1TBG,2TRC,1ERJ,1JV2


Conserved Protein Domain Family
WD40
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cd00200: WD40 
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WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Links
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Statistics
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PSSM-Id: 238121
Aligned: 90 rows
Threshold Bit Score: 141.318
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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structural
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:structural tetrad
Evidence:
  • Comment:[GAS]-H-X(3)-[VI]-X-[SAC][VLI]-X-[FWLIVY]-X(2-30)-[LIV][AVLI][ST][GA][SG]-X-D-X-[TS]-[IVL][KR][VLI]-[WFY]-[DN]
  • Comment:a hydrogen-bonding network
  • Comment:a hallmark of WD40-repeat blades
  • Comment:forms a stable propeller-like platform
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #                            #              #     ##              ##  
1TBG_A      47 TRRTLr---gHl------AK-IYAMHWGtd----srLLVSASq-----------DGKLIIWDSy--------tTNKVHAI 93   Bos taurus
1JV2_A       7 SPAEYs----Gpe----gSYfGFAVDFFvpsassrmFLLVGApkanttqpgiveGGQVLKCDWss-------tRRCQPIE 71   human
2498838      8 SHIEEn---aHq------AD-IYSLNVVa------gNLWSASg-----------DSKIKKWSIgdaehslveeIDTPHKL 60   fission yeast
6857755    941 KTGQIdy--lPe------AQ-VSCCCLSph----leYVAFGDe-----------DGAIKIIELpnnr---vfsSGVGHKK 993  house mouse
2494905     87 YTRAIlp-psYlnsfsneDW-VSSLDVGdg----skHIISGSy-----------DGIVRTWDLsgn----vqkQYSGHSG 145  baker's yeast
7509863    662 NHDAHd---vHad---keGF-LTAVALSnd-----dKYAACGt----------nNGIVALWDLevcq--cvftTIQNKGD 717  Caenorhabditis e...
3123032    312 PARTLk---gHn------KL-VTSLAFDta----skALYSGSy-----------DGVILQWNLetgi--avpiAGTGHTS 364  slime mold
462692      36 FLTLVdkfnpHts----pHG-ISSICWSsn----nnFLVTASs-----------SGDKIVVSSc--------kCKPVPLL 87   house mouse
3183237     13 FFGVIa---sSg-----cNI-LGQPSSSaks---vgRAIVGG------------LESVLEWDLk---------TGQLLSK 59   fission yeast
3025122     41 LERQFt---gSd------VA-INRIHFSpd----gqFLLTAAa-----------DGVGTLWTKege----mlgQLQGQKP 91   Synechocystis PC...

Feature 1                                            #                 #     ##                
1TBG_A      94 plr-----------------sswVMTCAyaps-gnyVACGGl--------------DNICSIYNLktreg---------- 131  Bos taurus
1JV2_A      72 fdatgnrdyakddplefkshqwfGASVRskq---dkILACAplyhwrtemkqerepVGTCFLQDGt-------------- 134  human
2498838     61 gv-------------------hhLATSLde----nvVVSCGf--------------GQDVYVWNPet------------- 90   fission yeast
6857755    994 av-------------------rhIQFTAdg----ktLISSSe--------------DSVIQVWNWqt------------- 1023 house mouse
2494905    146 pi-------------------raVKYISnt-----rLVSAGn--------------DRTLRLWKTknddlkltsqqqaqe 187  baker's yeast
7509863    718 pi--------------------tCIRYSvd----sqYCISGn-------------qAGCILILDAqng------------ 748  Caenorhabditis e...
3123032    365 s---------------------vTQAVVqg----nkLVSVSv--------------DDTTRFTPLn-------------- 391  slime mold
462692      88 ela-----------------egqKQTCVdlnstsmyLASGGl--------------NNTVNIWDLksk------------ 124  house mouse
3183237     60 wkdsd--------------csakVTCIAnf----deMYAVGy--------------ADGSIRLWKdg------------- 94   fission yeast
3025122     92 pm-------------------fnARLSPdr-----qILITTg-------------yDGTIRLWNLqg------------- 121  Synechocystis PC...

