Conserved Protein Domain Family
SLC13_permease

?
cd01115: SLC13_permease 
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Statistics
?
PSSM-Id: 238535
Aligned: 22 rows
Threshold Bit Score: 195.882
Created: 10-Jan-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
transmembrane
Feature 1:transmembrane helices
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             ####      ##############                                  ###############
P77741       9 LSLLAVAIVLFATGRVRMDAVALFVIVAFALsGTLTv--------------------PEVFSGFSDPNVVLIAALFIIGD 68   Escherichia coli...
P39535     442 MALVECVAFLWASEAIPLHITAFLVPLLVVLfKVLKtsdgaim--------saasasSEILAAMWSSTIMILLAGFTLGE 513  baker's yeast
P27514     460 FAILIYASLLWATETIPLFVTSLMIPLLIVVfPVIKdpitsqp-------msprdssQFILSTMWSSVIMLLLGGFTLAA 532  baker's yeast
XP_327979  570 LALLVFVSLLWATEAIPLFVTSLTIPFLCVVlRVFRdadkphhr------lgakattDAVFSAMWTPVIMLLLGGFTLAA 643  Neurospora crassa
Q13183      39 AYAIILMALFWCTEALPLAVTALFPLILFPMmGIVDa--------------------SEVAVEYLKDSNLLFFGGLLVAI 98   human
Q57486      40 LALLAFIAVLWLSEALHVTITALLVPLLAVAlGLVSt--------------------KQALVGFADPTIFLFFGGFSLAT 99   Haemophilus infl...
Q58086      30 IVILIVAGCLWFFELLPLPVTSLAIPIMAVFlGIFNl--------------------KEALTYFAHPIIFLFLGGFMLAQ 89   Methanocaldococc...
NP_638862   12 LVILVVALVLFISEKLRVDLVAMLATLALTLtGILTp--------------------TQALSGFSSEPAIIVAAVFVLSA 71   Xanthomonas camp...
NP_812650   66 ISIFIFATLMWVFEAVPAWTTSVLIVVLLLL-TVSDsslwfltqntpaeelgqtvkyKSILHCFADPIIMLFIGGFILAI 144  Bacteroides thet...
NP_865386   38 AGVAIVCALWWIFECLHIAVVGLLPFVALPTlGVVSh--------------------REVAEAYGHTMILLLLGGFLLSA 97   Pirellula sp. 1
Feature 1      ###                        ################# ##################                 
P77741      69 GLVRTGVATVMGTWLvkVAGNSEIK-MLVLLMLTVAGLGAFMSSTGVVAIFIPVVLSVAMRMQTSp-------------- 133  Escherichia coli...
P39535     514 VLAQYNIAKVLASWLlaFAGCKPRN-VLLMAMCVVFFLSMWISNVAAPVLTYSLLSPLLDAMDADsp------------- 579  baker's yeast
P27514     533 ALSKYNIAKVLSTHIlaSAGTNPHF-ILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNcs------------- 598  baker's yeast
XP_327979  644 ALSKCGIDKRIATFVlsKAGTQPRT-VLIANMAVAAFASMLISNVAAPVLCFGIIEPMLRNLPAGsn------------- 709  Neurospora crassa
Q13183      99 AVEHWNLHKRIALRVllIVGVRPAP-LILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsnnptf 177  human
Q57486     100 ALHIQKLDKLIANKIm-ALARGNLFiAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQLDREkdh------------ 166  Haemophilus infl...
Q58086      90 ALKNHNLDKFIAYKLl-NYGKDFKT-TCFLMFLSAYFLSMWISNTSATLILLPIALGLLHKKTGKl-------------- 153  Methanocaldococc...
NP_638862   72 GLSATGITDRIGAAIgrAAGGREWR-AIAVTMPATAALAAFSHHLMITAMMLPVMMRLAREQKLAa-------------- 136  Xanthomonas camp...
