Conserved Protein Domain Family
PRK00915

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PRK00915: PRK00915 
2-isopropylmalate synthase; Validated
Statistics
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PSSM-Id: 234864
Aligned: 562 rows
Threshold Bit Score: 492.319
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
166368187   4 SPDRVIIFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPGDFDAVQKIAASVgseaDSPIICGLART 83 
70607065    7 LHMKVGILDSTLREGEQTPGVVFTTDQRVEIAKALSDIGVQMIEAGHPAVSPDIYEGIRRIIKLKregvIKSEIVAHSRA 86 
18313014    1 --------------------MVFSEEWRIRIAKALSDIGVAMIEAGDPNVAPDIKSAIKKIIALKkngdIKSEIVVHSRA 60 
126460201   1 --------------------MVFSEEWRVRIAKALSDIGVAMVEVGDPNVAPDIKSAIKKIVALKkdgeIASEIVVHSRA 60 
145592255  20 GESRVSILDSTLREGEQTPGVVFSEEWRVRIAKALSDIGVGMIEVGDPSVAPDIKSAIKKIVKLKkdgeIRSHIVVHSRA 99 
156938036  15 AFERVKILDATLREGEQTPGVSFTIDQKLEIAKKLDEIGVHMIEAGHPAVAPDVYEAVRRIAWMKkegeIRAEVVAHSRA 94 
171185290   1 ---------------------MFSEEWRVRIAKALSDIGVGMVEVGDPNVAPDIKSAIKKIVGLKkqgeIKSDIVVHSRA 59 
227830205   1 -MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKkegiITSEIVGHSRA 79 
238619675   1 -MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKkegiITSEIVGHSRA 79 
284997627   1 -MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKkegiITSEIVGHSRA 79 
166368187  84 TQKDIKSAAdalrPAAKPRIHTFLATSDIHLQYKLKKTRQEVLEIVPEMVAYAKSFVDDVEFSPEDAGRSDPDFLYQVLE 163
70607065   87 VKRDIEVGA----EIEADRIAIFYGISDTHLKAKHHTTRDEALRSIAETVSYAKSHGVKVRFTAEDATRADYQYLLEVIK 162
18313014   61 VRQDLENAA----SLEPDRIAVFYGVSDLHLKYKHKKTREEALQIIAEMVSLAKSHGVSVRFTAEDGSRADLDYLIQVVK 136
126460201  61 VRQDIENAA----SLEPDRIAVFYGVSDIHLRHKHRKSREEALQVIAEMVSMAKSHGVKVRFTAEDASRADLDYLIQVVK 136
145592255 100 VKQDLENAA----SLEPDRVAVFYGVSDLHLKHKHRKTREEALSIIAEMVSFAKSHGVAVRFTAEDASRADLGYLIEVVK 175
156938036  95 VKSDIDKAA----ETEADRIAIFYGVSDIHLNAKHKKTREEALSIIGEMVEYAKGYGVKVRFTAEDASRADLQYLEQVVK 170
171185290  60 VKQDLETAA----SLEPDRVAVFYGVSDIHLKYKHKKSREEALQIIAEMVSLVKSHGVSVRFTAEDASRADLDYLVEVVK 135
227830205  80 VKRDIEIAA----ELEVNRIAIFYGVSDLHLKAKHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSK 155
238619675  80 VKRDIEIAA----ELEVDRIAIFYGVSDLHLKAKHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSK 155
284997627  80 VKRDIEIAA----ELEVNRIAIFYGVSDLHLKAKHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSK 155
166368187 164 RAIAAGATTVNIPDTVGYTTPSEFGALIRGIKENVPNidqAIISVHGHDDLGLAVANFLEAVKNGARQLECTINGIGERA 243
