Conserved Protein Domain Family
Mon1

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pfam03164: Mon1 (this model, PSSM-Id:367367 is obsolete)
Trafficking protein Mon1
Members of this family have been called SAND proteins although these proteins do not contain a SAND domain. In Saccharomyces cerevisiae a protein complex of Mon1 and Ccz1 functions with the small GTPase Ypt7 to mediate vesicle trafficking to the vacuole. The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologs to domains of known structure that assemble into cargo vesicle adapter (AP) complexes. describes orthologues in Fugu rubripes.
Statistics
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PSSM-Id: 367367
Aligned: 118 rows
Threshold Bit Score: 262.827
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAR30291                 123 HDKQFFIMSSAGKPIYTMHGQDELVMGLMGIIHTVINYFKlh----------------------dtKVHSIVNSSgssvk 180 Lac...
EAY08115                 113 QELHLFIVTDAGKPVYSRYGTVQKLSPILCTCVAILGHMEsl----------------------heELNHFRAGS----- 165 Tri...
EGC34692                  99 HKKHFFILSSSGKPIYSRYGDEVALNTFMASLSAMSSFVEsq----------------------ndTLRHLVAGK----- 151 Dic...
EGG22516                 142 HSKHFLIFSFSGKPIYSRYGDEVALNTFMATLSAMSSFIEsq----------------------kdELRHIKTGD----- 194 Cav...
A0DT76                    30 HKRHVFIMTNTGRPIYVRYGNEIKSSIFLATINAIFQKFLlfffe----------------dkekqTLFRISHDK----- 88  Par...
WGS:AAFB:cds.EHI_197260A  39 HHKHMFVYTLAGKPAFSRYGNDIELAPFMATLLAITSVVNdn----------------------ndELKYVRSNE----- 91  Ent...
WGS:AAFB:cds.EHI_010680A  37 KKKHILIYTDAGKPIFSRYGDEIKLAPFMGTLTALSSVVAdl----------------------sdSTDDVVCEDg---- 90  Ent...
Q8IDH2                   469 HKRHFFIFTFSGKPVFTRYGNEENLTSFFGTLLAILSKVEtfnfndinsdnnksnkktnglspkknTLKYIISNN----- 543 Pla...
3_pfamImport               5 HKRHFFIFTYSGKPVFTRYGNEENLTSFYGTLLAIISKVEsfsfsdystdtk--vnkrctgmyrknSLKYIICKN----- 77 
Q4Y2N2                   167 HKRHFFIFTYSGKPVFTRYGNEENLTSFYGTLLAIISKIGsfsfcsdsstdn--nsnkttsingknSLKCIVSKN----- 239 Pla...
CAR30291                 181 QRFVFLDKSPIILMAMSA-REESTNDLLQQLDFLYSYLISTLSRKQLTRLFSKRENFDLRRFLTDSDfQNLNHICDsiSR 259 Lac...
EAY08115                 166 HTFVFLPKSPFVFIAVSK-SSLPVSYLFKQLNFLYSLFLSLFSENLINQL-SARPACDFRQIAEGTR-PAWDGVVN--NM 240 Tri...
EGC34692                 152 YQFVFLCKYPLNLVCISS-TGEPNQVIRQQLEYIHSLIISVLTQSNMKAVFEAK--YDLRDLLGGTD-KYLDHLIH--QL 225 Dic...
EGG22516                 195 YVFVYLHRDPLCLVSIAN-TGETPAIISRQLEYIHSLIVSMLTQSNIKAVFDAK--YDLRDLLGGTD-KFLDNLIK--TI 268 Cav...
A0DT76                    89 CNIYILQRNQITYICTTNsLQDSEFIIYQMLDFLNTQLISIVTDQANVHLTQK-PNYDLAFSVGGSR-NLLTLAVK--NG 164 Par...