NP_812650  145 AATKSGLDVLLARVMlrPFGTQSRY-VLLGFILVTAVFSMFLSNTATAAMMLTFLTPVLKALPADgk------------- 210  Bacteroides thet...
NP_865386   98 AMERSGAHRRIAINMvkLVGGRGGKrLVLGFMLATASLSMWISNSATALMMLPIALAVLSQADDPkl------------- 164  Pirellula sp. 1
Feature 1                                               ########################               
P77741     134 -----------------------------------------SRLMMPLSFAGLISGMMTLVATPPNLVVNSELLREGYHg 172  Escherichia coli...
P39535     580 ---------------------------------------faQALVLGVALAANIGGMSSPISSPQNIISMSYLKPYGIGw 620  baker's yeast
P27514     599 ---------------------------------------yaKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWa 639  baker's yeast
XP_327979  710 ---------------------------------------msKAVIMGIALASNVGGMLSPIASPQNIVAIGLMEPPPTWg 750  Neurospora crassa
Q13183     178 elqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQn 257  human
Q57486     167 --------------------------------------ntyVFVLLGIAYSASIGGMGTLVGSPPNAIVASNLNLTFSDw 208  Haemophilus infl...
Q58086     154 ----------------------------------------rDFLLLGVAYSASIGGIATIIGSPPNAIASSYLDYGFFSw 193  Methanocaldococc...
NP_638862  137 -----------------------------------------SRLLMPMSLAASLGTTLTLISAPAFLLANAALERGGHGr 175  Xanthomonas camp...
NP_812650  211 ---------------------------------------gkIGLAMAIPVAANVGGMGTPIGTPPNAIALKYLNDPEGLn 251  Bacteroides thet...
NP_865386  165 ----------------------------------------rVPLLLGIAYSASVGGMATPIGTPPNVVFMGEMETKFGVe 204  Pirellula sp. 1
Feature 1               ###############                                                        
P77741     173 f---sFFSVTPIGLVVLVLGILYMLVMrfmlkgdtqtpqregwtrrtfrdlireyrltgrarrlairpgspmigqrlddl 249  Escherichia coli...
P39535     621 g--qfFAVALPSGILAMLLVWILLFTTfkmnktklekfk----------------------------------------- 657  baker's yeast
P27514     640 e---wFMIALPVCFICVMAIWVLLIITfppepnvkilql----------------------------------------- 675  baker's yeast
XP_327979  751 e---wFFIVIPVGVISLLLIWVLLLLTfqpgkgtsivpi----------------------------------------- 786  Neurospora crassa
Q13183     258 gnvvnFASWFSFAFPTMVILLLLAWLWlqilflgfnfrknfgigekmqeqqqaaycv----------------------- 314  human
Q57486     209 l---wYGLPIMIILLPLMIGILYIIFKpklhlnfeqtfeniemnpm---------------------------------- 251  Haemophilus infl...
Q58086     194 f---kVGFPISLLLFLICTLTLYIYFKkwipkediaiqa----------------------------------------- 229  Methanocaldococc...
NP_638862  176 l---dLFAITPIGAVLVGVGMLYMLAGrwllpkrqgeddggadylrleryytellvdadapwvgrplaefeaafterlqv 252  Xanthomonas camp...
NP_812650  252 ln-igFGEWMSFMLPYTIIVLFIAWFIllrlfpfkqksiel--------------------------------------- 291  Bacteroides thet...
NP_865386  205 v---pFGTWMMFGLPVTIIMLPIIWWWltrkiddvrpvsmpsmdsiarn------------------------------- 250  Pirellula sp. 1
Feature 1                                                                                      
P77741     250 klreryganvigverwrrfrrvivnvngvsefrardvllidmsaadvdlrqfcseqllepmvlrgeyfsdqaldvgmaei 329  Escherichia coli...
P39535         --------------------------------------------------------------------------------      baker's yeast
P27514         --------------------------------------------------------------------------------      baker's yeast
XP_327979      --------------------------------------------------------------------------------      Neurospora crassa
Q13183         --------------------------------------------------------------------------------      human
Q57486         --------------------------------------------------------------------------------      Haemophilus infl...
Q58086         --------------------------------------------------------------------------------      Methanocaldococc...
NP_638862  253 vdwlrngmrrrrssnegllragdvllvraspdeiasvkdepglslhavakyge----------qpredrtdpqrphealg 322  Xanthomonas camp...
NP_812650      --------------------------------------------------------------------------------      Bacteroides thet...
NP_865386      --------------------------------------------------------------------------------      Pirellula sp. 1
Feature 1                                                                                      
P77741     330 slipeseligksvreigfrtryglnvvglkrngvalegsladeplllgdiilvvgnwkligmlakqgrdfvalnlpeevs 409  Escherichia coli...
P39535     658 -----------------------------------------------------------------------------pik 660  baker's yeast
P27514     676 ----------------------------------------------------------------------------hpsr 679  baker's yeast
XP_327979  787 ----------------------------------------------------------------------------rpvk 790  Neurospora crassa
Q13183     315 ----------------------------------------------------------iqtehrllgpmtfaekaisilf 336  human
Q57486     252 ---------------------------------------------------------------------riltfiifpvi 262  Haemophilus infl...
Q58086     230 ----------------------------------------------------------------------------rmel 233  Methanocaldococc...
NP_638862  323 eeqlvqavvaphsefvgrsvsridflhtmgvvvvglwrkegwlhgelselqlqegdllvlwgrqhtfqqlsqhrgflmlm 402  Xanthomonas camp...
NP_812650  292 ---------------------------------------------------------------------------qiege 296  Bacteroides thet...
NP_865386  251 -------------------------------------------------------------------evyllivfavtaf 263  Pirellula sp. 1
Feature 1               #############       ###############                                    
P77741     410 easpahsqAPHAIFCLVLMVALMltdeipNPVAAIIACLLMGKFr--------------------------cIDAESAYK 463  Escherichia coli...
P39535     661 tkftvkqyYIITVTVATILLWCVesqiegAFGSSGQIAIIPIVLffg-----------------------tgLLSTQDLN 717  baker's yeast
P27514     680 dpftlkqwFVTLVCIITIVLWCLsnqisgIFGEMGIISIIPIVVffg-----------------------tgLLTSDDFN 736  baker's yeast
XP_327979  791 drftgvqwFVTLVTVATIGLWCAshqleaEFGHMGVIAIIPIVLffg-----------------------vgILTKEDFN 847  Neurospora crassa
Q13183     337 vilvllwfTREPGFFLGWGNLAFpna-kgESMVSDGTVAIFIGIimfiipskfpgltqdpenpgklkaplglLDWKTVNQ 415  human
Q57486     263 altwifsgKINPFISGLLGLQKNiasfdsIVALLAAIVICSTGV----------------------------ASWKQIQS 314  Haemophilus infl...
Q58086     234 srnaykllVIFVLIASLWIISDYlseifnVQYFDSVIAIFAIILlfv-----------------------fnLVEVNDFK 290  Methanocaldococc...
NP_638862  403 pfdgrrsrRRRAPLAVAIMLAAVaaaaaeWLPPHIAFLLGAVAMvlt-----------------------rcVSIEQAYA 459  Xanthomonas camp...
NP_812650  297 akkdwrsiVVYITFAITVLLWMFdkf-tgVNSNVVAMIPVAVFCit-------------------------gVITKRDLE 350  Bacteroides thet...
NP_865386  264 lwvfrtspFGGWTGLLPWDGTMIgda-tiALAASLFLFICPSGLndg-----------------------erLMDWNTAA 319  Pirellula sp. 1
Feature 1       ###################                        ################                    
P77741     464 SIHWPSIILIVGMMPFAVALQKTGGVALAVKGlmdiggGYGPHMMLGCLFVLSAVIGLFISNTATAVLMAPia------l 537  Escherichia coli...
