Conserved Protein Domain Family
SID-1_RNA_chan

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pfam13965: SID-1_RNA_chan 
dsRNA-gated channel SID-1
This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.
Statistics
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PSSM-Id: 464057
Aligned: 31 rows
Threshold Bit Score: 563.422
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008186416 173 SEPVYYYYSF--KQNASMVLLHVISDDVMCMTLSIQNSSCPVFD--SLETVQYDGLRQTVSKTGGIIISKDEYP-LGLFI 247
8_pfamImport   1 VKPLGYFLDAk-EQNVNAFHITVTSDDDICANLITVPADEPLYDrrVDLDKVDNRRILSFTRRADVLFPNSEIAnFEKFR 79 
Q9GZC8       197 VKPIGFFLNCs-EQNISQFHVTLYSEDDICANLITVPANESIYDrsVISDKTHNRRVLSFTKRADIFFTETEISmFKSFR 275 Caenorhabditis ...
EGT42616     204 VKPIGFFLDAi-EQNVKSFHITLLSDDDFCASLITVPANESIYDrpVDADKADNNRVITFTKRADIFFSQTEIEtFKSFR 282
XP_003113953 200 VKPMGFFLDAk-EQDVKSFHITVTSEDDICANVITVPANESIYDrpVDSDKADNQRVITFNRRADIFFSEKEIElFKSFR 278
CAP28349     192 VKPIGFFLDTe-EQIVKSFHITLTSADDICANVITAPANESIYErpVDSDRADNRRVLTFTRRADIFFSETEIQlFKTFR 270
Q9GYF0       151 SEPVYLRYDI--PGDVDSVAVHLDSNSTICMTVSVQKIGCPVFD--LPDNVNSMGLHQTMTTSATIPVEKSRMS--SFYV 224 Caenorhabditis ...
EFO97233     110 VENFHIGYTF--PDYVEKVNVRITSDSDVCAKIYARKANCPAFDasGLVELSDSSYYQSFTTFGGFSLRKSDIG-PKFHL 186
XP_015837739 152 SEPRYFSYDYvpQSHSSLVTIEIDSDDETCLMVSVQKHTCPVLD--LNNFINYQGFHQTILTKGGMRIRKKYYT-GGFFL 228
EFA10693     175 SESKYYYYKFh-DKKNTSAMIEINSDDDVCLTVSIQDSFCPVLD--LDKDITYEGKYQTINRKGGMTIRQREFP-DGFFL 250
XP_008186416 248 VFV-VHSDNSACNRGNYQATN----------SRTKSISFVVKPTVD----FNYQIINCLIVTFIFISILV--LTTFFYHA 310
8_pfamImport  80 IFVlISPDDSLCGASSRKTAL-----------QNKKLSLEFVK-LNda-sYSVPLIAMFTFLAIPALIFL--PFVTLTRF 144
Q9GZC8       276 IFVfIAPDDSGCSTNTSRKSF----------NEKKKISFEFKK-LEnq-sYAVPTALMMIFLTTPCLLFLpiVINIIKNS 343 Caenorhabditis ...
EGT42616     283 IFVfISPVDSPCSTNSSRKTF----------NENKKVTFEFAK-LEps-sYFFPTALMMAFLATPVLLFV--PALILNRI 348
XP_003113953 279 IFVfVSPVDSPCSLKTSRKTF----------NEQKKMTFEFKK-LEpd-sYFMPTLAMIAFFISPCLIVA--SILAVNVW 344
CAP28349     271 IFVfISPVNAPCSGNTSRKNY----------NEIKKITFDFTR-LEpn-sYFVPTLAMLVFFASPCLIFI--ASLTVNVI 336
Q9GYF0       225 VFV-VNTNDDLCSEILSIKPNkpt----kfpLRMKSFNVTIESSMKif-dYTIPIVFWACILLLVTIVVF--VYHYFDGI 296 Caenorhabditis ...
