2XWH


Conserved Protein Domain Family
RdRP_3

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pfam00998: RdRP_3 
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Viral RNA dependent RNA polymerase
This family includes viral RNA dependent RNA polymerase enzymes from hepatitis C virus and various plant viruses.
Statistics
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PSSM-Id: 395794
Aligned: 32 rows
Threshold Bit Score: 475.571
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XWH_A    3 SYSWTGALItpcSPEEEKLPIN-PLSNSLLRYHNKVYCTTTKSASLRAKKVTFdRMqvLDS-YYDSVLKDIKLAASKVTA 80   Hepatitis C virus i...
Q68798 2434 SYSWTGALItpcAAEEEKLPIS-PLSNTLIRHHNMVYSTTSRSAALRQKKVTFdRQq-VVDqHYYDTLKEMKARASTVSA 2511 Hepatitis C virus (...
O39929 2420 SYSWTGALVtpcAAEESKLPIS-PLSNSLLRHHNMVYATTTRSAVTRQKKVTFdRLq-VVDsTYNEVLKEIKARASRVKP 2497 Hepatitis C virus ED43
Q68801 2431 SYSWTGALItpcAAEEEKLPIS-PLSNSLLRHHNLVYSTSSRSAAQRQKKVTFdRLq-VLDdHYNTTLKEIKELASGVKA 2508 Hepatitis C virus (...
O39928 2426 SYTWTGALItpcSAEEEKLPIN-PLSNTLLRHHNLVYSTSSRSAGLRQKKVTFdRLq-VLDdHYREVVDEMKRLASKVKA 2503 Hepatitis C virus (...
O09796 2422 SYTWTGALItpcAAEESKLPIN-PLSNSLLRHHNMVYATTSRSAGLRQKKVTFdRLq-VLDdHYRDVLKEMKAKASTVKA 2499 Hepacivirus C
O39927 2430 SYSWTGALItpcAAEEEKLPIN-PLSNSLVRHHNMVYSTTSRSASLRQKKVTFdRVq-VFDqHYQDVLKEIKLRASTVQA 2507 Hepatitis C virus (...
Q69422 2277 SYTWTDVISf--KTASKVLSATrAITSGFLKQRSLVYVTEPRDAELRKQKVTInRQp-LFPpSYHKQVRLAKEKASKVVG 2353 GB virus-B
O09803 2373 SYIWSGVPLt--RATPAKPPVVrPVGSLLVADTTKVYVTNPDNVGRRVDKVTFwRAprVHDkFLVDSIERAKRAAQACLS 2450 GB virus C
O41892 2409 SYVWSGQPLg--CGRVIPPPITrPVGTHLTCDTTKVYATDPDRAAERAEKVTIwRGqrKYDkEYYSVVDEALKKARATKS 2486 Pegivirus A
2XWH_A   81 RLLtmeEACQLTPPHSARSKYGFGAK-EVRSLSG-RAVNHIKSVwKDLLEDSETPIPTTIMAKNEVFCVdptKGGKKAAR 158  Hepatitis C virus i...
Q68798 2512 KLLsveEACDLTPAHSARSKFGYGAK-DVRGRTS-KALNHINSVwEDLLEDNVTPIPTTIMAKNEVFCVdvsKGGRKPAR 2589 Hepatitis C virus (...
O39929 2498 RLLtteEACDLTPPHSARSKFGYGKK-DVRSHSR-KAINHISSVwKDLLDDNNTPIPTTIMAKNEVFAVnpaKGGRKPAR 2575 Hepatitis C virus ED43
Q68801 2509 ELLsveEACRLVPSHSARSKFGYGAK-EVRSLSS-KAINHINSVwEDLLEDNTTPIPTTIMAKNEVFAVaphKGGRKPAR 2586 Hepatitis C virus (...
O39928 2504 RLLpleEACGLTPPHSARSKYGYGAK-EVRSLDK-KALKHIEGVwQDLLDDSDTPLPTTIMAKNEVFAVepsKGGKKPAR 2581 Hepatitis C virus (...
