Conserved Protein Domain Family
PHA03144

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PHA03144: PHA03144 
helicase-primase primase subunit; Provisional
Statistics
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PSSM-Id: 223000
Aligned: 12 rows
Threshold Bit Score: 649.11
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
270339491  24 TPIDDIKWTHGYVCAASLYSLWID---HDKLNALVYLICNEDGE--YTARFTVVSVSENQL-IwGSRECPYITIRKAAAA 97 
83722576    2 GEEDGLAWAEESVCAVTLYAAWLPprtRDRLHALLYLLCRDARGd-AVARFAEVSVASSEL-Q-AFYGPSEISAAGAVAA 78 
56694730    1 MGEDGLAWAEESVCAVTLYAAWLPprtRDRLHALLYLLCRDARGd-AVARFAEVAVASSEL-Q-AFYGPGEISAAGAVAA 77 
9629277     1 MEAPGIVWVEESVSAITLYAVWLPprtRDCLHALLYLVCRDAAGe-ARARFAEVSVGSSDL-Q-DFYGSPDVSAPGAVAA 77 
9629388     1 MDTADIVWVEESVSAITLYAVWLPpraREYFHALVYFVCRNAAGe-GRARFAEVSVTATEL-R-DFYGSADVSVQAVVAA 77 
30984436    1 MGDAGLVWAEESICAITLYTAWLPprtRDRLHVLLYLFCRDARGd-GAARFAEVSIASTEL-Q-AFYGPAEISAAGAVAA 77 
9629867     1 ---MPVSHSNGCVCGVSLYSAWAAg--PDRARVLLALLCRMDDGg-CDAKFALVNVCARGV-TaLARGARDVTAARLEDL 73 
9629782     1 -MGENVEWFNGYVCATSIYSLWTDphqPGNLQALVYLLCRRVDN--YTAEFCHVVVSGELL-RhGARNPSLVTPARVASA 76 
51557534    1 ----MTAAAGERVCAAGIYTAWTEpgaPGELHALAHLLCRDGAGa-YAARFVHVTAAPWTG----------------SAA 59 
126801893   1 -MEGSVEWFNGHVCATSIYSLWTDphhPGHLQALVYMLCRRGSD--YTAEFCHVPVSGELL-KrGARDASLVTPARVASA 76 
216905907   1 -MEGSVEWFNGHVCATSIYSLWTDphhPGHLQALVYMLCRRGSD--YTAEFCHVAVSGELL-KrGARDASLVTPARVASA 76 
255683151  11 GTKEQFTSIDGYICSTSIYTLWTRpgsKNVLSVLSYILFRNIKNsrYEAHFTTVDINLNAMeEtSLAEEAALTTTWAMTA 90 
270339491  98 AGEAAAPNIWPLGALGQTVLWKAIYSSVMAVLKRSFKGFSFYSRVAFCMNIKTGMTVDIQPILNDKRtnsle-----pea 172
83722576   79 ARAAASPAAAPLETLNDPALWRALYASALAALEREVGRAPLFAPARVGRDPRTGLVARIEAAPGGRA------------- 145
56694730   78 ARAAASPAAAPLETLNDPALWRALYASALAALEREVGGAPLFVPARVGRDPRTGLVARIEAAPGGRP------------- 144
9629277    78 ARAATAPAASPLEPLGDPTLWRALYACVLAALERQTGRWALFVPLRLGWDPQTGLVVRVERASWGPP------------- 144
9629388    78 ARAATTPAASPLEPLENPTLWRALYACVLAALERQTGPVALFAPLRIGSDPRTGLVVKVERASWGPP------------- 144
30984436   78 ARAAASPAAAPLETLNDPVLWRALYACALVALEREVGRAALFAPARVAWDPRTGLVARIEGLPDGRS------------- 144