EFO97233     187 AFT-VEPDDVVCETYTNLTENp---------YRVKNVNISVIPIFDe----TVQPIVPVVLYISVSFAVI--VMTYFQCK 250
XP_015837739 229 VFT-VVEDEVCKKKDLPIIPNq---------NQSSTVHFTVTENIEsknhYIPAVFIVLACFILFSFVAI--AIFCVFER 296
EFA10693     251 VFV-AKADNYQCSQKHSVLLVehrkqhlilaNRTSTITFTINKGINgk-eYEIASLATLGALLSFCIVST--IMIFAFTR 326
XP_008186416 311 K-RdnlkTIDITQEEPSTSICSTPVNIqP--DNVSYDSSLDET-DIDILKSPEPW-----KDLIRTKACLYVS-DLSKKD 380
8_pfamImport 145 R--------------SMPIATDHLL------DLSTDLSSSSQPsPLIVLDESATD-----NSLGIAEVNADIT---VLED 196
Q9GZC8       344 R---------KLAPSQSNLISFSPVPSeQrdMDLSHDEQQNTSsELENNGEIPAAenqivEEITAENQETSVE-EGNREI 413 Caenorhabditis ...
EGT42616     349 R---------NTSTSQSTLISFAPDTP---------------DqSYQVEEGPSTD-----NDIVVPEEE-----NLQNQE 394
XP_003113953 345 R-------------------NRDPS------NTSADLVSFESDePNHPNANTSDE-----QLVVMEEEEVNLQ-NHENLQ 393
CAP28349     337 R---------NRSDLVADLISFSSD------QSANTSAIAENNmAHNEIAVIPEE-----ENL-----------QVQEIE 385
Q9GYF0       297 WeRrfvsRAYTHLEDNAQEQRIRDF------YDFQRMSEDDDLkDYDLLTDCQD------MMVVRAKASLTVA-DLSMTP 363 Caenorhabditis ...
EFO97233     251 W------------------------------LNRNENNEPNSQqEIDSENSLVVD-----KIILFDKPANIVSyNKYHKN 295
XP_015837739 297 Y------RKKKIAENTEQIA-----------INVDEKTEEEITkEEITEEEIHEE-----RDENNQQIPNNVA-DFSQNT 353
EFA10693     327 W---------------GTISKFRP-------SGDELDADWKEPpEPPITRELKHE--------LLSRQALTVN-LLARAP 375
XP_008186416 381 HRI----LKAKSSLYVWNLITVAVFYSLPVI-QLVFTSQKMLIET--GNQDLCYYNFLCSHSFvlgpWKFSDFNHIFSNI 453
8_pfamImport 197 VKL------TDSLSLHGEMLRYPVAIILPVLmHTAVEYHNWSKSSmaNRDEMCFYNHACANPY----GEFRAWNNIISNI 266
Q9GZC8       414 QVKi--pLKQDSLSLHGQMLQYPVAIILPVLmHTAIEFHKWTTSTmaNRDEMCFHNHACARPL----GELRAWNNIITNI 487 Caenorhabditis ...
EGT42616     395 GNIi--pLPEDSLSLHGQMLKYPLAIILPVFmHTAVEYHEWTTSTmaNRDEMCFHNNACARPY----GELRAWNNIISNI 468
XP_003113953 394 NHVeavsVKQDSLSLHGQVLRYPIAIILPVLmHTAVQFHNFTFSTmaNRDEMCFHNSACSKPL----GELRAWNNMISNI 469
CAP28349     386 PIP----IKQDSLSLHGQMFKYPVALILPVLmHTGVEFHNFTTSTmaNRDEMCFHNNACAKPL----GELRSWNNMISNI 457
Q9GYF0       364 YEE----RELKYDVYKIALAIIGIFYNITVL-QLIISKAGSLRQS--GDLDECTFNFQCARPL----WYFVAFNNVVSNG 432 Caenorhabditis ...
EFO97233     296 KLI----NESKYFNFLLFQFITTIILSVPVLqQLKSIFPNENTLTknVNLDNCYLNYLCSSSV----FGFNCFNGMISSN 367
XP_015837739 354 QK-----NQKRSMNYLWQILNVGLFYIIPVI-QLVVTLQSFLIQT--GDFDLCYYNFRCANPL----WIISDFNHVFSNI 421
EFA10693     376 EK-----DKRRSYNYLWHILSIAIFYSIPVV-QLVITYQRVVNRT--GDQDMCYYNFLCANPA----FGLSDFNHIFSNV 443
XP_008186416 454 GYIFFGLLFILITYKRECVN--------IPNQKFGIPNHCGLYYAMGSALAMEGLMSACYHVCPNHSNFQFDTSFMYIIC 525
8_pfamImport 267 GYAIYGLAFVAITVGRRRRSr--------QLVGYGVHESTLIDVTIGVFMVLQAIASATYHICPSNVSFQFDTPCIQMIC 338
Q9GZC8       488 GYTLYGAIFIVLSICRRGRHe--------YSHVFGTYECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVIC 559 Caenorhabditis ...
