15833505   1 MKKLTIGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTVERKEGQFSTTDHQVTLVDLPGTYSLTTIssqtSLDEQIACHY 80  Escherichia coli O1...
11497862  12 TAEKKVALVGNPNVGKSALFYALTGKYATISNYPGTTVDIAVAKLGDLE----IIDTPGMHSLVPV----TGEEEVARKL 83  Archaeoglobus fulgidus
15645310   1 MKEITIALVGQPNVGKSSLINALSNAHLKVGNFAGVTVDKMEVGLIHKEHQITIIDLPGTYALNDF----TTEEKVTKDF 76  Helicobacter pylori...
20094684   1 --MRTVALAGPPNVGKTTIMSRVCRANLEVGNWPGVTVERKTCTYEFRGDRYRLIDLPGTYSLTAF----SEDQRVARDY 74  Methanopyrus kandle...
14521269   1 -MLKVVALVGNPNVGKTTIFNALTGMRQHVGNWPGVTVEKKEGIMEYKGKEYLVVDLPGIYSLTAH----SVDELIARNF 75  Pyrococcus abyssi
18311866     --------------------------------------------------------------------------------     Pyrobaculum aerophilum
14591027   1 -MLKVVALVGNPNVGKTTIFNALTGMRQHVGNWPGVTVEKKEGIMKYKGEEYLIVDLPGIYSMTAH----SIDELIARNF 75  Pyrococcus horikoshii
17229611     --------------------------------------------------------------------------------     Nostoc sp. PCC 7120
15606480   1 MKKITVAVAGNPNVGKTTILNAIAGTALKVGNWPGVTVEKKEATVRYKDYEIHFVDLPGIYTLEPI----SEDEKIAVEF 76  Aquifex aeolicus
15611694   1 MKEIIVALVGQPNVGKSSLINALSNAHLKVGNFAGVTVDKMEVSLIHKDHQITIIDLPGTYALNDF----TTEEKVTKDF 76  Helicobacter pylori...

15833505  81 IL---SGDADLLINVVDASNLERNLYLTLQLLELGIP-CIVALNMLDIAEKQNIRIEIDALSARLGCPVIPLVSTRGRG- 155 Escherichia coli O1...
11497862  84 LE----EA-DLVVHVVDAKNIRRALPFTLQLIEAGFN-TILVLNLVDEAEKFGIFINEKLLEERLGIPVLKTVATEKRGv 157 Archaeoglobus fulgidus
15645310  77 LE---KGQYDLILNVVDSTNLERNLALSAQLLDTNKK-MLLALNMWDEAQKEGIKINTEKLSKELGVVCVPTSARSKEDr 152 Helicobacter pylori...
20094684  75 LLgrtDGKPDAVVVVGDALNVAGAVRVFLEIAELGYHhVILAVNMLDEAERAGIGIDLKRLERELGVPVVGISAKRGYG- 153 Methanopyrus kandle...
14521269  76 IL---EGNASVIVDIIDSTCLMRNLFLTLELFEMGVKnVIIALNKIDLLKKRGIHVNIKEMEKILGVPVVPTNAKSGEG- 151 Pyrococcus abyssi
18311866   1 --------------------------------------MILVFNMADLWKP---PYTQEELSKLLSVPVVFTSAVTGEG- 38  Pyrobaculum aerophilum
14591027  76 IL---EGNASVIVDIIDSSCLMRNLFLTLELFEMGVKnVIIVLNKIDMIKKKGVKIDIKEMERIFGVPVVPTNAKTGEG- 151 Pyrococcus horikoshii
17229611     --------------------------------------------------------------------------------     Nostoc sp. PCC 7120
15606480  77 LE---KGNVDVILTVLDSTNLERSLYLTVQLFEFEKP-TVLVLNLYDEAQKLGIEIDEKAFYELLGVKAVKTVGKKGTG- 151 Aquifex aeolicus
15611694  77 LE---KGQYDLILNVVDSTNLERNLALSAQLLDTNKK-MLLALNMWDEAKKEGININTEKLSQELGVVCVPTSARSKEDr 152 Helicobacter pylori...

