Conserved Protein Domain Family
UNC-50

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pfam05216: UNC-50 
UNC-50 family
Gmh1p from S. cerevisiae is located in the Golgi membrane and interacts with ARF exchange factors.
Statistics
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PSSM-Id: 461592
Aligned: 89 rows
Threshold Bit Score: 135.324
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EAZ63974      75 MARRLFKPTTLDFETAIWEIFHLIINPKKMYRSHYYYKQqtsnnGKSSYTRDDPSFLILLTVFLSISAVAWGLAYSP-RV 153
EDQ51507      24 YLRRIVKYKQMDMEYTFWQMLHLCTSPKVVYQQTKYHKQ-----TKNQWARDDPAFVVICSFLLAVAATAFCAAYGH-SV 97 
XP_001420594  15 YFRRAFRWRQMDVEYSLWQAASMCVNPKAVYRHTTYRKQ-----TKNQWARDDPTFVVMSCVFVTVAAIGYCAMYGG-GG 88 
Q00Y72        41 YLRRAFRWRQMDVEYSLWQAAAMCVNPKAVYRHTTYRKQ-----TKNHWARDDPTFVVLSCVAVGLAAIGWCAAYGD-GG 114 Ostreococcus tauri
XP_003054963  10 YLRRAMKWKQMDLEYAMWQMWLMCTNPKVVYRHTMYRKQ-----TKNQWARDDPAVVVLTSILVFATSSLYCCFFSK-SF 83 
XP_002503978  24 YVRRLMKFRQMDLEYTFWQMYLMCTNPKVVYRHTMYRKQ-----TKNQWARDDPAFVVLTAIMVFAVSILYCLFYSR-SL 97 
Q54DD7        33 YFRRIFHYPQMDIEYTFWIMFYLCFNPSRVYRVTSWHKQ-----TKNQWARDDPAFAVILVFFMAIASMSYAITFHFlSF 107 Dictyostelium d...
EWS76671      65 HFSKFFQMSVEEIKSSFEEMSLLLFNIKRIVQLFQWNQQ-----IRHKWGRNNPSFLFLLVILQINIAVCYSLFIKQ-SL 138
ESS35483      29 FCHRLAHLSLMDLQFSLAQFSLLLFSPRKVYEFASIRKK-----QKNYYARDDPGFLLLLFFFFLVTGVVYALAFSH-SA 102
XP_001568494  19 FLRRAVQVEQMEMDSALSQMYSLCLKPSLVSKMSRARKM-----TKGHYYRDDPAFLMLQLVFIVVVSVAQWLLL---GM 90 
EAZ63974     154 WD-ILKLIVYMVFIDFYLTGIVIATVSWFVTNKLFNntygnlggmNKY---------------------------NLNYI 205
EDQ51507      98 AQ-ATFTVVSVVFMHFFLVGVSLASICWFLSNHYLR---------EEFtvh---------------------thvVEQRV 146
XP_001420594  89 ASaTARIAARCAVGDYLGLGCVLATVSWYLANTYLR---------TKHmggh--------------------shaVEQRV 139
Q00Y72       115 TSgSARVVARCVIGDYLGVGAVLATVSWHLANTHLR---------TKLpggh--------------------shaVEQRV 165 Ostreococcus tauri
XP_003054963  84 KH-SVYVVASAGLIDYVGLGALIATGYWFVSNRFLR---------TGVghs----------------------haIEQRV 131
XP_002503978  98 GQ-AAYAVVRSVLVDFLGVGAGVATAYWYVANRYMR---------EGVnhs----------------------haVEQRV 145
Q54DD7       108 LN-VIKVMFWAVFVDFITVGLLIATIGWWVTNKFLR---------VSVhn-----------------------hsVDQSV 154 Dictyostelium d...
EWS76671     139 SE-YLTCIYKLL-AQFLIYGLIFTILPRLIVTRFLM---------KSE---------------------------VENHI 180
ESS35483     103 VGfLFTSLAPPVY-------LLLSALIFPFLHYVFL---------RCRprpshsrlrsshssrsregrhlapsssAGPRP 166
XP_001568494  91 SR-SLVGILFSAIAWYVLSGLGMACVWRAVAVMYLS---------PSStsthggvltgat----salgvdsvvdyLRPDL 156
EAZ63974     206 EWGFCFDIHCNSFLVIWCLLYLVQFLLLPLIRIRRsFLSILLGNSLYFGSIGYYFVITFYGFNSLPFISSNVrttsaagg 285
EDQ51507     147 EWLYAFDVHCNAYFPLYVVLYVLQYFLSPLLLAHG-FVATLLSNTLYFVALSYYHYLNFLGYDVLPFLERTT-------- 217
XP_001420594 140 EWMYAFDVHCNAFAPTYVVLYVLQLLLSPLLRRSG-YLASACSCVMYAIALAYHNYCVFVGYNALPFLERTE-------- 210
Q00Y72       166 EWLYAFDVHCNAFVPTYVLLYVVQLTLSPLLRAEG-RLASALSCALYAVALVYHNYCAFIGYNALPFLENTE-------- 236 Ostreococcus tauri
XP_003054963 132 EWLYAFDVHCNAFFPLFLQLYAAQLVLSPVLLAGG-FIPRMLSCALYAVALGYYQYCTFIGFNALPFLE-AM-------- 201
XP_002503978 146 EWMYAFDVHVNAFFTLFVSLYCGQLVLSPILMMNG-FLPRLLSGALYGVALSYYHYCVFCGYNVLPFLEHTA-------- 216
Q54DD7       155 EWLYAFDIHCNSFFPLFIILYVVQFFLLPILLSNS-LFAAILSNTLYIIGFSYYYYVTFLGYNALPFLQHTV-------- 225 Dictyostelium d...
EWS76671     181 SYIYSLDVFLNAYFVFLVFNYICLLILTPFWKNSNsFLIVIISSTLNLFANYRFYYIFFKFYSILPDVKKIE-------- 252
ESS35483     167 ELLFCFDVHWNASFLYLVFGLILYLVLLPLLrllplTLEVLLANSVQVVGLTAYCYITALGYARLGFSDSSL-------- 238
XP_001568494 157 DWRYAFDVHCNGYFTFFIWTEVIAYFLAPVM------SVSWVSNAVVSIGTTTYLYSVFLGYLEIPSLSYQQ-------- 222
EAZ63974     286 mfsntnnnparllqliVIAGILPVLALGWIISLIFRFNVADAMVDTYF 333
EDQ51507     218 ----------------FFLYPIGLLALLFPISLLTGFNPSRFALGLYF 249
XP_001420594 211 ----------------FFLYPAALVLVLAPFAALVAFNPTRFVLWLYF 242
Q00Y72       237 ----------------FFLYPAAAALIAAPIAALIAFNPTRFVLSIYF 268 Ostreococcus tauri
XP_003054963 202 ----------------LFLYPIAGVAFLAPMMCLFGFNPTKFVLGIYF 233
XP_002503978 217 ----------------LLVYPIALIMLVTPLAILVGFNPTKFVLGIYF 248
Q54DD7       226 ----------------VFLYPIGILFALYIVSVVMGKNLTVSIINFYF 257 Dictyostelium discoideum
EWS76671     253 ----------------SFLIPIGLQVAINIIMVISNHNYYLFMINYFL 284
ESS35483     239 ----------------PFFLPALLFLVVATVATVFSVNLGDILVSSLL 270
XP_001568494 223 ----------------RLLYPVLIVGVLFLLLSFSDINVGVKLWLQqc 254
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