Conserved Protein Domain Family
ThrB

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COG0083: ThrB (this model, PSSM-Id:223161 is obsolete and has been replaced by 439853)
Homoserine kinase [Amino acid transport and metabolism]
Statistics
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PSSM-Id: 223161
Aligned: 41 rows
Threshold Bit Score: 220.549
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
125396     2 VRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSqaqetnddpnncKLSYTKESEGYSTVPLRSDAnLITRTALY 81  baker's yeast
20177963   1 --MIRVKIPATSANMGAGFDTLGMALKLYNEITIEETEG------------ETEIKLLG---GELDRNYRNnLTYISIIK 63  Clostridium acetobu...
14194903   1 ---MKILVPATSANLGPGFDCLGLSLKLFNETQIQKSg-------------VFSISIGGEGSDNIFLKKNN-IFVNIFYE 63  Campylobacter jejuni
14194894   1 ---MVVSVPATSANLGPGFDCLGLSLNLRNRFFIEPSs-------------FHAVKLVGEGEGIPKFLTNN-IFTKVFYE 63  Helicobacter pylori
14285507   1 ---MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLEEsn------------dWKIDHDLG--NNIPTDEKN-LLLTTLSA 62  Lactococcus lactis ...
20177965   2 SNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGt-----------KWEYIFHDDASKQLPTDETN-FIYHVAQQ 69 
18270082   1 ---MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEErd------------eWLIEHQIG--KWIPHDERN-LLLKIALQ 62  Streptococcus pneum...
14194906   1 ---MKVLVPATTTNLGAGFDVFGLALDLFNEVEFSFDT--------------KETTIESTGKYASDLKDHN-LFFEVLRF 62  Thermotoga maritima
6225592    1 --MIKIEVPATTTNFGSGFDTFGLALSLTNTFSVDFSd-------------KYEVQIEGYS-SGIPKDQKN-LFIKVYKK 63  Aquifex aeolicus
14194909   1 ---MVVSVPATSANLGPGFDCLGLSLNLRNRFFIEPSn-------------IHAVKLVGEGEGIPKFLTNN-IFTKVFYE 63  Helicobacter pylori...
125396    82 VLRCNNIRNFpsgTKVHVSNPI-PLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGfcg 160 baker's yeast
20177963  64 VYEFFNKEFKg--FKIDMSKTNiPLSRGLGSSAACIVGGIVGANALLNEKMTIKDMLKIAVDIEGHPDNVAPALLGG--- 138 Clostridium acetobu...
14194903  64 IYEKLSGKKDn--FRFIFQNNI-PLSRGLGSSSAVIVGAIASAYYMSGFKVEKECILDEALIYENHPDNIAPATLGGf-- 138 Campylobacter jejuni
14194894  64 ILKKH-GNDGs--FKFLLHNKV-PITRGMGSSSAMIVGAVASAFAFLGFDFDRENIVNTALIYENHPDNITPAVFGGy-- 137 Helicobacter pylori
14285507  63 VLKAKNSSLSa-kYHLKMTSEV-PLARGLGSSSSVIIAGIELANQLAKLNLTTEEKLELACEIEGHPDNVAPALLGNlv- 139 Lactococcus lactis ...
20177965  70 VASKYSVDLPi--LCIEMRSDI-PLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGlia 146
18270082  63 IVPDLQP------RRLKMTSDV-PLARGLGSSSSVIVAGIELANQLGQLNLSDHEKLQLATKIEGHPDNVAPAIYGNlv- 134 Streptococcus pneum...
14194906  63 FERKTGYRVPp--VRIKQTCNI-PVSSGLGSSAAVIVAALHIANEGTGRNLSREDLMKLAVELEGHPDNVVPAFTGG--- 136 Thermotoga maritima
6225592   64 TCQSIGKKPKp--LKLIQENRV-PPARGLGSSATAIVGGIEAALALHKVELPLKEKLKIAFEFEKHPDNIIPAFVGG--- 137 Aquifex aeolicus
14194909  64 ILKKH-GNDGs--FKFLLHNKV-PITRGMGSSSAMIVGAVASAFAFLGFAFDRENILNTALIYENHPDNITPAVFGGy-- 137 Helicobacter pylori...
125396   161 sflRDLTPQeveRREIPLAEVLpepsggedtglvpplpptdigrhvkyqWNPAIKCIAIIPQFELSTADSRGVLPKAYPT 240 baker's yeast
20177963 139 ---VIISIKd--MENIIYSRIN---------------------------VKSQLKYAVMVPDFKVSTELSRKVLPNEYSR 186 Clostridium acetobu...
