Conserved Protein Domain Family
DUF4545

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pfam15078: DUF4545 
Domain of unknown function (DUF4545)
This family of proteins is found in eukaryotes. Proteins in this family are typically between and 417 amino acids in length. The human member of this family is C1orf141.
Statistics
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PSSM-Id: 464489
Aligned: 7 rows
Threshold Bit Score: 591.873
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016775923   1 MAEKILEKLDVLDKQAEIILARRTKINRLQSKGRKTTMAIPLTFDFQLEFEEALATSASKAISKIKEDKSCSITKSKMHV 80 
XP_005656203   1 MAETILQQLDILDEQAKTLLAKRAKKNCLQSQVKKKVSAIPLTFDFQWEFEEAVATSISETESKMEKDRACGIKKTKRYV 80 
XP_575875      1 MTEKILEKFDALEEKARILAAIREKNSNW--RLKKKPLITPMLFDHHVKFGDTITPAAFKTVANITEDESNDLKKSKKSV 78 
Q9D5Q8         1 MTEKILEKFDALEEKERILEAIRENNTDRHHRQRKKPLITPLLFDLHVQFGDTITPSASK----IIKNKPHDLKNPKRSV 76  house mouse
XP_017201691   2 MAEKILEKLDVLDKQEKTLLDQRAKKNRLQSEGRKKVLVIPLTFDFRLEFEEAVATPTAKALSKIRKNKLSDIKKPKAHV 81 
XP_012917137   1 MAEKILEKLDILDEQAKILLARRAKTNTLQSQGKKNTSVTPLTFDFQLEFEEDIVPFISKKVPKITGDNLYSIKKGKRYV 80  domestic ferret
XP_022274380   1 MTEKILEKLDILDEQEKILLARRTKKNRLQSQGKKKTLVTPLTFDFQLEFEEDIVPSTSKKVPRITEDKSYSIKKTKRYI 80  dog
XP_016775923  81 SFKCEPEPRKSNFEKSNLRPFFVQTNVKNKESESTEPVEEHLKSRSIRPYLYLKDTTEMENAGPLNVLYSQHRQACRRSL 160
XP_005656203  81 SFKNNPEPKKSDFEKSNLKLHSVPTNIKIQEIKSIEPAEEYLKSRSTRPFCYLKDTTEAENAKPFHEQYWQHRQPCRRTL 160
XP_575875     79 SFKYKPKP-RSDFEESDLRPPTLATVINDEESKLMEHKEENLKPSST-SLRFLKDK-ETGNTKPLPLPLPRSRHPSKKSA 155
Q9D5Q8        77 SFKYKPNNSRSDLEESDLRPPILGTMINYEESKLMDHKEENLKSRPI-SLRYLKDKDETEYANPLPFPQLWSKHLCKKSA 155 house mouse
XP_017201691  82 SFKCEHKPGKNDFEKSNLGPHLVPTNTKNEESKPIEKIEENLKSRSVELFHYLKDTPE-----PL--------HACGRSC 148
XP_012917137  81 FFKNEPEPRKSDFKRLNLRSHFIPTNIKNQEsksiEPVKENLKSRSFRPFLYLKDTAENT-------------QPCRRTL 147 domestic ferret
XP_022274380  81 CFKNEPEPRKSDFGKLNLGPHFVPTNIRTQESKSIEPVKENLKSRSFRPFLYLKDTAETK-------------QACRRTL 147 dog
XP_016775923 161 GSTDFSPMFNIQSNAHKKEKDStlftaqiekkprkpldsvghlegdrNKRKKSP-RMNDFNIKENKSVRNYQLSKYrSVR 239
XP_005656203 161 DPTILFPVSNMQPNVSKKEKDS-------------------------FCRIKSPaQMNDYNTKENKYIENYQLNEY-SVR 214
XP_575875    156 ESSILSPTLNKVSNAdqnesrakkst-----------hstdhsadssRNGRKHRpEVNNLITKESELTRNDQARMThPVK 224
Q9D5Q8       156 ESSVPTPKLTNESNASKKENVSppftdqhesrtkksmhstdhsadssTSRGKCPpKG---ITKESELTRNDEARKPhPVK 232 house mouse
XP_017201691 149 GSTVLSPVLSSHTNTCEKEKGSvsctaqienktgklldsfvqleddvNKRRKAPpQMNDINTKENKSTRNCQLSDYySVR 228