EGT42616     469 GYAIYGLVFIAITMCRRWRH---------GSPVVGIYECTLLDVTIGVFMILQAIASATYHICPSDVAFQFDTPCIQVIC 539
XP_003113953 470 GYAIYGFVFILITMFRRWRH---------HSALVGTYECTLLDITIGVFMILQAIASATYHICPSDIAFQFDTPCIQVIC 540
CAP28349     458 GYAIYGLVFIMVTMCRRWRH---------HSPLVGTYECTLLDITIGLFMILQAIASATYHICPSDIAFQFDTPCIQVIC 528
Q9GYF0       433 GYVYFGTLIIVMNYCRERSFrrlfavqpTLAERYGLPQHSGLMTAIGLAVIMEGISSATYHVCPNNINYQFDTALMYVIG 512 Caenorhabditis ...
EFO97233     368 SMVVVGVVNLFIVFRKKIFGyk----spKPPTAHGVQKQDAAKVVTLLGMFAMGLFWTLISNCPHKSSLHFYTYTHSWTF 443
XP_015837739 422 GYILMGIVFSINVFYRHFYS---------PPLTTGVPANYGVFYAMGAALIMEGVLSGCYHLCPNETNFQFDTSFMYVMI 492
EFA10693     444 GYIIVGILFLGVVLHRQt---------kIPNSSTGIPVHYGVYYAMGIALIIEGILSACYHICPSQSNYQFDTSFMYVMA 514
XP_008186416 526 MLSMIKIYQTRHPDINANAYLVFGVLAFVIILGLTGIMYEGPI----LFILFTCLHLIMIFWLSAQIYYMGRWKLDKKTp 601
8_pfamImport 339 CLLIIRQWLVRL-ESPSAAYSNLLLVVVVSVNFLVSALSKTWYi--rYLIAGIHMFIISSICLA---------------- 399
Q9GZC8       560 GLLMVRQWFVRH-ESPSPAYTNILLVGVVSLNFLISAFSKTSYv--rFIIAVIHVIVVGSICLAKE-RSLGSEKL----- 630 Caenorhabditis ...
EGT42616     540 GLLIIRQWRVRQ-ESPSASYTNLLLFGVVSLNFLISAFSKAKYv--rYLIAMIHISAIASMCLAK------RRTL----- 605
XP_003113953 541 GLLIIRQWLVRK-ESPSPAYTNMLLLAVVSLNFLISTLSKSSRv--rYVIATIHFIVVATICLKKQ-KKMGSRK-DAA-- 613
CAP28349     529 GLLIIRQWLVRQ-ESPSPAYTNILLFCVVSLNFLISACSKASGi--rYLIAIIHFGVVATVCLA---------------- 589
Q9GYF0       513 MLGKLKIWSLRHPDMVVSAYHAFGFLGVFLMAAIAGVYVH--Nm--iFWALFSIIYIASMLLVSLEFYFKGIWTLNLRE- 587 Caenorhabditis ...
EFO97233     444 ISAFMWLHAKRHGTHVWQHFFIIALFSVYGCLSFLEYAYEMTSnyvaF-LFKNILFVFVCVSSTVFIAFNYVYERPSG-- 520
XP_015837739 493 VLCLVKLYQNRHPDVTPTAYTTFSILGATILCGTIGIVFKAPPv---FIVFVTIAYLVLLIYASLNIYHFGTARN----- 564
EFA10693     515 VLCMIKLYQNRHPDVNATAYATFTVLGMAIFLAMIGILNG--Sl--tVWIVFVVIYSLLCAYISFKIYFIS-FVFDG--- 586
XP_008186416 602 krFLNHLMTAPNPCK---------PKYP--NRMVLLSIGIL---INLGLAISHW-I-IKFG--NFGNYLLILFMVNLILY 663
8_pfamImport 400 --KKRMLGINESAFRk--------QISL--TFIIYYSICNI---TMLLVYLVSA-K-IHLN--QIVTY---CCIFNCIMY 457
Q9GZC8       631 --KTRFFIMAFS-------------------------MGNF---AAIVMYLTLS-A-FHLN--QIATY---CFIINCIMY 673 Caenorhabditis ...
