Conserved Protein Domain Family
7tmA_OR2A-like
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cd15420: 7tmA_OR2A-like 
olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
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Statistics
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PSSM-Id: 320542
Aligned: 14 rows
Threshold Bit Score: 419.04
Created: 12-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #  ##           ######
Q6IF42        24 ILLCGLFSVFYTLTLLGNGVIFGIICLDSKlh--tpMYFFLSHLAIIDMSYASNNVPKMLANLmnqkRTISFvpCIMQTF 101 human
A4D2G3        24 MLLFGLFSLFYIFILLGNGTILGLISLDSRlh--tpMYFFLSHLAVVDIACACSTVPQMLVNLlhpaKPISFagCMTQMF 101 human
XP_007659634   9 FLFGLFSITFFKTTLLGNGVILGPCLLGMDgrlhtpMYFFLCHLAVVDISYACNTVPRMLVNLlrpaEPISLagCSAQTF 88  platypus
ELV13384      24 LLLFWVFSLLYIFGLLANGIILGLIWSAPQlh--tpMYFFLSHLAIIDITYATGSVPHTLRNLvqhkRTISFvsCVLQIA 101 Chinese tree shrew
XP_004694470  24 VLLCAVFSLLYVSNLLANGMILGLIWLDVRlh--tpMYFFLSHLAVIDISYASSTLPKLLENLvkhkKTISYasCAAQLL 101 star-nosed mole
XP_006021050  23 LFLFGLISVIYVITLTGNVIILVLIWLDSRlh--tpMYFFLRHLSIVDICYTSSTVPQMLANLlnsrKTISFagCSVQIY 100 Chinese alligator
XP_006278626  23 IVLFVLFLTIYTVALVGNALILLVICIDSQlh--tpMYFFLCHLSIVDICYASNNVPHILRNFlvlrKTISLvgCGTQMY 100 American alligator
XP_007443825  23 LLLLGLFSVVYALTLVGNAIILMLVWLDARlh--tpMYFFLSHLACVDICYTSSTVPQMLANLqsprQTISLaaCAIQMH 100 Burmese python
XP_006038264 258 SFFLGLFSIIYIITLLGNLVIFSLICLDPHlh--tpMYFFLSNLSVLDICYSSSTIFHLLSNFlfqrRTISLvgCAAQMY 335 Chinese alligator
XP_006278624  23 FFMFGIFSVIYTVSLVGNTLVFVVICHNSQlh--tpMYFFLCHLSILDICYASSNVPHILGNLllqrKTISFvgCGTQIY 100 American alligator

Feature 1         ##  #                                            # #####                       
Q6IF42       102 LYLAFAVTECLILVVMSYDRYVAICHPFqYTVIMsWRVCTILVLTSWSCGFALSLVHEILLlRLPFCGPRDVNHLfCEIL 181 human
A4D2G3       102 LFLSFAHTECLLLVVMSYDRYVAICHPLrYSTIMtWKVCITLALTSWILGVLLALVHLVLLlPLSFCGPQKLNHFfCEIM 181 human
XP_007659634  89 LFLTLAHTECFLLVVMSYDRFVAICRPLrYPLVVsRRACRILVGLCWALGSLLALLHLLLLlRLPFCGRREIDHFfCEIL 168 platypus
ELV13384     102 FCLTVGSIECMILMVMSYDRYVAICHPLqYIIIMnWRRCTVLAVISWVCGFSLIMVNIFLLvRLPFCGPQELNHFlCDVL 181 Chinese tree shrew
XP_004694470 102 LYVAFGCTEYMILMVMSYDRYVAICHPLhYTVIMsWRLCTVLAITSWVCGFSLALGHLLLFlRLPYCESQVVNFIfCELV 181 star-nosed mole
XP_006021050 101 LFLALGITECVLLAVMAYDRFVAICYPLsYTLIMnRRVCVGLTAVSWTCGFLLAMIHAVQTlQMPFCGPNEINHFyCDIL 180 Chinese alligator
XP_006278626 101 LYMALGHTECMLLAVMSYDRFVAICHPLrYSVIMnWRVCSVLVIASWACGSLLAAVHVILAwQLPFCGAREVDHFfCEIL 180 American alligator
XP_007443825 101 IFLALATAECFLLAVMAYDRYVAICHPLhYTVLMnKRMCILMAMTCWAGGLVLPVIHSVLTwQLPFCGPNLIDHFfCEMP 180 Burmese python
XP_006038264 336 LFLVLATTECILLSVMAYDRYVAICLPLnYTVIMnQRTRVTLAMVSWGSGLVVPVPFAVLTwRLPFCGPNVINHFfCEMP 415 Chinese alligator
XP_006278624 101 LYMALALTECVLLAVMSYDRYVAICHPLrYNVIMnWRVCTTMVACSWTCGFLFGAIQVGLTlRLPFCGLNEVDHFfCELL 180 American alligator

Feature 1                    #  ### ### ##                                            #  ## ##  #
Q6IF42       182 SVLKLACADtwVNQVVIFATCVFVLVGPLSLILVSYMHILGAILKIqtkEGRIKAFSTCSSHLCVVGLFFGIAMVVYMVP 261 human
A4D2G3       182 AVLKLACADthINEVMVLAGAVSVLVGAFFSTVISYVHILCAILKIqsgEGCQKAFSICSSHLCVVGLFYGTAIIMYVEP 261 human
XP_007659634 169 ALLRAACGDarINEALVLAGAVSVLVGPFFSILTSYLSILWTILRLrsrEGRRKAFSTCASHLGIVGLFYGTAIITYVGP 248 platypus
ELV13384     182 DVLKLACADtwVNTIYMFACGVFFLIVPLSLMLISYTCILWNILKIkskEGRKKAFSTCSSHLCVVGLYFGIAMLMYLVP 261 Chinese tree shrew
XP_004694470 182 AVLKEACGDtwINKLYILFSGSFILVGPLSLVLVSYTRILLTILRIrtnEGRSKAFSTCSSHFCVVGFYFGIAMMIYLVP 261 star-nosed mole
XP_006021050 181 ALLKLVCADthLNEIIVFVIGVLILLCPFVLILISYVRILGAILRIhsvEGRRKAFSTCASHLTVVALFYGSAMFMYMRP 260 Chinese alligator
XP_006278626 181 AVLKLACADitVNKLVIFAACVIILLLPFTLILISYLHILAAILRIsstEGQRKTFSTCSSHLSVVGLFYGAAMFVYMVP 260 American alligator
XP_007443825 181 ALLKLACADtrIIEKITSVGCIFTLLIPIAFILMTYICILAAFLKIqsaQGQRKAFATCGSHMTVVVLFYGTAIFMYMRP 260 Burmese python
XP_006038264 416 ALWRLACSDtqPIELATQVGSLFSLLAPIIFIFVSYVHILAAILKInysGGRQKAFSTCFSHLVVVALFYGTAFFRYIQP 495 Chinese alligator
XP_006278624 181 AVLKLACADitINQTVIFTACVLILLFPFLLVIVSYLHILATILHIhsaAGRRKTFSTCSSHLTVVGLYYGTAIIMYMGP 260 American alligator

Feature 1             ## ###  #  ##                     
Q6IF42       262 dsnqREEQEKMLSLFHSVFNPMLNPLIYSLRNAQLKGAL 300 human
A4D2G3       262 qyesPKEQKKYLLLFHSLFNPMLNPLIYSLRNKEVQGTL 300 human
XP_007659634 249 gtanPGEGKKYLLLFHSLLNPMLNPMIYSLKNGEVKKAL 287 platypus
ELV13384     262 ddsqQQEPQKILTLFYCLFNPLLNALIYSLRNAQVKGAF 300 Chinese tree shrew
XP_004694470 262 dngqRDEQKKVLTLFYVLFNPLLNPLVYSLRNAQMKAAF 300 star-nosed mole
XP_006021050 261 gstrSADQDKMVSLFYSIITPMFNPMIYSLRNKDVKGAL 299 Chinese alligator
XP_006278626 261 gtgnSTLQQKILSLFYSLVNPTLNPLIYSLRNKQVKGAL 299 American alligator
XP_007443825 261 esshSPGQDKMISLFYSIVIPLCNPIIYSLKNKDMKTAL 299 Burmese python
XP_006038264 496 sslrTPVLNKVISLFYTVLTPMLNPIIYSLRNREVKMAL 534 Chinese alligator
XP_006278624 261 mtshSAFREKILFLFYSFINPMLNPLIYSLRNEQVKGAL 299 American alligator

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