9629867    74 ARAAAAPRALPLATLGHAATWKALYVSALAALRAQIGPFRFYRETRFGVDNDTGLLVSAEEPPDAAD------------- 140
9629782    77 AKTAAVPGCWPLAPLGDAMLWKSVYGSVASALKLTLGSFAFYKPMMFGVNTQTGLLVTIKPAASEGVrgg---------d 147
51557534   60 AVAAALRDASGTGALADPALWRGAHGAVMAALRRALPALAFYEPLRFETDPATNLVTAATPAGGGGEeettgeggeeded 139
126801893  77 AQTAAVPGCWPLAPLGNAMLWKSVYGGITAALKRAVGSFAFYQPLVLGINTQTGLLVTLRPAASAGEggg---------d 147
216905907  77 AQTAAVPGCWPLAPLGNAMLWKSVYGGITAALKRAVGSFAFYQPLVLGINTQTGLLVTLRPAATAGEggg---------g 147
255683151  91 CRDTSRPGAWPMSSMANVGNWKRLSCLVSAHVRTKLRYMSFYSPVRLKVDSNTGLVIYTEPINLTSVp------------ 158
270339491 173 nPVPVPAILNVTAKVDLDPGAIKANSMNTE--GGGLARARLCTLRDgyfSQSMEEDI----SMDVEVITKRHTFRRRY-D 245
83722576  146 -PAPRGAALSVDAKVATDPLALAAHVAARP--GARLAWARLAAIQD---TPQCASAA----SLTVRIDTGAARFAREY-T 214
56694730  145 -VAPRGAALGVDAQVATDPLALAAHVAARP--AARLAWARLAAIQD---TPQCASAA----SLAVRIDTGTARFAREY-T 213
9629277   145 -AAPRAALLDVEAKVDVDPLALSARVAEHP--GARLAWARLAAIRD---SPQCASSA----SLAVTITTRTARFAREY-T 213
9629388   145 -AAPRAALLVAEANIDIDPMALAARVAEHP--DARLAWARLAAIRD---TPQCASAA----SLTVNITTGTALFAREY-Q 213
30984436  145 -PAPRAAALDVNAQIATDPLALAAHVAARP--DARLAWARLAAIQD---TPQCASAA----SLTVRIDTGAARFAREY-T 213
9629867   141 -AAPRAAVLRSALRLAVEEDAVRAAAAAAPagGGSLARARLCAMRDghaDLSAPGNV-----VEFELTTKTARFYRIF-A 213
9629782   148 pVSPRAALVNASVEVDLDPTGIEASAASVT--GSSLARARLCALKDgyfLT--KQDI----ALEVEITTKEVSFYRKY-D 218
51557534  140 eAGPRAGIIHVDADVVVDRDAARAHAT-----EAWLPHAQLRAMAGc-------------aALSVEITTRRTSFARAY-A 200
126801893 148 hVSPRAAIVNVSVEVDLDPAGIEASAASST--GSSLARARLCTLRDgyfLS--KRDI----ALEVEIATKEVSFYRKY-D 218
216905907 148 yVSPRAAIVNVSVDVDLDPAGIEASAASST--GSSLARARLCTLRDgyfLS--KRDI----ALEVEIATKDVSFYRKY-D 218
255683151 159 -IEPKVGILTATACLPIDNAAVVAQIRSSA--GPSLAKARMAAAFKldmTKSHHRPNdhiySLEVSISTKNAKYSRRYsD 235
270339491 246 SIQRPAVKQTGDFKDLFKIIDSRLVLQS--KTVMVRVLIPRYFDCFLVCSSTFSIISIMTLYKQWRETMFSntgelgSIP 323
83722576  215 TLTFPPVRKEGAVGDVFEVREAVLRPRGhaQAVTARVLVPRGYEYFAVPAEGFSAPALVALFRQWHLTVHA------APG 288
56694730  214 TLTFPPVRKEGAVGDVFEVREAVLRPRGhaQAVTARVLVPRGYEYFAVRAEGFSAPALVALFRQWHLTVHA------APG 287
9629277   214 TLAFPPTRKEGAFADLVEVCEVGLRPRGhpQRVTARVLLPRGYDYFVSAGDGFSAPALVALFRQWHTTVHA------APG 287
