1V2Y


Conserved Protein Domain Family
Ubl_SNRNP25

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cd17058: Ubl_SNRNP25 
ubiquitin-like (Ubl) domain found in small nuclear ribonucleoprotein U11/U12 subunit 25 (SNRNP25) and similar proteins
SNRNP25, also termed U11/U12 small nuclear ribonucleoprotein 25 kDa protein, U11/U12 snRNP 25 kDa protein (U11/U12-25K), or minus-99 protein, is a component of the U11/U12 snRNPs that are part of the U12-type spliceosome. It contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.
Statistics
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PSSM-Id: 340578
Aligned: 56 rows
Threshold Bit Score: 86.4181
Created: 26-Oct-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
key conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27/R (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this family; may have other functions, for example in NEDD8 K27 is involved in the mechanism of protein neddylation

cd17058 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd17058 is a member of the superfamily cl28922
Sub-family Hierarchy
cd00196Ubiquitin_like_foldcd01611Ubl_Autophagy_likecd01612Ubl_ATG12cd16108Ubl_ATG8_likecd16127Ubl_ATG8_GABARAP_likecd17232Ubl_ATG8_GABARAPcd17233Ubl_ATG8_GABARAPL1_likecd16128Ubl_ATG8cd16129Ubl_ATG8_MAP1LC3cd17234Ubl_ATG8_MAP1LC3Acd17235Ubl_ATG8_MAP1LC3Bcd17236Ubl_ATG8_MAP1LC3Ccd17163Ubl_ATG8_GABARAPL2cd01616TGScd01667TGS_ThrRScd01668TGS_RSHcd04938TGS_Obgcd01666TGS_DRGcd17230TGS_DRG1cd17231TGS_DRG2cd01669TGS_MJ1332_likecd04867TGS_YchF_OLA1cd01617DCXcd16109DCX1cd16112DCX1_DCXcd17140DCX1_DCLK1cd17141DCX1_DCLK2cd16110DCX1_RP_likecd17145DCX1_RP1cd17146DCX1_RP1L1cd16111DCX_DCLK3cd16113DCX2_DCDC2_likecd17152DCX2_DCDC2cd17153DCX2_DCDC2Bcd17154DCX2_DCDC2Ccd17069DCX2cd17142DCX2_DCXcd17143DCX2_DCLK1cd17144DCX2_DCLK2cd17070DCX2_RP_likecd17147DCX2_RP1cd17148DCX2_RP1L1cd17071DCX1_DCDC2_likecd17149DCX1_DCDC2cd17150DCX1_DCDC2Bcd17151DCX1_DCDC2Ccd17072DCX_DCDC5_likecd17155DCX_DCDC1cd17156DCX1_DCDC5cd17157DCX2_DCDC5cd17158DCX3_DCDC5cd17159DCX4_DCDC5cd17073KHAcd01760RBDcd01816RBD_RAFcd17133RBD_ARAFcd17134RBD_BRAFcd17135RBD_CRAFcd01817RBD1_RGS12_likecd17136RBD1_RGS12cd17137RBD1_RGS14cd17067RBD2_RGS12_likecd17138RBD2_RGS12cd17139RBD2_RGS14cd17068RBD_PLEKHG5cd01763Ubl_SUMO_likecd16114Ubl_SUMO1cd16115Ubl_SUMO2_3_4cd16116Ubl_Smt3_likecd17078Ubl_SLD1_NFATC2ipcd17079Ubl_SLD2_NFATC2ipcd17080Ubl_SLD2_Esc2_likecd01766Ubl_UFM1cd01767UBXcd01770UBX_UBXN2cd17160UBX_UBXN2Acd17161UBX_UBXN2Bcd17162UBX_UBXN2Ccd01771UBX_UBXN3Acd01772UBX_UBXN1cd01773UBX_UBXN7cd01774UBX_UBXN8cd16117UBX_UBXN4cd16118UBX2_UBXN9cd16119UBX_UBXN6cd16120UBX_UBXN3Bcd17075UBX1_UBXN9cd17076UBX_UBXN10cd17077UBX_UBXN11cd01768RA_FERM_F0_F1_likecd01765FERM_F0_F1cd17088FERM_F1_FRMPD1_likecd17168FERM_F1_FRMPD1cd17169FERM_F1_FRMPD3cd17170FERM_F1_FRMPD4cd17089FERM_F0_TLNcd17171FERM_F0_TLN1cd17172FERM_F0_TLN2cd17090FERM_F1_TLNcd17173FERM_F1_TLN1cd17174FERM_F1_TLN2cd17