P39535     718 AFPWSIVILAMGGIALGKAVSSSGLLSTIAKAlqkkieNDGVFAILCIFGILMLVVGTFVSHTVSAIIIIPlvq----ev 793  baker's yeast
P27514     737 NFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLikaqveHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPlms----ei 812  baker's yeast
XP_327979  848 NFPWTIIILAAGGLALGKAVNSSGLLHTVTRLitedvqDFSLYGVLIVFSSLILVIATFISHTVAALIILPlv-----yd 922  Neurospora crassa
Q13183     416 KMPWNIVLLLGGGYALAKGSERSGLSEWLGNKltp-lqSVPAPAIAIILSLLVATFTECTSNVATTTIFLPil------a 488  human
Q57486     315 NTDWGVLMLFGGGLTLSAVLKDSGASKILADSivfmidGQHFYLIGLLVAAFIIFLTEFTSNTASAALLVPif------i 388  Haemophilus infl...
Q58086     291 KIDWGTLILFGGALCLGGVIVKSGANTFLSEKliailgNLTPIVLLFLVVTITIILTNFISNTGLTGIIVPi-------- 362  Methanocaldococc...
NP_638862  460 EIDVRIYVMIAGVIPLGMAMDQTGTARWLAEHvlahahGLSPLSLLLLMFAAAALLTQVLSDAATTVLLTPva------l 533  Xanthomonas camp...
NP_812650  351 EISWSVLWMVAGGFALGVALQETGLAKHMIEAip--fsTWPPVLMIVGSGLICYAMANFISHTATAALLVPilaiagism 428  Bacteroides thet...
NP_865386  320 KIPWGILIMFGGGMALAIGFDQSGLSVSIGRQlaf-lkEAPPWLIVLSICMLVTFLTEITSSTATAMLLLPil------a 392  Pirellula sp. 1
Feature 1         ####################                                   #############      
P77741     538 AAAKTMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLgp------gnYSFSDFVKLGVPFTIIVMAVCVVMIPMLF 608  Escherichia coli O1...
P39535     794 GDKLGNPKAAPILVFGCALLSSCGMGLASSGFPNVTAIskvdrkgdryLSVMTFLTRGVPASILAFLCVITLGYGIM 870  baker's yeast
P27514     813 GSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAIsmidevgdryLTVGTFITRGVPASLLSYAAIVTVGYGIL 889  baker's yeast
XP_327979  923 VGKGLDEPHPNLLVMAGVLMCSAAMALPTSGFPNMTAImkedpagqryLQVKHFISRGVPSSLLTLLVTVTVGYAAM 999  Neurospora crassa
Q13183     489 SMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFsf------gdLKVLDMARAGFLLNIIGVLIIALAINSWG 559  human
Q57486     389 SIAQSLGMPEIGLALIIGIGASCAFMLPVATPPNAIVFgs------gqVKQSEMVKVGFLLNLVCVVVIATMGYMFW 459  Haemophilus influenzae
Q58086     363 LFGVSLGIPKEILILAVGMSASCSFILPVGTPPNAIVYse-------gVKKEEMMKIGMILSILSAAVITLYSILYL 432  Methanocaldococcus ...
NP_638862  534 ALAQGLGLPPIPFVVCTAMGAVASFLTPIGHHGNLLILnp------gqYRFADFLRVGVPLTVLIAFASAWMARYLW 604  Xanthomonas campest...
NP_812650  429 RENLSSLGGVETLLIGVAIGSSLAMILPISTPPNALAHat------gmIQQKDMEKVGIIMGIIGLILGYTMLIILG 499  Bacteroides thetaio...
NP_865386  393 ALSLEVGLPPELLMLPGTISCSCAFMLPVATAPNVIVFga------ggIRTDEMARNGLFLNLVAAVVITMVSLTVA 463  Pirellula sp. 1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap