6WGG


Conserved Protein Domain Family
ORC2

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pfam04084: ORC2 
Origin recognition complex subunit 2
All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.
Statistics
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PSSM-Id: 461163
Aligned: 132 rows
Threshold Bit Score: 195.832
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WGG_B       260 RHTMSMA--PDVTREEFSLVSNFFn--ENFQKR-PRQKLFEI--------QKKM-------------FPQYWFELTQ-GF 312 baker's yeast
EPS98601      92 aavfSQLv-PALDAPAYARALAG------SRALrSPHVLESTrlwtderaRAAL-------------FAQWADELRE-GF 150
EMD34387      38 SNVFSDLv-PPLTPEEHTAAIKR------VSESdAPANFTPLwqd--dflRKPF-------------FSRCFTELHE-GF 94 
Q5K9N9       168 GNSYSLLa-DPLSKQAYERYIAE---------------------------SSEVratlippetfmgkFRQWEKELEA-GF 218 Cryptococcus ne...
EKD03078     163 glSYSALa-RPLSQAEYEGIVSGAr-gKTKAVQeKLEELARF-------------------------FPQWASELET-GF 214
XP_009269763  66 rpsnslfpyPPLTAKETRTALEN--------AP-QKPCVPRQs-------HKRR-------------YLQWKAELFLlHR 116
XP_015788471  21 kpskyedtlPDFDPDESDGCKNK----YENHVK-EKLQLLNLy-------KENL-------------CPKIHALLIN-NY 74 
XP_001025157  31 KQAADEV--IEFNNKNLISYLED-----KYQVE-DTEKVKED--------KAKA-------------IVKSCFMIQS-GF 80 
Q8IC17       508 QENLDNL--DHIQKLQY--LIKNL---PYTHIK-EKRSLYHY--------NIKQ-------------FIKWKVYLLN-NI 557 Plasmodium falc...
XP_002140259  14 gklpmKSflPIIEESLYIRLLTEEkicQQSESK-KWKELHYS-------------------------IMMWSLS----GF 63 
6WGG_B       313 SLLFYGVGSKRNFLEEFAIDYLSpkiaysqlayenelqqnkpvnSIPCLILNGYNPSCNYRDVFKEIT-D--LLVPAelt 389 baker's yeast
EPS98601     151 SLLFYGFGSKRTVLNAFARALTKrrrvp-----------ggserGGHVVIANGYLPGFALKDLLNSIE-AipALQEAsda 218
EMD34387      95 NLIFYGFGSKRYVLNAFAKAASAr--------------------GGHVIVANGFQPSFGLKDLLGSIE-QipMVEDA--- 150
Q5K9N9       219 NLLFYGFGSKRPALNLFAQNRLAk--------------------KGHVVVVNGFFPGLGIRDVLSEVE-DrlEVPQNvs- 276 Cryptococcus ne...
EKD03078     215 NLLLYGYGSKRRLVNRFATETLNd--------------------LGDVVVVNGTFPGLGLKEVLAALE-ArlPLSDEvp- 272
XP_009269763 117 PLIFTGFGSKRGAIDDFVREls---------------------gEYDVITIDAFNPSITFRGVLEGLL----AVHQKs-- 169
XP_015788471  75 NVILYGVGSKRGIIDEFITSYLN---------------------QNIVIVFYGYKEDVNPRKILSAFR-Ealn------- 125
XP_001025157  81 NVCLHGYGSKRQIIQEISDQFI----------------------NYPKLIIQGYSAATQIQQILQKLKyIvvKITGQn-- 136
Q8IC17       558 NICLYGIGSKFHLLNLFTNICLN---------------------DGNKCIILGFEDEINFEEILVRIL-Eyh-------- 607 Plasmodium falc...
XP_002140259  64 SVLIHGYGSKRRFMNEFIHKMLKp--------------------QFLTLVIRGYCKHVKFKSSLVELI----NYLEDp-- 117
6WGG_B       390 rsetKYWGNHVILQIQKMIDFYKNQPLD------------IKLILVVHNLDGPSIRK--NTFQTM--LSFLSVI-RQIAI 452 baker's yeast
EPS98601     219 --qqGTAGTGLEAQVQRIYGYFSGADDKag--------ggERLYLVIHNIDGPGLRG--SKAQVV--ISRLATA-PRIHV 283
EMD34387     151 ----SLTGAGVEAQSQRIHEVFSSSQNDa------------KLYLIIHNLDSPALRT--AKAKAC--LSLIALS-SRIHI 209
Q5K9N9       277 --vpAYCSTPLERAAHRIYAYLLPPAAIqshsrkhwptasAPLYLVIHNIDAQSLRT--PRSIAT--LSLLASS-PRIHI 349 Cryptococcus ne...
EKD03078     273 ---aPLGASPLERAAYRVYQSYrs--------------gkDHLYMIIHNIDAPGMKA--PKSLAA--LSLLASC-PGIHI 330
XP_009269763 170 ----SIPSSTPTDELMRSVQLQYSRASTp------------RIVAVLHSMDALTLHA--RKNVDVdkLKRVLGS-ERISV 230
XP_015788471 126 --cdKMDEDVIMKKIDKLKEPI---------------------FLVIHSFDRLCIKH--NKIKPL--VNKILNRsSQIHL 178
XP_001025157 137 ---------SGQKRIEGILEYLKQQEENmgki----ssqvPFILILFHNIDSKQFIE----QDSVkiLSAVLNL-PYIKA 198
Q8IC17       608 ---yKYKSSKTLKSFDLLYELI---QRVnd--------snVPLYFIIHNLDNTKLYPyyEY------FSFLSQY-ENIYF 666 Plasmodium falc...