9629388   214 TLAFPPIKKEGAFGDLVEVCEVGLRPRGhpQRVTARVLLPRDYDYFVSAGEKFSAPALVALFRQWHTTVHA------APG 287
30984436  214 TLTFPPVRREGAVADVFEVREAVLRPRGhaQAVTARVLVPRGYEYFAVGAEGFSAPALIAMFRQWYLTVHA------GPG 287
9629867   214 DIAQPPRKRAGRLADVFAHREYRVRTEGsaAPVVVRALVPVNFDCVVADARAFSPMAAMLVFAQWHAALFT--------D 285
9629782   219 SVQQPANKRRGDMVDLFIVHERTLRLMGs-KHMSVKVLVPRTFDCFVASSQALSGLAAMALYKQWHATLFSl----eRSE 293
51557534  201 EAGAPPLKRRGEMSDPFDVRETVLRPAG--RRVAARVLVPRGFDCLV--AHGVSNAALVALYRRWHAAAYG------AGD 270
126801893 219 SVQQPANKRRGDMADLFVVHERTLLLGGc-KRMGVKVLLPRTFDCLVASSQSVSGLAAMALYKQWHATLFSv----eLPD 293
216905907 219 SVQQPANKRRGDMADLFVVHERTLLLGGc-KRMGVKVLLPRTFDCLVASSQAVSGLAAMALYKQWHATLFSv----eRPE 293
255683151 236 DVYAPPAKSSCSGDSMFEIIDRTLFLDG--REISIRVLLPNGFDCLVACADGFSALSVLAVYRHWHETIYDm----rKSC 309
270339491 324 ILLPIFAYIGPELSPTGEDRDYSCMLGFPGIPLIKVASPDVEA---VREAI-----DVYVSTDGMWPAMGMLAFHLLAPW 395
83722576  289 ALAPIFAFLGPEFEPRGGAVDHFAVLGFPGWPTLKVPAGAAAV---PAAAL-----AAHAELAGAWPAAGARALAPARLW 360
56694730  288 ALPPIFAFLGPEFEPRGGAVDHFAVLGFPGWPTLKVPAGAAAV---PAAAL-----TAHAELAGAWPAAGARALAPARLW 359
9629277   288 ALAPVFAFLGPGFEVRGGPVQYFAVLGFPGWPTFTVPAAAAAE---SARDLvrgaaATHAACLGAWPAVGARVVLPPRAW 364
9629388   288 ALAPVFAFLGPEFEVRGGPVPYFAVLGFPGWPTFTVPATAESArdlVRGAA-----AAYAALLGAWPAVGARVVLPPRAW 362
30984436  288 ALPPIFAFLGPEFEPRGGAVDHFSVLGFPGWATLKVSGGAAAA---PPAAL-----AAHAELAGAWPAAGARALGPARAW 359
9629867   286 GPAQVLGFLGPQLNPGGEERDYCFLLGFPGVPLV-VSAADAGA---VRDDL-----DAHVLTDGLWPAFGVHVYHALGPW 356
9629782   294 TVVQIFAYLGPELNPCGEDADYCCFVGFPGLPTLKAGLNTADA---VREAL-----DAYKLSDGLWPALGMSAFHFLHPW 365
51557534  271 ATPPVFAFLGPELAREGADEDYYCALGFPLFATIKVAAAAPEA---VRGAL-----AAHRLTDGLWPALGFRAFHALGPV 342
126801893 294 TVVQIFAYLGPELNPCGEEVDYCCFVGFPGLPTLKASSSTTEA---VRDAM-----AAYRLSDGLWPALGMSAFHFLAPW 365
216905907 294 TVVQIFAYLGPELNPCGEEADYCCFVGFPGLPTLKASSSTTEA---VRDAM-----AAYRLSDGLWPALGMSAFHFLAPW 365
255683151 310 AIVPIFAYVGPELYGRGEEHDYFFTVGFPGWPTLKAKASEDG----IKETV-----STYVDLDGLWPMSGGMALHLLAPW 380
270339491 396 DPTTDDVKRSHTTRLIhlesklt--kdqddkWPAGRISSILDHPIAMKGLWLAKFDFSAFFPSLYLAI---------FPE 464
