Conserved Protein Domain Family
CLASP_N
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pfam12348: CLASP_N 
CLASP N terminal
This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.
Links
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Statistics
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PSSM-Id: 432496
Aligned: 47 rows
Threshold Bit Score: 181.637
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001642417  330 LSNDMINLLQPFqetKETEQNWKLRQANILKFREIVNGN-LPKKTPIEFISICKelqfiECISKAILSLRTTLSLGAFHL 408 
Q5BEN5          1 MDYKARDILSVL---KNVNLSVDAKVTHLLGLKSDIKQKnVPEKAVPVIFECLR-----HAIASPFHALYSAGFSTLGHF 72   Aspergillus n...
Q2UCC9          1 MEGKATELLAVL---KNNNLAIDVKVSHLLSIKSDIKQKnVPDNAVHLIFESLR-----LAITSHHAALYAAGFSTFGHF 72   Aspergillus o...
Q1DS65          1 MDARATELLATL---RNGNVSVDVKTTSLAKLKSEIKQKhVPDAAISPLFESFR-----LAIASQHYSLSSAGFSALGHL 72   Coccidioides ...
Q4WSI0          2 MEVKAAELVAAL---KNSNMSVDTKVAHLQCVKSDIKQKnVPEGAVPSIFESIR-----LAIASQHSSLSGAGFSTLGHF 73   Aspergillus f...
XP_002146274    1 MEARATELLGTL---KNPNVSVDAKIAALTNVKSDIKQKnVPEPAVLPLFESLR-----VAISAQHSSLSSAGFSTLAHL 72  
Q0D0S3         77 MDMKVDDLQAAL---TNPNLSIENKYDRLISVKSDIKQKnVPASLIPSLFDCLR-----LAIAHNNIHIYTAGFATLSHL 148  Aspergillus t...
OQE12741        1 MEAKAAELLAAF---KNPNLSVDSKIAYLSSVKSDIKQKnVPEGAIRPIFETLR-----LAVGSQHYSVLGAGFSTLGHL 72   Penicillium f...
RDK47884       57 MEPKATELVATL---KNLNLAIDAKVSFLNSVKSDIKQKnVSEGAIPPIFESLR-----LSIASSHSTLLSAGFSTLGHF 128  Aspergillus p...
XP_002848749    1 MDERATELLAAL---RNTSLSVDAKIASLTKLKSEIKQRnVPTSAVGDIFDAIR-----LAIASQHASLSAGGFSALGHL 72   Microsporum c...

XP_001642417  409 IREFCENLNQN-LDSQiIDQIFTTLKTSLSSTKKITSQNSLHSLVILLLNSNfsNKL-FNICFTLVNEKNVSPRICSSIL 486 
Q5BEN5         73 LKRLYIQEHHQlVAAM-SDRILPTLVDRMGDNKDRIRQQTTHALADLWEGAG--PQIeNLVLSVGFQGKNPFQKQTCLNL 149  Aspergillus n...
Q2UCC9         73 LKRLFIQDQAHiVSAY-ARHFCPVLLERLGDHKERVRAQAAQIFTDLWPAAS--ADVeHYVLEVALTGKNPKAKETSLIW 149  Aspergillus o...
Q1DS65         73 LKRLTLQEQHEaIALQ-GRATYQLLLERLGDHKERIRSQAAQAFTDFWPAAS--ADVeHHVLGAALIGKNARAKETSMVW 149  Coccidioides ...
Q4WSI0         74 LKRLLIQELHHlVALQ-CRALYPLLVERLGDHKERIRAQAAQSFTDMWLAAP--EEVeQCVLGQALVGKNPRAKEMSMIW 150  Aspergillus f...
XP_002146274   73 LKRLYIQENHH-LVLFhARQLYPICLERLGDHKERLRAQASQAFTDLWIAAP--QDVeAHVLGTALVGKNARAREMSMIW 149 
Q0D0S3        149 LKRLFIEELHTeVAAH-ARSLYPTLLERLGDHKERVRALAAQAFADLWKAAP--MDAeKHVLGTALVGRNPKAKEASLTW 225  Aspergillus t...
OQE12741       73 LKRLAIQEQQQwIVHQ-AHSLYPILLERLNDPKERIRAQAASIFTELWPFAG--NEVeYHVLEVALVGKNHRAKEMSMLW 149  Penicillium f...
RDK47884      129 LKRLFIQEQHSiVASQ-ARHLYPLLLERLGDHKERVRAQAAQAFTDFWPAAS--HEVeQHVLGTALVGKNNRAREMSMIW 205  Aspergillus p...
XP_002848749   73 LKRLYLQEQTAlIASQ-GRHTYSLLLEKLGDHKERVRAQASQAFADFWQASP--TETeHHVLEVALVGKSPRAKETSMMW 149  Microsporum c...