091FERM_F0_SHANKcd17175FERM_F0_SHANK1cd17176FERM_F0_SHANK2cd17177FERM_F0_SHANK3cd17092FERM1_F1_Myosin-VIIcd17093FERM2_F1_Myosin-VIIcd17094FERM_F1_Max1_likecd17178FERM_F1_PLEKHH1cd17179FERM_F1_PLEKHH2cd17095FERM_F0_kindlinscd17180FERM_F0_KIND1cd17181FERM_F0_KIND2cd17182FERM_F0_KIND3cd17096FERM_F1_kindlinscd17183FERM_F1_KIND1cd17184FERM_F1_KIND2cd17185FERM_F1_KIND3cd17097FERM_F1_ERM_likecd17186FERM_F1_Merlincd17187FERM_F1_ERMcd17237FERM_F1_Moesincd17238FERM_F1_Radixincd17239FERM_F1_Ezrincd17098FERM_F1_FARP1_likecd17188FERM_F1_FRMD7cd17189FERM_F1_FARP1cd17190FERM_F1_FARP2cd17099FERM_F1_PTPN14_likecd17191FERM_F1_PTPN14cd17192FERM_F1_PTPN21cd17100FERM_F1_PTPN3_likecd17193FERM_F1_PTPN3cd17194FERM_F1_PTPN4cd17101FERM_F1_PTPN13_likecd17195FERM_F1_PTPN13cd17196FERM_F1_FRMPD2cd17197FERM_F1_FRMD1cd17198FERM_F1_FRMD6cd17102FERM_F1_FRMD3cd17103FERM_F1_FRMD4cd17199FERM_F1_FRMD4Acd17200FERM_F1_FRMD4Bcd17104FERM_F1_MYLIPcd17105FERM_F1_EPB41cd17106FERM_F1_EPB41Lcd17201FERM_F1_EPB41L1cd17202FERM_F1_EPB41L2cd17203FERM_F1_EPB41L3cd17107FERM_F1_EPB41L4Acd17108FERM_F1_EPB41L5_likecd17204FERM_F1_EPB41L4Bcd17205FERM_F1_EPB41L5cd17109FERM_F1_SNX17_likecd01777FERM_F1_SNX27cd16121FERM_F1_SNX17cd16122FERM_F1_SNX31cd17110FERM_F1_Myo10_likecd17206FERM_F1_Myosin-Xcd17207FERM_F1_PLEKHH3cd17208FERM_F1_DdMyo7_likecd17043RAcd00153RA_RalGDS_likecd17209RA_RalGDScd17210RA_RGLcd17211RA_RGL2cd17212RA_RGL3cd01775RA_PHLPP_likecd17213RA_PHLPPcd17240RA_PHLPP1cd17241RA_PHLPP2cd17214RA_CYR1_likecd01776RA_Rincd16130RA_Rin3cd16131RA_Rin2cd17215RA_Rin1cd01778RA_RASSF1_likecd17218RA_RASSF1cd17219RA_RASSF3cd17220RA_RASSF5cd01779RA_Myosin-IXcd17216RA_Myosin-IXacd17217RA_Myosin-IXbcd01781RA2_Afadincd01782RA1_Afadincd01783RA2_DAGK-thetacd01784RA_RASSF2_likecd17221RA_RASSF2cd17222RA_RASSF4cd17223RA_RASSF6cd01785RA_PDZ-GEF1cd01786RA_STE50cd16123RA_RASSF7_likecd16132RA_RASSF10cd16133RA_RASSF9cd16134RA_RASSF8cd16135RA_RASSF7cd16125RA_ASPP1_2cd17224RA_ASPP1cd17225RA_ASPP2cd17111RA1_DAGK-thetacd17112RA_MRL_likecd01787RA_MRLcd16136RA_MRL_Lpdcd16137RA_MRL_RIAMcd16138RA_MRL_MIG10cd16124RA_GRB7_10_14cd16139RA_GRB14cd16140RA_GRB7cd16141RA_GRB10cd17113RA_ARAPscd17226RA_ARAP1cd17227RA_ARAP2cd17228RA_ARAP3cd17114RA_PLC-epsiloncd01780RA2_PLC-epsiloncd17229RA1_PLC-epsiloncd17115RA_RHG20cd17116RA_Radil_likecd17117RA_ANKFN1_likecd16102RAWUL_PCGF_likecd17081RAWUL_PCGF1cd17082RAWUL_PCGF2_likecd17164RAWUL_PCGF2cd17165RAWUL_PCGF4cd17083RAWUL_PCGF3cd17084RAWUL_PCGF5cd17085RAWUL_PCGF6cd17086RAWUL_RING1_likecd17166RAWUL_RING1cd17167RAWUL_RING2cd17087RAWUL_DRIP_likecd16105Ubl_ASPSCR1_likecd17039Ubl_ubiquitin_likecd01788Ubl_ElonginBcd01789Ubl_TBCBcd01790Ubl_HERPcd17118Ubl_HERP1cd17119Ubl_HERP2cd01791Ubl_UBL5cd01792Ubl1_ISG15cd01793Ubl_FUBIcd01794Ubl_UBTDcd17120Ubl_UBTD1cd17121Ubl_UBTD2cd01795Ubl_USP48cd01796Ubl_Ddi1_likecd01797Ubl_UHRFcd17122Ubl_UHRF1cd17123Ubl_UHRF2cd01798Ubl_parkincd01799Ubl_HOIL1cd01800Ubl_SF3a120cd01801Ubl_TECR_likecd17124