O09796 2500 KLLsieEACKLTPPHSAKSKYGYGAK-DVRNLSS-RAVNHIRSVwEDLLEDTETPIDTTIMAKSEVFCVqpeKGGRKPAR 2577 Hepacivirus C
O39927 2508 KLLsieEACDLTPSHSARSKYGYGAQ-DVRSRAS-KAVDHIPSVwEGLLEDSDTPIPTTIMAKNEVFCVdpsKGGRKPAR 2585 Hepatitis C virus (...
Q69422 2354 VMWdydEVAAHTPSKSAKSHITGLRGtDVRSGAArKAVLDLQKCvEAGEIPS-HYRQTVIVPKEEVFVKtpqKPTKKPPR 2432 GB virus-B
O09803 2451 MGYtyeEAIRTVRPHAA---MGWGSKvSVKDLATpAGKMAVHDRlQEILEG--TPVPFTLTVKKEVFFKd--RKEEKAPR 2523 GB virus C
O41892 2487 PGWtyeQAISKVRRRAA---AGWGSKvTASTLDK--GWPHVKEMlDKIAFH--KEVPFTFVTKXEVFFS---KTTRKPPR 2556 Pegivirus A
2XWH_A  159 LIVYPDLGVRVCEKMALYDitqkLPQAVMGASYGFQYSPAQRVEFLLKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEES 238  Hepatitis C virus i...
Q68798 2590 LIVYPDLSVRVCEKRALYDvtrkLPVAVMGAAYGFQYSPSQRVEYLLKIWRSKKTPMGFSYDTRCFDSTVTERDIRTEES 2669 Hepatitis C virus (...
O39929 2576 LIVYPDLGSRVCEKRALHDvikkTALAVMGAAYGFQYSPAQRVEFLLTAWKSKNDPMGFSYDTRCFDSTVTEKDIRVEEE 2655 Hepatitis C virus ED43
Q68801 2587 LIVYPDLGVRICEKRALYDviqkLPSAIMGSAYGFQYSPKQRVEYLLKMWNSKKTPLGFSYDTRCFDSTVTEQDIRVEES 2666 Hepatitis C virus (...
O39928 2582 LIVYPDLGVRVCEKRALYDvaqkLPTALMGPSYGFQYSPAQRVDFLLKAWKSKKIPMAFSYDTRCFDSTITEHDIMTEES 2661 Hepatitis C virus (...
O09796 2578 LIVFPDLGVRVCEKMALYDvvstLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEES 2657 Hepacivirus C
O39927 2586 LIVYPDLGVRVCEKMALYDvtqkLPQAVMGPAYGFQYSPNQRVEYLLKMWRSKKVPMGFSYDTRCFDSTVTERDIRTEND 2665 Hepatitis C virus (...
Q69422 2433 LISYPHLEMRCVEKMYYGQvapdVVKAVMGDAYGF-VDPRTRVKRLLSMWSP--DAVGATCDTVCFDSTITPEDIMVETD 2509 GB virus-B
O09803 2524 LIVFPPLDFRIAEKLILGDpg-rVAKAVLGGAYAFQYTPNQRVREMLKLWESKKTPCAICVDATCFDSSITEEDVALETE 2602 GB virus C
O41892 2557 FIVFPPLDFRIAEKMILGDpg-iVAKAVLGSAYLFQYTPNQRVKALVAAWEGKKHPAAITVDATCFDSSIDEHDMQVEAA 2635 Pegivirus A
2XWH_A  239 IYRACSLPEEahTAIHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKaaGiIAPTMLVCGD 318  Hepatitis C virus i...
Q68798 2670 IYQCCELDPVarKAISSLTERLYVGGPMYNSQGQSCGYRRCRASGVLPTSMGNTLTCYLKAMAACKaaGlKNFDMLVCGD 2749 Hepatitis C virus (...
O39929 2656 VYQCCDLEPEarKVITALTDRLYVGGPMHNSKGDLCGYRRCRATGVYTTSFGNTLTCYLKATAAIRaaAlRDCTMLVCGD 2735 Hepatitis C virus ED43
Q68801 2667 IYQACDLKDEarRVITSLTERLYCGGPMFNSKGQHCGYRRCRASGVLPTSFGNTVTCYLKAKAATKaaGiKDPSFLVCGD 2746 Hepatitis C virus (...
O39928 2662 IYQSCDLQPEarVAIRSLTQRLYCGGPMYNSKGQQCGYRRCRASGVFTTSMGNTMTCYIKALASCRaaKlRDCTLLVCGD 2741 Hepatitis C virus (...
O09796 2658 IYQCCDLAPEakLAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRaaKlQDCTMLVNGD 2737 Hepacivirus C
O39927 2666 IYQSCQLDPVarRVVSSLTERLYVGGPMANSKGQSCGYRRCRASGVLPTSMGNTLTCYLKAQAACRaaNiKDCDMLVCGD 2745 Hepatitis C virus (...
Q69422 2510 IYSAAKLSDQhrAGIHTIARQLYAGGPMIAYDGREIGYRRCRSSGVYTTSSSNSLTCWLKVNAAAEqaGmKNPRFLICGD 2589 GB virus-B
O09803 2603 LYALASDHPD---WVRALG-KYYASGTMVTPEGVPVGERYCRSSGVLTTSASNCLTCYIKVKAACErvGlKNVSLLIAGD 2678 GB virus C
O41892 2636 IFAAASDDPV---RVHALC-RYYVEGPMVSPDGVMLGHRACRSSGVLTTSSANSXTCYIKXXAAXXraGvKEPTFXIAGD 2711 Pegivirus A
2XWH_A  319 DLVVISESQGTEEDERnlrAFTEaMTRYSaPPGDPPRPEYDLELITS--CSSNVSVALGPQGRRRYYLTRDPTTPIARAA 396  Hepatitis C virus i...
Q68798 2750 DLVVISESLGVSEDASalrAFTDaMTRYSaPPGDEPHPEYDLEHITS--CSSNVSVAHDHTGQRYYYLTRDPTNVLARAA 2827 Hepatitis C virus (...
O39929 2736 DLVVIAESDGVEEDNRalrAFTEaMTRYSaPPGDAPQPAYDLELITS--CSSNVSVAHDVTGKKVYYLTRDPETPLARAV 2813 Hepatitis C virus ED43
Q68801 2747 DLVVIAESAGIDEDKSalrAFTEaMTRYSaPPGDPPQPTYDLELITS--CSSNVSVAHDGAGKRYYYLTRDPETPLARAA 2824 Hepatitis C virus (...
O39928 2742 DLVAICESQGTHEDEAslrAFTEaMTRYSaPPGDPPVPAYDLELVTS--CSSNVSVARDASGNRIYYLTRDPQVPLAKAA 2819 Hepatitis C virus (...
O09796 2738 DLVVICESAGTQEDAAslrVFTEaMTRYSaPPGDPPQPEYDLELITS--CSSNVSVAHDASGKRVYYLTRDPTTPIARAA 2815 Hepacivirus C
O39927 2746 DLVVICESAGVQEDTAslrAFTDaMTRYSaPPGDAPQPTYDLELITS--CSSNVSVAHEGNGKKYYYLTRDCTTPLARAA 2823 Hepatitis C virus (...
Q69422 2590 DCTVIWKSAGADADKQamrVFASwMKVMGaPQDCVPQPKYSLEELTS--CSSNVTSGITKSGKPYYFLTRDPRIPLGRCS 2667 GB virus-B
O09803 2679 DCLIICERPMCDPSD----ALGRaLASY----GYACEPSYHASLDTApfCSTWLAECN-ADGKRHFFLTTDFRRPLARMS 2749 GB virus C
O41892 2712 DCLIIYENDGTDPCA----RLKAaLADY----GYRCDPVKHASLDTAecCSAYLAECV-AGGKKRWWLSTDMRKPLARAS 2782 Pegivirus A
2XWH_A  397 WETVrhSPVNSWLGNIIQYAPTIWARMVLMTHFFSILMAQDTld-qNLNFEMYGAVYSVspldlpaIIERLHGLDAFSLH 475  Hepatitis C virus i...
