3DCG,2C9W,2FNJ,2JZ3,1VCB,3ZTC,4B9K,4BKS,4BKS,4N9F,4WQO


Conserved Protein Domain Family
Ubl_ElonginB
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cd01788: Ubl_ElonginB 
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ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins
Elongin B, also termed Elongin 18 kDa subunit, or EloB, or RNA polymerase II transcription factor SIII subunit B (SIII p18), is part of an E3 ubiquitin ligase complex called VEC that activates ubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5. VEC is composed of von Hippel-Lindau tumor suppressor protein (pVHL), elongin C, cullin 2, NEDD8, and Rbx1. ElonginB binds elonginC to form the elonginBC complex which is a positive regulator of RNA polymerase II elongation factor Elongin A. The BC complex then binds VHL (von Hippel-Lindau) tumor suppressor protein to form a VCB ternary complex. Elongin B has a ubiquitin-like (Ubl) domain. Ub has a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.
Links
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Statistics
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PSSM-Id: 340486
Aligned: 29 rows
Threshold Bit Score: 146.672
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 39 residues -Click on image for an interactive view with Cn3D
Feature 1:elongin C interaction site [polypeptide binding site]
Evidence:
  • Comment:elonginB-elongin C interaction site
  • Comment:The BC box mediates the association with elongin B and elongin C (EloBC) at the VHL-EloBC-Cul2 complex
  • Structure:1VCB; Homo sapiens elongin B interacts with elongin C, contacts at 4A.
  • Structure:2C9W; Homo sapiens elongin B and elongin C in complex with Socs-2 , contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # #  #######                #        # # #  ##         # #    # #######     
3DCG_A         2 DVFLMIRRHKTTIFTDAKESsTVFELKRIVEGILKrPPDEQRLYKD--DQLLDDgKTLGECGFTSQTARPQAPATVGLAF 79  human
1VCB_A         2 DVFLMIRRHKTTIFTDAKESsTVFELKRIVEGILKrPPDEQRLYKD--DQLLDDgKTLGECGFTSQTARPQAPATVGLAF 79  human
NP_524416      2 DVFLMIRRQKTTIFTDAKENtTVAELKRMIEGILKvQPVDQRLYNQd-NDVMEDdSTLQDYGVTVSTAKAQAPAQLGLTF 80  fruit fly
XP_001177216   2 DVFLMIKRQKTTIFTDAKETnTVFELKRIIEGITKrGPEDQQLYKD--GDTLDDtKTLGDCGLTSNTAKAQAPAMLGLAF 79  purple sea urchin
XP_002115253  33 DIFFMIRRQKLTLFTDCKETnTVLDLKKIIDGVTKvNPEDQRLFKG--DEILDDsKLLSDCGFSTSTARAQEPAFLGLAF 110 Trichoplax adha...
XP_002410989   2 DVFLMVRRKKTTVFLDAKETtSVRELKKMIAGITKvAPENQMLYKD--EQCMDDnKMLTEYGLNSSTAKAQAPATVGLAF 79  black-legged tick
XP_002734124   2 DVFLMIRRKKSTIFTDAKETtTVYELKKIVEGITKrPPEDQRLHKD--ELILEDtKTLGDCGFTSSTARAQAPATVGLAF 79  Saccoglossus ko...
EFX75073       6 CVYLMIRRKKTTIFTDAKETtNVSELKKIIQGITKiAPESQRLFKD--DRIMEDnRCLADYGLISTTARAQSPASLSLAY 83  common water flea
XP_003389454   2 DVFLMIRRKKQTILLDATEEtTVTQLKKTLEAILKrPPDEIQLYKMdtNEALDDtRTLGDCGYKSSNSKAQDPSQIGLRL 81  Amphimedon quee...
ESN92019       2 DVFLMVRRKNVTLFLDAKEStTVIELKKIIKGILKkNLDEILLYKD--NQQIDEtKTLGDVGYTSVTAKAQAPATIGLVF 79  Helobdella robusta

Feature 1        #      ## #  #########   
3DCG_A        80 Rad--dtFEALCIEPFSSPPELPDV 102 human
1VCB_A        80 Rad--dtFEALCIEPFSSPPELPDV 102 human
NP_524416     81 Rnev-gdFETLDMTPYSAPPDLPEV 104 fruit fly
XP_001177216  80 RecegadFEQLNITPYSNPPELPDV 104 purple sea urchin
XP_002115253 111 Rged-geFEPLNIAPLTQPPDLPEV 134 Trichoplax adhaerens
XP_002410989  80 RdldsgkFENLDVTPLSSPPELPDV 104 black-legged tick
XP_002734124  80 Kege-edFEPLEVTPYSNPPELPDV 103 Saccoglossus kowalevskii
EFX75073      84 Rldn-geFETVDITPLSSPPELPDV 107 common water flea
XP_003389454  82 Kid--geYENFDITPYSTPPDLPDV 104 Amphimedon queenslandica
ESN92019      80 Kqdd-gtFEPLEITELSTPPDLPEV 103 Helobdella robusta

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