1I3O,5YUD,1M4M,3M0A,1TW6,4MTZ


Conserved Protein Domain Family
BIR
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pfam00653: BIR (this model, PSSM-Id:395528 is obsolete and has been replaced by 459891)
Inhibitor of Apoptosis domain
BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.
Links
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Statistics
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PSSM-Id: 395528
Aligned: 85 rows
Threshold Bit Score: 50.725
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1I3O_E        47 RLKSF-QnWPdya--hlTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFV 111
EDO30381      81 RLTTF-VdWPesspvrpW--ELSSAGFYYLGDQDSVKCYKCGVALRNWEPDDLPWVEHEKWSPHCPLV 145 starlet sea anemone
Q175J8         8 RLATY-VnWPis---hiSPSSLAKAGFYYTYNADQVKCAWCEGVIGQWELGDDPFVEHQKFFPNCAKV 71  yellow fever mosquito
Q6JPG0        12 RLESF-DsWPvky-iksE--DLAKSGFYYTGISDIVRCFDCRIEIKHWKEHDDPTYEHRRWSERCRMV 75  Neodiprion lecontei nucleop...
Q9EN27        13 RLQTF-EnWPinf-itpE--SFASNGFYYIGENDTVKCVYCGVQINKWVEGDKPEIDHKKFSPNCSFL 76  Amsacta moorei entomopoxvirus
XP_015042698  54 RLKTF-AnWPlaw-ldkH--QLARTGMFYTNDNDKVKCYFCEVEIGRWDLDDQPVPEHLRWSPNCPLL 117 Drosophila pseudoobscura ps...
XP_001237095  33 RLRTF-PlWTvpy-iypE--ELARWGFFYTGYRDCVRCYFCRIELGGWDEHDVVIEEHLKWSPHCRLM 96  Anopheles gambiae str. PEST
Q16WV1        44 RLESFr-gWMvs---fiSKTELARYGFYYVGPNDMVKCYFCRVEIGLWEPNDNVLSEHLRWSPYCPLL 107 yellow fever mosquito
Q8B9M2        32 RHSSF-EnYPien--taFINSLIVNGFKYNQVDDHVVCEYCEAEIKNWSEDECIEYAHVTLSPYCAYA 96  Rachiplusia ou MNPV
CAG08390     372 RLQTFsS-WPsav--pvRPQDLAQAGLYYLGQNDQVQCFCCGGILANWDAGDSAWGEHNKHFPSCFFI 436 spotted green pufferfish
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