XP_002140259 118 ----EEAVNMSEWSLDMLTSKIrklyklq----tlnfspkKRVFIIINNIDCISLRPylST------IAQLAQI-PILSI 182
6WGG_B       453 VASTDHIYAPLLWDNMKA-Q------------------NYNFVFHDISNFEPSTVESTFQD-VMKMGKsd---------- 502 baker's yeast
EPS98601     284 VASIDNVQAMGRWSLSEMfTrkrtqps----sydvprrGYAWLWHDLTTLAPYDAELASADpSSISGAstsgrranla-- 357
EMD34387     210 VASVDHINASQRWSFTELfArkpdpgvpe-qstkvpsrGFAWLWHDLTTLAPYDFELAFADpTSIYGVsalrggrardaa 288
Q5K9N9       350 IASFDHVHTPIIFSTSLSnSpphsypdggwrgtpqkdrGFNWIHHSLTTYAPYDLELSYLRlSAQSLTpsgs-------- 421 Cryptococcus ne...
EKD03078     331 VATFDHVHTPLLFSATLSnApphpptk----deipssrGFNWIYHSAPTFDDYDVELSYARlSSSAALgqs--------- 397
XP_009269763 231 VASVDHLNAPLLFPAHDAaV------------------GLPWLWHDLSTLEPHLMEM--AQrATSLLHssqaasst---- 286
XP_015788471 179 LTSVDHLNSPLLFTCSET-V------------------TLNLVWLNCPTFQDYNIEKSFAQlSTSRTSgsskhr------ 233
XP_001025157 199 VCSIDHVKYPIILTSKVL-E------------------SFNFSFIEVHTHQCYLHEFKVSQnTFNLKK------------ 247
Q8IC17       667 VCSIDDVSFELNMNFKNI-S------------------SINFFYIKCHTWLDYRHEIlrqwnkflpe------------- 714 Plasmodium falc...
XP_002140259 183 LVTVDNIRWPFLWSTSLL-H------------------KMNFIYIQVHTKDNYSVELkhqwegtnpqw------------ 231
6WGG_B       503 ----------tSSGAEGAKYVLQSLTVNSKKMYKLLIET---QMQ------------------------NmGNLSANTGP 545 baker's yeast
EPS98601     358 --tgtaaggprIVSETAARHVLASVTQKARRLFVLLGSK---QLE--------------------------LMAPAAGEV 406
EMD34387     289 vagangapgtvLVTESAARHVLASVTDKAKKLFVLLGAR---QLE--------------------------IMPEGAGAG 339
Q5K9N9       422 --------gtggISEEGALQILKSVPVKAARLLKLILTQ---QLSrlps-----------------hpkWhVAYPAPSSG 473 Cryptococcus ne...
EKD03078     398 ---------sgtISEEGALQILHSVPPMAARLLKLILLK---QLD--------------------------NGEGPLMGV 439
XP_009269763 287 ---------givptvsGARHVIASVPDRARRLFVAIAQL---QLErcs-------------------egEkSDATAQNTS 335
XP_015788471 234 ---------saaatiMAVSNVYDNLPDNSRKIFLLILNYystQLSngelsksskraikgknedtetesdEeADEGDKLDN 304
XP_001025157 248 -----------EKEGESLKYIFRSLTKVQKEIIQFVAKYiqdKLDq-----------------------NpGTAIQINGL 293
Q8IC17       715 --wvfnkkceeIDIKKNIETILNALSINHKRLFKIIASI---QLE----------------------------------- 754 Plasmodium falc...
XP_002140259 232 -lnlliedtnsKSKLDRFDTILKCLTPSHVQLTKLIATL---QLN----------------------------------- 272
6WGG_B       546 KRGTQRTGVELKLFNHLCAADFIASNEIALRSMLREFIEHKMANI---------------TKNNSGMEIIWVPYTYAE 608 baker's yeast
EPS98601     407 GAAGQDAAYDYERLFGAAREEFIATSDTALRALLGEFRDHGLVVSava---------pvgAGGTGGGEALWIPMRREA 475
EMD34387     340 AMQPAEGAFDYERLFGAARDNFVATSDTALRALLGEFRDHGLVVSn--------------AGTAGAGEMLWIPMRRDA 403
Q5K9N9       474 SGIAPPFAVDGYLLNKTAKDKFIATEDERFEAFIGEYKDHGLVAEasvasdvdenhdgavTEGRKEGRWFWVPLGKAA 551 Cryptococcus neof...
EKD03078     440 GGAAPAYALDVDLVQKAARDKFIAREEERFNALLGEFKDHGLVVTae------------lDAEGRQGRWAWVPLPRaa 505
XP_009269763 336 TTLTPSHASPRHALVSMAKQSFIATSEDAFEAALAEFRDHGLIQSsssp--------psnTHVDGPEQYIWIPLDQRs 405
XP_015788471 305 SGKKGFEGYSFNKLYLDCMDAFYVNSEGTLRSQLVEFIDHKLIRC---------------KSGTDGSEYVElliqpkl 367
XP_001025157 294 TEDGQIIGLTLKELLEMLIDEMILNSEQQLKENLLEILDHKVII----------------SIENQQKTYYTMNFSRQi 355
Q8IC17       755 NLDKGIYGVEKESLLQDKRIFTVGASSIRINSLLVEFVSHNVITE---------------TRLKEGNTFLKINADKEE 817 Plasmodium falcip...
XP_002140259 273 ----SPHGITEDQIFKDAKSSMLVTTKDALSHLLVELYTHDILV----------------KEHNNGKQIVKLSLSTDl 330
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