6XOL,5V89,4GBA


Conserved Protein Domain Family
Cullin_binding

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pfam03556: Cullin_binding 
Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Statistics
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PSSM-Id: 460971
Aligned: 185 rows
Threshold Bit Score: 84.1729
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XOL_A       263 KLKAQI-PKMEQELKEpg-rFKDFYQFTFNFAK---NPGQ--KG--LDLEMAIAYWNLVLn------------gRF---- 317
XP_002504293  89 egLATLfSSLTREFavdpqrFAAFYHFFFFVAR---DRGH--RN--LADATAVEGWRFLLgg------------gRf--- 146
EDQ52851      70 HLQAKLlda---------rnFSVFYRFVFFMCR---DPGQ--KN--ISVSTAIAGWRLALtg------------rFr--- 118
KQK15075      62 KLMSVLeldd-------arhFSTFYDFVFFISR---ENGQ--KN--ITIQKAVAAWRIVLng------------rFr--- 112
VDC68396      71 KLMSRLdlmas----vdfseFTRFYDFVFFMCR---ENGQ--KS--ITVAKAITAWKLVLag------------rFr--- 124
XP_004232218  70 KLRLNLead--------fseFSRFYDFVFFVFR---ENGQ--KN--ITISKAVTGWKIVLag------------rFr--- 119
Q4CTL1       116 AMRSHV-DEIDEVLHKdpdqFRKFYRFIFGWVRspeTTARslGElgMNIATAVELWQMLFpe------------yKt--- 179 Trypanosoma cruzi
Q38A65       115 ALRNHV-ETLDGALRGdvtkFRHFYRFIYKWVQsplTMERnmGQvgMSIETAVELWRMLFph------------yRe--- 178 Trypanosoma brucei
Q4Q0J0       118 aahdAI-VDLNNTIRSneekRSKFYQFLYNWCLkgnDASD-------RVDSAKELWSCFFsaspvsltveearrKFtayv 189 Leishmania major
XP_001564670 125 QLRQKL-GEWVKDVREssgaFLLMYTYMYDYIR-----GEedRR--MTRTTAINGWDVFFgq------------------ 178
6XOL_A       318 --KFLDLWNKF-LlEHHk----------Rs----IPKDTWNLLLDFS--Tmi-----aDDMSNYDEEGAWPVLIDDFVEF 373
XP_002504293 147 --aLLEPWCAF-VrERReg-------gkG-----VSEDTWCQVLDFAhsCndasrgggGCLDAYDPHGAWPVLVDEFVDH 211
EDQ52851     119 ---LLDQWCAF-VqVHQr---------hA-----VSEDTWRQVLEFSrsVh-------eDLSNYDVEGAWPVLVDEFVEN 173
KQK15075     113 ---LLDRWCNF-VeKYQr---------hN-----ISEDAWQQLLAFSrcVn-------eDLEGYDPKGAWPVVIDDFVEH 167
VDC68396     125 ---LLNRWCDF-TeKNQr---------hN-----ISEDTWQQVLAFSrcVh-------eNLEGYDSEGAWPVLIDEFVEH 179
XP_004232218 120 ---LLDHWCDF-VeKKQr---------yN-----ISEDTWQQVLAFSraVh-------eNLEGYDREGAWPVLIDDFVEH 174
Q4CTL1       180 -fLKMNDWITF-CtTKEi----------Fhr-eaISRDLWEQLLEFTslT---------RYDTYDVNDAWPSAIDDFVEY 237 Trypanosoma cruzi
Q38A65       179 -fKRLDDWITFcMsKKLfp-------hgI-----ISRDLWEQLLEFTfvT---------DYSKYDVSDAWPSAMDDFVEY 236 Trypanosoma brucei
Q4Q0J0       190 cfPRINQWLDF-ItMLGekatesksgrvAveqsgVSFDTWTQLLLFAr---------fDNYDAYDDEDSWPVTMDDFVVY 259 Leishmania major
XP_001564670 179 -nkRYAKWKTWaVaNLTg----------D-----VSRDLWRQLGIFLtmDtdatqssdDQVLAL----SWPSAIADFIEt 238
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