1NEK,1ZP0,1YQ4,2ACZ


Conserved Protein Domain Family
SQR_TypeC_SdhC

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cd03499: SQR_TypeC_SdhC 
Click on image for an interactive view with Cn3D
Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this family reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Proteins in this subfamily are classified as Type C SQRs because they contain two transmembrane subunits and one heme group. The heme and quinone binding sites reside in the transmembrane subunits. The SdhC or CybL protein is one of the two transmembrane subunits of bacterial and eukaryotic SQRs. The two-electron oxidation of succinate in the flavoprotein active site is coupled to the two-electron reduction of quinone in the membrane anchor subunits via electron transport through FAD and three iron-sulfur centers. The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.
Statistics
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PSSM-Id: 239579
Aligned: 106 rows
Threshold Bit Score: 57.5447
Created: 10-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:proximal heme binding site [chemical binding site]
Evidence:
  • Structure:1NEK; Escherichia coli Succinate Dehydrogenase membrane anchor subunits bind heme; contacts at 3.5A
  • Structure:1ZP0; Sus scrofa mitochondrial Respiratory Complex II membrane anchor subunits bind heme; contacts at 3.5A
  • Structure:1YQ4; Gallus gallus Respiratory Complex II membrane anchor subunits bind heme; contacts at 3.5A
  • Comment:Two histidines from different subunits coordinate with iron in heme.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             #     ##                                                  
1NEK_C        9 RPVNLDLQTIRFPitAIASILHRVSGVITFVAVGILLWLLGTSls-sPEGFEQASaim-------gsfFVKFIMWGILTA 80  Escherichia coli
YP_438859    15 IGFGDITLKYRMPlaARVSILHRVSGALLFLFLPFLLYLFDQSlt-sELSFEVFKafl-------snvIVKLIVLALSWA 86  Burkholderia tha...
BAA31213     17 NIEFPSLITYRWPlaSLASGMHRVSGAIMFFLMPFVIWMFDASis-sEVSFARFKaafnigmlgipgfLWKLVALGLIWA 95  Rhodoferax ferme...
CAD84957     10 RPKYLNLLKIRQPlpAIVSILHRISGVLLFLPGIPLFLYGLQMllqsPETFASLQsnl-------ahpLCKLFLLLATWF 82  Nitrosomonas eur...
CAE35655     14 NISVPQILSYRLPlaGKLSILHRISGALLFLCLPLVIVPLFAAsvtsPESYAQVAqya-------anpLVKLVLLALIWG 86  Bordetella bronc...
CAD15698     18 NIGLGDIARYRLPwaGKVSILHRASGALMFLLLPFVLYLFEQSlt-sEISFAKFTall-------sngFAKVVVLALIWA 89  Ralstonia solana...
CAI08714      8 APKFLNLSQIRFPigAIASIGHRISGVLLLITLPFLALALDRSlr-gEAEFEALRdlv-------sapGRALLLIVVVWA 79  Azoarcus sp. EbN1
ABB42621      8 RPVYLNLFKFHFPlnAILSILHRITGVLLVLSFVLGLVWLHGMil-qPESYVENRqil-------thpIGQLVLTLGGLS 79  Thiomicrospira c...
ABA58926     19 RPIFFNLALIRFPanAVVSALHRISGVILLFFIPVVVYLLDFSlr-dKESFVWVTeff-------sslPVRLVGIVALWA 90  Nitrosococcus oc...
ZP_00245260  17 NIHVSQIIGYRLPpaGIVSILHRISGAIMFLLLPFIVWLFDTSls-sEISYETFTsafvagigfvpgwFVKLVALALIWA 95  Rubrivivax gelat...
Feature 1          ##                                           
1NEK_C       81 LAYHVVVGIRHMMMDFGylee--tfeAGKRSAKISFVITVVLSLLAGV 126 Escherichia coli
YP_438859    87 FLFHFCAGIRHLMMDMNhdav--skeRGKKTSVVVFVVSTLLTIAVAL 132 Burkholderia thailandensis E264
BAA31213     96 MLHHFIAGIRHLWMDTHhhhv--skdFGRQTAAVVLGLTLSLTAVLGA 141 Rhodoferax fermentans
CAD84957     83 FIHHLLAGIRHLMLDLHygm---qleQARLSSKLVLVFGAILTALTGI 127 Nitrosomonas europaea ATCC 19718
CAE35655     87 YLHHFCAGIRYLVLDLHigl---dkvSAQKSAGVAFGVSLALTLVFGL 131 Bordetella bronchiseptica RB50
CAD15698     90 YLHHFCAGIRYLILDLHigi---dktTSSKSAVSVLIVSLLLTVVFGA 134 Ralstonia solanacearum
CAI08714     80 ASHHVLAGLRHLLMDLGvgs---rldQARTSAWAALVAAAVIALAVAA 124 Azoarcus sp. EbN1
ABB42621     80 LWFHWLSGLRHLAMEHNlggllshleRSRLSGQVMLLIFVIGSLWLLW 127 Thiomicrospira crunogena XCL-2
ABA58926     91 LLHHIFAGIRFLLFDIHmgki-vkdyRPSWSARITSILALVVTLLIVG 137 Nitrosococcus oceani ATCC 19707
ZP_00245260  96 YLLHFIAGVRHLWMDVThav---skeAGHRSALITLGLSTLLTLALMG 140 Rubrivivax gelatinosus PM1

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