Feature 1                           ##                   #        #     ##                     
1TBG_A     132 nvrvSRELA------------GHtg--yLSCCRFLDd-nQIVTSSg-----DTTCALWDie----------------tgQ 175  Bos taurus
1JV2_A     135 ---kTVEYApcrsqdidadgqGFcq--gGFSIDFTKa-dRVLLGGpgsfywQGQLISDQvaeivskyd---pnvysikyN 205  human
2498838     91 --neFRDLGnn---------aQHps--eCWSSCISPdgqTIAFTSv-----DGRIAVWDnp-----------------sD 135  fission yeast
6857755   1024 ---gDYVFLq-----------AHqe--tVKDFRLLQd-sRLLSWSf-----DGTVKVWNvi----------------tgR 1065 house mouse
2494905    188 ddddEVNIEdgktl---aileGHka--pVVSIDVSDn-sRILSASy-----DNSIGFWStiykemtvvdpledinnpnnK 256  baker's yeast
7509863    749 --gvVRELF------------MHss--eVLSIMSLVh-nKMISCDi-----QGKMVIWElfg--------------dddT 792  Caenorhabditis e...
3123032    392 ---pPQYAAq-----------GAkldsqPQSVAVAQg-kDIAVVVt-----LNSVVVLQge----------------kvA 435  slime mold
462692     125 --rlHRSLK------------DHkc--eVTCVAYNWndcYIASGSl-----SGEIILHSvt----------------tnT 167  house mouse
3183237     95 --elLITLN------------GHks--aVTTMDFDKmgtRLASGSm-----DTDIIVWDiv----------------aeT 137  fission yeast
3025122    122 --elLEEQQ------------PHra--aVADAIFSPd-sQIIVTCs----dDGQTKIFT--------------------R 160  Synechocystis PC...

Feature 1                                   #                                                  
1TBG_A     176 QTTTFt----------------------gHtg------dVMSLSLApd---------------------------trLFV 200  Bos taurus
1JV2_A     206 NQLATr----------------------tAqaifddsylGYSVAVGdfng-----------------------dgidDFV 240  human
2498838    136 CKISEld---------------------tKgk------fGLCIDYSpn----------------------------gRFI 160  fission yeast
6857755   1066 IERDFt----------------------cHqg------tVLSCAISsd---------------------------atKFS 1090 house mouse
2494905    257 ISTAArkrrkltmkdgtirrraplsllesHta------pVEQVIFDst---------------------------dnTVG 303  baker's yeast
7509863    793 PEMVAt----------------------gVk-------pPIFVPPTg-----------------------------rIMV 814  Caenorhabditis e...
3123032    436 STTAVk----------------------yQp-------tVVRVSVDg-----------------------------sEVA 457  slime mold
462692     168 SSTPFg-----------------------Hgsk----qpIRHIKYSlfr--------------------------ksLLG 194  house mouse
3183237    138 GLFRLr----------------------gHkd------qITKLLFItppskntaeetvvdtdidsgdmdvdskssdsFLL 189  fission yeast
3025122    161 QGQEIas--------------------vlKsg------tARNLAYHp-----------------------------qGLL 185  Synechocystis PC...

Feature 1      #        #     ##                ##                        #                #   
1TBG_A     201 SGAc-----DASAKLWDvr--egMCRQTFT---GHes---dINAICFFPng----naFATGSd-------------DATC 250  Bos taurus
1JV2_A     241 SGVpraartLGMVYIYDgk--nmSSLYNFT---GEqmaayfGFSVAATDingddyadVFIGAplfmdrgsdgklqeVGQV 315  human
2498838    161 VSGh----qTGQLFLISte--tgRLFHVLS---GHts---pVRSVAFSPgs-----tLLAAAg------------dSKMI 211  fission yeast
6857755   1091 STSa-----DKTAKIWSfd--llSPLHELK---GHng---cVRCSAFSLd------gILLATgd-----------dNGEI 1140 house mouse
2494905    304 YSVs----qDHTIKTWDlv--taRCIDTRT---TSy----sLLSIAQLStl-----nLLACGs------------sARHI 353  baker's yeast
7509863    815 GHCsl---sNKEMKIWAfpe-egPPVTRAKl--SHsd---eITCFATSPkg----gnFIATGs------------rDMSL 869  Caenorhabditis e...
3123032    458 VGAk-----DNSIHIYSlsgttlSEQAVLS---GHrg---fLTAIAYSPdg-----kHFASAd------------qNRDI 509  slime mold
462692     195 SVSd-----NGVVTLWDvn--sqSSYHTFDs--THka---pASGICFSPvn----elLFVTIg------------lDKRI 246  house mouse
3183237    190 SVGk-----DSFMKLWDls--iqHCVETHV---DHqg---eIWAMCVSPda----krCLTAGt-------------GSDV 239  fission yeast
3025122    186 IASvs---dSGSLHLINpn---gKIEREIStgqGRin---nVNFSPNGEq-------LLTSGi-------------NGSA 236  Synechocystis PC...

