Conserved Protein Domain Family
SPRING1

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pfam10218: SPRING1 
SREBP regulating gene protein
SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.
Statistics
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PSSM-Id: 463004
Aligned: 40 rows
Threshold Bit Score: 144.048
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001121865     109 VRPCRNSIQGKVLIVDERGIVCSRQEILPN-GCCSmeqkdsiknedtsttprrERYSCKTC-NAQGCCAIYEYCVSCCLH 186
EFJ30578          26 SFSCNNTVQGPHLLADSQGYVCSVRNIDFGrGCCPee---------------gQQFSCSGCnLVSQCCNTFEYCVSCCLD 90 
XP_009404274      42 NRVCRNTVQGRYLLSDDNGYVCTALSVDSWtRCCPvk---------------gDQFSCQGCnLISQCCNSYEYCVSCCLD 106
XP_015698065      42 PIMCRSTVQGRHLISDDNGYVCSSLSIDPWsGCCPrt---------------gSHFSCQGCkLDLQCCDSYEYCVSCCLN 106
ABK94599          32 SRSCRNTVQGRYLLSDDNGYVCDALSVDPPsRCCPen---------------gLRFSCQGCnLVSQCCNSYEFCVSCCLH 96 
JCVI:AT3G59390.1  37 ERSCRTTVQGRYLISDDEGNVCDALSLESRtRCCPwk---------------gERFSCHGCnILSQCCNSYEFCVSCCLN 101
CBI36657          36 KRICRTTVQGRYLRTDDNGHVCDALSMDPQsGCCFgk---------------rEQFSCHGCnLISQCCNSYEFCVSCCLN 100
EEF28938          39 MKICRTTVQGRFLLSDDNGHVCDALSLDPQsRCCPvr---------------gEKFSCHGCnLLSHCCNSYEFCVSCCLN 103
XP_001695899      34 KTRCRNTVQGLNMVTDDHGVVCKRSDLSYStGCCTs----------------gNQHDCALCdMRDRCCSEYESCVSCCLA 97 
Q016T5            39 GSLCRVSHASVSRVADDRGRSCEWYDVDTVsGCCPtt---------------sATHSCEKCdAAVECCERYETCVSCCLA 103 Ostreococcu...
XP_001121865     187 PGKQI-----------KGRKDVLLGLLrdnhkshrdqdvvkkrlrnLDRFQVCLAACRTSSASVRHENTYKDpHSKHCY 254
EFJ30578          91 PIHTSkefal-ssksaRQLTAANF----------------------VSVFEYCTGRCRHNSGSVVHENAYTS-EYHHCF 145
XP_009404274     107 PSRTDkdlam-kvkiaKPVTAGTY----------------------SSAFDFCAGRCRHNSASVVHENAYAS-DFHHCF 161
XP_015698065     107 PSRTKeadvl-klkvaKPVTSGTY----------------------KNVFDFCMGRCRHSSASVVHENAYAS-DFHHCF 161
ABK94599          97 PSRTQeaqvl-kvkiaKPSTAVSY----------------------TSVFDFCAGRCRHNSESVVHENAYRS-DFHHCF 151
JCVI:AT3G59390.1 102 PSQTLlekvv-kvkvaKPATSGTY----------------------KSVFDFCAGRCRHNSESVVHENAYHS-EFHHCF 156
CBI36657         101 PARTQkelal-kvkmaKPVTAGAY----------------------ASVFDFCTGRCRHNSESVVHENAYLS-DFHHCF 155
EEF28938         104 PARTQeeevm-klkiaKPATAGTY----------------------TSTFDFCAGRCRHNSESVVHENAYLS-DFHHCF 158
XP_001695899      98 PQHNAvsiakqalrspRHKDSGFW----------------------GDPFEYCKGICRTHSRSTAHENAYIS-SRHHCF 153
Q016T5           104 PARRAtlete-mrthaRGRNQVVTGFF-------------------DDPFDFCANRCRTQPSVTLHENEYAY-STKHCF 161 Ostreococcus...
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