Q68798 2828 WETArhTPVNSWLGNIIMYAPTIWVRMVLMTHFFGILQPQEQlh-kALDFDMYGVTYNItpldlpqIIQRLHGMAAFSLH 2906 Hepatitis C virus (...
O39929 2814 WETVrhTPVNSWLGNIIVYAPTIWVRMILMTHFFSILQSQEAle-kALDFDMYGVTYSItpldlpaIIQRLHGLSAFTLH 2892 Hepatitis C virus ED43
Q68801 2825 WETArhTPVNSWLGNIIMYAPTIWVRMVIMTHFFS-ILQAQEqlekALDFEMYGAVYSVtpldlpaIIERLHGLSAFSLH 2903 Hepatitis C virus (...
O39928 2820 WETAkhSPVNSWLGNIIMYAPTLWARIVLMTHFFSVLQSQEQle-kTLAFEMYGSVYSVtpldlpaIIQRLHGLSAFSLH 2898 Hepatitis C virus (...
O09796 2816 WETArhTPVNSWLGNIIMYAPTLWARMILMTHFFS-ILLAQEqlekALDCQIYGACYSIepldlpqIIERLHGLSAFSLH 2894 Hepacivirus C
O39927 2824 WETArhTPVNSWLGNIIMFAPTIWVRMVLMNHFFSILQSQEQle-kAFDFDIYGVTYSVspldlpaIIQRLHGMAAFSLH 2902 Hepatitis C virus (...
Q69422 2668 AEGLgyNPSAAWIGYLIHHYPCLWVSRVLAVHFMEQMLFEDKlp-eTVTFDWYGKNYTVpvedlpsIIAGVHGIEAFSVV 2746 GB virus-B
O09803 2750 SEYS--DPMASAIGYILLYPWHPITRWVIIPHVLTCAFRGGGtpsdPVWCQVHGNYYKFpldklpnIIVALHGPAALRVT 2827 GB virus C
O41892 2783 SEYT--DPIGSALGTILMYPWHPVVRYVLIPHVLIMAYRSGSspdeLVMCQVQGNHYSFplkllprVLVSLHGPWCIQVT 2860 Pegivirus A
2XWH_A  476 TYTPHELTRVASALrKLGAPPLRAWKSRARAVRASLISR 514  Hepatitis C virus isolate HC-J6
Q68798 2907 GYSPGELNRVGACLrKLGAPPLRAWRHRARAVRAKLIAQ 2945 Hepatitis C virus (isolate JK046)
O39929 2893 GYSPHELNRVAGALrKLGVPPLRAWRHRARAVRAKLIAQ 2931 Hepatitis C virus ED43
Q68801 2904 SYSPVELNRVAGALrKLGIPPLRAWRHRARAVRAKLISQ 2942 Hepatitis C virus (isolate JK049)
O39928 2899 SYSPSEINRVASCLrKLGVPPLRAWRHRARAVRAKLIAQ 2937 Hepatitis C virus (isolate EUH1480)
O09796 2895 SYSPGEINRVASCLrKLGVPPLRVWRHRARGVRAKLLSQ 2933 Hepacivirus C
O39927 2903 GYSPVELNRVGACLrKLGVLPSRAWRHRARAVRAKLIAQ 2941 Hepatitis C virus (isolate EUHK2)
Q69422 2747 RYTNAEILRVSQSLtDMTMPPLRAWRKKARAVLASAKRR 2785 GB virus-B
O09803 2828 ADTTKTKMEAGKVLsDLKLPGLAVHRKKAGALRTRMLRS 2866 GB virus C
O41892 2861 TDSTKTRMEAGAALrDLGMKSLAWHRRRAGNVRTRLLRG 2899 Pegivirus A
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