Ubl_TECRcd17125Ubl_TECRLcd01802Ubl_ZFAND4cd01803Ubl_ubiquitincd01804Ubl_midnolincd01805Ubl_Rad23cd16126Ubl_HR23Bcd17126Ubl_HR23Acd01806Ubl_NEDD8cd01807Ubl_UBL4A_likecd01808Ubl_PLICscd01809Ubl_BAG6cd01810Ubl2_ISG15cd01811Ubl1_OASLcd01812Ubl_BAG1cd01813Ubl_UBLCP1cd01814Ubl_MUBs_plantcd01815Ubl_UBL7cd12219Ubl_TBK1_likecd17127Ubl_TBK1cd17128Ubl_IKKEcd16103Ubl2_OASLcd16104Ubl_USP14_likecd16106Ubl_Dsk2p_likecd16107Ubl_AtUPL5_likecd17044Ubl_TBCEcd17045Ubl_TBCELcd17046Ubl_IKKA_likecd17047Ubl_UBFD1cd17048Ubl_UBL3cd17049Ubl_Sacsincd17050Ubl1_ANKUB1cd17051Ubl2_ANKUB1cd17052Ubl1_FAT10cd17053Ubl2_FAT10cd17054Ubl_AtBAG1_likecd17055Ubl_AtNPL4_likecd17056Ubl_FAF1cd17129Ubl1_FAF1cd17130Ubl2_FAF1cd17057Ubl_TMUB1_likecd17131Ubl_TMUB1cd17132Ubl_TMUB2cd17058Ubl_SNRNP25cd17059Ubl_OTU1cd17060Ubl_RB1CC1cd17061Ubl_IQUBcd17062Ubl_NUB1cd17063Ubl_ANKRD60cd17064Ubl_TAFs_likecd17065Ubl_UBP24cd17066Ubl_KPC2cd17040Ubl_MoaD_likecd00565Ubl_ThiScd00754Ubl_MoaDcd01764Ubl_Urm1cd17074Ubl_CysO_likecd17505Ubl_SAMP1_likecd17506Ubl_SAMP2_likecd17041Ubl_WDR48cd17042Ubl_TmoB
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #                                                    
1V2Y_A         7 GMTVRVCKmdGEVMPVVVVqnaTVLDLKKAIQRYVQLKQEREggvq-hisWSYVWRTYHLTSAGEKLTedrkklrdygIR 85  house mouse
OEL23060      56 RLRLTVHKldGSFFDVEIArsaAVWELKAAIEELFFALFDDTdkt---isWQHVWSHFCLCFKDERLTddkatlrafgIR 132 Dichanthelium o...
XP_010943279  48 LIKLTIIKldATSFDVQIArtaAVWELKMAIENLFKNSADDGgcy---isWSHVWRHFCLSYDGFKLTddhttlrtfgIK 124 African oil palm
XP_008443964  39 LLRLSVLKldGSSFEVQVErtaTVAAVRDAVESVFCEMSMNKedf--nisWPHVWGHFCLCYKHFKLMddksriqhfgIR 116 muskmelon
XP_015894210   4 FAGLPISKpeVLYTEVNVSrtaTVAELKEAVKDVFRQLPNETesn---isWSHVWSHFCLSFKGQKLIddktyirflgIR 80  Ziziphus jujuba
XP_001769021  51 SMKLSILKldGSHFDVVVLtnsRVRDLKQAVVKYVDHLEQSElghk-risWQHVWGHFCLCHGTEKLVdddarlagfgIR 129 Physcomitrella ...
ABK21326      28 SIRLCIFRmdNTSFDVSVPgtaSVLELKKAIEDKFGNSQMEEgk----isWCHVWGNFCLTYEDRELVndgsllssfgIK 103 Sitka spruce
OAE27918     194 AMKLSILKmdNTSFDVAVLntaSVRELKAELEKKVDSMEQGQlghr-hisWKHVWGNFCLTYNNEKLLnddallrefgIK 272 Marchantia poly...
NP_187443     51 AMRLSVVKldGSSLDVAVMnsaTLKDLKLLIKKKVNEMEQANmghr-hisWKHVWSNFCLSCNNEKLLddnavlqdvgIR 129 thale cress
XP_018837362  68 LISLTTQK--KKSLYYHISnpyDILAAKKALNQSSPPGLEDEklvqckisWSHLWGHFSLCYNGQKLVtetdftrnygIK 145 English walnut
Feature 1                  
1V2Y_A        86 NRDEVSFIKK 95  house mouse
OEL23060     133 DGDELHFAQH 142 Dichanthelium oligosanthes
XP_010943279 125 DGDELHFMRH 134 African oil palm
XP_008443964 117 DGDQLHFVEL 126 muskmelon
XP_015894210  81 DDDQLYFVQR 90  Ziziphus jujuba
XP_001769021 130 NNDQLRFEHH 139 Physcomitrella patens
ABK21326     104 DSDELFFVRH 113 Sitka spruce
OAE27918     273 NNDQACYAYC 282 Marchantia polymorpha subsp. polymorpha
NP_187443    130 NNSQVTFMPY 139 thale cress
XP_018837362 146 DGDQLKIVRH 155 English walnut

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