Feature 1        ##                                ##                            #         #   
1TBG_A     251 RLFDlra------------dqELMTY----------SHdni---icgITSVSFsks-----grlLLAGYd------DFNC 294  Bos taurus
1JV2_A     316 SVSLqras---------gdfqTTKLN----------GFevf---arfGSAIAPlgdldqdgfndIAIAApyggedkKGIV 373  human
2498838    212 TIYDvls------------gdQVGQLr---------GHaa------wIFAVAFnpv------gdLLLSAd-----vEGKI 253  fission yeast
6857755   1141 RIWNvsd------------gqLLHSCapisveegtaTHgg------wVTDVCFspd------skTLVSA-------GGYL 1189 house mouse
2494905    354 TLHDprvga-------sskvtQQQLI----------GHkn------fVSSLDTcpe-----neyILCSGs-----hDGTV 400  baker's yeast
7509863    870 KIWQidk------------gfLTQVLv---------GHenv----vtCCCISFde--------rLVVSGa-----rDEKI 911  Caenorhabditis e...
3123032    510 FVWDkasr----------kikVEGWV----------YHna------rVTSLAWnsn-----snnIVTGSl------DSHV 552  slime mold
462692     247 ILYDtss------------kkLVKTLv---------ADt-------pLTAVDFmpd-----gatLAIGSs------RGKI 287  house mouse
3183237    240 KVWEisfpddnnftpttkafqQLGTFtr-------qSRd-------rPITLAYdvs-----nryVVFQAh------DRLL 294  fission yeast
3025122    237 KLWN-----------------LAGEL----------IHeykvvptgwVNSAQFypk------geWLATAs-----dDGTI 278  Synechocystis PC...

Feature 1        ##                                            ##                      #   #   
1TBG_A     295 NVWDalk--------------------------adRAGVLA-------GHdnrVSCLGVTdd-----gmAVATGSWDs-F 335  Bos taurus
1JV2_A     374 YIFNgrstg----------------------lnavPSQILEgqwaarsMPpsfGYSMKGAtdidkngypDLIVGAFGvdR 431  human
2498838    254 KIWDi-----------------------------dTMECIStq----sETdgaIWAVAWYk-------nGFIVAGADk-S 292  fission yeast
6857755   1190 KWWNvat--------------------------gdSSQTFYt-----nGTn--LKKIHVSpd------fRTYVTVDNlgI 1230 house mouse
2494905    401 KVWDvrstsp-------------------mytitrEDKSVQk------GVndkVFAVKWAek------vGIISAGQDk-K 448  baker's yeast
7509863    912 IVWNvq----------------------------sGDMVCTv------NTtaaITSLSMTgd-----stVVFSTTEDg-W 951  Caenorhabditis e...
3123032    553 YVWSvse--------------------------psKHIAIKn------AHrggVNAVLWVde------hTVASAGLDc-S 593  slime mold
462692     288 YQYDlrm-------------------------lksPVKTIS-------AHktsVQCIAFQys------tSLTKASLSk-G 328  house mouse
3183237    295 EVFRlrssaelekilnrrrrrkksedvsitlkdeyEPFALI-------RTtarASSVAWIpgn---rtpTLVTSLQNn-S 363  fission yeast
3025122    279 RFWQkd---------------------------gqLIYELP-------LVnarLTSLSFSpd-----gkQLAATSSQg-Q 318  Synechocystis PC...

Feature 1         ##
1TBG_A     336 LKIWN 340  Bos taurus
1JV2_A     432 AILYR 436  human
2498838    293 IRWYR 297  fission yeast
6857755   1231 LYILQ 1235 house mouse
2494905    449 IQINK 453  baker's yeast
7509863    952 VETWS 956  Caenorhabditis elegans
3123032    594 IKTWT 598  slime mold
462692     329 SSNKA 333  house mouse
3183237    364 IEVYA 368  fission yeast
3025122    319 VWVFN 323  Synechocystis PCC6803

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