1NIJ


Conserved Protein Domain Family
CobW_C

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pfam07683: CobW_C 
Cobalamin synthesis protein cobW C-terminal domain
This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.
Statistics
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PSSM-Id: 462228
Aligned: 151 rows
Threshold Bit Score: 37.2178
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NIJ_A       224 ISSIVVELDYPVDI----SEVSRVMENlllesaDKLLRYKGMLWIDGEpnRLLFQGVQRLYSADwdr-----pwGDEKPH 294
Q7V1S7       247 LVSDSVKLNYFLDKkefeKEIANVLSE------IDILRIKGRIWIPKKslPLQIQIVGKKINTWyeeaplncwrPIDSGG 320 Prochlorococcus...
Q7V818       271 MVSGVVRFEGSVDRatveALLPELATL------HQVVRLKGRLWLPGKalPLQLQMVGPRLSSWfeaap-knawHPEEAG 343 Prochlorococcus...
Q7NPD2       243 IRALSVRLEGPQDP----DRLVAALQRlv--rsDEIYRVKGFVHAAGKplRLVIQGVGHRFERYfdrp----wgkDETRR 312 Gloeobacter vio...
Q31Q10       254 IAAVHLNLDAEWQP----EALAERLQAlq--qsQTLYRVKGFLAVPGKsmRLVFQGVGPRFDWFydrp----wrsPEERR 323 Synechococcus e...
WP_011851604 259 FDSVVVEA-RVSSR----EAALGALGAlv--eaHAIYRVKGFAALPGVpmRLVVQGVGRRFDSYfdrr----wrdGEAPA 327 Burkholderia ps...
Q0FSM4       253 FDSIAVEIPELSDP----AALVRAIEGla--reHNILRVKGYAAVAGKpmRLLVQAVGARVRHQfdrp----wgaGEARH 322 Salipiger bermu...
Q2S880       264 FDSCVITLGAV-DS----DKLLAITRDli--saNTIYRVKGFVANGDKpmRQVVQAVGDRIAHYfdrl----wgaDEDRK 332 Hahella chejuen...
WP_006033157 266 FDSFVLKFGEV-DG----PRLQQILTQll--teHNIFRAKGFAALPGKpmRQVLQAVGERLDVHfdrm----wnsDEVRQ 334 Moritella sp. PE36
WP_006012996 256 FESFVVEAGSVADP----KAFAEKLKAvi--aeHDILRLKGFVDVSGKpmRLVVQAVGPRIEHYfdrp----wgkDETRS 325 Brucella ovis
1NIJ_A       295 STMVFIg--iQLP---EEEIRAAFAGLR 317
Q7V1S7       321 LELVII----SFD---SESINKFIKKIK 341 Prochlorococcus marinus subsp. pastoris str. CCMP1986
Q7V818       344 VDLVVL----SFEkqaAEAIRFDLESSL 367 Prochlorococcus marinus str. MIT 9313
Q7NPD2       313 TDLVIIg--kDLE---AETIGRALAEGA 335 Gloeobacter violaceus
Q31Q10       324 SQLVVIg--eDLN---AEVLQSALNSVA 346 Synechococcus elongatus PCC 7942
WP_011851604 328 SRFVLIg--eDLD---AAALQRAFDAAL 350 Burkholderia pseudomallei
Q0FSM4       323 GRLVVIaehdDIR---RDVIEAALGAAR 347 Salipiger bermudensis HTCC2601
Q2S880       333 TRLVFIg--qGID---ASALRDTLSAAE 355 Hahella chejuensis KCTC 2396
WP_006033157 335 TQLVVIg--kNLD---RNVLESALQQAV 357 Moritella sp. PE36
WP_006012996 326 TRLVVIgl-hDID---EAAIAQAVKDAA 349 Brucella ovis
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