70607065  163 TVRDAGADRVSIADTVGVLYPSRTRELFKDLTSRFPD---IEFDIHAHNDLGMAVANVLAAAEGGATIIHTTLNGLGERV 239
18313014  137 TAYEAGADRVSIADTVGVFTPERAREVFSKVKAAVPG---VGLDIHAHNDFGMAVANSLAAVEGGADVVHTTVNGLGERA 213
126460201 137 TARDAGADRVSIADTVGVFTPDRAREVFSKVKAAVPD---VGLDIHAHNDFGMAVANSLAAVEGGADVVHTTVNGLGERA 213
145592255 176 TAYEAGADRVSIADTVGVFTPDRAREVFAKVKAAVPG---VGLDIHAHNDFGMAVANSLAAVEGGADVVHTTVNGLGERA 252
156938036 171 TARDAGADRVSLADTVGVLTPWTAQKFFEHMVKAVPN---VEYDIHAHNDLGMALATAFGAVMGGATAVHVTVNGLGERV 247
171185290 136 TAYQAGADRVSIADTVGVFTPDRAREVFAKIKAAVPG---VKLDIHAHNDFGMAVANSLAAVEGGADVVHTTVNGLGERA 212
227830205 156 TARDAGADRVSIADTVGILYPSKTKELFSALTREVPN---LEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERV 232
238619675 156 TARDAGADRVSIADTVGILYPSKTKELFSALTREVPN---LEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERV 232
284997627 156 TARDAGADRVSIADTVGILYPSKTKELFSALTREVPN---LEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERV 232
166368187 244 GNASLEELVMALHVRRSYFnpflgrpaestepltKINTKEIYRTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVL 323
70607065  240 GIAPLQVVAAALKYHFGIE---------------VVDLKKLSEVASLVEKYSGIALPPNFPITGDYAFVHKAGVHVAGVL 304
18313014  214 GITPLQVFAAAYYYHYGVK---------------LIKLEKLPEITAMVEAATGITIMPTFPIVGENAFTHKAGVHQAGVL 278
126460201 214 GITPLQAFAAAYYYHKGAK---------------LVKLEKLPEITAMVEVASGITVMPTFPIVGENVFTHKAGVHQAGVL 278
145592255 253 GITPLQVFAAAYYYHKGVK---------------LVELEKLPEITAMVEAASGITLMPTYPIVGENAFTHKAGVHQAGVL 317
156938036 248 GIVPLQLFAVAVKVHFDVE---------------LVKLSGLMELTRMVERYSGIEVPYNMPVIGDYAFLHKAGVHVAGIL 312
171185290 213 GITPLQAFAAAYYYHKGVK---------------LIKLEKLPEITAMVEAASGITIMPTFPIVGENVFTHKAGVHQAGVI 277
227830205 233 GIVPLQQIAAAIKYHFGIE---------------VVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVL 297
238619675 233 GIVPLQQIAAAIKYHFGIE---------------VVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVL 297
284997627 233 GIVPLQQIAAAIKYHFGIE---------------VVKLDKLQYVSSLVEKYSGIPMSPNYPITGDYAFLHKAGVHVAGVL 297
166368187 324 KHKLTYEIMDAESIGLThNQIVLGKLSGRNAFRSRLQELGFELSETELNNAFIQFKEMADRKKEITDRDLEAIVNDEID- 402
70607065  305 NDPKTYEFLPPETFGRS-RDYVIDKYTGKHAVKDRFDRLGVKLTDSEIDQVLAKIK-SNPNVRFYRDVDLLELAESVTGr 382
18313014  279 SNPETYEPIPPETVGRN-RDFSLDKYSGRKAIQHRLEKLGISVPQDVVEKVVEEVK-RINLPR-LRDEDLLEILEKVSNm 355
126460201 279 ANPETYEPIPPEVVGRT-RDFSLDKYSGRKAIQHRLERMGISVPPEVLDKVVEEVK-RTNARR-LRDEDLLEILEKVTNa 355
