Conserved Protein Domain Family
MARVEL

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pfam01284: MARVEL 
Membrane-associating domain
MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.
Statistics
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PSSM-Id: 366555
Aligned: 88 rows
Threshold Bit Score: 36.1546
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9PUN1  38 RWSSPPGIIKIMSiliVVMCVGIFACVASTLPwdlditgqsmgygmgsgsysg--------gytgygfggsqmglgfayg 109 African clawed frog
O43759  20 LVRQPHTILRVVS---WLFSIVVFGSIVNEGYlnsa------------------------------------------se 54  human
O43761  20 FARRPQTLLRVAS---WVFSIAVFGPIVNEGYvntd------------------------------------------sg 54  human
O43760  20 FLTQPQVVARAVC---LVFALIVFSCIYGEGYsnah------------------------------------------es 54  human
Q9Z1L2  18 FLRRPKSISRIFG---GVFSLVIFSSLLTDGYqnrt------------------------------------------es 52  house mouse
O95473  18 FLRRPKTITRVFE---GVFSLIVFSSLLTDGYqnkm------------------------------------------es 52  human
O44511  12 AFKFPLGFIRIIQ---FVFIIIAIAAINSWGLelnyhcvdgtgnitrnstqk----------vytfslskvkltgcdnqt 78  Caenorhabditis elegans
P07825  15 VVKEPLGFVKVLQ---WVFAIFAFATCGSYTGelrlsvecanktesalnievef-----eypfrlhqvyfdapscvkggt 86  Norway rat
O57343  15 VVKEPLGFIKVLQ---WLFSIFAFATCGGYSGqfslsiecknkneskpnikvdf------eypfrlhqeyfdaptcrgat 85  African clawed frog
O09117  28 PLKEPLGFIKILE---WFASIFAFATCGGFKGkteiqvncpkvgvnknqtvtatfgypfrlnqasfhtppnvsvcdvnwe 104 house mouse
Q9PUN1 110 gNY----TDPRAAKGFILAMAAFCFIIGLVIFVMLVTR---TPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVA 182 African clawed frog
O43759  55 gEEfciyNRNPNACSYGVAVGVLAFLTCLLYLALDVYFpqiSSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVs- 133 human
O43761  55 pELrcvfNGNAGACRFGVALGLGAFLACAAFLLLDVRFqqiSSVRDRRRAVLLDLGFSGLWSFLWFVGFCFLTNQWQR-- 132 human
O43760  55 kQMycvfNRNEDACRYGSAIGVLAFLASAFFLVVDAYFpqiSNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAV-- 132 human
Q9Z1L2  53 pQLrcvlNSNHMACSFAVGAGFLSFLSCLVFLAIDAYErrlVGTRFKIAFQLLDFILAVLWAGVWFVAFCFLASQWQH-- 130 house mouse
O95473  53 pQLhcilNSNSVACSFAVGAGFLAFLSCLAFLVLDTQEtriAGTRFKTAFQLLDFILAVLWAVVWFMGFCFLANQWQH-- 130 human
O44511  79 rTFwsgdDSASGSAGFFYFVNVTALIYVIFICFVYVIFw--NIYQTEKRIPLVDLGATALLFILFFFCSSIWWAGANTIG 156 Caenorhabditis elegans
P07825  87 tKIfl-vGDYSSSAEFFVTVAVFAFLYSMGALATYIFLq--NKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVK 163 Norway rat
O57343  86 rKVfl-vGDYSSSAEFFVTIAVFSFLYSLAAMAVYMFLq--NKYRENNKGPMIDCIATAIFTFLWLVSSSAWAKGLADIK 162 African clawed frog
O09117 105 kHVl--iGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYt--NLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIK 180 house mouse
Q9PUN1 183 qasgsafytqivsicnqfyspvqtgvfVNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFF 244 African clawed frog
O43759 134 ----------------------------KPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVL 167 human
O43761 133 ----------------------------TAPGPATTQAGDAARAAIAFSFFSILSWVALTVK 166 human
O43760 133 -----------------------------TNPKDVLVGADSVRAAITFSFFSIFSWGVLASL 165 human
Q9Z1L2 131 -----------------------------SKSKHFLLGNSSAKAAIALSFFSVPVWILQAYL 163 house mouse
O95473 131 -----------------------------SPPKEFLLGSSSAQAAIAFTFFSILVWIFQAYL 163 human
O44511 157 natsderlte--------lfgqgswkgQNAQFLSRDVNNGKLAISVLANWVCVLCFAFNCWF 210 Caenorhabditis elegans
P07825 164 matdpeniik--------empmcrqtgN-TCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWF 216 Norway rat
O57343 163 latdpelviet------qipecmksenEMNCSELRDPVMSGLNTSVAFGFLNCILWLGNVWF 218 African clawed frog
O09117 181 vatghrive---------eleicnpesGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWF 233 house mouse
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