Conserved Protein Domain Family
TRF4

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COG5260: TRF4 
DNA polymerase sigma [Replication, recombination and repair]
Statistics
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PSSM-Id: 227585
Aligned: 9 rows
Threshold Bit Score: 378.346
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3219960   315 INRISKLGKMITSNHAEEKLTTIPITEAKkesvsntALIARKNIIRERKYLSrmfd-----ifehIDSYFNHEINMLLVD 389  fission yeast
19074403    1 MIFSFGFYPHINFTVKMSAKPIREVKTKIn------PKDSKSVSIESLLETS-------------MSSVSLGNLARLDLE 61   Encephalitozoon c...
11182453  103 SNDKSKNNESLKKSSKNEIPGFMRQRGRFfhe-aneKSDSNRKRKRQAYELDsqsc-----pwhrQYKVEREVSRIFHQD 176  fission yeast
15213942    1 MNISSAQFIPGVHTVEEIEAEIHKNLHIS-----------KSCSYQKVPNSH---------------K-------EFTKF 47   fission yeast
19114069    1 -------MDNANCVGGCKFETRSFQYRRRi------PYSLGADPLPPVHPLS-------------LKNLVDIDTDLISSQ 54   fission yeast
19112002    1 --------MELLTFTCCPFEGQMQQKKRR--------FDANLVQLQESEHRN--------------DQINETVDAELTNE 50   fission yeast
19075773    1 -------------------------------------------MGKVLLELH--------------SVPWNEEGLSDNAR 23   fission yeast
1353104   100 SLEDNQDFIAFSDSSEDETEQIKEDDDERssflltdEHEVSKLTSQQSLNTEsacnveypwirnhCHSKQRRIADWLTSE 179  baker's yeast
1717744   116 DLANNDDFISLSASSEDEQAEQEEEREKQ-------ELEIKKEKQKEILNTDypwi------lnhDHSKQKEISDWLTFE 182  baker's yeast
3219960   390 LLLEPLQVAFVYKNLARRWISLEEIENLWLKVFDSShpLGKSITSTLQAIGTRKILTQLSINMIPRYNQDNCSAG-DIYI 468  fission yeast
19074403   62 LLQLYQKLAPTTIEINARIYIFEKIKKLIVREFPSA--SVMPFGSYTTGLIVPSSDIDINVQLSDNIDKEHVNKHlSKIK 139  Encephalitozoon c...
11182453  177 ILHFIDYITPTPEEHAVRKTLVSRINQAVLQKWPDV--SLYVFGSFETKLYLPTSDLDLVIISPEHHYRGTKKDMfVLAH 254  fission yeast
15213942   48 CYEVYNEIKISDKEFKEKRAALDTLRLCLKRISPDA--ELVAFGSLESGLALKNSDMDLCVLMDSRVQSDTIA----LQF 121  fission yeast
19114069   55 LYELYDSIILNDSGLERRYAFVQKLEQILKKEFPYKniKTSLFGSTQSLLASNASDIDLCIITDPPQCAPTTC----EVS 130  fission yeast
19112002   51 CWKLYMRLKPSNEEVSRRQQFVDKLRTILSTEIKDAklDLFVFGSTENNLAIQQSDVDVCIITNGSKYLNSTC----QLA 126  fission yeast
19075773   24 LYSFLEFVSPKIEELKYRKLLLEKLQTHIREVVLDA--ELQVYGSMYIGTTLSISDVDVSLKSPRVGELEKRR-----VT 96   fission yeast
1353104   180 IKDFVHYISPSKNEIKCRNRTIDKLRRAVKELWSDA--DLHVFGSFATDLYLPGSDIDCVVNS-RNRDKEDRNYIyELAR 256  baker's yeast
1717744   183 IKDFVAYISPSREEIEIRNQTISTIREAVKQLWPDA--DLHVFGSYSTDLYLPGSDIDCVVTS-ELGGKESRNNLySLAS 259  baker's yeast
3219960   469 LCFSENCWLYSVLQKTIDhwvNENVELFYKkfeilKSLLIEDIANSTFSKEVSLNSSLRWYCVAILVTPLQLIINHLKDK 548  fission yeast
19074403  140 TLMFRANFVKKETVFHIKkcrIPILKFRDG-----IFGFRIDISVNQANGVNAAKFITYTLKEYPYIKVFAILLKHFLTI 214  Encephalitozoon c...