EGT42616     606 --ETKKTFQVFTACFa--------------------AINFL---IMLTYLAPSI---LHLN--QIVTY---CFISNCIMY 652
XP_003113953 614 ------------------------------KFMIFFAVANF---ILMMMYLTSS-K-IHLN--QITTY---CFILNCIVY 653
CAP28349     590 --KRKTLRSK--------------QVYK--VFVGTFAIFNF---FAITIYVTSS-Y-IHLN--QISTY---CFILNCILY 641
Q9GYF0       588 --LRNSIRLSWVSSRhls---cvvPAYK--ARFFVILLLNI---ANTAVVVYGL-E-AHPK--DFLSFLLIPFIGNLFIY 653 Caenorhabditis ...
EFO97233     521 --LQKHQWISSPLRKkeiiqcdenEIYRplPSKKVFAVGLIllsVGWSVFS------FYPDdiSVTKCIFCLEQCQVGFY 592
XP_015837739 565 --FLRRCCLRNSEVPrpi----qsPNT---HRWWLLLLAIT---VNILLYGLGLiLfYHTKtiDFATFILQILAGNAFLY 632
EFA10693     587 --FKQLKQSLKSSNKvea----iaPIRK--SRFALLVIANI---INYAMLITGLcL-YNTGvtDFGTFLLGLLMGNSVLY 654
XP_008186416 664 LSFYIVMKLI--------SKEKLHFWPLLYILLAMIFWSASLYFYMHKSSSWTL--SAAQSRTYNTPCTFMDFYDNHDIW 733
8_pfamImport 458 LIYYALIKYM--------CHERISHLAKLYGSLALVGWFVSAWFFFQDDMDWTQ--SAAVSRSLNKPCVLLQFFGSHDLW 527
Q9GZC8       674 LMYYGCMKVL--------HSERITSKAKLCGALSLLAWAVAGFFFFQDDTDWTR--SAAASRALNKPCLLLGFFGSHDLW 743 Caenorhabditis ...
EGT42616     653 LVYYAVMKLV--------SRERIGLKGKVCGGLAVIGWIVAAVFFFQDDTDWTR--SSAASRALNKPCLLLNFFGSHDLW 722
XP_003113953 654 LTYYATMKAV--------SRESIGLKAKICGTLAIVGWITAGYFFFQDDTDWTR--TAAASRALNKPCLLLDFFGSHDLW 723
CAP28349     642 LTYYALMKFA--------SRESIELKAKVCGVSAIFGWLIAGFFFFQDDTDWTR--TAAMSRALNTPCLLLDFFGSHDLW 711
Q9GYF0       654 IIYYILMKMI--------YREKIPKRAIALLFAAVISWTCAGILFNQRVSDWSK--MPAISRELNKPCIFLNFYDNHDLW 723 Caenorhabditis ...
EFO97233     593 LVYYVVQKIRfe----rsTFNRKFVLTLVLIILTSIPVIIFYLIIINYESPWYLlwTPAKSRTLNRECITPGI-DWADMD 667
XP_015837739 633 TVVYTCMKIKctsvrectCSEKICAQAIIYGFLALVTWVLAGVFFFAEASKWTE--SPAQSRQLNKQCIFADFYDSHDLW 710
EFA10693     655 AVFYTGMKLV--------NGERICFEAIIYGLLAIAAWATATVYFLDNATLWTV--TPAESRQWNQECIVMSFYDKHDVW 724
XP_008186416 734 HFLSAISLYLSFMVLFTLDDDVINKPTATIPVF 766
8_pfamImport 528 HIFGAMAGLFTFLFVSYVDDDLLNIPKCSVTVF 560
Q9GZC8       744 HIFGALAGLFTFIFVSFVDDDLINTRKTSINIF 776 Caenorhabditis elegans
EGT42616     723 HIFGALAGLFTFLFVSFVDDDLVNTPKSAINVY 755
XP_003113953 724 HIFGALAALFTFFSVSFVDDDLVNTPKSSINIF 756
CAP28349     712 HMFGAIAGLFTFLFVSFVDDDLINTPKSSINMY 744
Q9GYF0       724 HLSSAFAIFFSFTAINVIDDDLMFVMRNTIRVF 756 Caenorhabditis elegans
EFO97233     668 YYMTSAIFILFIIFMDFIDSNVKHIPKKHIFVF 700
XP_015837739 711 HFFSSLALYFTFMYLLCIDDNL-YTNRADIPLF 742
EFA10693     725 HLLSAPALYLTFMFLLSLDDDLVDTKREEITVF 757
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