1CMX,1UD7,1YJ1,2JVC,3CMM,4GSW,4II2,4V3L


Conserved Protein Domain Family
Ubl_ubiquitin

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cd01803: Ubl_ubiquitin 
Click on image for an interactive view with Cn3D
ubiquitin-like (Ubl) domain found in ubiquitin
Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. Ubiquitin-like (Ubl) proteins have similar ubiquitin beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ubiquitin (Ub)and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Ub includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin protein chains.
Statistics
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PSSM-Id: 340501
Aligned: 59 rows
Threshold Bit Score: 144.894
Created: 9-Jun-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:E1 interaction site [polypeptide binding site]
Evidence:
  • Comment:ubiquitin-ubiquitin activating enzyme (E1) interaction site
  • Comment:ubiquitin is covalently conjugated to its cellular target proteins, by the sequential reactions of Ub-activating (E1), Ub-conjugating (E2), and Ub-protein ligase (E3) enzymes
  • Structure:3CMM; Saccharomyces cerevisiae ubiquitin-activating enzyme (Uba1) interacts with yeast ubiquitin, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #####                  #####    # # # ####                  # #######
1CMX_B      1 MQIFVKTLTGKTITLEVEPsDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX 76  baker's yeast
1UD7_A      1 MQVFLKTLTGKTVTIEVEPsDTVENFKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTIHLVLRLRGG 76  zebra finch
2JVC_A      6 MQIFVKTLTGKTITIDVDHaDTVGAVKAKIYDKEGIPPDQQRLIFGGKQLEDSNAMSDYNVQKESTLHLVLRLRGG 81  Paramecium tetraurelia...
3CMM_B      1 MQIFVKTLTGKTITLEVESsDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76  baker's yeast
CAA49657    1 MQIFVKTLTGKTVTLEVEPtDTINNIKAKIQDKEGIPPDQQRLIFSGKQLEDNRTLQDYSIQKDATLHLVLRLRGG 76  Giardia intestinalis
EAY20402   35 MQIFVKTLTGKHITLEVEPtDRIEDVKAKIQDKEGIPPDQQRLIFAGKQLEDGNTLQDYSIQKDSTLHLVLRLRGG 110 Trichomonas vaginalis G3
EED91895    1 MQIFVKTLTGKTITLDVEPsDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76  Thalassiosira pseudona...
P22589      1 MQIFVKTLTGKTITLDVEPsDSIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76  potato late blight agent
ETO12799   23 TYRFVKTLTGKTITLDVEPnDTIQNVKAKIQDKEGIPPEQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 98  Reticulomyxa filosa
KJE89884  298 YQLFIKTLTGKTVTVEASArDTLETIKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSEYNIQSESTLHLVLRLRGD 373 Capsaspora owczarzaki ...

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