XP_001642417  487 LRLILIRFNns-------vDNERRLDNLNLF--IEEWLIKGIADAQTSVRESMRLTFWYY------------------FK 539 
Q5BEN5        150 LSIAFTRSE----------ITAAYAEATAk--eYLPQIISFVEDADPTVRQGARALLVQMfigerdsskhelkraleqYK 217  Aspergillus n...
Q2UCC9        150 LSNMSRNHG-------------------LLFrsYVPSVVSCLEDADSFVRHTAKSTVVEL------------------FQ 192  Aspergillus o...
Q1DS65        150 LAKMTREYG-------------------LLFriYVPALVTCLEDADGVVRDTAKSTVIEL------------------FQ 192  Coccidioides ...
Q4WSI0        151 LSNVSSSFNiggfssfltiALQMTKNYGLLFrsYVSSLVACLEDADSNVRNTAKNTVIEL------------------FE 212  Aspergillus f...
XP_002146274  150 LATMTREHN-------------------ILFrsHVPSLVAALEDADSGVRDTAKTTIIEI------------------FQ 192 
Q0D0S3        226 ILSMHTSHD-------------------LLFrpYVASLVACLEDADSAVRDTAKSTVVGL------------------FN 268  Aspergillus t...
OQE12741      150 LANMTKNHG-------------------LLFrqYVPSLVSCLEDADSAVRDTAKLVVIDL------------------FR 192  Penicillium f...
RDK47884      206 LANMAKQYG-------------------LLFrpYVPSLVACLEDADSAVRDTAKATIVEL------------------FQ 248  Aspergillus p...
XP_002848749  150 LVKMTKERG-------------------VLFraHVPSLVVGLEDADSAVRETAKAAVIEL------------------FQ 192  Microsporum c...

XP_001642417  540 CYPSNARKLLt-DSFSSQLKKAIE 562 
Q5BEN5        218 VRPSHAREILagIGLDPELYDESH 241  Aspergillus nidulans FGSC A4
Q2UCC9        193 GAPARAKADLtkEMTAQNVRQSIV 216  Aspergillus oryzae RIB40
Q1DS65        193 SAPPRAISDLkkQLIQNNVRKSIA 216  Coccidioides immitis RS
Q4WSI0        213 NASERAKSDLkrQMATHNVRKSFV 236  Aspergillus fumigatus Af293
XP_002146274  193 NAPSRAKSDLkrQLSEHGVRKSIV 216 
Q0D0S3        269 SAPAHAKADLqrEMAEQHVRKSIV 292  Aspergillus terreus NIH2624
OQE12741      193 NGPARAKSDLqkQMAARSVRKSIA 216  Penicillium flavigenum
RDK47884      249 NAPAHAKADLkkQLSELNVRKSIV 272  Aspergillus phoenicis ATCC 13157
XP_002848749  193 NAPSRAISDLkkQIQSHNVRRSIT 216  Microsporum canis CBS 113480
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