83722576  361 SAAAAAAPGRLPPALR---------------RPATPGLRLLDPPAVIGPVCLARFRFPGLGARLAAALggl---glgPGA 422
56694730  360 AAAAAGAPGRLSPALR---------------RPATPGLRLLDPPAVIGPVCLARFRFPGLEARLAAALcgl---glePRA 421
9629277   365 PAVASEAAGRLLPAFReav---------arwHPTATTIQLLDPPAAVGPVWTARFCFSGLQAQLLAALag--------lg 427
9629388   363 PGVASAAAGCLLPAVReav---------arwHPATKIIQLLDPPAAVGPVWTARFCFPGLRAQLLAALad--------lg 425
30984436  360 AAVSAAAAERLPPALR---------------RPAAAGLRLLDPPAVIGPVCLARFRFPGLQPRLLAALyelglrgdpRAA 424
9629867   357 NFLDGAAVASLNRRIAaaraalppggsdgsdWPAGRVSTILNSPACVRGLWLAKFDFSAFFPTLYAHL---------VPE 427
9629782   366 EPEDKWPGETAAKRLEsvapilq--iesadvWGAGRVTCILESDAVMQGPWFAKFDFSAFFPTLYLLL---------FPT 434
51557534  343 SCGLRLRCDV---------------------WPAGRATSAVEHPCALRGAWLAKFDFAAFFPNLFLAL---------CPG 392
126801893 366 DPEDRWPGESEAKRVEgavhrlq--lgteddWGAGRVSCILESDAVMQGPWFAKFDFSAFFPTLYLLL---------FPA 434
216905907 366 EPEDRWPGESAAKRVDgvahrlq--lspedgWGAGRVSCILESDAVMQGPWFAKFDFSAFFPTLYLLL---------FPT 434
255683151 381 APEKRPGNDFGTDVVDvlanakm--nalrekWPAGRMTCVLPHGTFIDGAHVVQMDFSAFTPSLYLTL---------YPS 449
270339491 465 HTRLAQIISAR----------IRREKGGLKAALVSLFGGLQHIQPLAYRVIIGLANGISRHLERLLNNEQFGICTYIKDG 534
83722576  423 DPRDPLARGARrwr-----alAEDGRPWARAVAARALAEAREECPAFARILDGVVSAVGLRLERAAGDADLAVCGNEGAS 497
56694730  422 DPRDPLARGARcwr-----alAADARPWARAVAALALAEAREECPAFARVLDGVVAAVGLRLEAAAGDVDLAVCGNEGAS 496
9629277   428 EAGLPEARGRAglerldalvaAAPSEPWARAVLERLVPDACDACPALRQLLGGVMAAVCLQIEQTASSVKFAVCGGTGAA 507
9629388   426 GSGLADPHGRTglarldalvvAAPSEPWAGAVLERLVPDTCNACPALRQLLGGVMAAVCLQIEETASSVKFAVCGGDGGA 505
30984436  425 DPRDPLGRGARrwrdlaggegAAEQAPWPREVLALATDEVRREYPAVARTLDGIVSAVGVGLEKAAGAVDMAVCGDGGGR 504
9629867   428 HARLARAICAR-----------RDGRPGLKPSLLTFFGGLRHVHAPAYEAVIALANAVAAAVERAANARNFAVCTYVKDG 496
9629782   435 NERLAQVVIKR----------ARGQNPALKPALVSFFGGLQHINPMAYRLIIAISNEISRRLEHEVNQMGFAICTYVKDG 504
51557534  393 HERLRRAVRAR----------------AVKPALVAFFGGLKHTCPEAYHSVIALANGVSRAVEAAAAEAGLVTCAYVKDG 456
126801893 435 NERLAEVVRLR----------ARGQHPTLKLALVSFFGGLQHINPVAYRSIIALSNGISKRLEHEVNQRGFAICTYVKDG 504
216905907 435 NERLAEVVRLR----------ARGHHPTLKLALVSFFGGLQHINPVAYRSIIALANGISKRLEHEVNQKGFAICTYVKDG 504
