Conserved Protein Domain Family
PH-GRAM_GRAMDC

?
cd13220: PH-GRAM_GRAMDC 
GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
The GRAMDC proteins are membrane proteins. Nothing is known about its function. Members include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, GRAMDC4, and GRAMDC-like proteins. All of the members, except for GRAMDC4 are included in this hierarchy. Each contains a single PH-GRAM domain at their N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.
Statistics
?
PSSM-Id: 275406
Aligned: 73 rows
Threshold Bit Score: 114.14
Created: 3-Feb-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q8IUY3         83 LEEVVLKVCSCALqrDFLLQGRLYISPNWLCFHAslfgkdIKVVIPVVSVQmIKKHKMArl---lPNGLAITTnt-sQKY 158  human
NP_010613     660 PNEKLIVDHSCALsrDILLQGRMYISDAHIGFFSnilgwvSTVFIPFKEIVqIEKKTTAgi---fPNGIVIDTl--hTKY 734  Saccharomyces...
XP_003669091  762 SNEKLITEFTCALskDILLQGKLYISNKHLAFYSnilgwiTTVVISFQEIIqIKKKTTMgi---fPNAIVIDTl--nSRY 836  Naumovozyma d...
EIE91113      137 QTDKLIEVYKCAVqkEILLQGHIYISEHHICFKSnifgwvTNLIINFDEIIsVEKRMTAkl---fPNGIMIDTh--aSRH 211  Rhizopus oryz...
XP_500125     280 EDDFLLDDFSCAYsrEILVQGRMFVSERHICFFAnilgwqTHHVIAFDEIVsLDKKTTAgl---fPNGIVVQTl--hSTY 354  Yarrowia lipo...
XP_003672899  306 EDDNLLDEFNCSLskEFLYQGKLYISESFLCFNSkmltwvAKEMIPFDKIVfFQKTSTAgl---fNNAISIELdn-dTKV 381  Naumovozyma d...
EGA83062      209 KDDRLLDDFNCGLnrELLYQGKLYITETHLCFNSnvlgwiAKVLIAFEDVTfMEKTSAAgl---fPSAISIETk--mGKT 283  Saccharomyces...
XP_449340     139 STDRLIDDFGCLMhkSHTYNGRIYISENHLSFNSsfvdwmNKVTIPLVDIKhIEKTLSSsiggtiTQAITIEGad-dSIY 217  Candida glabr...
EDZ70694      175 PNTRLITDYFCYFhrEFPYQGRIYLSNTHLCFNStvlnwmAKLQIPLNEIKyLDKVTTN------SSAISVETv--tNRY 246  Saccharomyces...
XP_003678350  259 TSDRLLDDFICVLnrEFPYQGSLYISENHVCFNStllgwvAKIEIPLQDIIsLEKTSSNgl---fPGGISIVAknhaMRT 335  Naumovozyma c...
Q8IUY3        159 IFVSLLSRDSVYDLLRRVC 177  human
NP_010613     735 IFASFMSRDATFDLITDVW 753  Saccharomyces cerevisiae S288c
XP_003669091  837 TFASFVQRDTIFKLVTNIW 855  Naumovozyma dairenensis CBS 421
EIE91113      212 IFASFLSRDRAYHQITTLW 230  Rhizopus oryzae RA 99-880
XP_500125     355 IYASFISRDATFAFMNTIW 373  Yarrowia lipolytica CLIB122
XP_003672899  382 QFNGFNSRDYTYDFIKDIW 400  Naumovozyma dairenensis CBS 421
EGA83062      284 LFNGFISRDAAFGLMKEVW 302  Saccharomyces cerevisiae Lalvin QA23
XP_449340     218 VLTGFISTDVTFDILMTVW 236  Candida glabrata CBS 138
EDZ70694      247 TFSGFIARDEVFQLITRVW 265  Saccharomyces cerevisiae AWRI1631
XP_003678350  336 QFNGFVSRDAVFELLILLW 354  Naumovozyma castellii CBS 4309
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap