Conserved Protein Domain Family
FH_FOXS1
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cd20037: FH_FOXS1 
Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1)
FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410811
Aligned: 3 rows
Threshold Bit Score: 196.773
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                 ##  #                  ## ##  #      #         ### #    
O43638     17 TKPPYSYIALIAMAIQSSPgqRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDP 96  human
Q61574     17 TKPPYSYIALIAMAIQSSPgqRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDP 96  house mouse
PKK18814   31 TKPPYSYIALITMAIQSAPekRITLSGIYRYIMGRFTFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGNYWTLDP 110 rock pigeon

Feature 1                         
O43638     97 DCHDMFEHGSFLRRRRRFTR 116 human
Q61574     97 DCHDMFQHGSFLRRRRRFTK 116 house mouse
PKK18814  111 DCYNMFENGSFLRRRRRFTR 130 rock pigeon

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