WGS:AAFB:cds.EHI_197260A  92 HLYVFLNKGPLQFCCVSN-TKEQPEIIIKQLQFLFCTICSIIPFPSIQSIFDKSYGTDFRNVIGGTY-NQMKCAIS--HG 167 Ent...
WGS:AAFB:cds.EHI_010680A  91 KIIIFHSVGPIEIVIVAK-TGETPQQLKIEAEMIGRKLCSIVPYTTILSLFQKKTSYDFRRLIL-TEyDQMKFLIH--SM 166 Ent...
Q8IDH2                   544 TKVVFLDKEVLYLVCISK-VNESINYIMNILNYIYSQIISLLT-KSIDKSFQIKPSFDIRYLLDGAD-LLMCNLIS--SC 618 Pla...
3_pfamImport              78 TKVVYLDKEVLCLVCISK-ANESTNYILKILNYMYFQIISLLT-KSIEKSFQIKPSFDVRYLLDGSD-ILMCNLIS--SC 152
Q4Y2N2                   240 TKIVYLDKEVLCLICISS-VNESNNYILNILNYMYLQIISLLT-KSIEKSFKIKPSFDVRYLLDGAD-LLMCNMIS--SY 314 Pla...
CAR30291                 260 GFNPE-FLLGALRCLPLRKSTRQIIDNTMLAQiq---dPGTNvgrgtLLYGLIVApGGQLCSVLRPRG-HTLHTTDLHLL 334 Lac...
EAY08115                 241 SEDPAfIFAPSVPVSHMRPEQRAAVISHFD--------KLPScklsmLMYR------NRVLAVGK----CSCDSLSLRLI 302 Tri...
EGC34692                 226 NKDFS-ILLNSIQCLRLNNNVRNQITNILSQY------KCDS-----LLFSLLIS-DNKLISQVKHKKtTSLKSQDIHLL 292 Dic...
EGG22516                 269 DKDIS-ILLNSVNCLRLNYTPRNDITNIIQSN------KHES-----VLFALLVS-GNKLISFVKQKK-YSLKPQDIHIV 334 Cav...
A0DT76                   165 LYSPC-IAFNSICTLPMAVSLRQFIHNNLKEI------KLPN-----IIASLLLT-ETFVIDIWRQKN-MEFKTSDILII 230 Par...
WGS:AAFB:cds.EHI_197260A 168 NMSSG-LLFNAFDIEQFPTTIRNYLTENIQTIvsqtniELFKanndcILFSALIL-NSKIVVLGKRS--ANLTPMDSQVL 243 Ent...
WGS:AAFB:cds.EHI_010680A 167 NVSTA-ILYNAVSIL--PCTMREQINDVIINLvntcndKLINdn-dsIVFTLLFN-ELNLIYINQRSG-CTLSPKDIHIL 240 Ent...
Q8IDH2                   619 SKNLY-SLLDGFEPLPLKPDYRNKVHNLISSF------KINN-----VLLSFLII-DDKIIGLSLSK--YTLNSMDIIIL 683 Pla...
3_pfamImport             153 SRNMY-SIFDGFEPLPLKQDYRNKIHNLISSF------KINN-----VLLSFLIV-HDKIIGISVSK--YAIHSMDIIIL 217
Q4Y2N2                   315 SKNMY-SIFDGFEPLPLKQEYRNQIHNLISSF------KISN-----VLLSFLFI-NDKIIGISVSK--YTISSIDIVIL 379 Pla...
CAR30291                 335 FSLVFNqFQGLQdDQELWLPICFPKFNSSGFLHCYIRLLphhaskprpadarstvshsqepldslsqirnrtdlsstrLR 414 Lac...
EAY08115                 303 VDLMW--TPAFQ-NGESWTPF-FARDSTDGMHHLYINKHk-------------------------------------sSD 341 Tri...
EGC34692                 293 MNYVSS-TASFKe-SESWIPICLPNYNDTYFLHLYICFLy--------------------------------------PG 332 Dic...