145592255 318 ANPETYEPIPPEVVGRT-RDFSLDKYSGRKAIQHRLEKLGVSLQPEALDKVVEEVKRMNAPR--LRDEDLLEIVEKVSGv 394
156938036 313 ADPRTYEAFPPEMIGRS-RDYVIDKYTGKKAVKAKLEKLGIKVDDDTLMKILEEIK-RSNLRF-LTDDALISIAEKVSGk 389
171185290 278 ANPETYEPIPPEVVGRT-RDFSLDKYSGRRAIQYRLERMGISVPPEVVDKLVEEVKRINARR--LRDDDLLEILEKITNt 354
227830205 298 NDPRTYEFMPPETFGRT-RDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAKIK-SNTTIRFYRDVDLLELAEEVTGr 375
238619675 298 NDPRTYEFMPPETFGRT-RDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAKIK-SNTTIRFYRDVDLLELAEEVTGr 375
284997627 298 NDPRTYEFMPPETFGRT-RDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAKIK-SNTTIRFYRDVDLLELAEEVTGr 375
166368187 403 --TVPDHFRLELVQVSCGNS--ARPTATVTIrtpdgsELSDAAIGTGPVDALCKAIDRVVKIPNELISFSVREVTEGIDA 478
70607065  383 ilKPRPPENIMALISVKCDSnvYTTSVTRRI------VLIEGVREVMEISGDYDILVKVEAKDSTELNQIIESIRAVKGV 456
18313014  356 kfKAIVNRHIEAYVWLKVAN--NVYTTSVARrv---aTLKNV-VSVSEITGDYDIVVKII--------------AENTEE 415
126460201 356 vyKARVNKHIEAYVWLKVAN--NVYTTSVARrv---aAIRNV-VAVSEVTGEYDIVAKVV--------------ADNTEE 415
145592255 395 ryRAIVNRHIEAYIWLKVAN--NVYTTSVARrv---aALKNV-VSVSEITGEYDIVVKLV--------------AENTEE 454
156938036 390 vlRPKATENVEAVVWVKVDS--NAFTGSVARrl---sNIEGV-KEVSEVTGDYDLLVRIE--------------APDHKV 449
171185290 355 ayRARVNRHIEAYVWLKVAN--NVYTTSVARrv---aAIKNV-VSVAEVTGDYDIIVKVV--------------AENTEE 414
227830205 376 vlKPRPPEQIEALISVKCDSnvYTTSVTRRL-------------------SVINGVKEVMEI------------SGDYDI 424
238619675 376 vlKPRPPEQIEALISVKCDSnvYTTSVTRRL-------------------SVINGVKEVMEI------------SGDYDI 424
284997627 376 vlKPRPPEQIEALISVKCDSnvYTTSVTRRL-------------------SVINGVKEVMEI------------SGDYDI 424
166368187 479 LGEV-TIRLRYEGRT-YSAHAADTDIIVASARAYVSALNRLHVALQQ 523
70607065  457 KSTLtSLILK---KM-------------------------------- 468
18313014  416 LNRV------------IENIREIKGVASTLTSIVLKELPTNH----- 445
126460201 416 LNAT------------IESIREVKGVVSTLTSLVLKEIPVSNGRA-- 448
145592255 455 LNQA------------IESIRQIKGVASTFTSIVLKELPTISMQTRA 489
156938036 450 LNTI------------LDTVRGMKGIVGTHTQIVLKKLEK------- 477
171185290 415 LNQV-IESIRE-----VKGVHSTLTSLVLKELPTNAPLSQ------- 448
227830205 425 LVKV-QAKDSNELNQiIESIRATKGVRSTLTSLVLKKM--------- 461
238619675 425 LVKV-QAKDSNELNQiIESIRATKGVRSTLTSLVLKKM--------- 461
284997627 425 LVKV-QAKDSNELNQiIESIRATKGVRSTLTSLVLKKM--------- 461
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