Conserved Protein Domain Family
TMEM192

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pfam14802: TMEM192 (this model, PSSM-Id:405488 is obsolete and has been replaced by 434223)
TMEM192 family
The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time.
Statistics
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PSSM-Id: 405488
Aligned: 28 rows
Threshold Bit Score: 215.204
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007231301  33 SQDALESAIRRE--FQKLPTAWITGLLTAAHVAYVSVSVVLAVLCWLAEDHSEqcnavlngvdSQTVVLLGKVGLWLLVF 110 Mexican tetra
KMZ02957      27 LDPVLFSNDNGS--YK-LNTVPAFSLHLVISTAISIVGIVLAASFPTDR-RCD----------AYFIMLYLRATFWVITY 92  Drosophila simu...
EDV93785      25 LDPVLVSDNNGP--YK-LKTVPAFSIHLLISTVISSVGIGLAVGFPADR-RCE----------AYFIMLYLRATFWVITF 90  Drosophila grim...
EDS36700       6 LDPILATEDDDG--FRPLKTVPAFSFHLLISTCISLTGVILAATWQDSC-RCE----------AYFIMLYMRAAFWLITF 72  southern house ...
ETN61777      30 QEPILATQENGD--FEPFYTAPVFSFHLLISSIISVTGIALAATWDDTR-RCE----------AYFIMMYLRVAFWIITY 96  Anopheles darlingi
Q7QBM9        18 SPPCLMEGKPR---FRPIFVISLFSAHLFLAIAIITAGTVASVAGWPQPAGDTdrs-----ssVYFLIIYLRIVYWLVTY 89  Anopheles gambi...
Q16JL1        48 FGTTIGDIETVG--FERIGTTHASWIQLIFSMILTMTGFIFAYHGCYSGNECP----------GYYMVLYLRALFWLATY 115 yellow fever mo...
ETN61776      38 FHSTSNTMQEDSmqFDELRTVASACIHLFVTIGLTVLSVIYTLQQCDTDTTCS----------YYYMLLYLRGIYWAAIY 107 Anopheles darlingi
XP_019882176   7 FQPILSSQEEDN--FQQLNTVPIVSMSLLLGISLEITGIVFVSVWPEEQNKCD----------TYFIYLYLHCAYWLIVM 74  Florida carpent...
XP_001123128  30 LQPVLTSQEEH---FHKLDTVLITFIPLIFGVSLEITGIIFIAVWPEENNKCD----------TYFIYLYLHCAYWLLIM 96  honey bee
XP_007231301 111 GFEWCVNHHHTTARRRGYLQFYRANQDLKRLPLFIHSAGNAALLVVIGPAPLLDKKVKn------------LSVYLLLCI 178 Mexican tetra
KMZ02957      93 LFDHFVKKQHDNLRMQGYHDFHRETNMQKGIPLQLVSLWNSMLLAVQALIHHYYAENFwehca----agwlSPVSYVTAF 168 Drosophila simu...
EDV93785      91 LLDKFTKKQHDDLRLNGYHDFHRETKKQTDVPLQVVSLWNSALLAVQAAIHHYYGDGFgthca----egwlSPITYVTVF 166 Drosophila grim...
EDS36700      73 LIDHYVKRHHEKLRLDGYHDFHRATTGHRAVPLQIVSLWNTFLLAVQALIQHYYGDSFaekcv---vvgflSPIVYITMF 149 southern house ...
ETN61777      97 LVDYLVKKHHRALAMKGYLDFNRATKHHSTVPLQIVSLWNTFLLAIHTLMQHYYGEDFgtkci---vlgwlSPIVYITAF 173 Anopheles darlingi
Q7QBM9        90 VIHERNKAEFVRLAEPDF-DHYRALAVYRKAPLQIATLWNVILLTVQNQVRYLFPYERpdhgaggalnpaiTPQVFVVVV 168 Anopheles gambi...
