58260  97 SSRTRWCRPDCRVEGTSLPPCCVVSCTPPSCCQLYYAQASCCRPSYCGQSCCRPAC-------CCQptciepicepsCCE 169
P08131   107 SSRTKWCRPDCRVEGTSLPPCCVVSCTSPSCCQLYYAQASCCRPSYCGQSCCRPAC-------CCQptciepvceptCCE 179 sheep
P02440    77 SSRTRWCRPDCRVEGTSLPPCCVVSCTSPSCCQLYYAQASCCRPSYCGQSCCRPAC-------CCQptctepvceptCSQ 149 sheep
Q07627   113 STRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQLHHAEASCCRPSYCGQSCCRPVC-------CCY-----------CSE 174 human
P02443    73 ------CRPITCCPTSCQAVVCRPCCWATTCCQPVSVQCPCCRPTSC-PSAPRTTCrtfrtspC---------------- 129 sheep
Q28707    76 ------CRPTCCRPTCCRPTCCRPTSCQTTCCRT-----QCCRPSCCVSTCCRPCCss---gsC---------------- 125 rabbit
Q8IUG1   113 STRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCGQSCCRPVC-------CCY-----------SCE 174 human
O70148   186 PSC 188 Norway rat
ADV58260 170 PTC 172
P08131   180 PTC 182 sheep
P02440   150 PIC 152 sheep
Q07627   175 PTC 177 human
P02443   130 --C 130 sheep
Q28707   126 --C 126 rabbit
Q8IUG1   175 PTC 177 human
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