255683151 450 HKRLEHAVRAR----------HKREKPWLKKALVEFCGMLKHTHPEALDATIAISNAISEAIEETATANGLAICTYIKDG 519
270339491 535 FWGVFGSLTQETTSladvEIAAENIRNTCQMAAIKYLEDMGLVLPEGTNLHLRL-EGIYTDVMSWTTNSYWLWNRE---T 610
83722576  498 LWGVLNVDPLDAAG----PAAVERARAALETAAGEALAGGGLLGAEEAPPPLEL-EGTYTHAVLWSQTGAWFWNAR---T 569
56694730  497 LWGVLNVDPQGAAG----PAAVERARAALEGVAGEALAGGGLLRPEEPPPSLEL-EGIYTHAVLWSQTGAWFWNAR---T 568
9629277   508 FWGLFNVDPGDADAa---HGAIQDARRALEASVRAVLSANGI--RPRLAPSLAP-EGVYTHVVTWSQTGAWFWNSR---D 578
9629388   506 FWGVFNVDPQDADAa---SGVIEDARRAIETAVGAVLRANAV--RLRHPLCLAL-EGVYTHAVAWSQAGVWFWNSR---D 576
30984436  505 VWGVLNVDPRDAAGagaaAAAAERARAALAASASEALAGWGL--RLDAPPPLVL-EGTYTHAVLWSQTGAWFWNSD---T 578
9629867   497 FWGAFGDAAPEVVPreaaLAAALALRDDCQRAAEAVLRAAGLHPAEGAELHLRF-EGLFTHAVSWSANKYWLWDATaggA 575
9629782   505 FWGAAGNMLVDSVSysdaLVYAEALRSAAQGAALSYVSELGLSLPDGVDLRLRL-EGLFTDAISWSTHCYWLYNRI---T 580
51557534  457 FWGVLGDVPAAAPEaa-aAAAAERVRVACEAAAARHLADAG---AAATDVTLRC-EGVFDAALAWSCHAYWLRRR----E 527
126801893 505 FWGAAGNLPSDSVSyadaLVYAEELRSAAQKAALGHVSEMGFSLPEGVHLNLRL-EGLFTDAISWSTHCYWLYNRF---T 580
216905907 505 FWGAAGNMPADSVSyadaLVYAEELRSAAQNAALGHVSEMGFSLPEGVHLNLRL-EGLFTDAISWSTHCYWLYNRF---T 580
255683151 520 FWGVLPKENNQRPN-----DDIVNICALCQKAAENVLHDLHLLRPTGPGIKLRVeEGTYTHAMSLGMHHYWLGGVD---S 591
270339491 611 DMEAFVGFPTR----SAICRAMKNRLSMLLrmsARMGCYADLEALLSKAREMCDELLELSYMKRWDFEFWSVPMNIENRH 686
83722576  570 DADLLEGFPLRgpayAAAAAATRRALRGVV---AAAAEGGAAEKARLAAEEALDGLVLEAFARRLDAEYWAVAEGPSDPG 646
56694730  569 DADRLEGFPQRgpayAAAAAATRRALRGAV---AAYAEGAGAEKARLAAEEALDGLVLEAFARRLDAEYWAVAEGPSDPG 645
9629277   579 DTDFLQGFPLRgaayAAAAEVMRDALRRILrrpAAGPPEEAVCAARGVMEDACDRFVLDAFGRRLDAEYWSVLTPPGEAD 658
9629388   577 NTDHLGGFPLRgpayTTAAGVVRDTLRRVLgltTACVPEEDALTARGLMEDACDRLILDAFNKRLDAEYWSVRVSPFEAS 656
30984436  579 DEDRLEGFPLRgpayAAAAAVARRALRAVVa--AGSEGGAGAEEALRIAHDACDRLVMEAFERRLDAEYWGVAETPSDRG 656
9629867   576 EGELFVGFPCR----TEFGRMAKRSLAGLLr--RAVAQPERPSDTVAAAAAACDALVHAAFERRGDVRFWSATAPIAD-W 648
9629782   581 NIEDFVGFPTK----SEASRAAKASLSALLprvAAVADSGDLDMLHQLVKESCEQLVAEAFAKRNDPKFWSTKTEIDS-S 655