Q16JL1       116 VIHLYMKSKHNRLKLLGYHKFLRITHRQKKAPLQLVSLSNLLILTIHTIILELYGTNFindcy----vkglSLTLFLSIW 191 yellow fever mo...
ETN61776     108 LIHLYSKSRHQALKRGGYHSFARKVHRHKKSSLLLVTASNTVLLLVHTVMGHVYRGAFlqqcf----tqgfSSVVFVAFF 183 Anopheles darlingi
XP_019882176  75 VTDHVVKARHHKLRIDGYLDFYQITYRLIRIPLFITSLWNTCYLLLAVILHHTHKIDYeryck---tsewfTPLNYIFVL 151 Florida carpent...
XP_001123128  97 LTDHLVKRKHHKLRIYGYLDFYQSTYQQIRTPLFIASLWITCYLLLAVFLHHTHKVNYeqycr---asewfTPLNYIVLL 173 honey bee
XP_007231301 179 ICLELLFTLICLIVYTVRVARFNSQRPGPDINEEEKSHAYSNNisgtHAHTETGFRD-GSSLEEVVEKQADLIEYLKQHN 257 Mexican tetra
KMZ02957     169 TVAENLVLAVSHSLYIDKVRKFNSAKLAPDVLRGAD-----------RAGGSLGLMQpGGDTEELLEKQADLIAYLRDHT 237 Drosophila simu...
EDV93785     167 NVAENLVLTASHSFYINKVRKFNKAKLSPDVLRGDN-----------RATGSLGLMQpGGDTAELLEKQADLIAYLRDHT 235 Drosophila grim...
EDS36700     150 CSLETFVLALVNGSYIGKVVRFNRTAAPPDALQGSRG----------HSSGSLGLTQrGLSTTELLEKQADLINYLKDHN 219 southern house ...
ETN61777     174 SCLETGVLSIVNGSYIAKVRRFNRTAAPPDALQDNRG----------MRGGSVGLTQrGLSTTELLEKQADLINYLKDHN 243 Anopheles darlingi
Q7QBM9       169 CALELLVLLCFYVPLV---------RILIDIRRGEGHGKVTDLryrrMTDTELA----EQPIEWQLERQAVLIKRLRAER 235 Anopheles gambi...
Q16JL1       192 CLVECMILTYIHVTYFVKVRVFNTMRSPPDALTSAEIRRNAHH---------------RVSAEELINQQFLMIVKMMDDN 256 yellow fever mo...
ETN61776     184 TLFESLILIPIQLSYIVHVRVFNLTRPAPDVLVKEEALIMEISpt-eDYSVDESFKS-VTDRKEFIQLQSVLIRNLKHQN 261 Anopheles darlingi
XP_019882176 152 TNLELVIIVPAYINYIKRVMRFNQLRPLPDVTRDEWLSSFTQDs--ySGMGEIGYHErGTNMEELLEKQADLIRYLRDHN 229 Florida carpent...
XP_001123128 174 TTLELIIIVPVYINYIKQVLRFNRLRPPADVAREEWLSSFTQDt--yAGSNEVGYHHrESNLEELLEKQADLIRYLRDHN 251 honey bee
XP_007231301 258 TLLSRRILSL 267 Mexican tetra
KMZ02957     238 HKLNQKLHQM 247 Drosophila simulans
EDV93785     236 HKLNQKLHQM 245 Drosophila grimshawi
EDS36700     220 LKLNQKIMQM 229 southern house mosquito
ETN61777     244 LKLNQKIMQM 253 Anopheles darlingi
Q7QBM9       236 DRLQREAKLl 245 Anopheles gambiae str. PEST
Q16JL1       257 RHLQDKIREV 266 yellow fever mosquito
ETN61776     262 NQLRAKIRDi 271 Anopheles darlingi
XP_019882176 230 INLSHRIMLL 239 Florida carpenter ant
XP_001123128 252 VKLSHRMMLL 261 honey bee
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