1MG4,1MFW,1UF0


Conserved Protein Domain Family
DCX1_DCLK1
?
cd17140: DCX1_DCLK1 
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.
Links
?
Statistics
?
PSSM-Id: 340660
Aligned: 7 rows
Threshold Bit Score: 186.361
Created: 25-Jun-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative tubulin binding site [polypeptide binding site]
Evidence:
  • Comment: DCX binds the corner of four tubulin dimers and stabilizes both lateral and longitudinal lattice contacts.
  • Comment:Mutations in N- and C- terminal of DCX domain cause severe neuronal migration disorders in humans.
  • Comment:based on the structural evidence of the human doublecortin repeat in complex with mammalian tubulin, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        #          ###     #    ## #       #       ### ##  #                          # 
1MG4_A        14 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGlKKISSLDQLVEGESYVCGSI 93  human
1MFW_A         8 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGlKKISSXDQLVEGESYVCGSI 87  human
1UF0_A         9 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGlKKISSLDQLVEGESYVCGSI 88  human
NP_001244186  55 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGsKKISSLDQLVEGESYVCGSI 134 chicken
KKF29347      50 KAKKIRFYRNGDRYFKGIVYAISQERfRSIEALLADLTRSLSDNVNLPQGVRTIYTVDGtTKITSMDQLVEGESYVCASI 129 large yellow cr...
XP_007889454  60 KAKKVRFYRNGDRYFKGIVYAVSQDRfRSFEALLADLTRTLSDNVNLPQGVRVIYTIDGfRKISSMDELVAGESYVCASI 139 elephant shark
OCT93095      55 KAKKVRFYRNGDRYFKGIVYAISPDRfRSFEALLADLTRTLSDNVNLPQGVRTIYTVDGcKKITSLDQLVEGESYVCGSI 134 African clawed ...

Feature 1                 
1MG4_A        94 EPFKKLEYT 102 human
1MFW_A        88 EPFKKLEYT 96  human
1UF0_A        89 EPFKKLEYT 97  human
NP_001244186 135 EPFKKLEYT 143 chicken
KKF29347     130 EPYKKLEYT 138 large yellow croaker
XP_007889454 140 ELFRKLDYT 148 elephant shark
OCT93095     135 EPFKKLDYT 143 African clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap