2GMF


Conserved Protein Domain Family
CSF2
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cd00040: CSF2 
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Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine receptor family, mainly the GM-CSF receptor.
Links
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Statistics
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PSSM-Id: 238000
Aligned: 14 rows
Threshold Bit Score: 218.508
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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glycosylation
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:glycosylation sites [posttranslational modification site]
Evidence:
  • Comment:glycosylation hinders receptor binding
  • Comment:glycosylation site is shifted in some sequences
  • Citation:PMID 1837174
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #         #                                          
2GMF_A      1 APARSPSPSTQPWEHVNA-IQEARRLLNLSRDTAaemNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTM 79  human
117560     18 APTRPPNTATRPWQHVDA-IKEALSLLNHSSDTDa-vMNDTEVVSEKFDSQEPTCLQTRLKLYKNGLQGSLTSLMGSLTM 95  Bos taurus
117562     18 APTRSPITVTRPWKHVEA-IKEALNLLDDMPVTL---NEEVEVVSNEFSFKKLTCVQTRLKIFEQGLRGNFTKLKGALNM 93  house mouse
P28773     18 APTRQPSPVTRPWQHVDA-IKEALSLLNDSTDTAavmDETVEVVSEMFDSQEPTCLQTRLELYKQGLRGSLTSLTGSLTM 96  sheep
1345845     1 APTRSPNPVTRPWKHVDA-IKEALSLLNDMRALEnekNEDVDIISNEFSIQRPTCVQTRLKLYKQGLRGNLTKLNGALTM 79  Norway rat
P51748     18 APTRPASPVTRPWQHVDA-IKEALSLLNHSSDTAavmNETVEVVSEMFDSQEPTCLQTRLKLYKQGLRGSLTSLSGSLTM 96  red deer
2493787    18 APTDLLSPVTQSWKHVDAtINEALSLLNHTSDPAavmNETVEVVYDQFEPQEPTCLQTRLALFMKGLRGNLTRLEGSLTL 97  domestic guinea pig
2493788    18 APTRPPSPVTRPWQHVDA-IKEALSLLNNSNDTAavmNETVDVVCEMFDPQEPTCVQTRLNLYKQGLRGSLTRLKSPLTL 96  pig
O62757     18 APTSSPSSVTRPWQHVDA-MKEALSLLNNSSEITavmNETVEVVSEMFDPEEPKCLQTHLKLYEQGLRGSLISLKEPLRM 96  cat
AAG49541   18 APIGPPGPVPQPRKYVDAiIKEALSLLNHSNDTGa-eTNETEVVSNVFDPTEPTCLQTRLKLYEQGLPGSFTKLKSLLST 96  woodchuck

Feature 1                                               
2GMF_A     80 MASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDC 121 human
117560     96 MATHYEKHCPPTPETSCGTQFISFKNFKEDLKEFLFIIPFDC 137 Bos taurus
117562     94 TASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 135 house mouse
P28773     97 MASHYKKHCPPTQETSCETQIITFKSFKENLKDFLFIIPFDC 138 sheep
1345845    80 IASHYQTNCPPTPETDCEIEVTTFEDFIKNLKGFLFDIPFDC 121 Norway rat
P51748     97 MARHYEQHCPPTQETSCETQTITFKSFKENLKDFLFIIPFDC 138 red deer
2493787    98 MANFYKQHCPPTPETSCMTQIITFKSFKENLKRFLFAIPFDC 139 domestic guinea pig
2493788    97 LAKHYEQHCPLTEETSCETQSITFKSFKDSLNKFLFTIPFDC 138 pig
O62757     97 MANHYKQHCPLTPETPCETQTITFKNFKEKLKDFLFNNPFDC 138 cat
AAG49541   97 MASHYKEYCPPTPETSCKTHFITFKSFKVDLKKFLSDISSSC 138 woodchuck

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