Conserved Protein Domain Family
Shisa

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pfam13908: Shisa 
Wnt and FGF inhibitory regulator
Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.
Statistics
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PSSM-Id: 464036
Aligned: 24 rows
Threshold Bit Score: 87.96
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015203759  25 SDDCESYIDSLGKFHGEQKCSL------FQFCCGSCENRYCCGRFSDKLDedeQKTCFIRRRwdEMGKSGEIAYSAWESM 98 
XP_006627819  27 GEYCHGGLDGQGAWREGFQCPErfdsvdATICCGKCALRYCCSSTEARLD---QGSCENDRR--APDTGADSKDSRDNAA 101
XP_003201351  27 GEYCHGWHDAQGVWKDGFQCPErfdtpdAIICCGKCELRYCCSSTEARLD---QGTCDNDKQ--TQETNTGSKDDKNSGA 101
XP_005797960  27 GEYCHGWRDSQGAWKDGFQCPEkidgedSIICCGKCELRYCCASTDARLD---QGSCENDKQ--AEVPGTESKQDKDSRA 101
1_pfamImport   1 GEYCHGWQDSQGAWKEGFQCPEkidaedAIICCGKCELRYCCSSVDARLD---QGSCQNDRE--AQEPGAENRENKDSDA 75 
XP_003968005  27 GEYCHGWQDSQGAWKEGFQCPEkidaedAIICCGKCELRYCCSSVDARLD---QGSCENDQE--AQKPGAENKDNKESDA 101
XP_003482906  34 GEYCHGWLDAQGVWRIGFQCPErfdggdATICCGSCALRYCCSSAEARLD---QGGCDNDRQqgAGEPGRADKDGPDGSA 110
XP_003221598  31 GEYCHGWVGASGRAADGFLCPErfdaadATLCCGSCALRYCCAAAEARLQ---QDACTNDPR---------APLRPQEPA 98 
A0PJX4        25 GEYCHGWVDVQGNYHEGFQCPEdfdtldATICCGSCALRYCCAAADARLE---QGGCTNDRR---------ELEHPGITA 92  human
KAE8629481    21 GEYCHGWLDAAGNYQAGFQCPEdfdtvdATICCGSCALRYCCAAADARLE---QGSCTNDRE----------LEKSGVSA 87  tropical clawed...
XP_015203759  99 ttSHtsgmgmSIaigVTIFIIFIIIIISCCTCSCCCLY-KMCRKPpRPIVTTtatTTVMQIpyPQQPAAPQTYPGPQYPG 177
XP_006627819 102 --VPiyvpflIV---GSVFVAFVILGSLVAVCCCRCLRpKQEPQQsRGPGGG---ARLMETi-PMIAGAGAPRGSSSRQS 172
XP_003201351 102 --VPiyvpflIV---GSVFVAFVLVGSVVAVCCCRCLRpKQEPTSgGGSGGAsssARVLETi-PMMASTGTSRGSSSRQS 175
XP_005797960 102 --VPiyvpflIV---GSVFVAFILVGSVVAVCCCRCLRpKQELSSaGASGSGstgGRLLETi-PMMASS--SRGSSSRQS 173
1_pfamImport  76 --VPiyvpflIV---GSVFVAFVLVGSGVAVCCCRCLRpKQGEERaAGAGSG----RLLETi-PMMASTSTSRGSSSRQS 145
XP_003968005 102 --VPiyvpflIV---GSVFVAFILVGSGVAVCCCRCLRpKQELSSgGGTGSGsgsGRLLETi-PMMASTSTSRGSSSRQS 175
XP_003482906 111 --VPiyvpflIV---GSVFVAFIIVGSLVAACCCRCLRpKQEPPQsRAPGGP----RLTETi-PMIPSASTSRGSSSRQS 180
XP_003221598  99 gtQPiyvpflIV---GSIFIAFIFVGSFVAVYCCTCLRpKQTLQQ---PMRFslrSYQMETl-PMILTSGSLR-TPSRQC 170
A0PJX4        93 --QPvyvpflIV---GSIFIAFIILGSVVAIYCCTCLRpKEPSQQ---PIRFslrSYQTETl-PMILTSTSPR-APSRQS 162 human
KAE8629481    88 --QPiyvpflIV---GSIFIAFIIVGSLVAIYCCTCLRpKQTSQQ---PMRFtlrSYPPETl-PMILTSGNLR-TPSRQS 157 tropical clawed...
XP_015203759 178 YQPVPVQPGYGnqplPTA----PYPgQQYAPTypASGp--pPPY 215
XP_006627819 173 STATSSSSSAN----SAA----RPPmVRAQAN--CCL----PPD 202
XP_003201351 176 STATSSSSSAP----PAAprpaPAPlLRAQAS--CCL----PPD 209
XP_005797960 174 STATSSSSSAP----PAGarpgPAPlMRAQAS--CCL----PPD 207
1_pfamImport 146 STATSSSSl-----------------VRAQAS--CCL----PPD 166
XP_003968005 176 STATSSSSSAP----AAVprpsAPAlMRAQAS--CCL----PPD 209
XP_003482906 181 STATSSSSSAN----SGA----RAPpTRSQTN--CCL-----PE 209
XP_003221598 171 SSAASSSCAAG----SVH----RFSlARPESG--CPAtsspPPY 204
A0PJX4       163 STATSSSSTGG----SIR----RFSfARAEPG--CLVpsppPPY 196 human
KAE8629481   158 STATSSTSTGG----SVR----RLSsSRADPGylVSsp--pPPY 191 tropical clawed frog
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