EGG22516                 335 MNFVSS-TSSFRe-SEAWIPICLPNFNNTGFLHLYICYIl--------------------------------------PD 374 Cav...
A0DT76                   231 QSMIQGqGQLKK--GENWIPICLPGLSAMGFVYAYINFFe--------------------------------------KP 270 Par...
WGS:AAFB:cds.EHI_197260A 244 ISFVRSiSSRKT---ISWMPLCLNDFNEKAQIHVFVKYIt--------------------------------------TS 282 Ent...
WGS:AAFB:cds.EHI_010680A 241 MTFVQGlPTI----NDKWVPIGLYDFNQSGQLFVFCKFFt--------------------------------------SK 278 Ent...
Q8IDH2                   684 INMITS-MKSFKn-AESWTPICLPIYNPNLFLYAYINYIk--------------------------------------KK 723 Pla...
3_pfamImport             218 INMITS-MKSFKn-AESWTPICLPIYNPSLFLYAYINYIr--------------------------------------KK 257
Q4Y2N2                   380 INMITS-MKSFKn-AESWIPICLPIYNPNQFLYGYINCIk--------------------------------------NK 419 Pla...
CAR30291                 415 PALVLIS--AQKESF-FALKKIGQGIIDELD-RQG---ITNQIS--------------MASd-----sGFTMADIPaKFV 468 Lac...
EAY08115                 342 FALVMLC--SDSPNLgVAYHSAATHIFAELE-EKYiatLEKPLDwepkvfycwalhsiTYGqvy----------itdPIS 408 Tri...
EGC34692                 333 VCLLLFS--NQPESF-YQLSDCKNQIIKGLE-QEN---IAEELKka-----------vNNH-------DYTTSITEiPNL 387 Dic...
EGG22516                 375 VCLLLFS--ALPESF-YHLSNCKNLIVKEME-SKG---LMEELTka-----------vQNH-------GYTSAMTGvPHL 429 Cav...
A0DT76                   271 IGIVMISddNSLDMF-EQCKEAAQVLIQKFNsNNLqqtLLSNLQ--------------NNPntpkcldKY-------TQI 328 Par...
WGS:AAFB:cds.EHI_197260A 283 FSIVLVA--TQPTSM-NYLTKCYKTFKHTIK-QSK---FWNQIEaptptv---------------------cpyiikNEI 334 Ent...
WGS:AAFB:cds.EHI_010680A 279 LSLVLLA--TKNESL-PIISTCAETIENEII-NVP---FINQLIngpsv----dvqfeESS----------------SLY 331 Ent...
Q8IDH2                   724 ICCVYICshASSRDF-FHLSRHTSMIESTLI-STG---CYDEIVka-----------sNNA-------PFVLPQIPgIDI 780 Pla...
3_pfamImport             258 ICCVYICshASPRDF-FHLSRHTSMIETVLI-SSG---CYDEIVka-----------sDNS-------PFTLPEIPgIDI 314
Q4Y2N2                   420 IFCVYICsgASSQDF-FHLSSHTSMIETTLT-SSG---CYEEIIka-----------sNTS-------SFELPDIPgIDI 476 Pla...
CAR30291                 469 HHFI-YKSKRHV-QYVMPHLgpladlsfpiidddsrstfsvegnqdnrseengpGAAsSNdKtrqKLYLQKLMSYYTHIR 546 Lac...
EAY08115                 409 PHFKgQKP-----Q----------------------------------------------------DSIKKMQELSKQLA 431 Tri...
EGC34692                 388 LHFL-YKNKTNN-YSTFPTF----------------------------------SPP-YSiH---KKEKKRLFRLYQHIT 427 Dic...
EGG22516                 430 LHFM-YRSRTSY-FSTSPKF----------------------------------TAP-YS-D---KKERKRLFRLYQHIV 468 Cav...
A0DT76                   329 KHFI-VKHNSG--QVYLPVFqafg-------------------------------------------vnnKTFKFYMQQY 362 Par...
WGS:AAFB:cds.EHI_197260A 335 LHFV-VYSKNDN-QVFMSPFtih----------------------------------------ttRKEQKRLFRIYENLY 372 Ent...
WGS:AAFB:cds.EHI_010680A 332 LHYIfVKIEGDNaQLHEPEFqepy--------------------------------------kssYTEQKRIHRMFRTVY 373 Ent...
Q8IDH2                   781 IHLC-YYIPNLK-QYYSSKIs--------------------------------------------NDKIKRIFRVYQKCD 814 Pla...
3_pfamImport             315 IHVC-YYIPYLK-QYYSSKIs--------------------------------------------VDKVKRILRVYQKCD 348
Q4Y2N2                   477 THMC-YYIPYLK-QYYSTKIc--------------------------------------------SNKIKRIFRAYQKCD 510 Pla...
CAR30291                 547 NNAVsdngksfnnstltfikwsndqpsleGLPSGEPINVLCLAW------------LTPTFELLLIC--NNGVSdRNTAL 612 Lac...
EAY08115                 432 KSCDmvetn----------------avdgEYMFRDEKE-VIVVY------------KCSTHEIYAVA--NSADLkDSELS 480 Tri...
EGC34692                 428 THVNsniia----------------nkphKYYYHTSQTETIMVA------------TSNNHELYATF--SPLET-KKSIF 476 Dic...
EGG22516                 469 DRVNnscs------------------kphKYFYHTSRYETVIVA------------VSSTHEIYATF--SPLET-KQTVF 515 Cav...
A0DT76                   363 Gelykd-------------------fmisQSLGNSDAKQNYFVWdsk------gfgITQYHDVVILFcfNELIE-FQQMV 416 Par...
WGS:AAFB:cds.EHI_197260A 373 IGLT-----------------------------KEKLKQEMFVFddei----ivtvENNTHYAFITF--SKFQEnKVKMM 417 Ent...
WGS:AAFB:cds.EHI_010680A 374 DEMK---------------------------------NQNLKEYcskggvdciyatLRSDYFFCGTF--NILLE-RDEVI 417 Ent...
Q8IDH2                   815 DIMKdcklptqiyi--------------------------------eseyekfyciKTNLYHLYLSV--PFYVI---IND 857 Pla...
3_pfamImport             349 DILRdsklpaqiyl--------------------------------eaeyekfyciKTNLYHLYLSV--PFHVE---VND 391
Q4Y2N2                   511 DIIKdsklpaqiym--------------------------------eteyenfyfiKTNLYYLYLSV--PFYVN---INE 553 Pla...
CAR30291                 613 KSAKNIVDWCRKNEHRLFVSNGAI 636 Lachancea thermotolerans CBS 6340
EAY08115                 481 AKLQELKNFINAHFNELIIVESkf 504 Trichomonas vaginalis G3
EGC34692                 477 ESFSNLLLWIKNQENSLFIQ---- 496 Dictyostelium purpureum
EGG22516                 516 ESFSFLLQWIKDNESSLFLq---- 535 Cavenderia fasciculata
A0DT76                   417 QNVHILQRMFRTEELGYYfvlkqs 440 Paramecium tetraurelia
WGS:AAFB:cds.EHI_197260A 418 KTATAVLSWAIK-EDSLWIKKFAQ 440 Entamoeba histolytica HM-1:IMSS
WGS:AAFB:cds.EHI_010680A 418 NRGNKIISLVRSKLDTLFITptkk 441 Entamoeba histolytica HM-1:IMSS
Q8IDH2                   858 ENINEILKVIATYHKEIFINnikq 881 Plasmodium falciparum 3D7
3_pfamImport             392 DNINEILKVISAHHKEIFINN--- 412
Q4Y2N2                   554 ESINEILKVIAKYHKEIFINNikq 577 Plasmodium chabaudi
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