14194903 139 --vCSLVEK----NKVYSIKKE---------------------------IDKDLAAVVVIPNLAMSTEQSRQALAKNLSF 185 Campylobacter jejuni
14194894 138 --nAAFVEK----KKVISLKTK---------------------------IPSFLKAVMVIPNRAISTKQSRHLLPKRYSV 184 Helicobacter pylori
14285507 140 -iaSTVADK----TNY----VSs-------------------------dFP-SCKLLAFVPDYELKTVESRKVLPKELAY 184 Lactococcus lactis ...
20177965 147 gfyNDVSKE----TSVAHIDIP------------------------------DVDVIVTIPTYELKTEASRRALPQKLTH 192
18270082 135 -iaSSVEGQ----VSA----IVa-------------------------dFP-ECDFLAYIPNYELRTRDSRSVLPKKLSY 179 Streptococcus pneum...
14194906 137 ---LVVCYQn--GSHLDFEKFE-----------------------------IDLSLTFLVPNFPVCTNEMRKILPEKVPF 182 Thermotoga maritima
6225592  138 ---FTVCATs--ESGVIFKKLP---------------------------FPEDIKIVFVIPDFEVSTSEARRVLPKKVEL 185 Aquifex aeolicus
14194909 138 --nAAFVEK----KKVISLKTK---------------------------IPSFLKAVMVIPNRVISTKQSRHLLPKRYSV 184 Helicobacter pylori...
125396   241 QDLVFNLQRLAVLTTALTMDPpnADLIYPAMQDRVHQPYRKTLIPGLTEILscvTPSTYPGLLGICLSGAGPTILALATE 320 baker's yeast
20177963 187 EDALFNISRCSMLVSALNNGE--NEKLRYLFEDKIHQPYRKKLINNIDSIF---LKAKEYGSLGEFISGSGSTLIAVLEE 261 Clostridium acetobu...
14194903 186 NDAVFNLSHASFLTACFLEKK--YEFLKFASQDKLHEINRMKNLPELFEVQk---FALENKALMSTLSGSGSSFFSLAFK 260 Campylobacter jejuni
14194894 185 QESVFNLSHASLMTMAIVQGK--WDLLRCCSKDRMHQYKRMQTYPVLFAIQk---IALENNALMSTLSGSGSSFFNMCYE 259 Helicobacter pylori
14285507 185 KEAVAASSIANVLTASLLTKNl-KVAGQMIESDHFHENYRASLVPELKILR---EIGHEFGAYGTYLSGAGPTVMLLLPD 260 Lactococcus lactis ...
20177965 193 SEAVKSSAISNTMICALAQHNy-ELAGKLMQQDGFHEPYRQHLIAEFDEVK---TIASQHNAYATVISGAGPTILIFSRK 268
18270082 180 KEAVAASSIANVAVAALLAGDm-VTAGQAIEGDLFHERYRQDLVREFAMIK---QVTKENGAYATYLSGAGPTVMVLASH 255 Streptococcus pneum...
14194906 183 EDAVFNIKNSCQFLAKIAAGK--IKEALKYVGDRLHQNYRINGNKKMKEFV---EAILSKNPEYWFVSGSGPSVCSNIND 257 Thermotoga maritima
6225592  186 KEAVFNVQRSALFVSALLTKD--YKLLREAVRDKLHQPYREKLVPGLSEAI---LVSYKEGALATFLSGAGPTICSLTTE 260 Aquifex aeolicus
14194909 185 QESVFNLSHASLMTMAIVQGK--WDLLRCCSKDRMHQYKRMQTYPVLFAIQk---LALENNALMSTLSGSGSSFFNMCYE 259 Helicobacter pylori...
125396   321 NfEEISQEIINRFAKN--GIKCSWKLLEPAYDG-ASVEQ 356 baker's yeast
20177963 262 Ad-ENFILKMKTYLDSl-KDGWRIFEVENDNNGaVII-- 296 Clostridium acetobutylicum
14194903 261 ---DDALALAKKIQTK--FKDFRVQYLEFDDNG-FEIC- 292 Campylobacter jejuni
14194894 260 ---EDAPKLKQVLSKK--FPKFRVAVLDFDNDG-VLIEK 292 Helicobacter pylori
14285507 261 ---DKLNLLTEKINEQ--NLSGQLYSLEVDSNG-LQVKE 293 Lactococcus lactis subsp. lactis
20177965 269 ---ENSGELVRSLNSQ--VVSCHSELVDINISGvKERIV 302
18270082 256 ---DKMPTIKAELEKQ--PFKGKLHDLRVDTQG-VRVEA 288 Streptococcus pneumoniae
14194906 258 F--EGIPYLKDVLKLR---VNNRGMIVSE---------- 281 Thermotoga maritima
6225592  261 N-EEKIGEAIREVITKfsGYDAQVMVLKARNEGvKVYS- 297 Aquifex aeolicus
14194909 260 ---EDAPKLKQVLSKK--FPKFRVAVLDFDNDG-VLIEK 292 Helicobacter pylori J99
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