15833505 156 --IEALKLAIDRYKANEN---VELVHYAQPLLNEADSLAkVMPSDIplk---qrRWLGLQML-E-GDIYSRAYAGEAS-- 223 Escherichia coli O1...
11497862 158 grLKDEIRKRIGLKPEKKrliRFSPQVEKVVSEVEGLIEgEYSISK--------RGLAILLL-LkDSVSLEAVKREKN-- 226 Archaeoglobus fulgidus
15645310 153 lnTELLLDEIVRLYSQNTt--------------------------------------------------nNENIKVP--- 179 Helicobacter pylori...
20094684 154 --IEHLKRAIADVVQGRVepnPRSPRYPREVERAVKELApEVGERLpey---ppRWAVLKLL-EgDPELLRELEKRDPel 227 Methanopyrus kandle...
14521269 152 --LDELKRKISLMAEGKIttnPIVPRYDEDIEREIQHVS-EVIKGTplaekypiRWLAIKLI-QrDEEVIKLVIKHVGq- 226 Pyrococcus abyssi
18311866     --------------------------------------------------------------------------------     Pyrobaculum aerophilum
14591027 152 --LDELKRKISLMVEGKIttnPLIPKYDEDIEREIRHVS-EVIKDTplaekysiRWLAIKLL-QrDEEVIKLIIKHVGq- 226 Pyrococcus horikoshii
17229611   1 -----MISQVIYPEPIEAaiaQLESWWQTLG--NR-YLFhNYSLSP--------RSLALLLL-QkDPGLWQILQQDQEq- 62  Nostoc sp. PCC 7120
15606480 152 --VEKILPLIVEAYEEKHv--pR-LKYSEELEEFLSEVA--Q------------KYKSLKAQpFtKHELIEFALRDKE-- 210 Aquifex aeolicus
15611694 153 lnTELLLDEIVRLYSQNTt--------------------------------------------------nNENIKVP--- 179 Helicobacter pylori...

15833505 224 -QHLDAALARLRN-EMDd---pALHIADARYQCIAAICDVVSNTLTAE-PSRFTTAVDKIVLNRFLGLPIFLFVMYL-MF 296 Escherichia coli O1...
11497862 227 ---YPQILEKVSKsNL------LPYEIMREIYENAERILDGVIEE-RDvESSIARKIGILALNPLFGIPLTILSLAF-IY 295 Archaeoglobus fulgidus
15645310 180 ---SQSFKES-----------------LKYSQSAQRIAQLVISENQQNaSFEHTYKIDKILMHKRYGIFIFLGFMFI-IF 238 Helicobacter pylori...
20094684 228 lKRVKEVKKRIAErTSHd---pAVLISQARDELATRIARNCVTGRPS---LSRQDRIDRVLTHPVWGTLIALGVLGT-VF 300 Methanopyrus kandle...
14521269 227 -AKIEEILKHVSElEEKykrslDIVIASQKYEFLGELLRKFVRHPTEI-KETLSDQLDKLLTHPVYGIVSMLVVFYI-LF 303 Pyrococcus abyssi
18311866  39 ---VARLRELLFKn-----------------VPKSSLRLQDLKVPEYAvIKSAILSRPPIALATLLALGVLTTIFLMaVI 98  Pyrobaculum aerophilum
14591027 227 -AKIDEVLKHVSElEEKykrslDIVIASQKYEFLHEILRKFVQHPKEV-RETLSDQLDKLLTHPVYGTISMLIVFYI-LF 303 Pyrococcus horikoshii
17229611  63 -CRHLEVLITVTQnQLHq---pLGLAIANTRQSQARTIERAVLHEAREaRSSITETIHKLTVNPITGFPILVVILYYgVY 138 Nostoc sp. PCC 7120
15606480 211 --LQKKFKEKYGKeFKK-------YLEDERYAFAHGIYEEVVKQKGID-VRTLTDFLDNLLLHPVLGFVFFVVIMFL-LF 279 Aquifex aeolicus
15611694 180 ---SQSFKES-----------------LKYSQSAQRIAKSVISENKQNaSFEHTYKIDKILMHQRYGIFIFLGFMFI-IF 238 Helicobacter pylori...

