Conserved Protein Domain Family
CENP-W
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pfam15510: CENP-W (this model, PSSM-Id:373910 is obsolete and has been replaced by 434767)
CENP-W protein
CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.
Links
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Statistics
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PSSM-Id: 373910
Aligned: 3 rows
Threshold Bit Score: 137.804
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003121266  1 MAPTTTVSQRKLIKRKAPRGFLKRVFKRRKPHLRLTTDSDLLVHLNCLLFVHRLAEESRANACENKCGVIKKDHVLAAAK 80  pig
XP_006095134  1 MAVAATISQRKRIKRKAPRGFLRRVFKRRKPHLRLEASCDLLVHLNCLLFIRRLAEEARTDACKNKCGIIKDQHVLAAAK 80  little brown bat
Q3URR0        1 MAPSTTVTRR--VKRKAPRAFLKRTLKQKKPHLGLGRCCDLLIHLNCLLFIQRLAEESRTNACESKSRVIKKDHVLAAGK 78  house mouse

XP_003121266 81 VILKKSRG 88  pig
XP_006095134 81 VMLKKSRG 88  little brown bat
Q3URR0       79 VILKKSRG 86  house mouse
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