51557534  528 GPADFVGFPSR----SGFGRAAKAALDALLr--EAVEGRADAE----AARAACDGLVERAFASRHDPDFWAAPGDALAPA 597
126801893 581 KMEDFVGFPAK----SGAGRAAKASLSALLplvAAVCDSSDMSTLHQSVRGACEQLVAGAFAERNNPQFWSTRTGIES-S 655
216905907 581 KTEDFVGFPAK----SGAGRAAKASLSGLLplvASVCDSSDLSTLHQSVRGACEQLVAVAFAERNNPQFWSTRTGIES-S 655
255683151 592 EDYKLVGFPIR----NTFSENVAKTVATLL---SCVAANSNYRILYPLFKEAFDRLITTAFENRNDSTFWSVDVPISD-- 662
270339491 687 NKLPNAIYCGGSVLDRDHRPRECVPVKNHDHE-VIQIPWKLYPHPAIIPQIDCYSKLEPLFGKFSTMLNRSIEAYY---- 761
83722576  647 DAPPAAALRGGALLDSERHSRRVVRVCGGADGgSVAVPIDLYPRPLVLPPIDCAHHLRDVLAEAEAVLRGALAGLW---- 722
56694730  646 DTPPAAALRGGALLDSERHSRRVVRVCGGPDGgSVAVPIDLYPRPLVLPPIDCAHHLRDVLAEAEAVLRGALAGLW---- 721
9629277   659 DPLPQTAFRGGALLDAEQYWRRVVRVCPGGGE-SVGVPVDLYPRPLVLPPVDCAHHLREILREIQLVFTGVLEGVW---- 733
9629388   657 DPLPPTAFRGGALLDAEHYWRRVVRVCPGGGE-SVGVPVDLYPRPLVLPPVDCAHHLREILREIELVFTGVLAGVW---- 731
30984436  657 DPLPTAAFRGGALLDAERYERRVVRVCGGPDGgSVSVPIDLYPRPLVLPPIDCAHHLREVLAEMEAVFRGALTGLW---- 732
9629867   649 GAVPRSALSGGDLLDADHGPRPYVLVAGHEAA-PFPLPWALYRSPVLLPDIACRAHMAPVLQELARMLNGALAALAareg 727
9629782   656 TQLPTAVYRSGCLLDQDRGQRDIVLTRRSDCEsALPVPWMLFPPPLVLGRIDCMVYLTSIFKTYLGMLNRAISALC---- 731
51557534  598 ACAGATAGRGGA-----RCSRRCVRLRG-----AGPVPYEQLRPPLILPWIDCLAHMEPIFAALVGMYNRALEALSa--- 664
126801893 656 TLLPPAVYRNGSLLDRDCGQREIVLTRKHDCEsPSPVPWTLFPPPLVLGRIDCMVYLTSIFKTYLSMLNRAISASC---- 731
216905907 656 TLLPPAVYRNGSLLDRDCVQREIVLTLRHDCGsPSPVPWTLFPPPLVLGRIDCMVYLTSIFKTYLSMLNRAISASC---- 731
255683151 663 EPIPSGAFSYNDHMDMDHGRRRVVEVKTFSE--PVTIPCSLLPGPMIVPGIMCLKYIRPALNSACSILSHAVSSKW---- 736
270339491 762 DTSETKpvfSYPISE-YTFLFS 782
83722576  723 GDEGGF---AYPFEErFLFLFD 741
56694730  722 GEDGGF---AYPFEErFLFLFD 740
9629277   734 GEGGSF---VYPFDEkIRFLFP 752
9629388   732 GEGGKF---VYPFDDkMSFLFA 750
30984436  733 GEGCGF---AYPFEErSLFMFD 751
9629867   728 DDEPPIeefEYNLAD-FDFLFA 748
9629782   732 DADKPVn-vEFQITD-YAFLFT 751
51557534  665 GDAPPPfvfTYTPDA---FLFG 683
126801893 732 DADESMn-vDFPISD-YAFLFT 751
216905907 732 DADESMn-vEFPISD-YAFLFT 751
255683151 737 -CNEDVeafTYDVEQ-FEPLFA 756
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