15833505 297 LLAINIGG-ALQPLFDVGSVa----LFVHGIQWIGYTLHFPDWLTIFLAQGLGGGINTVLPLVPQIGMMYLFLSFLEDSG 371 Escherichia coli O1...
11497862 296 LLAGILGAqILVDLIETWFEenvntAVNTFLEQNIPNYWLRELIGGEYGIITLGIRYAIAIIFPIVTTFFIAFSLLEDSG 375 Archaeoglobus fulgidus
15645310 239 SLSFLIGG-GVQKALETGFK-----FLSDGIKENVANEDLASLVG----DGIIGGVGATVSFLPLIVVLYFGISLLETTG 308 Helicobacter pylori...
20094684 301 ASAFLLGD-PLSELVEGAFE-----HLAGFARS-LPAP-WSDLLA----EGVIPGVGTVLAMYPYVFVMLLLLTVLEDAG 368 Methanopyrus kandle...
14521269 304 QFVFSLGG-PLQELLDNAFS-----SFGEWLGERIANETLRGLVV----DGIIGGVGAVLSFFPLVFLLFVGMSILEDSG 373 Pyrococcus abyssi
18311866  99 EGITPWGG-NLPVSLVSLFD-----LLDQHVSQA-VMASIGGPAGRFIIEALWESVLTLLILSVYVIIAFTLIVLYEDSG 171 Pyrobaculum aerophilum
14591027 304 QFVFAVGG-PLQELLDDAFS-----SFGEWLGERIANETIRGLVV----DGIIGGVGTVLSFFPLVFLLFVGMSILEDSG 373 Pyrococcus horikoshii
17229611 139 KFVGEFGAgELVDRIESFFEsqinpLVNQVTAQIIPWRPIQDLIAHDYGIITLGIRYATAIVLPVVATYFLMFSLLEDSG 218 Nostoc sp. PCC 7120
15606480 280 KVTFDFSS-PFVDWVDGFFTd----FLNPAVKEFLASLGAPEFISRFFSEAVIGGVGFVLTFVPLIFTLYFLITFLEMSG 354 Aquifex aeolicus
15611694 239 SLSFLIGG-GVQKALEEGFK-----ILSDSIKENVANEDLASLVG----DGIIGGVGATVSFLPLIVVLYFGISLLETTG 308 Helicobacter pylori...

15833505 372 YMARAAFVMDRLMQALGLPGKSFVPLIVGFGCNVPSVMGARTLDAPRERLMTIMMAPFMS-CGARLAIFAVFAAAFFGQN 450 Escherichia coli O1...
11497862 376 ILPRTAYLLDGIFKKIGMSGRAVIPLLLGTGCGTMAVIVTRILETWRERVIATILLAVGIpCSAQLGVMLG-IAPDFRAM 454 Archaeoglobus fulgidus
15645310 309 YMSRVAFLLDGILHKFGLHGKSFIPLITGFGCSVPAYMATRTLQNYNERLITLFVIGFMS-CSARLPIYVLFVGSFFPSS 387 Helicobacter pylori...
20094684 369 YTARLAALASGLLARFGLHGKTVFPAVLSLSCNVPAITASRIIEDERARLLTAIVVPLIP-CGARLEVITFLTAKLPDPW 447 Methanopyrus kandle...
14521269 374 YLARVAAVMERYLRMFKLPGKAIIPMVLAFGCNVPAVMATRILEEEKDRILTMLVNPLIP-CVARMTVITFLAGTFFPDK 452 Pyrococcus abyssi
18311866 172 LIALLSKSVERRLSYLGIPPRGVVCLFVAASCNVPAATTAKALWGRGSRVLTALLTPYVP-CVARLAIFVAVAAAALSRI 250 Pyrobaculum aerophilum
14591027 374 YLARVAAVMERYLRVFKLPGKAIIPMVLAFGCNVPAVMATRILEEEKDRILTMLINPLIP-CVARMTVITFLAGTFFPNK 452 Pyrococcus horikoshii
17229611 219 YLPRLSLMLDRLFKSVGLSGRAVIPMVLGLGCDTMATIVTRTLETRRERLIATFLLSLAIpCAAQWGVIVGLLAQKPAAL 298 Nostoc sp. PCC 7120
15606480 355 YVPRVAFLMDKFLHRMGLHGKSVIPLILALGCNVPAIVATRTLETTREKLIVIAMIPFIS-CPARLVVFSFFAITFFPNN 433 Aquifex aeolicus
15611694 309 YMSRVAFLLDGILHKFGLHGKSFIPLITGFGCSVPAYMATRTLQNYNERLITLFVIGFMS-CSARLPIYVLFVGSFFPSS 387 Helicobacter pylori...

