Conserved Protein Domain Family
TFP_LU_ECD_Ly6H

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cd23549: TFP_LU_ECD_Ly6H 
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins
Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Statistics
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PSSM-Id: 467079
Aligned: 4 rows
Threshold Bit Score: 97.1305
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

cd23549 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd23549 is a member of the superfamily cl45932
cd23549 Sequence Cluster
Sub-family Hierarchy
cd00117TFPcd00206TFP_snake_toxincd23532TFP_LU_ECD_BMPR1cd23612TFP_LU_ECD_BMPR1Acd23613TFP_LU_ECD_BMPR1Bcd23533TFP_LU_ECD_BMPR2_likecd23614TFP_LU_ECD_BMPR2cd23615TFP_LU_ECD_ACVR2cd23631TFP_LU_ECD_ACVR2Acd23632TFP_LU_ECD_ACVR2Bcd23616TFP_LU_ECD_AMHR2cd23617TFP_LU_ECD_Daf4cd23618TFP_LU_ECD_Witcd23534TFP_LU_ECD_ALK1cd23535TFP_LU_ECD_ALK2cd23536TFP_LU_ECD_ALK4cd23537TFP_LU_ECD_ALK5cd23538TFP_LU_ECD_TGFR2cd23539TFP_LU_ECD_CinHb4_likecd23540TFP_LU_ECD_ALK7cd23541TFP_LU_ECD_Ly6A_likecd23542TFP_LU_ECD_Ly6Dcd23543TFP_LU_ECD_Ly6Ecd23544TFP_LU_ECD_Ly6G5bcd23545TFP_LU_ECD_Ly6G5ccd23546TFP_LU_ECD_Ly6G6ccd23547TFP_LU_ECD_Ly6G6dcd23548TFP_LU_ECD_Ly6G6ecd23549TFP_LU_ECD_Ly6Hcd23550TFP_LU_ECD_Ly6Kcd23551TFP_LU_ECD_Ly6Lcd23552TFP_LU_ECD_Ly6Mcd23553TFP_LU_ECD_Ly6PGEcd23554TFP_LU_ECD_CD59cd23555TFP_LU_ECD_GMLcd23556TFP_LU_ECD_uPAR_rpt1cd23557TFP_LU_ECD_uPAR_rpt2cd23558TFP_LU_ECD_uPAR_rpt3cd23559TFP_LU_ECD_LYPD1cd23560TFP_LU_ECD_SLURP1_likecd23619TFP_LU_ECD_SLURP1cd23620TFP_LU_ECD_LYPD2cd23561TFP_LU_ECD_SLURP2cd23562TFP_LU_ECD_LYPD3_rpt1cd23563TFP_LU_ECD_LYPD3_rpt2cd23564TFP_LU_ECD_LYPD4_rpt1_likecd23621TFP_LU_ECD_LYPD4_rpt1cd23622TFP_LU_ECD_TEX101_rpt1cd23623TFP_LU_ECD_CD177_rpt1cd23624TFP_LU_ECD_CD177_rpt3cd23565TFP_LU_ECD_LYPD5_rpt1cd23566TFP_LU_ECD_LYPD5_rpt2cd23567TFP_LU_ECD_LYPD6_likecd23625TFP_LU_ECD_LYPD6cd23626TFP_LU_ECD_LYPD6Bcd23568TFP_LU_ECD_LYPD8_rpt1cd23569TFP_LU_ECD_LYPD8_rpt2cd23570TFP_LU_ECD_LYPD9cd23571TFP_LU_ECD_PINLYP_rpt1cd23572TFP_LU_ECD_PINLYP_rpt2cd23573TFP_LU_ECD_PSCAcd23574TFP_LU_ECD_SPACA4cd23575TFP_LU_ECD_GPIHBP1cd23576TFP_LU_ECD_BAMBIcd23577TFP_LU_ECD_PATE1cd23578TFP_LU_ECD_PATE2cd23579TFP_LU_ECD_PATE3cd23580TFP_LU_ECD_PATE4cd23581TFP_LU_ECD_mPATE6_likecd23582TFP_LU_ECD_TRPcd23583TFP_LU_ECD_Prod1cd23584TFP_LU_ECD_PMFcd23585TFP_LU_ECD_LYNX1cd23586TFP_LU_ECD_sma6cd23588TFP_LU_ECD_PLIGcd23629TFP_LU_ECD_PLIGAcd23630TFP_LU_ECD_PLIGBcd23589TFP_LU_ECD_Rtvcd23590TFP_LU_ECD_Boucd23591TFP_LU_ECD_Crimcd23592TFP_LU_ECD_Crokcd23593TFP_LU_ECD_Twitcd23594TFP_LU_ECD_Atillacd23595TFP_LU_ECD_Qvrcd23596TFP_LU_ECD_Tkvcd23597TFP_LU_ECD_Bncrcd23598TFP_LU_ECD_Babocd23599TFP_LU_ECD_Coldcd23600TFP_LU_ECD_Saxcd23610TFP_LU_ECD_C9orf57cd23611TFP_LU_ECD_THFP5cd23627TFP_LU_ECD_UPcd23628TFP_LU_ECD_SP10_like
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O94772        26 LWCQDCTLTTnsSHCTPKq--CQPSDTVCASVRITDpsssrkdHSVNKMCAs--SCDFvkrhffsdylmgfinsgILKVD 101 human
XP_005395813  47 LWCQDCTLTTnsSQCTPKr--CQPADTVCVSVRITDpsssrkdHSVNKMCAl--SCEFikrhffseylmgfinsgILRVD 122 long-tailed chi...
ELW63419     351 LWCQDCTLTTnsSHCAPKq--CQPSDTVCASVRITDpsssrkdHSVNKMCAs--SCDFvrrhffsdylmgfinsgILKVD 426 Chinese tree shrew
XP_030067176  21 LSCQECTDLQh-NNCTSApkqCQSSQTHCVSILRQTvlsgsnmMSIIKSCGtkkDCDMttstn--------agnfQMITI 91  Microcaecilia u...
O94772       102 VDCCEKDLCNGA 113 human
XP_005395813 123 VECCDKDLCNGV 134 long-tailed chinchilla
ELW63419     427 VDCCRGDLCNGA 438 Chinese tree shrew
XP_030067176  92 SRCCNTDNCNTP 103 Microcaecilia unicolor
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