11182453  255 HLKKLKLASEVQVITTAN---VPIIKFVDP-----LTKVHVDISFNQPGGLKTCLVVNGFMKKYPALRPLVIIIKHFLNM 326  fission yeast
15213942  122 YEELIAEGFEGKFLQRAR---IPIIKLTSDtkngfGASFQCDIGFNNRLAIHNTLLLSSYTKLDARLKPMVLLVKHWAKR 198  fission yeast
19114069  131 AAFARNGLKKVVCISTAK---VPIVKVWDS-----ELQLSCDCNINKTISTLNTRLMRSYVLCDPRVRPLIVMIKYWAKR 202  fission yeast
19112002  127 QLLYSYGMKQIVCVSRAR---VPIVKIWDP-----QFDIHCDLNINNDVAKINTKMLRLFVSIDPRVRPLGLIIKYWAKQ 198  fission yeast
19075773   97 MVLRKYLDADADFHSSAR---VPRINLVD------VSGIGVDLTFGNDKACRTAELQKAYNEEHPIFGRLLMLLKHWLFE 167  fission yeast
1353104   257 HLKNKGLAIRMEVIVKTR---VPIIKFIEP-----QSQLHIDVSFERTNGLEAAKLIREWLRDSPGLRELVLIIKQFLHS 328  baker's yeast
1717744   260 HLKKKNLATEVEVVAKAR---VPIIKFVEP-----HSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRELVLIVKQFLHA 331  baker's yeast
3219960   549 TEMLSLDaVMTLILGKNTREVNSSIEELKItdc------------------lsFLLEHNIFNTFLVYNEGIVKLNKDFDD 610  fission yeast
19074403  215 RKQSDAA-TGGLNSYSQFLLLLSFFQLHP--------------------------LVQEGLVSPL------KNIGVLFMD 261  Encephalitozoon c...
11182453  327 RALNEVF-LGGLSSYAIVCLVVSFLQLHP--------------------------RLSTGSMREE------DNFGVLLLE 373  fission yeast
15213942  199 KQINSPY-FGTLSSYGYVLMVLYYLIHVIK-----------------------PPVFPNLLLSPLKQEKIVDGFDVGFDD 254  fission yeast
19114069  203 RCLNDAAeGGTLTSYTISCMVINFLQKRDPpilpslqmlphlqdsstmtdgldVSFFDDPDLVHGFGDKNEESLGILFVE 282  fission yeast
19112002  199 RALCDAAgSGTITSYTISCMLVNFLQTRNPpilpamld--------lmsnddnKMFVDDIVGFKEKATLNKTSLGRLLID 270  fission yeast
19075773  168 RDLENVH-HGGIASCALSYMLIGWLEMR---------------------------FHKKGIDSEV------QPIRALLQK 213  fission yeast
1353104   329 RRLNNVH-TGGLGGFTVICLVYSFLNMHP--------------------------RIKSNDIDVL------DNLGVLLID 375  baker's yeast
1717744   332 RRLNNVH-TGGLGGFSIICLVFSFLHMHP--------------------------RIITNEIDPK------DNLGVLLIE 378  baker's yeast
3219960   611 FTPLnLLKCVNYSLMEFQKNSTfDMLEKLYEiGREIDMSKfStLKYNLQLPN-VDLLKESEAVSETKNTKNNTFILkSDL 689  fission yeast
19074403  262 FFQY-YGCDFPYKVAKISINKT-----------GYVKNNA---GMLSIEDPT--NPECDVAAVCRNSGLVLGIFSH-AFK 323  Encephalitozoon c...
11182453  374 FLEL-YGKQFYYDAVGIAVHNG-GFYFSKKK-MGWLKPNQ-P-YLLSIQDPV--DFQNDVSKSSRGLLRVKATFAN-GFD 445  fission yeast
15213942  255 KLED-IPPSQNYSSLGSLLHGFfRFYAYKFEpREKVVTFRrPdGYLTKQEKGwTSATEHTGSADQIIKDRYILAIEdPFE 333  fission yeast
19114069  283 FFRF-FGYLFDYEHFVLSIRHG--TFLSKRA-KGWQFQLN---NFLCVEEPFhTSRNLANTADEITMKGIQLEFRR-VFR 354  fission yeast
19112002  271 FFYY-YGFSFNYLDSVVSVRSG--TVLNKQE-KGWAMEVN---NSLCVEEPFnTARNLANTADNPSVKGLQSEFQR-AFR 342  fission yeast
19075773  214 FFYF-WGVEWTYELFVLRPLTG--QIVPKLQ-KGWLNEVQ-P-NLLSIEDPI--DRNNDIGKQSFQISMIKAAFVAsANE 285  fission yeast
1353104   376 FFEL-YGKNFGYDDVAISISDGyASYIPKSC-WRTLEPSRsK-FSLAIQDPG--DPNNNISRGSFNMKDIKKAFAG-AFE 449  baker's yeast
1717744   379 FFEL-YGKNFGYDDVALGSSDGyPVYFPKST-WSAIQPIKnP-FSLAIQDPG--DESNNISRGSFNIRDIKKAFAG-AFD 452  baker's yeast
3219960   690 KEEERLt---------nFTIEEINKHKAIGvalrkLLEEadtssnfsssnnhvldsskhtvssastssrkFIENYKSLES 760  fission yeast
19074403  324 VMSAAL-----------KTKIPSQKSLASL------------------------------------------WFGKEMKE 350  Encephalitozoon c...