15833505 451 ---GALAVFSLDMLGIVMAVLTGLMLKYTIMRG--EATPFVMELPVYHVPHVKSLIIQTWQRLKGFVLRAGKVIIIVSIF 525 Escherichia coli O1...
11497862 455 m---------IWISVVTAVLLIAGFISSRVIPG--ERAVFFMEIPPIRVPRPENVFYKTVSRLEWYFKEVLPIFVLISVL 523 Archaeoglobus fulgidus
15645310 388 s--AGFVLFCIYILGAVVALVMAKLLKLSVFKG--QTESFIMEMPKYRFPSWRMVYFSIYTKSLSYLKKAGTYILVGAIL 463 Helicobacter pylori...
20094684 448 r---VPAAVSIYVVALSLFVATSYILHRLLFGKpePHRGHVIELPRLRKPHLRTVLTVTWLRSNEFLQKAGTIILAASVL 524 Methanopyrus kandle...
14521269 453 ---AALVAVSIYAIAIVLALISALILGKLVVKS--EESPFIIELPEYSIPSWKTVVLHSWERSKEFLRKAATVILLGSIL 527 Pyrococcus abyssi
18311866 251 pylIPVAVFIPYLISFGFALIASFIYRKALGIK--TEAIGIVPPAPLMWPRWNIYFKKVAVSYKEFILKVGPLLSAVIIA 328 Pyrobaculum aerophilum
14591027 453 ---AALVAVSIYVIAIAIALISAFILGKFVVKS--EESPFIIELPEYSIPSWRTIAIHSWERSKEFLRKAATVILLGSIL 527 Pyrococcus horikoshii
17229611 299 i---------FWGGFITAIFLVVGYLTARLLPG--TSGRFYMEIPPLRLPKLRNVFTKTWVRMKWYFLEVLPLFIWASVL 367 Nostoc sp. PCC 7120
15606480 434 ---AALVITGLYLLGVAVALLTAFLMRKSIARG--ASSHFVIELPPYRMPSLKTVLNISWIHVKDFLYRAGTLIFAASIF 508 Aquifex aeolicus
15611694 388 s--AGFVLFCIYILGAVVALVMAKLLKLSVFKG--QTESFIMEMPKYRFPSWRMVYFSIYTKSLSYLKKAGTYILVGAIL 463 Helicobacter pylori...

15833505 526 LSAFNSFSlsGKIVD------------------------------------NINDSALASVSRVITPVFKPIGVHedNWQ 569 Escherichia coli O1...
11497862 524 IWIGRITT------------------------------------------------AFDIIVSALSVPVSAIGLP---PK 552 Archaeoglobus fulgidus
15645310 464 IWFMSQYP--KSDAAmkaykqesllvnkdttlsseakeeklkelkteldkkNLKNSIVGRGGAYLEKVFSPMDF---DWR 538 Helicobacter pylori...
20094684 525 LWVATRYPe-PLG---------------------------------------TGGSAIELVGKALEPVTVALLGl--DWK 562 Methanopyrus kandle...
14521269 528 IWYLSSYPe-PVG---------------------------------------SGISYAEKLGRAFEPIARLMGL---DWK 564 Pyrococcus abyssi
18311866 329 LWPLSAYG--PGGYVe-----------------------------------DISQSYLAAIGNALEPLFEPMGLP---WQ 368 Pyrobaculum aerophilum
14591027 528 IWYLSSYPe-PVG---------------------------------------SGVSYAEKLGRILEPLAKLMGL---DWK 564 Pyrococcus horikoshii
17229611 368 IWVGRLTG------------------------------------------------LFDVIIRAIEPLTLALGMP---KQ 396 Nostoc sp. PCC 7120
15606480 509 IWILLNLP--PNVK-------------------------------------NPKDSLAADIGRVLVPVFEPMGIS--DWR 547 Aquifex aeolicus
15611694 464 IWFMSQYP--KNDAAmktykqesllvqknanlsseakeeklkelkteldkkNLKNSVVGRGGAYLEKVFNPMDF---DWR 538 Helicobacter pylori...

