1RMH,1M63,1CWA,1C5F,1LOP


Conserved Protein Domain Family
cyclophilin
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cd00317: cyclophilin 
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cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing.
Links
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Statistics
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PSSM-Id: 238194
Aligned: 91 rows
Threshold Bit Score: 106.579
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
active site
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1CWA_A, Homo sapiens cyclophilin A bound to cyclosporin A, contacts at 3.5 A
  • Citation:PMID 8652511
  • Citation:PMID 8263916
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        # #         #
1RMH_A      6 FFDIAvdg------eplGRVSFELfa--dkVPKTAENFRALSTgek-----------gfgYKGSCFHRIIp-------gF 59  human
1CWA_A      7 FFDIAvdg------eplGRVSFELfa--dkVPKTAENFRALSTgek-----------gfgYKGSCFHRIIp-------gF 60  human
NP_015261  14 ILYTTk-----------GNIAIELwa--keCPETCKRFLSMLSdg--------------tFTNGEFKELK---------P 57  baker's yeast
AAM63062   34 VVFQTs----------yGDIEFGFyp--tvAPKTVDHIFKLVRlg--------------gYNTNHFFRVDk-------gF 80  thale cress
EAA22721  302 KKNSYvrli-----tdvGMINIELya--ykSPKLCHNFLFLCEyk--------------yYNKTDIFKRDkd------iD 354 Plasmodium yoelii ...
NP_704514   6 YVYLEfsin----ritlGKVYFELfnd-eeIKKSVDNFLSLCKgqdy----------hsiYSNDILSYKYckierikkgK 70  Plasmodium falcipa...
NP_893272   7 VVFKTs----------kGNIDVQLyg--knKPVTVSNFIQNVNkn--------------iYKNKRFYKIInfp----qvK 56  Prochlorococcus ma...
NP_908419  88 FLDVSigg------epaGRITIGLfg--daAPAGASRFLSLVTgv--------------gYRRKEFVKIVp--------G 137 Japanese rice
XP_447857  42 ISMTIsyfpkgsdvkkeVDFSIDVyg--tvCPKARDNFITLIRgikaviegrgsgvmtlrYPGTKFTNVLp-------nK 112 Candida glabrata C...
XP_458546   4 TFHTKt-----------GPLKFELrlssiaQCKHVENFLRHCAng-------------tyEDNRILRYVPn--------F 51  Debaryomyces hanse...

Feature 1     # #                                                                             
1RMH_A     60 MCQGGDFTrhngtgg------------------------------ksiygeKFEDEnfilk------------------- 90  human
1CWA_A     61 MCQGGDFTrhngtgg------------------------------ksiygeKFEDEnfilk------------------- 91  human
NP_015261  58 TQWLMFNAnstg------------------------------------eyrTVAEEknprir------------------ 83  baker's yeast
AAM63062   81 VAQVADVAsgrsapmne--------------------------eqrkeaekKIVGEfsdvk------------------- 115 thale cress
EAA22721  355 IVFLGARKnnihsaasgfywrkkl-----------kkyklrkkiddekiinKFKEEinvnsdndsdigikylryndnrhv 423 Plasmodium yoelii ...
NP_704514  71 CIKSGYLRnkininddktyylnnnnggdddgdynsidniynslknkmknskKNKYEkveciygnyynk--------eysk 142 Plasmodium falcipa...
NP_893272  57 VIYSGIYPennyykkenqnl--------------------nklrrnipleiKLKKEiepkygyqildpa------givtl 110 Prochlorococcus ma...
NP_908419 138 YVQHGGVVsypai---------------------------------pavteRLAAEmgavraqcgg------------er 172 Japanese rice
XP_447857 113 YILGGEILpgispy--------------------------------siygdKWPEEnfdlk------------------- 141 Candida glabrata C...
XP_458546  52 IIQTGDPSqsgkesepadt---------------------kinttngyiskEFQYSnargwn------------------ 92  Debaryomyces hanse...

Feature 1                ##                                 # #         ##   #                
1RMH_A     91 --htgpgILSMANagpn-------------------------tngsQFFICta--kTEWLDGKHv--VFGKVke---gMN 136 human
1CWA_A     92 --htgpgILSMANagpn-------------------------tngsQFFICta--kTEWLDGKHv--VFGKVke---gMN 137 human
NP_015261  84 --fnrdgLLGWDRrr------------------------------nTWFITvl-adSKHVLNDCn--VFGKIvg--ksIY 126 baker's yeast
AAM63062  116 ---hvrgTLSMGRyddp--------------------------nsaQSSFSmllgnAPHLDRQYa--VFGKVtkgdetLS 164 thale cress
EAA22721  424 tetnsygNIYMFKyynq-------------------------kysnMFYISl----SEDYTTNNp--CIGKVvg---gND 469 Plasmodium yoelii ...
NP_704514 143 rkhtcagLLTIVQvedk-------------------------kyssIFKITln--kTHTYNNKNi--IIGQVik---nMH 190 Plasmodium falcipa...
NP_893272 111 tnffekgSLAMVKsgern-----------------------sstteFFFVTn---kFPELDGRYs--IFGKVvk---gIE 159 Prochlorococcus ma...
NP_908419 173 sphaaagAVSIVVrdpslpppkpklvarggklevdqeqvgvvpngtEFVITtg--dAPELDASAl--VVGRVvd---gMD 245 Japanese rice
XP_447857 142 --fdrpgRIAMWNhgqg-------------------------kqesQFFIStnpkpDTELDGRYs--IFGQVvs--glDV 190 Candida glabrata C...
XP_458546  93 -qikrgtLLTVNNagned------------------------glgsQFFISlsnehQNILGDSSkytAIGMVid---gYE 144 Debaryomyces hanse...

Feature 1                                                      
1RMH_A    137 IVEAMerfgsr--------------------------ngktskKITIAD 159 human
1CWA_A    138 IVEAMerfgsr--------------------------ngktskKITIAD 160 human
NP_015261 127 IFREIlggeieassrdnd------------vkrfmypavlkdvEITIPF 163 baker's yeast
AAM63062  165 KLEEVptrregi-------------------------fvmpteRITILS 188 thale cress
EAA22721  470 TLEKLknldta--------------------------smndehYTLNET 492 Plasmodium yoelii yoelii
NP_704514 191 ILRAIemlptcn-------------------------ngnpkvLLYISD 214 Plasmodium falciparum 3D7
NP_893272 160 ILQEIdred-------------------------------liyEIIISN 177 Prochlorococcus marinus subsp. pastoris str. CCMP...
NP_908419 246 VLGKIaavptvkdntaspyfrvakligdkravvaergfnrpytKILITN 294 Japanese rice
XP_447857 191 ILNEVqhaevsstkd-------------------milkymvkeDLRLAK 220 Candida glabrata CBS138
XP_458546 145 AIETLesdeslnnqdktkks---------gkprgiwkkeswikHVEIHF 184 Debaryomyces hansenii CBS767

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