1OCC


Conserved Protein Domain Family
Cyt_c_Oxidase_Va

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cd00923: Cyt_c_Oxidase_Va 
Click on image for an interactive view with Cn3D
Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit Va is one of three mammalian subunits that lacks a transmembrane region. Subunit Va is located on the matrix side of the membrane and binds thyroid hormone T2, releasing allosteric inhibition caused by the binding of ATP to subunit IV and allowing high turnover at elevated intramitochondrial ATP/ADP ratios.
Statistics
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PSSM-Id: 238463
Aligned: 17 rows
Threshold Bit Score: 117.03
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Subunit Va/II interface [polypeptide binding site]
Evidence:
  • Structure:1OCC_E: Interface with 1OCC_B (subunit II), defined using 3.5A contacts
  • Citation:PMID 8638158

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       # #                                 #         
1OCC_E      4 SHETDEEFDARWVTYFNKPdIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGp---HKE 80  cow
ABI52811   37 STETDEEFDARYEAYFNRKdIDGWEIRKAMNDLQGMDLVPEPKIVIAALKACRRLNDFALAVRFLEGIKEKCGs--rVKE 114 Argas monolakensis
Q94514     33 TEESAEEFDKRYEKYFSREgIDGWEIRKGMNDLLGMDLVPSPKIIEAGLRASRRVNDIALAIRWLEGCKDKCGd--qKAT 110 fruit fly
XP_392368  35 PQETEEEFNKQYVTYLNRTnLDHWEFRQAMNKLAAMDLVPDPSIICAALRACRRLNDFALAIRVLEMIKDKCGs--kVKE 112 honey bee
XP_972718  37 WRIHDDDLTCRYECFFSREdIDGWDIRQGMNDLLGYDAVPEPPVIIAALHACRRVNDYAMTVRFLEAIKDRCGd--kANE 114 red flour beetle
NP_499681  37 EKWPADKFDNHFINYLNRPeIDGWEVRKALSELHDYDVIPDPKVVEAALRACRRVNDFALAVRFLEAIKIKCGaqknRDT 116 Caenorhabditis ele...
ABG81988   40 VEESDEEFVKRYVAFFNQPdIDGWDIRRGLMNLAHDDCVPDPEIIIAALKAIRRVNDYALAIRFLETTEFKTGg--sHDK 117 Diaphorina citri
XP_569185  39 ETESYESFNARYETFFKSV-SDLFELQRGLNNAFAYDLVPSTEVINAALQAARKVNDYATAVRILEGVKEKVE----NKG 113 Cryptococcus neofo...
CAD70919   44 HEETFEEFTARYEKEFDAV-QDVFELQRNLNNAFAYDLVPSPSVLAAALKAARRVNDFPTAVRVFEGIKAKVE----NKG 118 Neurospora crassa
P00427     45 DEETFEEFTARYEKEFDEA-YDLFEVQRVLNNCFSYDLVPAPAVIEKALRAARRVNDLPTAIRVFEALKYKVE----NED 119 baker's yeast
Feature 1                               
1OCC_E     81 IYPYVIQELRPTLNELGISTPEELGL 106 cow
ABI52811  115 IYPYIINEVRPTLTELGINTPEELGY 140 Argas monolakensis
Q94514    111 LYPYLLEKITPTLQELGIPTIEELGY 136 fruit fly
XP_392368 113 IYPYILQEIKPTLDELGINTIEELGY 138 honey bee
XP_972718 115 IYPYIVQEIAPTLCELGCDLPETLCY 140 red flour beetle
NP_499681 117 VYAYIVKQVEPVLKELGIDTPEQLGY 142 Caenorhabditis elegans
ABG81988  118 IWPYIVQEITPTLKELGIETPSQLGY 143 Diaphorina citri
XP_569185 114 QYQAYLDELKPTIEELGISTKEELYG 139 Cryptococcus neoformans var. neoformans JEC21
CAD70919  119 QYEQYLAELKPLREELGITLKEDLYP 144 Neurospora crassa
P00427    120 QYKAYLDELKDVRQELGVPLKEELFP 145 baker's yeast

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