15833505 570 ATVGLFTGAMAKEVVVGTLNTLYTAEniqdeefnpaefnlgeelfsavdetwqslkdtfslsvlmnpieaskgdgEMGtg 649 Escherichia coli O1...
11497862 553 ASEVFLYGFFRRDYGAAGLFDISS-------------------------------------------------------- 576 Archaeoglobus fulgidus
15645310 539 LSVSLVTGFMAKEVVVSTLGVLFSLGd-----------------------------------------------qNEKsd 571 Helicobacter pylori...
20094684 563 GAVALLNGIVAKEIVISTLAMLHAH------------------------------------------------------- 587 Methanopyrus kandle...
14521269 565 AAVSLIFGIIAKENVIATYSVIYGVS-------------------------------------------------EES-- 593 Pyrococcus abyssi
18311866 369 VVMPLVGGWIFKEVVLGLLEATGG-------------------------------------------------------- 392 Pyrobaculum aerophilum
14591027 565 AAVSLIFGIIAKENVIATYSVIYGVS-------------------------------------------------EES-- 593 Pyrococcus horikoshii
17229611 397 AAPIFLYGFFRRDYGAAGLFDLQQ-------------------------------------------------------- 420 Nostoc sp. PCC 7120
15606480 548 ATTSLIPAFLAREIVLSSMGVIYTATevvqekekfsfseelknqlsgl-----leatktavksvfslkiqaleveEEEtg 622 Aquifex aeolicus
15611694 539 LSVSLVTGFMAKEVVVSTLGVLFSLGd-----------------------------------------------qNEKsd 571 Helicobacter pylori...

15833505 650 aMGVMDQKFGSAAAAYSYLIFVLLYVPCISVMGAIARESS-RGWMGFSILWGLNIAYSLATLFYQVASYSQH 720 Escherichia coli O157:H7
11497862 577 -----EG-LLSYGQVVVAMVTLTLFVPCIAQFSIICKERG-IKQGIAVFLLSVAIAFTAGYAT---AVMMGV 638 Archaeoglobus fulgidus
15645310 572 aFRGILRKEVSVPSGIAFIVFVMFYIPCFAATITFGREAGgIKFVAYLFIFTTVVAYAFSLIAFYATQILV- 642 Helicobacter pylori 26695
20094684 588 ---------LTPENAYVLTLVSALYIPCAATIGAVYSETGsMRYAALSVAANLSLATLVGAAVHHALVALGG 650 Methanopyrus kandleri AV19
14521269 594 -LGSAMAHIMTPLQAYVLALVTTLYLPCIATIAAIRAEGG-WKWAGVAVVYNLILATVVGIIAYHIGAVL-- 661 Pyrococcus abyssi
18311866 393 ---LQIISTLPLSSIMAFLVFTAFYSACIATLSVLYRTVG-LKLTALSVVVNLALAYIAALAVYAALSLVPL 460 Pyrobaculum aerophilum
14591027 594 -LGSAMIHAMTPLQAYILALVTTLYFPCLATIGAIRAEGG-MKWATIAIIYNLLLATTVGIIAYHLGLLV-- 661 Pyrococcus horikoshii
17229611 421 -----QG-SLTGNQLVIAAIVLTLFLPCIAQLQMLIKERG-TKTTLAIVLFIFPFAFLMGYVVNLGLILFGV 485 Nostoc sp. PCC 7120
15606480 623 qLRDLIRNSFTPASAFAFMVFILIYTSCLGTYATMGREIG-YGKATAFLVYSFVLAWIIGTISYKLLS---- 689 Aquifex aeolicus
15611694 572 aFREIIRKEVSVPSGIAFIVFVMFYIPCFAATITFGREAGgIKFVAYLFIFTTVVAYAFSLIAFYATQILV- 642 Helicobacter pylori J99