XP_012917137 148 GPTVISPVRRIQSKAYKKEKDStlfaaqteknpgesfdlaghsedyvSKRRKSApQMDDFSTEENKTIKNHQLSDYcSIR 227 domestic ferret
XP_022274380 148 GPTTIYPAPKIQSSAYKKEKDStlfaaqtgenpeesfdlagrledymNKRRKSPpQTGDFSKEENKTIRNDQLSEYcSIR 227 dog
XP_016775923 240 KKSLLPLCFEDELKNPHAKIINVSPTKTVTSHMEQKDTNPIIFHDTEYVRMLLLTKNRFSSHPLENENIYPHKRTNFVLE 319
XP_005656203 215 KKSLLPLCFEDELKNPNAKIISISPAKTVTSHMEHNDTNPIIFHKTEYVKMFLLTKNRLLPHSVEKGTDYLHQRSNVVLE 294
XP_575875    225 QNILFPLDCEDLLKDPKMKTIDLGPTETVHTSMEQNHASPIIFYDTKYVQMLFQTK-WFTPYALN------YTKKNIVLE 297
Q9D5Q8       233 QSIMLPLDCEDLLKNPKIKTIDLRPAVTVHTSMKQSHANPIIFYDTEYVQMLFLTK-RFTPYAMK------CTERNIVLE 305 house mouse
XP_017201691 229 KKSLVPLCFEDELKNPNAKII--CPAKREPFHMEESETNPIIFHDTRNVQMLLLTKNRHSTYPLNNENTYLRKRTNFILE 306
XP_012917137 228 KKSLLPLCFEDELKKPNAKIINTSPPKTVTSHVEQNDTNPIIFHETGYVQMLLLTKNRLPLHCMEKENIYPYKRADFVLE 307 domestic ferret
XP_022274380 228 KKNLLPLCFEDELKKPNAKIINISPAKTVTSHMEQNDTNPIIFHETGYVQMLLLTKNRLPLYPMEKENIYPHKRPDFVLE 307 dog
XP_016775923 320 RNCEILKSIIGNQSISLFKPQKTMPTVQRKDIQiPMSFKAGHTTVDDKLKKKTNKQTLENRSWNTLYNFSQNFSSLTKQF 399
XP_005656203 295 RNCGMLKSVVRGQSITPSKLKRTMPTTQRKDEP-AIPFEVGRGRVTDQLRRKTSKQTFENVSWHKLYSVSQTFSSLTKKF 373
XP_575875    298 KNCEIVKTLFNDEPSTISKPESTKSVAQQKRLR-VLSGELAQKSISEKRKKKHDSLVSKKISPNPLYNLSQTFSSLSKRF 376
Q9D5Q8       306 KNYEVLKVLFSDEPSAVSEP------IQQKHLQ-VFSAEYAQKSINEKRKKKHDRLVSKKISPNTRYNLSQTFSSLSKKF 378 house mouse
XP_017201691 307 RNCDVHKSLVSGQSITLCKPQKTTSIARRNETR-PMPFEVGRRIT----KEKSNNQKLENGSCNRS---PQASSSLTKKI 378
XP_012917137 308 RNYEILKSLISDQFIISSKPKRIMPTTWKRDIQ-AISFEVGRRVVEGKLRKKTNKQTLENISWSKLYNFSQTFSSLTKKF 386 domestic ferret
XP_022274380 308 RNCEILKSLISDQCIIPSKPKRIMPTAWKRDIR-ALAFKVGHRVVEGKLKKETSKQTFENISWSKLYDFSQTFSSLTKKF 386 dog
XP_016775923 400 VGYLDKAVIHEMSAQTGKFERMFSAGKPTSipTSSALPVKCYSKPFKYI---YKLNNVTPLDNLLN 462
XP_005656203 374 VGLLDKTIIQEKVAKTSNFEKMFSTVKPMS--KFSASPVKYCSKPSKNIlkvHKINGVTPLDDLLN 437
XP_575875    377 VGYFDKDVIQEKSDKADKYEL-FSKTKPPPtrKFTTLPIKYDSKPLRNIleiRKLNNITPLDNLLG 441
Q9D5Q8       379 VGYFDKDVTQGKSYKANRFER-FSKTKPPPtrKLTTLPIKYDSKPLKNIfeiHKLNNMTPLDNLLG 443 house mouse
XP_017201691 379 VHYLDKTVVQEMNTKVGKCEKMFYTVKRTDthKFGTSPFTCFSKPVKNIlkiHKSKNITPLDDLLN 444
XP_012917137 387 VGFFDGSVIQEMSARHGNFERMFSTIKPRS--KFSASPVKHRSKPSKNIlevHKLNNVTPMDDLLN 450 domestic ferret
XP_022274380 387 VGFFDKTVIQEMSARHGNLERMFSTVKPIS--KFSALPVKYGSKPLKTIlevHKLSNITPLDDLLK 450 dog
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