11182453  446 LLTSKL-----------YALASRIEREGVNrvkdfPSIL-------------------------------STILSVDEGV 483  fission yeast
15213942  334 ISHNVG-----------RTVSSSGLYRIRG--------E-------------------------------FMAASRLLNS 363  fission yeast
19114069  355 LLAYNCnvddacsqftfPSLTDTSFMDDYVnelqlEIVPgfshgrdssdtsctesppepshfawafdpynATASPYYNQN 434  fission yeast
19112002  343 LMSENN-----------ACERLCKICEEYQ-----FLDI-------------------------------TNEANYGNTN 375  fission yeast
19075773  286 LLSDKT-----------WFSTFAITEDEMF-------LC-------------------------------KQFENVINTK 316  fission yeast
1353104   450 LLVNKC-----------WELNSATFKDRVG-----KSIL-------------------------------GNVIKYRGQK 482  baker's yeast
1717744   453 LLTNRC-----------FELHSATFKDRLG-----KSIL-------------------------------GNVIKYRGKA 485  baker's yeast
3219960   761 IGLTSFVKDNKLKASkeLQKLIeENVFPKNlilfIFRKCVIGIKSFEKLQsyVFTYYCERYPKLILKRVLRFLEEIGFIT 840  fission yeast
19074403  351 ITGKEEVRRIYTKVL--RHRRK---------------------------------------------------------- 370  Encephalitozoon c...
11182453  484 RQHREHMLKCYKNNP--VPLEP-LVEVDAL----ASIDVDKLPLQDVGLQ--YVEDESDSDETDAAKDDLFKVNESIETN 554  fission yeast
15213942  364 RSYPIPYDSLFEEAP--IPPRR-QKKTDEQ----SNKKLLNETDGDNSE------------------------------- 405  fission yeast
19114069  435 INSSIDYSSIYSNDVpaIPPNVpYTFVDPYtyacYINNNSYLPPSYMDFYtwYNSPYPKSSHHFDERHGGDRHEKNLSNS 514  fission yeast
19112002  376 TPFNTAYESFGCNHT--VLPEA-AAYPKPY----YPPQITLSDGGNMNFL--YYIPDESNHQSYENKANRDSDFQGQTSL 446  fission yeast
19075773  317 RSLVEGYDSDTESDE--LQAGG---------------------------------------------------------- 336  fission yeast
1353104   483 RDFNDERDLVQNKAI--IENER-YHKRRTR----IVQEDLFINDTEDLPV--EEIYKLDEPAKKKQKAKKDKREGEIKKS 553  baker's yeast
1717744   486 RDFKDERGLVLNKAI--IENEN-YHKKRSR----IIHDEDFAEDTVTSTA--TATTTDDDYEITNPPAKKAKIE---EK- 552  baker's yeast
3219960   841 SQYPRKLtdtgalflkhpsewgVLQHtfisSNFFENVPCYISLEQSLQNFQNDIRPDTV 899  fission yeast
19074403      -----------------------------------------------------------      Encephalitozoon cuniculi
11182453  555 GHENFQKqa------------lTSTGeqssSNSRANPSKLFNISSDDSEDEVPIIEDTT 601  fission yeast
15213942      -----------------------------------------------------------      fission yeast
19114069  515 RRYSRNK---------------FHKKkqssGPFQYYPDAFSFTPTDNNSPPSNSSSSEV 558  fission yeast
19112002  447 TQGSAPP-----------------------WHYIPCQSWLVWYPSEDASNPASGN---- 478  fission yeast
19075773      -----------------------------------------------------------      fission yeast
1353104   554 AIPSPPPdfgvsrsklkrkvkkTDQGsllhQNNLSIDDLMGLSENDQESDQDQKGRDTL 612  baker's yeast
1717744   553 --PESEPa-------------kRNSG----ETYITVS-----SEDD---DEDGYNPYTL 584  baker's yeast
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